THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: January 14, 2009 07:00 AM Wednesday; Rod Welch

Millie sunitinib 55 treatments IBC 5th relapse cycle 3 and 6th treatment.

1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
3...Sunitinib Cyclophosmaide Methotrexate Patient History
4...Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
5...Exercise Hiking Maintain Fitness Strengthen Immune System
6...Case Study on Pateint History Exercising


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS J4 0000. ref SDS J1 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS J4 505G, ref SDS J1 505G.
040904 -
040905 - Background pausing treatment on 081219 for a week enabled Millie's
040906 - blood counts to recover, and resumed on 081226 with sunitinib and
040907 - cyclophosphamide. ref SDS G3 505G  On 081230 case study dilemma cancer
040908 - treatmnets cause low blood counts, which prevents getting treatment;
040909 - not getting treatment incerases cancer; UCSF paused treatment for a
040910 - week and prescribed Neupogen to increase blood counts. ref SDS G8 I87N
040911 - On 090108 treatment with sunitinib was continued at full strength, and
040912 - cyclophosphamide was discontinued until blood counts rise above NEUTS
040913 - 1.00, and then cyclophosphamide will be reduced from 7 to 5 days a
040914 - week. ref SDS I2 9V4I
040916 -  ..
040917 - IBC rash and nodules in the breastbone area seems about the same as on
040918 - 090110, ref SDS I8 124N, and after 5 days of treatment with only
040919 - sunitinib, and 20 total treatments with sunitinib since the pause on
040920 - 081218 and resuming on 081226, shown below. ref SDS 0 6C4J
040922 -  ..
040923 - Often on Wednesdays, Millie goes to cancer support group meetings at
040924 - the Wellness Community.
040926 -  ..
040927 - Today, Millie stayed in bed most of the day; she did not go to the gym
040928 - for aerobic exercise; and did not go hiking, per below, ref SDS 0 X64F
040929 - Rising side effects of sunitinib cause fagitue, ref SDS 0 LF8M, muscle
040930 - weakness, ref SDS 0 KL4J, and perpherial neuropathy. ref SDS 0 HY8M
040931 - In the afternoon, Millie went to the mall and walked through the shops
040932 - for exercise.  Millie reported pain in her feet and toes.
040934 -  ..
040935 - NEUTS patient history of neutropenia from chemotherapy everyday with
040936 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
040938 -  ..
040939 - Neupogen treatments prescribed on 090108 by the medical team at UCSF
040940 - for 090109 and 090110, help maintain blood counts to strengthen the
040941 - immunity system, shown in Millie's letter to the medical team on
040942 - 090109. ref SDS I6 UF3Q  On 090110, Millie had the 2nd Neupogen
040943 - treatment at Kaiser. ref SDS I9 P73J
040944 -
040946 -  ..
040947 - Sunitinib Cyclophosmaide Methotrexate Patient History
040948 -
040949 - Follow up ref SDS J4 OE6K, ref SDS J1 OE6K.
040950 -
040952 -        Cycle 1  begin 081128 after 14 treatmenst sunitinib alone
040953 -        Cohort: 3
040955 -         ..
040956 -        Cycle 2 begin 081218 was paused a week and
040957 -        so began on 081226 and without
040958 -        methotrexate............................... ref SDS J4 9I6T
040960 -         ..
040961 -        Cycle 3 began 090109 with only
040962 -        sunitinib.................................. ref SDS J4 6C4J
040964 -        ..
040965 -                                          Cyclophos  Metho
040966 -                               Sunitinib   phamide   trexate
040967 -       Days  Date  Time  Cycle    37.5       50        5
040968 -       =======================================================
040969 -       Follow up ref SDS J4 PA8Y, ref SDS J1 PA8Y.
040970 -
040971 -        1.  081114 0700  Load    37.5         0         0 ... ref SDS 94 OE6K
040972 -        2.  081115 0700  Load    75.0         0         0 ... ref SDS 95 OE6K
040973 -        3.  081116 0700  Load   112.5         0         0 ... ref SDS 96 OE6K
040974 -        4.  081117 0700  Load   150.0         0         0 ... ref SDS 97 OE6K
040975 -        5.  081118 0700  Load   187.5         0         0 ... ref SDS A0 OE6K
040976 -        6.  081119 0700  Load   225.0         0         0 ... ref SDS A2 OE6K
040977 -        7.  081120 0700  Load   263.5         0         0 ... ref SDS A3 OE6K
040978 -        8.  081121 0700  Load   301.0         0         0 ... ref SDS A4 OE6K
040979 -        9.  081122 0700  Load   338.5         0         0 ... ref SDS A5 OE6K
040980 -       10.  081123 0700  Load   376.0         0         0 ... ref SDS A6 OE6K
040981 -       11.  081124 0700  Load   413.5         0         0 ... ref SDS A7 OE6K
040982 -       12.  081125 0700  Load   451.0         0         0 ... ref SDS A8 OE6K
040983 -             ..
040984 -       13.  081126 0700  Load   488.5         0         0 ... ref SDS A9 OE6K
040985 -             ..
040986 -            081126 0820  NEUTS........1.50................... ref SDS B0 PU6K
040988 -             ..
040989 -       14.  081127 0700  Load   526.0         0         0 ... ref SDS B1 OE6K
040990 -       15.  081128 0700  1  1   563.5   1    50    1    5 ... ref SDS B4 OE6K
040991 -       16.  081129 0700  1  2   601.0   2   100    2   10 ... ref SDS B7 OE6K
040992 -       17.  081130 0700  1  3   638.5   3   150    2   10 ... ref SDS B8 OE6K
040993 -       18.  081201 0700  1  4   676.0   4   200    2   10 ... ref SDS B9 OE6K
040994 -       19.  081202 0700  1  5   713.5   5   250    2   10 ... ref SDS C1 OE6K
040995 -             ..
040996 -       20.  081203 0700  1  6   751.0   6   300    2   10 ... ref SDS C3 OE6K
040997 -
040998 -            081203 0735. NEUTS....... 0.624 ...... .......... ref SDS C2 RN5G
040999 -
041000 -                Rate of change per day = 1500 - 624 = 876 / 7
041001 -
041002 -                                       = 120+ per day
041004 -             ..
041005 -       21.  081204 0700  1  7   788.5   7   350    2   10 ... ref SDS C4 OE6K
041006 -             ..
041007 -       22.  081205 0700  1  8   826.0   8   400    3   15 ... ref SDS C5 OE6K
041008 -
041009 -            081205 1300  Neupogen...... 480 mcg  480......... ref SDS C6 KV84
041011 -             ..
041012 -       23.  081206 0700  1  9   863.5   9   450    4   20 ... ref SDS C9 OE6K
041013 -
041014 -            081206 0930  Neupogen...... 480 mcg  960......... ref SDS D0 BI4J
041016 -             ..
041017 -       24.  081207 0700  1 10   901.0  10   500    4   20 ... ref SDS D1 OE6K
041018 -       25.  081208 0700  1 11   938.5  11   550    4   20 ... ref SDS D2 OE6K
041019 -       26.  081209 0700  1 12   976.0  12   600    4   20 ... ref SDS D3 OE6K
041020 -             ..
041021 -       27.  081210 0700  1 13  1013.5  13   650    4   20 ... ref SDS D5 OE6K
041022 -
041023 -            081210 1301. NEUTS....... 1.085 ................. ref SDS D6 QY6H
041025 -             ..
041026 -       28.  081211 0700  1 14  1050.0  14   700    4   20 ... ref SDS D9 OE6K
041027 -             ..
041028 -       29.  081212 0700  1 15  1087.5  15   750    5   25 ... ref SDS E1 OE6K
041029 -
041030 -            081212 1115. NEUTS....... 1.054 ................. ref SDS E2 QY6H
041032 -             ..
041033 -       30.  081213 0700  1 16  1125.0  16   800    6   30 ... ref SDS E4 OE6K
041034 -       31.  081214 0700  1 17  1162.5  17   850    6   30 ... ref SDS E5 OE6K
041035 -       32.  081215 0700  1 18  1200.0  18   900    6   30 ... ref SDS E6 OE6K
041036 -       33.  081216 0700  1 19  1237.5  19   950    6   30 ... ref SDS E7 OE6K
041037 -             ..
041038 -       34.  081217 0700  1 20  1275.0  20  1000    6   30 ... ref SDS E8 OE6K
041039 -       35.  081218 0700  1 21  1312.5  21  1050    canceled.. ref SDS F0 OE6K
041040 -
041041 -            081218 0830. NEUTS....... 0.740 ................. ref SDS F1 QY6H
041043 -             ..
041044 -            081219 0700  2  1  paused until 081226........... ref SDS F3 OE6K
041046 -             ..
041047 -            081219 1130  Neupogen...... 480 mcg 1440 ........ ref SDS F4 UZ7K
041048 -            081220 0900  Neupogen...... 480 mcg 1920 ........ ref SDS F6 UZ7K
041050 -             ..
041051 -       36.  081226 0700  2  1  1350.0  22  1100.............. ref SDS G3 OE6K
041052 -       37.  081227 0700  2  2  1387.5  23  1150.............. ref SDS G5 OE6K
041053 -       38.  081228 0700  2  3  1425.0  24  1200.............. ref SDS G6 OE6K
041054 -       39.  081229 0700  2  4  1462.5  25  1250.............. ref SDS G7 OE6K
041055 -       40.  081230 0700  2  5  1500.0  26  1300.............. ref SDS G9 OE6K
041056 -       41.  081231 0700  2  6  1537.5  27  1350.............. ref SDS H1 OE6K
041057 -       42.  090101 0700  2  7  1575.0  28  1400.............. ref SDS H2 OE6K
041058 -       43.  090102 0700  2  8  1612.5  29  1450.............. ref SDS H3 OE6K
041059 -       44.  090103 0700  2  9  1650.0  30  1500.............. ref SDS H4 OE6K
041060 -       45.  090104 0700  2 10  1687.5  31  1550.............. ref SDS H5 OE6K
041061 -       46.  090105 0700  2 11  1725.0  32  1600.............. ref SDS H6 OE6K
041062 -       47.  090106 0700  2 12  1762.5  33  1650.............. ref SDS H8 OE6K
041063 -       48.  090107 0700  2 13  1800.0  34  1700.............. ref SDS I1 OE6K
041064 -             ..
041065 -       49.  090108 0700  2 14  1837.5  35  1750.............. ref SDS I2 OE6K
041066 -             ..
041067 -       50.  090109 0700  3  1  1875.0..paused................ ref SDS I7 OE6K
041068 -             ..
041069 -       51.  090110 0700  3  2  1910.5..paused................ ref SDS I8 OE6K
041070 -       52.  090111 0700  3  3  1948.0..paused................ ref SDS J0 OE6K
041071 -       53.  090112 0700  3  4  1985.5..paused................ ref SDS J1 OE6K
041072 -       54.  090113 0700  3  5  2023.0..paused................ ref SDS J4 OE6K
041073 -       55.  090114 0700  3  6  2060.5..paused................ ref SDS 0 OE6K
041074 -
041075 -
041076 -
041077 -
041078 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
050401 -  ..
050402 - Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
050403 -
050404 - Follow up ref SDS J4 LF8M, ref SDS J1 LF8M.
050405 -
050406 - Fatigue is a likely side effect of sunitinib with cyclophosphamide,
050407 - listed in the Consent document reviewed on 081017. ref SDS 76 4G7G
050409 -  ..
050410 - Blood counts NEUTS 0.87 reported for labs on 090108 at UCSF,
050411 - ref SDS I3 QY6H, show another significant decline from NEUTS 1.710
050412 - reported on 081226, ref SDS G4 B35J, as a result of getting 20 daily
050413 - cancer treatments starting on 081226, shown by patient history above.
050414 - ref SDS 0 9I6T  Low blood counts are side affects for some patients of
050415 - sunitinib, listed on 081017, ref SDS 76 ZP5L, that contribute to
050416 - fatigue, also listed as the primary side effect of sunitinib.
050417 - ref SDS 76 4G7G  Chemotherapy also causes low blood counts, which
050418 - compounds the problem of fatigue that prevents exercise, causing
050419 - fitness to decline, shown by case study below. ref SDS 0 X64F  Lack of
050420 - exercise weakens the immune system, enabling cancer and other disease
050421 - to rise.  Since the doctor paused cyclophosphamide chemotherapy for a
050422 - week on 090108, ref SDS I2 9V4I, this may reduce the problem of lower
050423 - blood counts and so help relieve fatigue.  Additionally, Neupogen
050424 - treatments on 090109 and 090110 ref SDS J0 RG7J, prescribed by medical
050425 - team at UCSF on 090108, ref SDS I2 9V4I, further enable blood counts
050426 - to rise so that treatment with sunitinib can continue at full
050427 - strength, explained in Millie's letter to the medical team on 090109.
050428 - ref SDS I6 UF3T  A blood test will be performed at Kaiser next Friday
050429 - on 090116; if NEUTS > 1.00 cyclophsphamide will be continued at
050430 - reduced dose of 5 days per week, instead 7. ref SDS I6 UF3W  This
050431 - aligns with letter from UCSF on 090108 summarizing instructions from
050432 - medical team. ref SDS I5 UX5S
050434 -  ..
050435 - Millie did not go to the gym for aerobics today; and, she did not go
050436 - hiking at Lafayette reservoir.  She was in bed most of the morning.
050437 - In the afternoon, she went window shopping at the mall for exercise
050438 - for about an hour or so.  She complained if pain in her feet and toes
050439 - from walking.  On 090111, and the day before on 090110 Millie had
050440 - severe pain in her feet, discussed below, ref SDS J4 HY8M, and muscle
050441 - weakness in the legs, while hiking at Lafayette on 090111, ref SDS J0
050442 - 3E4K, which are listed as a separate side effect of sunitinib on
050443 - 081017. ref SDS 76 4G7G  Millie's legs tire quickly, reported below,
050444 - ref SDS 0 3E4K, cited previously on 090102. ref SDS H3 6E7G  Increased
050445 - exercise the past few days increased fatigue from 20 cancer treatments
050446 - beginning on 081226, shown above, ref SDS 0 9I6T, even with blood
050447 - counts rising from 2 Neupogen treatments, and from pausing treatment
050448 - with cyclophosphamide on 090109, per above. ref SDS 0 6M7G
050450 -  ..
050451 - Background on Neupogen treatments and UCSF comments are reported on
050452 - 081207. ref SDS D1 673J
050454 -  ..
050455 - NEUTS blood tests show patient history of treatments with Nuepogen to
050456 - recover from neutropenia caused by getting chemotherapy everyday with
050457 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
050459 -  ..
050460 - Schedule for Neupogen treatments is listed in the record on 090110.
050461 - ref SDS I9 HS5M
050463 -  ..
050464 - Neupogen treatments prescribed on 090108 by the medical team at UCSF
050465 - for 090109 and 090110, help maintain blood counts to strengthen the
050466 - immune system, shown in Millie's letter to the medical team on 090109.
050467 - ref SDS I6 UF3Q  On 090110, Millie had the 2nd Neupogen treatment at
050468 - Kaiser. ref SDS I9 P73J
050470 -  ..
050471 - Feet and toes very sensitive from peripheral neuropathy caused by side
050472 - effects of sunitinib, reported on 090112, ref SDS J1 HY8M, and citing
050473 - possible dilemma about treatment with cyclophosphamide. ref SDS J1
050474 - OG9G  Millie went shopping at the mall for several hours in the
050475 - afternoon.  She complained of pain in her feet and toes from this
050476 - reduced activity.
050478 -  ..
050479 - Tearing eyes reported during examination on 090108; Tara, ref SDS I4
050480 - XB3M, prescribed over-the-counter eye drops.
050482 -  ..
050483 - Joint pain, discomfort, and total ill feeling, commonly associated
050484 - with chemotherapy, reported on 081218, ref SDS F0 E38H, and discussed
050485 - with the medical team at UCSF also on 081218, ref SDS F2 QW7H, has now
050486 - mostly disipated, as a result of the doctor stopping all treatment for
050487 - 1 week, ref SDS F2 QW48, as shown in patient history above.
050488 - ref SDS G6 053F
050490 -  ..
050491 - Interstitional lung disease discussed in the record on 081218,
050492 - ref SDS F0 KM5F, shows no evident symptoms.
050494 -  ..
050495 - Vitals were taken today at home after minimal activity sitting up in
050496 - bed reading, and walking about the house.
050497 -
050498 -                   BP 147 69 pulse 51
050500 -  ..
050501 - Millie reports continued relief from heartburn with daily treatments
050502 - using Prilosce started on 081208. ref SDS D2 7J6K
050504 -  ..
050505 - Sore throat problem, reported initially on 081218, as having begun
050506 - days earlier, ref SDS F0 2B8M, seems better today today continuing
050507 - relief reported yesterday on 081222. ref SDS F8 TT4O  This increases
050508 - interest in eating food.  Millie had eggs and a baggel for a late
050509 - lunch after returning from the gym.  Swallowing seems much more normal
050510 - now.
050512 -  ..
050513 - Millie reports improved taste from some foods today (e.g., soup),
050514 - cited in study consent documents, reviewed on 081017. ref SDS 76 6T5H
050516 -     ..
050517 -                                   Date
050518 -    Description Adverse Event   Start  Stop     Medication
050519 -    ---------------------------------------------------------
050520 -    Follow up ref SDS J4 MV5H, ref SDS J1 MV5H.
050521 -
050522 -    Diarrhea                    081114 081114   Imodium........ ref SDS 94 LF8M
050523 -    Low pulse                   081120 081120   None........... ref SDS A3 LF8M
050524 -    Low pulse                   081121 081121   None........... ref SDS A4 7G8M
050525 -    BP 144 84 Pulse 48          081121 081121   Hiking......... ref SDS A4 LF8M
050526 -    Joint pain minor            081121 081121   Hiking......... ref SDS A4 LF8M
050527 -    Fatigue minor               081121 081121   Hiking......... ref SDS A4 LF8M
050528 -    Low pulse                   081122 081122   None........... ref SDS A5 7G8M
050529 -    Fatigue minor               081122 081122   Hiking......... ref SDS A5 LF8M
050530 -    Low pulse                   081123 081122   None........... ref SDS A6 7G8M
050531 -    BP 121 74 Pulse 53          081123 081123   Hiking......... ref SDS A6 LF8M
050532 -    Fatigue minor               081123 081122   Hiking......... ref SDS A6 LF8M
050533 -    Joint pain minor            081124 081124   Hiking......... ref SDS A7 LF8M
050534 -    Fatigue minor               081124 081124   Hiking......... ref SDS A7 LF8M
050535 -    Heartburn                   081124 081124   None........... ref SDS A7 HS9K
050536 -    BP 144 78 Pulse 52          081125 081125   Hiking......... ref SDS A8 LF8M
050537 -    Joint pain minor            081125 081125   Hiking......... ref SDS A8 LF8M
050538 -    Fatigue minor               081125 081125   Hiking......... ref SDS A8 LF8M
050539 -    Heartburn                   081125 081125   None........... ref SDS A8 HS9K
050540 -    Heartburn                   081126 081126   None........... ref SDS A9 HS9K
050541 -    Heartburn                   081127 081127   None........... ref SDS B3 HS9K
050542 -    BP 135 73 Pulse 48          081128 081128   Hiking......... ref SDS B4 5X6K
050543 -    Upset stomach               081128 081128   Hiking......... ref SDS B4 T76O
050544 -    BP 140 75 Pulse 50          081129 081129   Hiking......... ref SDS B7 5X6K
050545 -    Heartburn                   081129 081129   None........... ref SDS B7 HS9K
050546 -     ..
050547 -    Fatigue                     081129 081129   Rest........... ref SDS B7 LF8M
050548 -    Fatigue                     081130 081130   Rest........... ref SDS B8 LF8M
050549 -    BP 136 79 Pulse 46          081201 081201   Hiking......... ref SDS B9 5X6K
050550 -    Fatigue                     081201 081201   Rest........... ref SDS B9 LF8M
050551 -    Taste altered               081201 081201   Rest........... ref SDS B9 VP4G
050552 -    BP 141 77 Pulse 46          081202 081202   Aerobics gym... ref SDS C1 5X6K
050553 -    Fatigue                     081202 081202   Rest........... ref SDS C1 LF8M
050554 -    Taste altered               081202 081202   Rest........... ref SDS C1 VP4G
050555 -    BP 138 77 Pulse 48          081203 081203   Hiking......... ref SDS C3 5X6K
050556 -    Fatigue                     081203 081203   Rest........... ref SDS C3 LF8M
050557 -    Taste altered               081203 081203   Rest........... ref SDS C3 VP4G
050558 -    NEUTS (ANC)     0.624       081203 081203   Neupogen.......
050559 -    BP 133 72 Pulse 45          081204 081204   Rest........... ref SDS C4 5X6K
050560 -    Fatigue                     081204 081204   Rest........... ref SDS C4 LF8M
050561 -    Taste altered               081204 081204   Rest........... ref SDS C4 VP4G
050562 -    BP 138 76 Pulse 49          081205 081205   Rest........... ref SDS C5 5X6K
050563 -    Diarrhea                    081205 081114   Imodium........ ref SDS C5 Q67F
050564 -    Fatigue                     081205 081205   Rest........... ref SDS C5 LF8M
050565 -    Taste altered               081205 081205   Rest........... ref SDS C5 VP4G
050566 -    BP *** ** Pulse **          081206 081206   Rest........... ref SDS C9 5X6K
050567 -    Fatigue                     081206 081206   Rest........... ref SDS C9 LF8M
050568 -    BP 128 70 Pulse 53          081207 081207   Hiking......... ref SDS D1 5X6K
050569 -    Fatigue                     081207 081207   Rest........... ref SDS D1 LF8M
050570 -    BP 137 68 Pulse 53          081208 081208   Rest........... ref SDS D2 5X6K
050571 -    Fatigue                     081208 081208   Rest........... ref SDS D2 LF8M
050572 -    BP *** ** Pulse **          081209 081209   Rest........... ref SDS D2 5X6K
050573 -    Fatigue                     081209 081209   Rest........... ref SDS D2 LF8M
050574 -    Heartburn                   081209 081209   Prilosec....... ref SDS D3 7J6K
050575 -    BP 136 70 Pulse 53          081210 081210   Rest........... ref SDS D5 5X6K
050576 -    Fatigue                     081210 081210   Rest........... ref SDS D5 LF8M
050577 -    Heartburn                   081210 081210   Prilosec....... ref SDS D5 7J6K
050578 -    BP *** ** Pulse **          081211 081211   Rest........... ref SDS D9 5X6K
050579 -    Fatigue                     081211 081211   Exercise gym... ref SDS D9 LF8M
050580 -    Heartburn                   081211 081211   Prilosec....... ref SDS D9 7J6K
050581 -    BP 137 76 Pulse 53          081212 081212   Rest........... ref SDS E1 5X6K
050582 -    Fatigue                     081212 081212   Exercise gym... ref SDS E1 LF8M
050583 -    Heartburn                   081212 081212   Prilosec....... ref SDS E1 7J6K
050584 -    BP 147 80 Pulse 51          081213 081213   Rest........... ref SDS E4 5X6K
050585 -    Fatigue                     081213 081213   Exercise gym... ref SDS E4 LF8M
050586 -    BP *** ** Pulse **          081214 081214   Rest........... ref SDS E5 5X6K
050587 -    Fatigue                     081214 081214   Rest........... ref SDS E5 LF8M
050588 -    BP *** ** Pulse **          081215 081215   Rest........... ref SDS E6 5X6K
050589 -    Fatigue                     081215 081215   Rest........... ref SDS E6 LF8M
050590 -    BP 144 79 Pulse 54          081216 081216   Rest........... ref SDS E7 5X6K
050591 -    Fatigue                     081216 081216   Exercise gym... ref SDS E7 LF8M
050592 -     ..
050593 -    Joint pain minor            081216 081216   Rest........... ref SDS E7 E38H
050594 -    BP 137 69 Pulse 63          081217 081217   Rest........... ref SDS E8 5X6K
050595 -    Fatigue                     081217 081217   Rest........... ref SDS E8 LF8M
050596 -    Feet toes neuropathy        081216 081217   Rest........... ref SDS E8 HY8M
050597 -    Joint pain minor            081217 081217   Rest........... ref SDS E8 E38H
050598 -    Nosebleed minor             081217 081217   Rest........... ref SDS E8 ZF5F
050599 -     ..
050600 -    BP *** ** Pulse **          081218 081218   Rest........... ref SDS F0 5X6K
050601 -    Fatigue                     081218 081218   Rest........... ref SDS F0 LF8M
050602 -    Joint pain minor            081218 081218   Rest........... ref SDS F0 E38H
050603 -    Nosebleed moderate          081218 081218   Rest........... ref SDS F0 ZF5F
050604 -    Throat pain eating          081218 081218   Eating less.... ref SDS F0 2B8M
050605 -    Feet toes neuropathy        081216 081218   Rest........... ref SDS F0 HY8M
050606 -    BP 155 84 Pulse 53          081219 081219   Rest........... ref SDS F3 5X6K
050607 -    Fatigue                     081121 081219   Rest........... ref SDS F3 LF8M
050608 -    Feet toes neuropathy        081216 081219   Rest........... ref SDS F3 HY8M
050609 -    Joint pain ill feeling      081121 081219   Rest........... ref SDS F3 E38H
050610 -    Throat sore eating          081218 081219   Eating less.... ref SDS F3 TT4O
050611 -    BP 123 69 pulse 53          081220 081220   Rest........... ref SDS F5 5X6K
050612 -    Fatigue                     081121 081220   Rest........... ref SDS F5 LF8M
050613 -    Feet toes neuropathy        081216 081220   Rest........... ref SDS F5 HY8M
050614 -    Joint pain ill feeling      081121 081220   Rest........... ref SDS F5 E38H
050615 -    Throat sore eating          081218 081220   Eating less.... ref SDS F5 TT4O
050616 -    BP 117 71 pulse 65          081221 081221   Rest........... ref SDS F7 5X6K
050617 -    Fatigue                     081121 081221   Rest........... ref SDS F7 LF8M
050618 -    Feet toes neuropathy        081216 081221   Rest........... ref SDS F7 HY8M
050619 -    Joint pain ill feeling      081121 081221   Rest........... ref SDS F7 E38H
050620 -    Throat sore eating          081218 081221   Eating less.... ref SDS F7 TT4O
050621 -    BP 117 71 pulse 65          081222 081222   Rest........... ref SDS F8 5X6K
050622 -    Fatigue                     081121 081222   Rest........... ref SDS F8 LF8M
050623 -    Feet toes neuropathy        081216 081222   Rest........... ref SDS F8 HY8M
050624 -    Joint pain ill feeling      081121 081222   Rest........... ref SDS F8 E38H
050625 -    Throat sore eating          081218 081222   Eating less.... ref SDS F8 TT4O
050626 -    BP 143 68 pulse 65          081223 081223   Rest........... ref SDS F8 5X6K
050627 -    Fatigue more energy         081121 081223   Exercise gym... ref SDS F9 LF8M
050628 -    Feet toes neuropathy better 081219 081223   Exercise gym... ref SDS F9 HY8M
050629 -    Joint pain subsides         081121 081223   Exercise gym... ref SDS F9 E38H
050630 -    Throat sore improved        081218 081223   Eating normal.. ref SDS F9 TT4O
050631 -    BP *** ** pulse **          081224 081224   Rest........... ref SDS G1 5X6K
050632 -    Fatigue more energy         081121 081224   Exercise gym... ref SDS G1 LF8M
050633 -    Feet feel better            081219 081224   Exercise gym... ref SDS G1 UO8I
050634 -    Joint pain subsides         081121 081224   Exercise gym... ref SDS G1 E38H
050635 -    Throat sore improved        081218 081224   Eating normal.. ref SDS G1 TT4O
050636 -    BP 124 80 pulse 66          081225 081225   Rest........... ref SDS G2 5X6K
050637 -    Fatigue more energy         081121 081225   Activity....... ref SDS G2 LF8M
050638 -    Fatigue more energy         081121 081226   Activity....... ref SDS G3 LF8M
050639 -    BP *** ** pulse **          081227 081227   Rest........... ref SDS G5 5X6K
050640 -    Fatigue more energy         081121 081227   Hiking......... ref SDS G5 LF8M
050641 -    BP *** ** pulse **          081228 081228   Rest........... ref SDS G6 5X6K
050642 -    Fatigue more energy         081121 081228   Rest........... ref SDS G6 LF8M
050643 -    BP 112 76 pulse 63          081229 081229   Rest........... ref SDS G7 5X6K
050644 -    Fatigue more energy         081121 081229   Rest........... ref SDS G7 LF8M
050645 -    BP *** ** pulse **          081230 081230   Rest........... ref SDS G9 5X6K
050646 -    Diarrhea                    081230 081230   Imodium........ ref SDS G9 KZ9N
050647 -    Fatigue more energy         081121 081230   Rest........... ref SDS G9 LF8M
050648 -    BP *** ** pulse **          081231 081231   Rest........... ref SDS H1 5X6K
050649 -    Fatigue more energy         081121 081231   Rest........... ref SDS H1 LF8M
050650 -    BP *** ** pulse **          090101 090101   Rest........... ref SDS H2 5X6K
050651 -    Fatigue more energy         081121 090101   Hiking......... ref SDS H2 LF8M
050652 -    BP *** ** pulse **          090102 090102   Rest........... ref SDS H3 5X6K
050653 -    Fatigue more energy         081121 090102   Hiking......... ref SDS H3 LF8M
050654 -    BP *** ** pulse **          090103 090103   Rest........... ref SDS H4 5X6K
050655 -    Fatigue less energy         081121 090103   Exercise gym... ref SDS H4 LF8M
050656 -    BP *** ** pulse **          090104 090104   Rest........... ref SDS H5 5X6K
050657 -    Fatigue less energy         081121 090104   Rest........... ref SDS H5 LF8M
050658 -    BP *** ** pulse **          090105 090105   Rest........... ref SDS H6 5X6K
050659 -    Fatigue less energy         081121 090105   Rest........... ref SDS H6 LF8M
050660 -    BP *** ** pulse **          090106 090106   Rest........... ref SDS H8 5X6K
050661 -    Fatigue less energy         081121 090106   Exercise gym... ref SDS H8 LF8M
050662 -    BP *** ** pulse **          090107 090107   Rest........... ref SDS H8 5X6K
050663 -    Fatigue less energy         081121 090107   Rest........... ref SDS I1 LF8M
050664 -    BP *** ** pulse **          090108 090108   Rest........... ref SDS I2 5X6K
050665 -    Fatigue less energy         081121 090108   Rest........... ref SDS I2 LF8M
050666 -    Eyes tearing                090108 090108   Eye drops...... ref SDS I2 518H
050667 -    BP *** ** pulse **          090109 090109   Rest........... ref SDS I7 5X6K
050668 -    Fatigue less energy         081121 090109   Rest........... ref SDS I7 LF8M
050669 -    Eyes tearing                090108 090109   Eye drops...... ref SDS I7 518H
050670 -    BP *** ** pulse **          090110 090110   Rest........... ref SDS I8 5X6K
050671 -    Fatigue less energy         081121 090110   Hiking......... ref SDS I8 LF8M
050672 -    Eyes tearing                090108 090110   Eye drops...... ref SDS I8 518H
050673 -    BP *** ** pulse **          090111 090111   Rest........... ref SDS J0 5X6K
050674 -    Fatigue more energy         081121 090111   Hiking......... ref SDS J0 LF8M
050675 -    Eyes tearing                090108 090111   Eye drops...... ref SDS J0 518H
050676 -    Feet toes neuropathy        090111 090111   Hiking......... ref SDS J0 HY8M
050677 -    BP 144 78 pulse 54          090112 090112   Rest........... ref SDS J1 5X6K
050678 -    Fatigue more energy         081121 090112   rest........... ref SDS J1 LF8M
050679 -    Eyes tearing                090108 090112   Eye drops...... ref SDS J1 518H
050680 -    Feet toes neuropathy        090111 090112   rest........... ref SDS J1 HY8M
050681 -    BP 153 74 pulse 49          090113 090113   Rest........... ref SDS J4 5X6K
050682 -    Fatigue more energy         081121 090113   Exercise gym... ref SDS J4 LF8M
050683 -    Eyes tearing                090108 090113   Eye drops...... ref SDS J4 518H
050684 -    Feet toes neuropathy        090111 090113   Exercise gym... ref SDS J4 HY8M
050685 -    Diarrhea                    090113 090113   Imodium........ ref SDS J4 KZ9N
050686 -    BP 147 69 pulse 51          090114 090114   Rest........... ref SDS 0 5X6K
050687 -    Fatigue more energy         081121 090114   Rest........... ref SDS 0 LF8M
050688 -    Eyes tearing                090108 090114   Eye drops...... ref SDS 0 518H
050689 -    Feet toes neuropathy        090111 090114   Rest........... ref SDS 0 HY8M
050690 -
050691 -
050692 -
0507 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS J4 3E4K, ref SDS J1 3E4K.
060405 -
060406 - Today, Millie did not go to the gym for aerobic exercise; she did
060407 - not hike at Lafayette reservoir due to rising...
060408 -
060409 -          Fatigue............................... ref SDS 0 LF8M
060410 -          Muscle weakness....................... ref SDS 0 KL4J
060411 -          Perpherial neuropathy
060412 -          pain in feet and toes................. ref SDS 0 HY8M
060414 -  ..
060415 - Walking around the mall for a few hours was difficult on Millie's legs
060416 - and feet this afternoon, reported previously on 090102, ref SDS H3
060417 - 6E7G, due to rising side effects of fatigue from 20 cancer treatments
060418 - beginning on 081226. ref SDS 0 9I6T  Neupogen treatments on 090109 and
060419 - on 090110, and pausing cyclophosphamide may enable blood counts and
060420 - energy to rise, per above. ref SDS 0 LF8M
060422 -  ..
060423 - NEUTS blood tests show patient history treatments with Nuepogen for
060424 - neutropenia from chemotherapy everyday with cyclophosphamide reported
060425 - in case study on 081205. ref SDS C5 EC5N
060427 -  ..
060428 - On 081110, Millie complained about difficulty lifting herself from a
060429 - full squatting position. ref SDS 90 HX67  For several weeks, she was
060430 - exercising to strengthen legs, and arms, shown by going to the gym on
060431 - 081211. ref SDS D9 3E4K  Rising fatigue now prevents continuing
060432 - exercise.
060433 -
060435 -  ..
060436 - Case Study on Pateint History Exercising
060437 -
060438 - Follow up ref SDS J4 X64F, ref SDS J1 X64F.
060439 -
060440 -                                              +- scm = Sunitinib Cyclophosphmaide Methotrexate
060441 -                                              +- sc  = Sunitinib Cyclophosphmaide
060442 -                           Time     Pulse     |
060443 -    Location        Miles Minutes  Avg Max  Chem  Neupo  Date
060444 -    ----------------------------------------------------------------
060445 -    Concord home                              s         090114, ref SDS 0 3E4K
060446 -    Concord home (gym)                        s         090113, ref SDS J4 3E4K
060447 -    Concord home                              s         090112, ref SDS J1 3E4K
060448 -    Lafayette        4.75   90.4    95 111    s         090111, ref SDS J0 3E4K
060449 -    Lafayette        2.75   58.9    85 105    s         090110, ref SDS I8 3E4K
060450 -    Concord home                              s         090109, ref SDS I7 3E4K
060451 -    Concord home                              sc        090108, ref SDS I2 3E4K
060452 -    Concord home                              sc        090107, ref SDS I1 3E4K
060453 -    Concord home (gym)                        sc        090106, ref SDS H8 3E4K
060454 -    Concord home                              sc        090105, ref SDS H6 3E4K
060455 -    Concord home                              sc        090104, ref SDS H5 3E4K
060456 -    Concord home (gym)                        sc        090103, ref SDS H4 3E4K
060457 -    Clayton Safeway  3.00   58.7    83  94    sc        090102, ref SDS H3 3E4K
060458 -    Lafayette        2.75   58.4    87 103    sc        090101, ref SDS H2 3E4K
060459 -    Concord home                              sc        081231, ref SDS H1 3E4K
060460 -    Concord home                              sc        081230, ref SDS G9 3E4K
060461 -    Concord home                              sc        081229, ref SDS G7 3E4K
060462 -    Concord home                              sc        081228, ref SDS G6 3E4K
060463 -    Lafayette        2.75   56.2    90 112    sc        081227, ref SDS G5 3E4K
060464 -    Concord home                              sc        081226, ref SDS G3 3E4K
060465 -    Concord travel                                      081225, ref SDS G2 3E4K
060466 -    Concord home                                        081224, ref SDS G1 3E4K
060467 -    Concord home (gym)                                  081223, ref SDS F9 3E4K
060468 -    Concord home                                        081222, ref SDS F8 3E4K
060469 -    Concord home                                        081221, ref SDS F7 3E4K
060470 -    Concord home                                        081220, ref SDS F5 3E4K
060471 -    Concord home                                        081219, ref SDS F3 3E4K
060472 -    Concord home                              sc        081218, ref SDS F0 3E4K
060473 -    Concord home                              sc        081217, ref SDS E8 3E4K
060474 -    Concord home (gym)                        sc        081216, ref SDS E7 3E4K
060475 -    Concord home                              sc        081215, ref SDS E6 3E4K
060476 -    Concord home                              sc        081214, ref SDS E5 3E4K
060477 -    Concord home (gym)                        scm       081213, ref SDS E4 3E4K
060478 -    Concord home                              scm       081212, ref SDS E1 3E4K
060479 -    Concord home (gym)                        sc        081211, ref SDS D9 3E4K
060480 -    Concord home                              sc        081210, ref SDS D5 3E4K
060481 -    Concord home                              sc        081209, ref SDS D3 3E4K
060482 -    Concord home                              sc        081208, ref SDS D2 3E4K
060483 -    Lafayette        4.75   78.6    95 110    sc        081207, ref SDS D1 3E4K
060484 -    Concord home                              scm       081206, ref SDS C9 3E4K
060485 -    Concord home                              scm       081205, ref SDS C5 3E4K
060486 -    Concord home                              sc        081204, ref SDS C4 3E4K
060487 -    Lafayette        2.75   62.7    90 117    sc        081203, ref SDS C3 3E4K
060488 -    Concord home (gym)                        sc        081202, ref SDS C1 3E4K
060489 -    Lafayette        5.50  102.3    95 122    sc        081201, ref SDS B9 3E4K
060490 -    Concord home                              sc        081130, ref SDS B8 3E4K
060491 -    Lafayette        2.75   56.7    90 115    scm       081129, ref SDS B7 3E4K
060492 -    Lafayette        2.75   46.5   100 128    scm       081128, ref SDS B4 3E4K
060493 -    Lafayette        5.50   93.3   100 122    s         081127, ref SDS B3 3E4K
060494 -    Concord home                              s         081126, ref SDS A9 3E4K
060495 -    Lafayette        4.00   73.7   105 127    s         081125, ref SDS A8 3E4K
060496 -    Lafayette        5.50   91.4   100 129    s         081124, ref SDS A7 3E4K
060497 -    Concord home                              s         081123, ref SDS A6 3E4K
060498 -    Lafayette        5.50   92.8    95 122    s         081122, ref SDS A5 3E4K
060499 -    Lafayette        5.50   94.4    85 112    s         081121, ref SDS A4 3E4K
060500 -    Lafayette        5.50   94.7    90 122    s         081120, ref SDS A3 3E4K
060501 -    San Francisco    1.00   60.0    65  75    s         081119, ref SDS A2 3E4K
060502 -    Lafayette        2.75   49.2    97 130    s         081118, ref SDS A1 3E4K
060503 -    Lafayette        5.50   93.6   115 138    s         081117, ref SDS 98 3E4K
060504 -    Concord home                              s         081116, ref SDS 96 Y68J
060505 -    Concord home                              s         081115, ref SDS 95 EK7I
060506 -    Concord home                              s         081114, ref SDS 94 XW6H
060507 -    Lafayette        5.50   94.2   115 138              081110, ref SDS 90 3E4K
060508 -    Lafayette        2.75   48.4   105 128              081109, ref SDS 89 3E4K
060509 -    Kaiser                                         x    081108, ref SDS 88 UZ7K
060510 -    Kaiser                                         x    081107, ref SDS 87 UZ7K
060511 -    Lafayette        5.50   90.2   120 143              081025, ref SDS 83 3E4K
060512 -    Kaiser                                         x    081025, ref SDS 83 UZ7K
060513 -    Kaiser                                         x    081024, ref SDS 82 UZ7K
060514 -    UCSF                                      c         081023, ref SDS 81 V94O
060515 -    Lafayette        5.50   90.6   115 141              081021, ref SDS 80 3E4K
060516 -    Lafayette        5.50   90.4   110 128              081020, ref SDS 79 3E4K
060517 -    Kaiser                                         x    081018, ref SDS 78 UZ7K
060518 -    Kaiser                                         x    081017, ref SDS 77 UZ7K
060519 -    UCSF                                      e         081016, ref SDS 75 V94O
060520 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 74 3E4K
060521 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 73 3E4K
060522 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 72 3E4K
060523 -    Kaiser                                         x    081011, ref SDS 71 UZ7K
060524 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 70 3E4K
060525 -    Kaiser                                         x    081010, ref SDS 70 UZ7K
060526 -    UCSF                                      e         081009, ref SDS 69 V94O
060527 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 68 3E4K
060528 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 67 3E4K
060529 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 66 3E4K
060530 -    UCSF                                      c         081002, ref SDS 65 V94O
060531 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 64 3E4K
060532 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 64 3E4K
060533 -    Kaiser                                         x    080927, ref SDS 63 UZ7K
060534 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 62 3E4K
060535 -    UCSF                                      c         080925, ref SDS 61 V94O
060536 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 60 3E4K
060537 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 60 3E4K
060538 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 60 3E4K
060539 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 59 3E4K
060540 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 58 3E4K
060541 -    UCSF                                      c         080918, ref SDS 57 V94O
060542 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 58 3E4K
060543 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 56 3E4K
060544 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 55 3E4K
060545 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 54 3E4K
060546 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 53 3E4K
060547 -    UCSF                                      c         080911, ref SDS 52 V94O
060548 -    Lafayette        2.75   46.8   113 140              080909
060549 -    Lafayette        5.50   89.2   117 143              080908
060550 -    Lafayette        5.50   92.1   115 138              080907
060551 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 51 3E4K
060552 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 50 3E4K
060553 -    UCSF                                      c         080904, ref SDS 49 V94O
060554 -    Lafayette        8.25  140.4   116 131              080903
060555 -    Lafayette        5.50   94.9   115 134              080902
060556 -    Kaiser                                         x    080830
060557 -    Kaiser                                         x    080829
060558 -    UCSF                                      c         080828, ref SDS 48 V94O
060559 -    Lafayette        5.50   93.6   120 137              080826
060560 -    Lafayette        5.50   93.2   117 138              080825
060561 -    Lafayette        5.50   93.2   123 136         x    080823
060562 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 47 3E4K
060563 -    UCSF                                      e         080821, ref SDS 46 V94O
060564 -    Lafayette        5.50   94.7   115 137              080820
060565 -    Lafayette        5.50   94.3   115 135              080819
060566 -    Lafayette        8.25  141.7   118 134              080815
060567 -    UCSF                                      e         080814, ref SDS 45 V94O
060568 -    Lafayette        5.50   93.8   120 136              080813
060569 -    Lafayette        5.50   94.4   116 139              080812
060570 -    Lafayette        5.50   94.2   119 133              080810
060571 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 43 3E4K
060572 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 42 3E4K
060573 -    UCSF                                      c         080807, ref SDS 41 V94O
060574 -    Lafayette        8.25  143.7   115 132              080805
060575 -    Concord          7.00  127.6   105 118              080804
060576 -    Lafayette        8.25  143.2   112 134              080802
060577 -    Lafayette        5.50   93.4   115 138              080801
060578 -    Lafayette        5.50   92.2   118 140              080729
060579 -    Lafayette        5.50   92.6   116 137              080728
060580 -    Lafayette        8.25  142.6   114 134              080727
060581 -    Lafayette        5.50   91.5   120 143              080726
060582 -    Lafayette        8.25  140.8   117 135              080725
060583 -    Lafayette        5.50   91.8   122 141              080723
060584 -    Lafayette        5.50   91.3   120 139              080722
060585 -    Lafayette        8.25  143.3   115 133              080720
060586 -    Lafayette        5.50   90.7   125 144              080719
060587 -    Lafayette        5.50   92.4   123 142              080716
060588 -    Lafayette        2.25   46.8   116 137              080715
060589 -    Lafayette        8.25  141.8   116 136              080712
060590 -    Lafayette        5.50   92.9   116 139              080711
060591 -    Lafayette        8.25  143.3   113 137              080704
060592 -    Lafayette        5.50   90.2   121 147              080630
060593 -    Lafayette        8.25  142.4   116 138              080628
060594 -    Lafayette        5.50   91.4   118 138              080625
060595 -    Lafayette        2.25   47.9   116 136              080623
060596 -    Lafayette        5.50   94.2   112 138              080622
060597 -    Lafayette        5.50   94.7   115 133              080621
060598 -    Lafayette        2.25   48.3   110 129              080620
060599 -    Mt Diablo        7.00  129.4   130 153              080616
060600 -    Lafayette        5.50   90.8   120 146              080615
060601 -    Lafayette        5.50   91.3   124 144              080614
060602 -    Lafayette        5.50   89.7   122 143              080613
060603 -    Lafayette        2.76   45.8   120 147              080611
060604 -    Lafayette        5.50   90.5   123 145              080609
060605 -    Lafayette        5.50   92.7   115 138              080607
060606 -    Lafayette        5.50   94.2   118 139              080602
060607 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 19 WO8M
060608 -
060609 -
060610 -
060611 -
060612 -
060613 -
0607 -