THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: December 6, 2008 09:30 AM Saturday; Rod Welch

Millie 2nd Neupgogen at Kaiser recover from sunitinib treatment.

1...Summary/Objective
2...Neupogen Treatment at Kaiser Prescribed at UCSF for Clinical Trial
3...Schedule Neupogen Treatments Extended through August
4...Side Effects Neupogen Treatments Increase May Be Chemotherapy


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CONTACTS 

SUBJECTS
Neupogen Side Effects Bone Pain Fatigue No Headache Suffered Today A

1503 -
1503 -    ..
1504 - Summary/Objective
1505 -
150501 - Follow up ref SDS C8 0000. ref SDS C2 0000.
150502 -
150503 -
150504 -
150505 -
150506 -
150508 -  ..
1506 -
1507 -
1508 - Progress
1509 -
150901 - Neupogen Treatment at Kaiser Prescribed at UCSF for Clinical Trial
150902 -
150903 - Follow up ref SDS C8 9W9I, ref SDS C2 9W9I.
150904 -
150905 - Patient history of low blood counts for NEUTS (ANC at Kaiser) showing
150906 - missing treatments at UCSF, and including Millie's current treatments
150907 - with sunitinib for the 5th relapse of IBC are reported in the record
150908 - on 081205. ref SDS C6 EC5N
150910 -  ..
150911 - Case study on 060809 shows Millie has often received chemotherapy when
150912 - blood counts are below the standard for safe treatments, and on some
150913 - occassions has received Neupogen to increase blood counts. ref SDS 9
150914 - HV45
150916 -  ..
150917 - Research on neutropenia was reported on 070301, ref SDS 10 O59H, when
150918 - Doctor Rugo was concerned about holding blood counts with weekly
150919 - Carboplatin treatments. ref SDS 10 VF6O
150921 -  ..
150922 - Background on Neupogen treatment is reported on 081107. ref SDS B9
150923 - 1M9O  Tara gave instructions at UCSF on 081126 to defer Neupogen with
150924 - NEUTS 1.50 until labs are checked again at UCSF on 081218. ref SDS C5
150925 - AT8U  Yesterday, Doctor Rugo clarified that Neupogen should not be
150926 - self-medicated, and is not needed until neutrophils are low.
150927 - ref SDS C9 JE5I
150929 -  ..
150930 - Kathi was Millie's nurse today.
150932 -  ..
150933 - Millie brought a copy of Doctor Rugo's letter last night on 081215
150934 - saying Neupogen should not be given until neutrophils are low.
150935 - ref SDS C9 JE5I
150937 -  ..
150938 - Kathi checked Kaiser's computer.  She said that WBC 2.4 and
150939 - neutrophils 26 are both low.  Like Bonnie yesterday, Kathi used a
150940 - small calculator to compute ANC 673 (NEUTS .673 at UCSF).
150942 -  ..
150943 - Kathi advised that ANC is very low. ref SDS C8 CH40  She advised there
150944 - is not a doctor on staff today in the Oncology Department on
150945 - Saturdays.  Millie's ANC 624 is approximately 60% below the target
150946 - range of 1500, and neutrophils 26 are about 45% below the target range
150947 - of 41, shown in the lab report reported on 081205. ref SDS C6 QY6H
150949 -  ..
150950 - Kathi gave Millie 1 injection in the left abdomen for the 2nd Neupogen
150951 - treatment following treatment yesterday on 081205, ref SDS C8 KV84,
150952 - and using the UCSF protocol...
150953 -
150954 -            Neupogen 480 mcg SQ
150955 -
150956 - ...as shown in UCSF Chemotherapy Order on 080918, ref SDS 83 PWSY, and
150957 - ordered by primary care physician at Kaiser on 080609. ref SDS 38 L16I
150959 -  ..
150960 - This is the first time Millie has been treated with Neupogen in the
150961 - abdomen.
150963 -  ..
150964 - Kathi explained that Neupogen treatment in the abdomen can be safely
150965 - given with a single injection, and so does not conflict with prior
150966 - instructions on Kaiser protocol for 480 mcg be given with 2
150967 - injections, discussed on 080801 ref SDS 58 9W9I, and originally
150968 - presented by Laura on 080628. ref SDS 43 Q74G
150969 -
150970 -
150971 -
150972 -
1510 -

SUBJECTS
Default Null Subject Account for Blank Record

1603 -
160401 -  ..
160402 - Schedule Neupogen Treatments Extended through August
160403 -
160404 - Follow up ref SDS C8 WJ4O, ref SDS C2 WJ4O.
160405 -
160406 - Millie's schedule for Neupogen was updated yesterday on 081218,
160407 - ref SDS C8 1X5H, and she planned to extend the schedule.  Today, Kathi
160408 - submitted anther updated schedule.
160410 -  ..
160411 - Neupogen schedule....
160412 -
160413 -                                    UCSF Treatment Prescription
160414 -                                              Cyclophos  Metho
160415 -                         Neupogen  Sunitinib   phamide   trexate
160416 -    #   Date    Time NEUTS   MCG    #    MG    #   MG     #   MG    Neupogen            IBC Treatment
160417 -   =================================================================================================
160418 -    1.  081205  1300 0.624   480   22  826.0   8   400    3   15 .. ref SDS C8 KV84 and ref SDS C6 PY5I
160419 -    2.  081206  0900         960   23  863.5   9   450    4   20 .. ref SDS 0 BI4J and ref SDS D0 PY5I
160420 -        081210  1302 1.085   960   27 1013.5  13   650    4   20 .. ref SDS D2 QY6H and ref SDS D2 X59G
160421 -    3.  081212  1300        1540
160422 -    4.  081213  0900        2020
160423 -    5.  081219  1300        2500
160424 -    6.  081220  0900        2980
160425 -    7.  081226  0930        3460
160426 -    8.  081227  0930        3940
160427 -    9.  090102  0800        4420
160428 -   10.  090103  0930        4900
160429 -   11.  090109  0830        5380
160430 -   12.  090110  0930        5820
160431 -   13.  090116  1030        6300
160432 -   14.  090117  0930        6780
160433 -   15.  090123  0830        7260
160434 -   16.  090124  0930        7740
160435 -   17.  090130  0830        8120
160436 -   18.  090131  0930        8600
160437 -
160438 -
160439 -
1605 -

SUBJECTS
Default Null Subject Account for Blank Record

1703 -
170401 -  ..
170402 - Side Effects Neupogen Treatments Increase May Be Chemotherapy
170403 -
170404 - Follow up ref SDS C8 SB8I, ref SDS C2 SB8I.
170405 -
170406 - Research on Neupogen side effects was reported on 080629. ref SDS 43
170407 - RQ9I
170409 -  ..
170410 - Millie last reported side effects on 081018 experiencing bone pain,
170411 - headache, and fatigue associated with Neupogen and chemotherapy.
170412 - ref SDS A3 Y17L
170414 -  ..
170415 - Kathi did not take vitals today. ref SDS 0 BI4J
170417 -  ..
170418 - Side effects of Neupogen reported on...
170419 -
170420 -               081018................, ref SDS A3 Y17L
170421 -               081011................, ref SDS 96 FL4H
170422 -               081010................, ref SDS 95 SB8I
170423 -               081006................, ref SDS 93 3E4K
170424 -               081004................, ref SDS 92 Y17L
170425 -               081002................, ref SDS 90 Y17L
170426 -               080930................, ref SDS 89 Y17L
170427 -               080923................, ref SDS 85 K16F
170428 -               080915................, ref SDS 81 9W9I
170429 -               080810................, ref SDS 63 9W9I
170430 -               080803................, ref SDS 59 9W9I
170431 -               080726................, ref SDS 56 9W9I
170432 -               080721................, ref SDS 54 9W9I
170433 -               080713................, ref SDS 48 RM94
170434 -               080629................, ref SDS 43 6Q5J
170435 -               080628................, ref SDS 41 6Q5J
170436 -
170437 -
170438 -
170439 -
170440 -
170441 -
170442 -
170443 -
170444 -
170445 -
1705 -