THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: November 8, 2008 02:00 PM Saturday; Rod Welch

Millie 2nd Neupgogen at Kaiser preparing start sunitinib treatment at UCSF.

1...Summary/Objective
2...Neupogen Treatment at Kaiser Prescribed at UCSF for Clinical Trial
3...Schedule Neupogen Treatments Extended through August
4...Exercise Hiking Maintain Fitness Strengthen Immune System
5...Side Effects Neupogen Treatments Increase May Be Chemotherapy


..............
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CONTACTS 

SUBJECTS
Neupogen Side Effects Bone Pain Fatigue No Headache Suffered Today A

1503 -
1503 -    ..
1504 - Summary/Objective
1505 -
150501 - Follow up ref SDS B9 0000. ref SDS B3 0000.
150502 -
150503 -
150504 -
150505 -
150507 -  ..
1506 -
1507 -
1508 - Progress
1509 -
150901 - Neupogen Treatment at Kaiser Prescribed at UCSF for Clinical Trial
150902 -
150903 - Follow up ref SDS B9 9W9I, ref SDS B3 9W9I.
150904 -
150905 - Background on missing treatment at UCSF due to low blood counts, and
150906 - requirements for Neupogen are reported in the record on 081016.
150907 - ref SDS A0 OK67
150909 -  ..
150910 - Case study on 060809 shows Millie has often received chemotherapy when
150911 - blood counts are below the standard for safe treatments, and on some
150912 - occassions has received Neupogen to increase blood counts. ref SDS 9
150913 - HV45
150915 -  ..
150916 - Research on neutropenia was reported on 070301, ref SDS 10 O59H, when
150917 - Doctor Rugo was concerned about holding blood counts with weekly
150918 - Carboplatin treatments. ref SDS 10 VF6O
150920 -  ..
150921 - Background on getting Neupogen treatment today is reported in the
150922 - record yesterday on 081107. ref SDS B9 1M9O
150924 -  ..
150925 - Yesterday, the Infusion Clinic accessed Millie's Power Port at 1230,
150926 - ref SDS B7 58A5, and then Millie went to the CT Department for a test
150927 - using the Power Port to inject contrast medium. ref SDS B8 3G5I
150929 -  ..
150930 - Sheree was on duty this weekend in the Infusion Clinic, along with
150931 - Julie.  They were in the Infusion Clinic on 080719 the day after
150932 - Millie at a CT test that resulted in failure trying to use the Power
150933 - Port for injecting contrast medium. ref SDS 53 SR3J  At that time,
150934 - Julie helped Millie recover from problems the day before in the CT
150935 - Department. ref SDS 53 SR37
150937 -  ..
150938 - Today, Sheree asked about results of the CT test yesterday?
150940 -  ..
150941 - Millie explained that work in the Infusion Clinic was timely and
150942 - effective. ref SDS B7 58A5  Injection of contrast medium in the CT
150943 - Department worked perfectly using the Huber needle that accessed the
150944 - Power Port. ref SDS B8 TO7M
150946 -  ..
150947 - Millie advised there were still some rough edges getting the CT
150948 - Department to use the Power Port, ref SDS B8 MX6K; eventually
150949 - everything worked out okay. ref SDS B8 2E82
150951 -  ..
150952 - Julie was Millie's nurse again today.  She gave Millie 2 injections
150953 - required for the 2nd Neupogen treatment prescribed this week...
150954 -
150955 -            Neupogen 480 mcg SQ on D2 3 3 carbo
150956 -
150957 - ...as shown in UCSF Chemotherapy Order on 080918, ref SDS 83 PWSY, and
150958 - ordered by primary care physician at Kaiser on 080609. ref SDS 38 L16I
150960 -  ..
150961 - Prior instructions describe Kaiser protocol calls for 480 mcg be given
150962 - with 2 injections, discussed on 080801 ref SDS 58 9W9I, and originally
150963 - presented by Laura on 080628. ref SDS 43 Q74G
150964 -
150965 -
150966 -
150967 -
1510 -

SUBJECTS
Default Null Subject Account for Blank Record

1603 -
160401 -  ..
160402 - Schedule Neupogen Treatments Extended through August
160403 -
160404 - Follow up ref SDS B9 WJ4O, ref SDS B3 WJ4O.
160405 -
160406 - Millie's schedule for was last updated on 081018. ref SDS A3 WJ4O
160407 -
160408 -
160409 -
1605 -

SUBJECTS
Default Null Subject Account for Blank Record

1703 -
170401 -  ..
170402 - Exercise Hiking Maintain Fitness Strengthen Immune System
170403 -
170404 - Follow up ref SDS B9 3E4K, ref SDS B3 3E4K.
170405 -
170406 - Millie could not go hiking today, because of medical meetings and
170407 - tests most of the day, similar to yesterday. ref SDS B9 3E4K
170409 -  ..
170410 - Had a long day getting to Kaiser in Antioch, because directions were
170411 - wrong. ref SDS C1 FR5H
170413 -  ..
170414 - Hiking will be reduced this coming week, because of meetings getting
170415 - setu for changing treatments.
170416 -
170417 -                                              +- c = Carboplatin
170418 -                                              +- e = Erbatex cetuximab
170419 -                           Time     Pulse     |
170420 -    Location        Miles Minutes  Avg Max  Chem Neupo  Date
170421 -    ----------------------------------------------------------------
170422 -    Kaiser                                         x    081108, ref SDS 0 UZ7K
170423 -    Kaiser                                         x    081107, ref SDS B9 UZ7K
170424 -    Lafayette        5.50   90.2   120 143              081025, ref SDS B3 3E4K
170425 -    Kaiser                                         x    081025, ref SDS B3 UZ7K
170426 -    Kaiser                                         x    081024, ref SDS A9 UZ7K
170427 -    UCSF                                     c          081023, ref SDS A6 V94O
170428 -    Lafayette        5.50   90.6   115 141              081021, ref SDS A5 3E4K
170429 -    Lafayette        5.50   90.4   110 128              081020, ref SDS A4 3E4K
170430 -    Kaiser                                         x    081018, ref SDS A3 UZ7K
170431 -    Kaiser                                         x    081017, ref SDS A2 UZ7K
170432 -    UCSF                                     e          081016, ref SDS A0 V94O,
170433 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 99 3E4K
170434 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 98 3E4K
170435 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 97 3E4K
170436 -    Kaiser                                         x    081011, ref SDS 96 UZ7K
170437 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 95 3E4K
170438 -    Kaiser                                         x    081010, ref SDS 95 UZ7K
170439 -    UCSF                                      e         081009, ref SDS 94 V94O
170440 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 93 3E4K
170441 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 92 3E4K
170442 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 91 3E4K
170443 -    UCSF                                      c         081002, ref SDS 90 V94O
170444 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 89 3E4K
170445 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 89 3E4K
170446 -    Kaiser                                         x    080927, ref SDS 88 UZ7K
170447 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 87 3E4K
170448 -    UCSF                                      c         080925, ref SDS 86 V94O
170449 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 85 3E4K
170450 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 85 3E4K
170451 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 85 3E4K
170452 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 84 3E4K
170453 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 83 3E4K
170454 -    UCSF                                      c         080918, ref SDS 82 V94O
170455 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 83 3E4K
170456 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 81 3E4K
170457 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 80 3E4K
170458 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 79 3E4K
170459 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 78 3E4K
170460 -    UCSF                                      c         080911, ref SDS 77 V94O
170461 -    Lafayette        2.75   46.8   113 140              080909
170462 -    Lafayette        5.50   89.2   117 143              080908
170463 -    Lafayette        5.50   92.1   115 138              080907
170464 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 76 3E4K
170465 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 75 3E4K
170466 -    UCSF                                      c         080904, ref SDS 74 V94O
170467 -    Lafayette        8.25  140.4   116 131              080903
170468 -    Lafayette        5.50   94.9   115 134              080902
170469 -    Kaiser                                         x    080830
170470 -    Kaiser                                         x    080829
170471 -    UCSF                                      c         080828, ref SDS 71 V94O
170472 -    Lafayette        5.50   93.6   120 137              080826
170473 -    Lafayette        5.50   93.2   117 138              080825
170474 -    Lafayette        5.50   93.2   123 136         x    080823
170475 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 69 3E4K
170476 -    UCSF                                      e         080821, ref SDS 68 V94O
170477 -    Lafayette        5.50   94.7   115 137              080820
170478 -    Lafayette        5.50   94.3   115 135              080819
170479 -    Lafayette        8.25  141.7   118 134              080815
170480 -    UCSF                                      e         080814, ref SDS 65 V94O
170481 -    Lafayette        5.50   93.8   120 136              080813
170482 -    Lafayette        5.50   94.4   116 139              080812
170483 -    Lafayette        5.50   94.2   119 133              080810
170484 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 62 3E4K
170485 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 61 3E4K
170486 -    UCSF                                      c         080807, ref SDS 60 V94O
170487 -    Lafayette        8.25  143.7   115 132              080805
170488 -    Concord          7.00  127.6   105 118              080804
170489 -    Lafayette        8.25  143.2   112 134              080802
170490 -    Lafayette        5.50   93.4   115 138              080801
170491 -    Lafayette        5.50   92.2   118 140              080729
170492 -    Lafayette        5.50   92.6   116 137              080728
170493 -    Lafayette        8.25  142.6   114 134              080727
170494 -    Lafayette        5.50   91.5   120 143              080726
170495 -    Lafayette        8.25  140.8   117 135              080725
170496 -    Lafayette        5.50   91.8   122 141              080723
170497 -    Lafayette        5.50   91.3   120 139              080722
170498 -    Lafayette        8.25  143.3   115 133              080720
170499 -    Lafayette        5.50   90.7   125 144              080719
170500 -    Lafayette        5.50   92.4   123 142              080716
170501 -    Lafayette        2.25   46.8   116 137              080715
170502 -    Lafayette        8.25  141.8   116 136              080712
170503 -    Lafayette        5.50   92.9   116 139              080711
170504 -    Lafayette        8.25  143.3   113 137              080704
170505 -    Lafayette        5.50   90.2   121 147              080630
170506 -    Lafayette        8.25  142.4   116 138              080628
170507 -    Lafayette        5.50   91.4   118 138              080625
170508 -    Lafayette        2.25   47.9   116 136              080623
170509 -    Lafayette        5.50   94.2   112 138              080622
170510 -    Lafayette        5.50   94.7   115 133              080621
170511 -    Lafayette        2.25   48.3   110 129              080620
170512 -    Mt Diablo        7.00  129.4   130 153              080616
170513 -    Lafayette        5.50   90.8   120 146              080615
170514 -    Lafayette        5.50   91.3   124 144              080614
170515 -    Lafayette        5.50   89.7   122 143              080613
170516 -    Lafayette        2.76   45.8   120 147              080611
170517 -    Lafayette        5.50   90.5   123 145              080609
170518 -    Lafayette        5.50   92.7   115 138              080607
170519 -    Lafayette        5.50   94.2   118 139              080602
170520 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 30 WO8M
170521 -
170522 -
170523 -
170524 -
1706 -

SUBJECTS
Default Null Subject Account for Blank Record

1803 -
180401 -  ..
180402 - Side Effects Neupogen Treatments Increase May Be Chemotherapy
180403 -
180404 - Follow up ref SDS B9 SB8I, ref SDS B3 SB8I.
180405 -
180406 - Research on Neupogen side effects was reported on 080629. ref SDS 44
180407 - RQ9I  Previous case study on Neupogen side effects listed on 081002.
180408 - ref SDS 87 SB8I
180410 -  ..
180411 - She had another long day starting at 0530 leaving for a meeting with
180412 - UCSF in San Francisco.  She signed Consent documents and discussed
180413 - scope of sunitinib clinical study starting treatment on 081113.  She
180414 - then had laboratory work performed on the 5th floor in the Infusion
180415 - clinic.  Millie returned to Kaiser in Walnut Creek for a meeting with
180416 - the Kaiser in the Infuson Clinic to access her Power Port.  She then
180417 - met with the CT Department for a test, which was very tiring and
180418 - stressful. ref SDS B8 GR9K  Millie then returned to the Infusion
180419 - Clinic on the 2nd floor to have a nurse remove the Huber needle and
180420 - maintain the Power Port. ref SDS B7 W8DG  She then received a Neupogen
180421 - treatment reported in this record. ref SDS B9 UZ7K  After the Neupogen
180422 - treatment, Millie went to the Head and Neck Department at 1600 on the
180423 - 3rd floor for a core biopsy procedure. ref SDS C0 7P5O
180425 -  ..
180426 - Despite all of this emotional activity, Millie did not complain of
180427 - specific bone pain, fatigue, nor headache, which are side effects of
180428 - chemotherapy and Neupogen.
180430 -  ..
180431 - Millie last reported side effects on 081018 experiencing bone pain,
180432 - headache, and fatigue associated with Neupogen and chemotherapy.
180433 - ref SDS A3 Y17L
180435 -  ..
180436 - Side effects of Neupogen may be increasing, reported on...
180437 -
180438 -               081018................, ref SDS A3 Y17L
180439 -               081011................, ref SDS 96 FL4H
180440 -               081010................, ref SDS 95 SB8I
180441 -               081006................, ref SDS 93 3E4K
180442 -               081004................, ref SDS 92 Y17L
180443 -               081002................, ref SDS 90 Y17L
180444 -               080930................, ref SDS 89 Y17L
180445 -               080923................, ref SDS 85 K16F
180446 -               080915................, ref SDS 81 9W9I
180447 -               080810................, ref SDS 63 9W9I
180448 -               080803................, ref SDS 59 9W9I
180449 -               080726................, ref SDS 56 9W9I
180450 -               080721................, ref SDS 54 9W9I
180451 -               080713................, ref SDS 48 RM94
180452 -               080629................, ref SDS 43 6Q5J
180453 -               080628................, ref SDS 41 6Q5J
180454 -
180455 -
180456 -
180457 -
180458 -
180459 -
180460 -
1805 -