THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: October 12, 2008 10:16 AM Sunday; Rod Welch

Millie hiking at Lafayette reservoir erratic pulse again.

1...Summary/Objective
2...Exercise Hiking Maintain Fitness Strengthen Immune System
3...Pulse Elevated 60% Near 200 2 Laps Returned to Normal Third Lap


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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

2203 -
2203 -    ..
2204 - Summary/Objective
2205 -
220501 - Follow up ref SDS 92 0000, ref SDS 88 0000.
220502 -
220503 -
220504 -
220506 -  ..
2206 -
2207 -
2208 - Progress
2209 -
220901 - Exercise Hiking Maintain Fitness Strengthen Immune System
220902 - Pulse Elevated 60% Near 200 2 Laps Returned to Normal Third Lap
220903 -
220904 - Follow up ref SDS 95 3E4K, ref SDS 94 3E4K.
220905 -
220906 - Millie went hiking at Lafayette reservoir and did 3 laps, about 8.25
220907 - miles.  Time was pretty good, 146.4 minutes.
220909 -  ..
220910 - Research on Neupogen side effects was reported on 080629. ref SDS 42
220911 - RQ9I  Case study on Neupogen side effects listed on 081011.
220912 - ref SDS 95 SB8I
220914 -  ..
220915 - Side effects reported yesterday on 081011 of bone pain and headaches
220916 - have dissipated today. ref SDS 95 FL4H
220918 -  ..
220919 - Pulse spiked significantly for the first 2 laps.  Millie reported
220920 - pulse was 202 just starting out.  Normally, this would be 55 - 70, and
220921 - going up to 85 hiking for .25 miles on flat terrain.  Kept close watch
220922 - with observations about every 5 minutes, mostly climbing hills, and
220923 - checking to see the pulse drop normally with decline of effort.
220924 -
220925 -        [On 081013 next day pulse was normal, averaging 115, and
220926 -        maximum was 138 despite increased speed compared with today.
220927 -        ref SDS 96 3E4K
220929 -  ..
220930 - First lap was slow about 50 minutes, compared to 46 - 47 minutes
220931 - normally, and in order to closely monitor for adverse effects of
220932 - exercising at elevated pulse.
220933 -
220934 -        [On 081016 INR 4.2 increases above target range on UCSF blood
220935 -        test. ref SDS 97 5260
220937 -         ..
220938 -        [On 081016 notified Gloria at Kaiser Coagulation Control Clinic
220939 -        in Martinez, that did not take Coumadin. ref SDS 98 J37J
220941 -         ..
220942 -        [On 081019 Millie notified Gloria that Coumadin treatment
220943 -        was resumed the next day on Friday, 081017. ref SDS 99 TH7T
220945 -         ..
220946 -        [On 081105 primary care physician orders Muga test for heart
220947 -        damage prior to starting sunitinib clinical study that has some
220948 -        heart related side effects. ref SDS 90 WO72
220950 -  ..
220951 - Millie's normal pulse on this hike is about 115, even when the pace is
220952 - at 45 minutes for a lap.  It can elevate to 135 - 145, when running up
220953 - a hill, and can drop to below 100 on flat sections, and going slow.
220955 -  ..
220956 - Today, on the first 2 laps the pulse averaged about 180.  It got to
220957 - 224 once, and was over 200 on 5 - 10 occassions.  It might have
220958 - dropped into the 120s maybe once or twice.  Curiously, it went up
220959 - after climbing a hill, and starting down the other side, or on flat
220960 - tereain, whereas normally pulse rises while going up hill, and then
220961 - drops quickly.  Today, Millie experience very unusual big increases
220962 - and decreases in pulse that seemed unrelated to climing hills.
220964 -  ..
220965 - There was concern the equipment might not be reporting accurately.
220966 - The patient assistant used the equipment for about half a mile, and it
220967 - reported consistent with past history.
220969 -  ..
220970 - Naturally, there was concern about consequences of vigorous exercise
220971 - with reports of elevated pulse in relation to patient history of
220972 - pulmnary embolism, and recently findings on 080723 of Interstitional
220973 - lung disease from the CT test on 080718, ref SDS 54 TS4J, and which
220974 - occurs from side effects of cetuximab treatments. ref SDS 54 PF5H
220976 -  ..
220977 - Today, Millie did not report any symptoms.  No dizziness, weakness, no
220978 - difficulty breathing, no increased perspiration, nothing that signaled
220979 - increase stress cardio-pulmonary activity, except elevated pulse.
220980 - Diet has been normal: soup, fish, rice, broccoli, spinich, asparagas,
220981 - tomatoes, eggs, pancakes - normal.  She had a glass of wine the day
220982 - before with dinner.
220984 -  ..
220985 - Decided to try a 3rd lap.  On this lap the pulse returned to normal
220986 - averaging about 118 even while hiking faster.  Maximum on 2 occassions
220987 - during the 3rd lap was 136, and these occurred as expected while
220988 - climbing the most difficult hills.  Pulse dropped into the 120s and
220989 - then to between 110 - 119 after starting down the other side, and on
220990 - flat terrain.
220992 -  ..
220993 - Millie reported today that she has experienced additional pulse spikes
220994 - the past several weeks, but none lasted for even one lap, and most
220995 - returned to normal after a few minutes, similar to the report several
220996 - months ago on 080507. ref SDS 29 PQ5L  Occassional elevated pulse was
220997 - reported to the medical team in a letter on 080520. ref SDS 31 TV7P
220998 - This was reported again to the medical team in a follow up letter on
220999 - 080528. ref SDS 33 IK5P  Due to a change in personnel, and difficult
221000 - coordination that impeded communication elevated pulse was not
221001 - discussed with the medical team during the meeting at UCSF on 080529.
221002 - ref SDS 34 4F53  Similarly, during the meeting at Kaiser on 080627 the
221003 - doctor did not have time to discuss the spike in pulse that occurred
221004 - on 080507. ref SDS 40 J54I  On 080829 the doctor did not have time to
221005 - review Millie's report on 080507 of spike in pulse. ref SDS 70 J54I
221006 - At that time, on 080829 Millie notified the medical team about
221007 - increased exercise, and that there have been no further episodes of
221008 - elevated pulse since the report on 080507.
221010 -  ..
221011 - Elevated pulse is listed in the medical chart for the meeting at
221012 - Kaiser on 080829. ref SDS 70 2W4I
221014 -  ..
221015 - Hiking was interrupted last week with side effects of chemotherapy and
221016 - Neupogen treatments, going out only 3 days.  This week hiking was
221017 - interrupted yesterday with a social event.
221018 -
221019 -                                              +- c = Carboplatin
221020 -                                              +- e = Erbatex cetuximab
221021 -                           Time     Pulse     |
221022 -    Location        Miles Minutes  Avg Max  Chem Neupo  Date
221023 -    ----------------------------------------------------------------
221024 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 0 3E4K
221025 -    Kaiser                                         x    081011, ref SDS 95 3E4K
221026 -    Lafayette        5.50   93.3   116 138         x    081010, ref SDS 94 3E4K
221027 -    UCSF                                      e         081009, ref SDS 93 V94O
221028 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 92 3E4K
221029 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 91 3E4K
221030 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 90 3E4K
221031 -    UCSF                                      c         081002, ref SDS 89 V94O
221032 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 88 3E4K
221033 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 88 3E4K
221034 -    Kaiser                                         x    080927, ref SDS 87 UZ7K
221035 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 86 3E4K
221036 -    UCSF                                      c         080925, ref SDS 85 V94O
221037 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 84 3E4K
221038 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 84 3E4K
221039 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 84 3E4K
221040 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 83 3E4K
221041 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 82 3E4K
221042 -    UCSF                                      c         080918, ref SDS 81 V94O
221043 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 82 3E4K
221044 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 80 3E4K
221045 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 79 3E4K
221046 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 78 3E4K
221047 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 77 3E4K
221048 -    UCSF                                      c         080911, ref SDS 76 V94O
221049 -    Lafayette        2.75   46.8   113 140              080909
221050 -    Lafayette        5.50   89.2   117 143              080908
221051 -    Lafayette        5.50   92.1   115 138              080907
221052 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 75 3E4K
221053 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 74 3E4K
221054 -    UCSF                                      c         080904, ref SDS 73 V94O
221055 -    Lafayette        8.25  140.4   116 131              080903
221056 -    Lafayette        5.50   94.9   115 134              080902
221057 -    Kaiser                                         x    080830
221058 -    Kaiser                                         x    080829
221059 -    UCSF                                      c         080828, ref SDS 69 V94O
221060 -    Lafayette        5.50   93.6   120 137              080826
221061 -    Lafayette        5.50   93.2   117 138              080825
221062 -    Lafayette        5.50   93.2   123 136         x    080823
221063 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 67 3E4K
221064 -    UCSF                                      e         080821, ref SDS 66 V94O
221065 -    Lafayette        5.50   94.7   115 137              080820
221066 -    Lafayette        5.50   94.3   115 135              080819
221067 -    Lafayette        8.25  141.7   118 134              080815
221068 -    UCSF                                      e         080814, ref SDS 64 V94O
221069 -    Lafayette        5.50   93.8   120 136              080813
221070 -    Lafayette        5.50   94.4   116 139              080812
221071 -    Lafayette        5.50   94.2   119 133              080810
221072 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 62 3E4K
221073 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 61 3E4K
221074 -    UCSF                                      c         080807, ref SDS 60 V94O
221075 -    Lafayette        8.25  143.7   115 132              080805
221076 -    Concord          7.00  127.6   105 118              080804
221077 -    Lafayette        8.25  143.2   112 134              080802
221078 -    Lafayette        5.50   93.4   115 138              080801
221079 -    Lafayette        5.50   92.2   118 140              080729
221080 -    Lafayette        5.50   92.6   116 137              080728
221081 -    Lafayette        8.25  142.6   114 134              080727
221082 -    Lafayette        5.50   91.5   120 143              080726
221083 -    Lafayette        8.25  140.8   117 135              080725
221084 -    Lafayette        5.50   91.8   122 141              080723
221085 -    Lafayette        5.50   91.3   120 139              080722
221086 -    Lafayette        8.25  143.3   115 133              080720
221087 -    Lafayette        5.50   90.7   125 144              080719
221088 -    Lafayette        5.50   92.4   123 142              080716
221089 -    Lafayette        2.25   46.8   116 137              080715
221090 -    Lafayette        8.25  141.8   116 136              080712
221091 -    Lafayette        5.50   92.9   116 139              080711
221092 -    Lafayette        8.25  143.3   113 137              080704
221093 -    Lafayette        5.50   90.2   121 147              080630
221094 -    Lafayette        8.25  142.4   116 138              080628
221095 -    Lafayette        5.50   91.4   118 138              080625
221096 -    Lafayette        2.25   47.9   116 136              080623
221097 -    Lafayette        5.50   94.2   112 138              080622
221098 -    Lafayette        5.50   94.7   115 133              080621
221099 -    Lafayette        2.25   48.3   110 129              080620
221100 -    Mt Diablo        7.00  129.4   130 153              080616
221101 -    Lafayette        5.50   90.8   120 146              080615
221102 -    Lafayette        5.50   91.3   124 144              080614
221103 -    Lafayette        5.50   89.7   122 143              080613
221104 -    Lafayette        2.76   45.8   120 147              080611
221105 -    Lafayette        5.50   90.5   123 145              080609
221106 -    Lafayette        5.50   92.7   115 138              080607
221107 -    Lafayette        5.50   94.2   118 139              080602
221108 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 29 WO8M
221109 -
221110 -
221111 -
221112 -
221113 -
221114 -
2212 -