THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net
S U M M A R Y
DIARY: November 24, 2008 07:00 AM Monday;
Rod Welch
Millie sunitinib #11 IBC 5th relapse hiking6 miles.
1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
........Patient History Sunitinib Loading Dose 14 Days
3...Side Effects Sunitinib Study
4...Exercise Hiking Maintain Fitness Strengthen Immune System
5...Case Study on Pateint History Exercising
..............
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CONTACTS
SUBJECTS
Default Null Subject Account for Blank Record
0403 -
0403 - ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 75 0000. ref SDS 74 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 - ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - On 081113 Millie received sunitinib drugs from UCSF to treat the 5th
040904 - relapse of IBC.
040906 - ..
040907 - Millie began the 14 day "charging" treatment on 081114. ref SDS 63
040908 - EK7I After 14 treatments, if Millie tolerates sunitinib at the
040909 - prescribed dose, then she begins adding 2 chemotherapy drugs once a
040910 - day for 2 days a week as prescribed in the treatment protocol,
040911 - reviewed on 081017. ref SDS 49 004O
040913 - ..
040914 - Patient History Sunitinib Loading Dose 14 Days
040915 -
040916 - Follow up ref SDS 75 OE6K, ref SDS 74 OE6K.
040917 -
040919 - Cycle 1
040920 - Cohort: 3
040922 - ..
040923 - Sunitinib MG Cyclophos Metho
040924 - Amount Today Cum phamide trexate
040925 - Days Date Time Cycle 25 12.5 Total Total Amnt Total Amnt Total
040926 - --------------------------------------------------------------------
040927 - Follow up ref SDS 75 PA8Y, ref SDS 74 PA8Y.
040928 -
040929 - 1. 081114 0700 1 1 1 37.5 37.5 0 0 0 0 ..... ref SDS 63 OE6K
040930 - 2. 081115 0700 1 1 1 37.5 75.0 0 0 0 0 ..... ref SDS 64 OE6K
040931 - 3. 081116 0700 1 1 1 37.5 112.5 0 0 0 0 ..... ref SDS 65 OE6K
040932 - 4. 081117 0700 1 1 1 37.5 150.0 0 0 0 0 ..... ref SDS 66 OE6K
040933 - 5. 081118 0700 1 1 1 37.5 187.5 0 0 0 0 ..... ref SDS 69 OE6K
040934 - 6. 081119 0700 1 1 1 37.5 225.0 0 0 0 0 ..... ref SDS 71 OE6K
040935 - 7. 081120 0700 1 1 1 37.5 263.5 0 0 0 0 ..... ref SDS 72 OE6K
040936 - 8. 081121 0700 1 1 1 37.5 301.0 0 0 0 0 ..... ref SDS 73 OE6K
040937 - 9. 081122 0700 1 1 1 37.5 338.5 0 0 0 0 ..... ref SDS 74 OE6K
040938 - 10. 081123 0700 1 1 1 37.5 376.0 0 0 0 0 ..... ref SDS 75 OE6K
040939 - 11. 081124 0700 1 1 1 37.5 413.5 0 0 0 0 ..... ref SDS 0 OE6K
040940 -
040941 -
040942 -
040943 -
0410 -
SUBJECTS
Default Null Subject Account for Blank Record
0503 -
050401 - ..
050402 - Side Effects Sunitinib Study
050403 -
050404 - Follow up ref SDS 75 LF8M, ref SDS 74 LF8M.
050405 -
050406 - Sunitinib side effects are listed in the study Consent document,
050407 - reviewed on 081017. ref SDS 49 4G7G
050409 - ..
050410 - Today, Millie reports minor joint pain, ref SDS 49 U18H, and fatigue,
050411 - side effects listed for sunitinib on 081017. ref SDS 49 4G7G
050413 - ..
050414 - Actually, her energy is noticably increased today, after taking a day
050415 - off yesterday from hiking.
050417 - ..
050418 - Millie's record of exercising shows correlation between treatments and
050419 - exercise that indicates mild effects so far. ref SDS 0 X64F She
050420 - plans continued hiking to work through side effects.
050422 - ..
050423 - Blood pressure seems more normal for Millie again today.
050425 - ..
050426 - Blood pressure 121 74 and pulse 53 today shows perhaps lessening
050427 - sunitinib side effects of high blood pressure, also listed on 081017.
050428 - ref SDS 49 C78M Yesterday, on 081122 there was improvement while
050429 - hiking, ref SDS 74 X64F, possibly recovering from generally a 30 point
050430 - drop in patient profile for pulse while hiking on 081121. ref SDS 73
050431 - X64F
050433 - ..
050434 - Millie also has side effects from Neupogen; but nothing for several
050435 - weeks since she stopped treatments pending evaluation with new
050436 - sunitinib treatments, last reported on 081120. ref SDS 72 SB8I
050438 - ..
050439 - Date
050440 - Description Adverse Event Start Stop Medication
050441 - ---------------------------------------------------------
050442 - Follow up ref SDS 75 LF8M, ref SDS 74 LF8M.
050443 -
050444 - Diarea 081114 081114 Imodium........ ref SDS 63 LF8M
050445 - Low pulse 081120 081120 None........... ref SDS 72 LF8M
050446 - Low pulse 081121 081121 None........... ref SDS 73 7G8M
050447 - BP 144 84 Pulse 48 081121 081121 Hiking......... ref SDS 73 LF8M
050448 - Joint pain minor 081121 081121 Hiking......... ref SDS 73 LF8M
050449 - Fatigue minor 081121 081121 Hiking......... ref SDS 73 LF8M
050450 - Low pulse 081122 081122 None........... ref SDS 74 7G8M
050451 - Fatigue minor 081122 081122 Hiking......... ref SDS 74 LF8M
050452 - Low pulse 081123 081122 None........... ref SDS 75 7G8M
050453 - BP 121 74 Pulse 53 081123 081123 Hiking......... ref SDS 75 LF8M
050454 - Fatigue minor 081123 081122 Hiking......... ref SDS 75 LF8M
050455 -
050456 -
050457 -
050458 -
0505 -
SUBJECTS
Default Null Subject Account for Blank Record
0603 -
060401 - ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS 75 3E4K, ref SDS 74 3E4K.
060405 -
060406 - Millie went hiking at Lafayette reservoir, and did 2 laps about 5.5
060407 - miles in 91.4 minutes, showing increased pace without running.
060408 - ref SDS 0 X64F Pulse seems to be rising again today, more toward
060409 - patient history norms, possibly correcting significantly lower pulse
060410 - the past few days, reported on 081121. ref SDS 73 7G8M
060412 - ..
060413 - Millie has not had another attack of Cellulitis and lymphedema since
060414 - going to the emergency care unit on 080409. ref SDS 4 0001 There was
060415 - a slight flare up on 080520. ref SDS 6 OU5J
060417 - ..
060418 - Millie had her 11th treatment with sunitinib this morning at 0700.
060419 - ref SDS 75 PA8Y
060421 - ..
060422 - On 081110, Millie complained about diffiuclty lifting herself from a
060423 - full squatting position. ref SDS 61 HX67 She has since been
060424 - exercising to strengthen her legs, and arms.
060426 - ..
060427 - This morning Millie did...
060428 -
060429 - Arm presses 3 sets of 10 leaning against bannister.
060430 - Squats 3 sets of 10 vary depth useing bannister for leverage
060432 - ..
060433 - There have been no indications of Cellulitis nor lymphedema that has
060434 - occurred previously with exercising the left arm, reported on 070607.
060435 - ref SDS 3 ZH6I
060436 -
060438 - ..
060439 - Case Study on Pateint History Exercising
060440 -
060441 - Follow up ref SDS 75 X64F, ref SDS 74 X64F.
060442 -
060443 - +- s = Sunitinib
060444 - +- c = Carboplatin
060445 - +- e = Erbatex cetuximab
060446 - Time Pulse |
060447 - Location Miles Minutes Avg Max Chem Neupo Date
060448 - ----------------------------------------------------------------
060449 - Lafayette 5.50 91.4 100 129 s 081124, ref SDS 0 3E4K
060450 - Concord home s 081123, ref SDS 75 3E4K
060451 - Lafayette 5.50 92.8 95 122 s 081122, ref SDS 74 3E4K
060452 - Lafayette 5.50 94.4 85 112 s 081121, ref SDS 73 3E4K
060453 - Lafayette 5.50 94.7 90 122 s 081120, ref SDS 72 3E4K
060454 - San Francisco 1.00 60.0 65 75 s 081119, ref SDS 71 3E4K
060455 - Lafayette 2.75 49.2 97 130 s 081118, ref SDS 70 3E4K
060456 - Lafayette 5.50 93.6 115 138 s 081117, ref SDS 67 3E4K
060457 - Concord home s 081116, ref SDS 65 Y68J
060458 - Concord home s 081115, ref SDS 64 EK7I
060459 - Concord home s 081114, ref SDS 63 XW6H
060460 - Lafayette 5.50 94.2 115 138 081110, ref SDS 61 3E4K
060461 - Lafayette 2.75 48.4 105 128 081109, ref SDS 60 3E4K
060462 - Kaiser x 081108, ref SDS 59 UZ7K
060463 - Kaiser x 081107, ref SDS 58 UZ7K
060464 - Lafayette 5.50 90.2 120 143 081025, ref SDS 56 3E4K
060465 - Kaiser x 081025, ref SDS 56 UZ7K
060466 - Kaiser x 081024, ref SDS 55 UZ7K
060467 - UCSF c 081023, ref SDS 54 V94O
060468 - Lafayette 5.50 90.6 115 141 081021, ref SDS 53 3E4K
060469 - Lafayette 5.50 90.4 110 128 081020, ref SDS 52 3E4K
060470 - Kaiser x 081018, ref SDS 51 UZ7K
060471 - Kaiser x 081017, ref SDS 50 UZ7K
060472 - UCSF e 081016, ref SDS 48 V94O
060473 - Lafayette 5.50 90.1 115 154 081014, ref SDS 47 3E4K
060474 - Lafayette 5.50 92.7 115 138 081013, ref SDS 46 3E4K
060475 - Lafayette 8.25 146.4 180 224 081012, ref SDS 45 3E4K
060476 - Kaiser x 081011, ref SDS 44 UZ7K
060477 - Lafayette 5.50 93.3 116 138 081010, ref SDS 43 3E4K
060478 - Kaiser x 081010, ref SDS 43 UZ7K
060479 - UCSF e 081009, ref SDS 42 V94O
060480 - Lafayette 5.50 92.1 113 137 081006, ref SDS 41 3E4K
060481 - Lafayette 2.75 48.5 110 136 x 081004, ref SDS 40 3E4K
060482 - Lafayette 5.50 98.2 117 136 x 081003, ref SDS 39 3E4K
060483 - UCSF c 081002, ref SDS 38 V94O
060484 - Lafayette 5.50 94.7 115 142 080929, ref SDS 37 3E4K
060485 - Lafayette 8.25 150.4 115 135 080928, ref SDS 37 3E4K
060486 - Kaiser x 080927, ref SDS 36 UZ7K
060487 - Lafayette 5.50 90.2 120 140 x 080926, ref SDS 35 3E4K
060488 - UCSF c 080925, ref SDS 34 V94O
060489 - Lafayette 5.50 92.3 116 138 080923, ref SDS 33 3E4K
060490 - Lafayette 5.50 98.4 112 134 080922, ref SDS 33 3E4K
060491 - Lafayette 5.50 98.2 114 137 080921, ref SDS 33 3E4K
060492 - Lafayette 5.50 101.6 110 133 x 080920, ref SDS 32 3E4K
060493 - Lafayette 5.50 89.3 115 144 x 080919, ref SDS 31 3E4K
060494 - UCSF c 080918, ref SDS 30 V94O
060495 - Lafayette 2.75 46.2 117 139 080916, ref SDS 31 3E4K
060496 - Lafayette 5.50 91.8 117 142 080915, ref SDS 29 3E4K
060497 - Clayton Safeway 3.00 62.4 98 118 080914, ref SDS 28 3E4K
060498 - Lafayette 8.25 129.7 123 147 x 080913, ref SDS 27 3E4K
060499 - Lafayette 5.50 88.4 118 146 x 080912, ref SDS 26 3E4K
060500 - UCSF c 080911, ref SDS 25 V94O
060501 - Lafayette 2.75 46.8 113 140 080909
060502 - Lafayette 5.50 89.2 117 143 080908
060503 - Lafayette 5.50 92.1 115 138 080907
060504 - Lafayette 2.75 45.3 120 144 x 080906, ref SDS 24 3E4K
060505 - Lafayette 2.75 56.8 93 120 x 080905, ref SDS 23 3E4K
060506 - UCSF c 080904, ref SDS 22 V94O
060507 - Lafayette 8.25 140.4 116 131 080903
060508 - Lafayette 5.50 94.9 115 134 080902
060509 - Kaiser x 080830
060510 - Kaiser x 080829
060511 - UCSF c 080828, ref SDS 21 V94O
060512 - Lafayette 5.50 93.6 120 137 080826
060513 - Lafayette 5.50 93.2 117 138 080825
060514 - Lafayette 5.50 93.2 123 136 x 080823
060515 - Lafayette 8.25 142.5 110 131 x 080822, ref SDS 20 3E4K
060516 - UCSF e 080821, ref SDS 19 V94O
060517 - Lafayette 5.50 94.7 115 137 080820
060518 - Lafayette 5.50 94.3 115 135 080819
060519 - Lafayette 8.25 141.7 118 134 080815
060520 - UCSF e 080814, ref SDS 18 V94O
060521 - Lafayette 5.50 93.8 120 136 080813
060522 - Lafayette 5.50 94.4 116 139 080812
060523 - Lafayette 5.50 94.2 119 133 080810
060524 - Lafayette 8.25 143.6 114 132 x 080809, ref SDS 16 3E4K
060525 - Lafayette 8.25 141.1 117 135 x 080808, ref SDS 15 3E4K
060526 - UCSF c 080807, ref SDS 14 V94O
060527 - Lafayette 8.25 143.7 115 132 080805
060528 - Concord 7.00 127.6 105 118 080804
060529 - Lafayette 8.25 143.2 112 134 080802
060530 - Lafayette 5.50 93.4 115 138 080801
060531 - Lafayette 5.50 92.2 118 140 080729
060532 - Lafayette 5.50 92.6 116 137 080728
060533 - Lafayette 8.25 142.6 114 134 080727
060534 - Lafayette 5.50 91.5 120 143 080726
060535 - Lafayette 8.25 140.8 117 135 080725
060536 - Lafayette 5.50 91.8 122 141 080723
060537 - Lafayette 5.50 91.3 120 139 080722
060538 - Lafayette 8.25 143.3 115 133 080720
060539 - Lafayette 5.50 90.7 125 144 080719
060540 - Lafayette 5.50 92.4 123 142 080716
060541 - Lafayette 2.25 46.8 116 137 080715
060542 - Lafayette 8.25 141.8 116 136 080712
060543 - Lafayette 5.50 92.9 116 139 080711
060544 - Lafayette 8.25 143.3 113 137 080704
060545 - Lafayette 5.50 90.2 121 147 080630
060546 - Lafayette 8.25 142.4 116 138 080628
060547 - Lafayette 5.50 91.4 118 138 080625
060548 - Lafayette 2.25 47.9 116 136 080623
060549 - Lafayette 5.50 94.2 112 138 080622
060550 - Lafayette 5.50 94.7 115 133 080621
060551 - Lafayette 2.25 48.3 110 129 080620
060552 - Mt Diablo 7.00 129.4 130 153 080616
060553 - Lafayette 5.50 90.8 120 146 080615
060554 - Lafayette 5.50 91.3 124 144 080614
060555 - Lafayette 5.50 89.7 122 143 080613
060556 - Lafayette 2.76 45.8 120 147 080611
060557 - Lafayette 5.50 90.5 123 145 080609
060558 - Lafayette 5.50 92.7 115 138 080607
060559 - Lafayette 5.50 94.2 118 139 080602
060560 - Lafayette 5.50 96.2 110 202 080507, ref SDS 5 WO8M
060561 -
060562 -
060563 -
060564 -
060565 -
060566 -
0606 -