THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net
S U M M A R Y
DIARY: November 22, 2008 07:00 AM Saturday;
Rod Welch
Millie sunitinib #9 IBC 5th relapse hiking6 miles.
1...Summary/Objective
........Patient History Sunitinib Loading Dose 14 Days
2...Side Effects Sunitinib Study
3...Exercise Hiking Maintain Fitness Strengthen Immune System
4...Case Study on Pateint History Exercising
..............
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CONTACTS
SUBJECTS
Default Null Subject Account for Blank Record
0403 -
0403 - ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 73 0000. ref SDS 72 0000.
040502 -
040503 -
040504 -
040505 -
040507 - ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - On 081113 Millie received sunitinib drugs from UCSF to treat the 5th
040902 - relapse of IBC.
040904 - ..
040905 - Millie began the 14 day "charging" treatment on 081114. ref SDS 63
040906 - EK7I After 14 treatments, if Millie tolerates sunitinib at the
040907 - prescribed dose, then she begins adding 2 chemotherapy drugs once a
040908 - day for 2 days a week as prescribed in the treatment protocol,
040909 - reviewed on 081017. ref SDS 49 004O
040911 - ..
040912 - Patient History Sunitinib Loading Dose 14 Days
040913 -
040914 - Follow up ref SDS 73 OE6K, ref SDS 72 OE6K.
040915 -
040917 - Cycle 1
040918 - Cohort: 3
040920 - ..
040921 - Sunitinib MG Cyclophos Metho
040922 - Amount Today Cum phamide trexate
040923 - Days Date Time Cycle 25 12.5 Total Total Amnt Total Amnt Total
040924 - --------------------------------------------------------------------
040925 - Follow up ref SDS 72 PA8Y, ref SDS 71 PA8Y.
040926 -
040927 - 1. 081114 0700 1 1 1 37.5 37.5 0 0 0 0 ..... ref SDS 61 OE6K
040928 - 2. 081115 0700 1 1 1 37.5 75.0 0 0 0 0 ..... ref SDS 62 OE6K
040929 - 3. 081116 0700 1 1 1 37.5 112.5 0 0 0 0 ..... ref SDS 63 OE6K
040930 - 4. 081117 0700 1 1 1 37.5 150.0 0 0 0 0 ..... ref SDS 64 OE6K
040931 - 5. 081118 0700 1 1 1 37.5 187.5 0 0 0 0 ..... ref SDS 67 OE6K
040932 - 6. 081119 0700 1 1 1 37.5 225.0 0 0 0 0 ..... ref SDS 69 OE6K
040933 - 7. 081120 0700 1 1 1 37.5 263.5 0 0 0 0 ..... ref SDS 70 OE6K
040934 - 8. 081121 0700 1 1 1 37.5 301.0 0 0 0 0 ..... ref SDS 72 OE6K
040935 - 9. 081122 0700 1 1 1 37.5 338.5 0 0 0 0 ..... ref SDS 0 OE6K
040936 -
040937 -
040938 -
040939 -
040940 -
040941 -
0410 -
SUBJECTS
Default Null Subject Account for Blank Record
0503 -
050401 - ..
050402 - Side Effects Sunitinib Study
050403 -
050404 - Follow up ref SDS 73 LF8M, ref SDS 72 LF8M.
050405 -
050406 - Sunitinib side effects are listed in the study Consent document,
050407 - reviewed on 081017. ref SDS 49 4G7G
050409 - ..
050410 - Millie reports again minor fatigue, side effects listed for sunitinib
050411 - on 081017. ref SDS 49 4G7G
050413 - ..
050414 - Millie's record of exercising shows correlation between treatments and
050415 - exercise that indicates mild effects so far. Recently, Millie has
050416 - reduced exercise from 3 to only 2 laps. ref SDS 0 X64F She plans
050417 - continued hiking to work through side effects.
050419 - ..
050420 - Blood pressure seems to be rising today toward normal. Today, there
050421 - seemed to be increase in pulse while hiking, ref SDS 0 X64F, showing
050422 - some improvement to generally a 30 point drop in patient profile for
050423 - pulse while hiking, reported yesterday on 081121. ref SDS 73 X64F
050425 - ..
050426 - Millie also has side effects from Neupogen; but nothing for several
050427 - weeks since she stopped treatments pending evaluation with new
050428 - sunitinib treatments, reported on 081120. ref SDS 72 SB8I
050430 - ..
050431 - Date
050432 - Description Adverse Event Start Stop Medication
050433 - ---------------------------------------------------------
050434 - Follow up ref SDS 73 LF8M, ref SDS 72 LF8M.
050435 -
050436 - Diarea 081114 081114 Imodium........ ref SDS 63 LF8M
050437 - Low pulse 081120 081120 None........... ref SDS 72 LF8M
050438 - Low pulse 081121 081121 None........... ref SDS 73 7G8M
050439 - BP 144 84 Pules 48 081121 081121 Hiking......... ref SDS 73 LF8M
050440 - Joint pain minor 081121 081121 Hiking......... ref SDS 73 LF8M
050441 - Fatigue minor 081121 081121 Hiking......... ref SDS 73 LF8M
050442 - Low pulse 081122 081122 None........... ref SDS 0 7G8M
050443 - Fatigue minor 081122 081122 Hiking......... ref SDS 0 LF8M
050444 -
050445 -
050446 -
050447 -
0505 -
SUBJECTS
Default Null Subject Account for Blank Record
0603 -
060401 - ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS 73 3E4K, ref SDS 72 3E4K.
060405 -
060406 - Millie went hiking at Lafayette reservoir, and did 2 laps about 5.5
060407 - miles in 92.8 minutes, showing increased pace without running.
060408 - ref SDS 0 X64F Pulse seems to be rising today, more toward patient
060409 - history norms, possibly correcting significantly lower pulse the past
060410 - few days, reported yesterday. ref SDS 73 7G8M
060412 - ..
060413 - Millie has not had another attack of Cellulitis and lymphedema since
060414 - going to the emergency care unit on 080409. ref SDS 4 0001 There was
060415 - a slight flare up on 080520. ref SDS 6 OU5J
060417 - ..
060418 - Millie had her 9th treatment with sunitinib this morning at 0700.
060419 - ref SDS 0 PA8Y
060421 - ..
060422 - This morning Millie reports not sleeping well last night.
060424 - ..
060425 - On 081110, Millie complained about diffiuclty lifting herself from a
060426 - full squatting position. ref SDS 61 HX67 She has since been
060427 - exercising to strengthen her legs, and arms.
060429 - ..
060430 - This morning Millie did...
060431 -
060432 - Arm presses 3 sets of 10 leaning against bannister.
060433 - Squats 3 sets of 10 vary depth useing bannister for leverage
060435 - ..
060436 - There have been no indications of Cellulitis nor lymphedema that has
060437 - occurred previously with exercising the left arm, reported on 070607.
060438 - ref SDS 3 ZH6I
060439 -
060441 - ..
060442 - Case Study on Pateint History Exercising
060443 -
060444 - Follow up ref SDS 73 X64F, ref SDS 72 X64F.
060445 -
060446 - +- s = Sunitinib
060447 - +- c = Carboplatin
060448 - +- e = Erbatex cetuximab
060449 - Time Pulse |
060450 - Location Miles Minutes Avg Max Chem Neupo Date
060451 - ----------------------------------------------------------------
060452 - Lafayette 5.50 92.8 95 122 s 081122, ref SDS 0 3E4K
060453 - Lafayette 5.50 94.4 85 112 s 081121, ref SDS 73 3E4K
060454 - Lafayette 5.50 94.7 90 122 s 081120, ref SDS 72 3E4K
060455 - San Francisco 1.00 60.0 65 75 s 081119, ref SDS 71 3E4K
060456 - Lafayette 2.75 49.2 97 130 s 081118, ref SDS 70 3E4K
060457 - Lafayette 5.50 93.6 115 138 s 081117, ref SDS 67 3E4K
060458 - Concord home s 081116, ref SDS 65 Y68J
060459 - Concord home s 081115, ref SDS 64 EK7I
060460 - Concord home s 081114, ref SDS 63 XW6H
060461 - Lafayette 5.50 94.2 115 138 081110, ref SDS 61 3E4K
060462 - Lafayette 2.75 48.4 105 128 081109, ref SDS 60 3E4K
060463 - Kaiser x 081108, ref SDS 59 UZ7K
060464 - Kaiser x 081107, ref SDS 58 UZ7K
060465 - Lafayette 5.50 90.2 120 143 081025, ref SDS 56 3E4K
060466 - Kaiser x 081025, ref SDS 56 UZ7K
060467 - Kaiser x 081024, ref SDS 55 UZ7K
060468 - UCSF c 081023, ref SDS 54 V94O
060469 - Lafayette 5.50 90.6 115 141 081021, ref SDS 53 3E4K
060470 - Lafayette 5.50 90.4 110 128 081020, ref SDS 52 3E4K
060471 - Kaiser x 081018, ref SDS 51 UZ7K
060472 - Kaiser x 081017, ref SDS 50 UZ7K
060473 - UCSF e 081016, ref SDS 48 V94O
060474 - Lafayette 5.50 90.1 115 154 081014, ref SDS 47 3E4K
060475 - Lafayette 5.50 92.7 115 138 081013, ref SDS 46 3E4K
060476 - Lafayette 8.25 146.4 180 224 081012, ref SDS 45 3E4K
060477 - Kaiser x 081011, ref SDS 44 UZ7K
060478 - Lafayette 5.50 93.3 116 138 081010, ref SDS 43 3E4K
060479 - Kaiser x 081010, ref SDS 43 UZ7K
060480 - UCSF e 081009, ref SDS 42 V94O
060481 - Lafayette 5.50 92.1 113 137 081006, ref SDS 41 3E4K
060482 - Lafayette 2.75 48.5 110 136 x 081004, ref SDS 40 3E4K
060483 - Lafayette 5.50 98.2 117 136 x 081003, ref SDS 39 3E4K
060484 - UCSF c 081002, ref SDS 38 V94O
060485 - Lafayette 5.50 94.7 115 142 080929, ref SDS 37 3E4K
060486 - Lafayette 8.25 150.4 115 135 080928, ref SDS 37 3E4K
060487 - Kaiser x 080927, ref SDS 36 UZ7K
060488 - Lafayette 5.50 90.2 120 140 x 080926, ref SDS 35 3E4K
060489 - UCSF c 080925, ref SDS 34 V94O
060490 - Lafayette 5.50 92.3 116 138 080923, ref SDS 33 3E4K
060491 - Lafayette 5.50 98.4 112 134 080922, ref SDS 33 3E4K
060492 - Lafayette 5.50 98.2 114 137 080921, ref SDS 33 3E4K
060493 - Lafayette 5.50 101.6 110 133 x 080920, ref SDS 32 3E4K
060494 - Lafayette 5.50 89.3 115 144 x 080919, ref SDS 31 3E4K
060495 - UCSF c 080918, ref SDS 30 V94O
060496 - Lafayette 2.75 46.2 117 139 080916, ref SDS 31 3E4K
060497 - Lafayette 5.50 91.8 117 142 080915, ref SDS 29 3E4K
060498 - Clayton Safeway 3.00 62.4 98 118 080914, ref SDS 28 3E4K
060499 - Lafayette 8.25 129.7 123 147 x 080913, ref SDS 27 3E4K
060500 - Lafayette 5.50 88.4 118 146 x 080912, ref SDS 26 3E4K
060501 - UCSF c 080911, ref SDS 25 V94O
060502 - Lafayette 2.75 46.8 113 140 080909
060503 - Lafayette 5.50 89.2 117 143 080908
060504 - Lafayette 5.50 92.1 115 138 080907
060505 - Lafayette 2.75 45.3 120 144 x 080906, ref SDS 24 3E4K
060506 - Lafayette 2.75 56.8 93 120 x 080905, ref SDS 23 3E4K
060507 - UCSF c 080904, ref SDS 22 V94O
060508 - Lafayette 8.25 140.4 116 131 080903
060509 - Lafayette 5.50 94.9 115 134 080902
060510 - Kaiser x 080830
060511 - Kaiser x 080829
060512 - UCSF c 080828, ref SDS 21 V94O
060513 - Lafayette 5.50 93.6 120 137 080826
060514 - Lafayette 5.50 93.2 117 138 080825
060515 - Lafayette 5.50 93.2 123 136 x 080823
060516 - Lafayette 8.25 142.5 110 131 x 080822, ref SDS 20 3E4K
060517 - UCSF e 080821, ref SDS 19 V94O
060518 - Lafayette 5.50 94.7 115 137 080820
060519 - Lafayette 5.50 94.3 115 135 080819
060520 - Lafayette 8.25 141.7 118 134 080815
060521 - UCSF e 080814, ref SDS 18 V94O
060522 - Lafayette 5.50 93.8 120 136 080813
060523 - Lafayette 5.50 94.4 116 139 080812
060524 - Lafayette 5.50 94.2 119 133 080810
060525 - Lafayette 8.25 143.6 114 132 x 080809, ref SDS 16 3E4K
060526 - Lafayette 8.25 141.1 117 135 x 080808, ref SDS 15 3E4K
060527 - UCSF c 080807, ref SDS 14 V94O
060528 - Lafayette 8.25 143.7 115 132 080805
060529 - Concord 7.00 127.6 105 118 080804
060530 - Lafayette 8.25 143.2 112 134 080802
060531 - Lafayette 5.50 93.4 115 138 080801
060532 - Lafayette 5.50 92.2 118 140 080729
060533 - Lafayette 5.50 92.6 116 137 080728
060534 - Lafayette 8.25 142.6 114 134 080727
060535 - Lafayette 5.50 91.5 120 143 080726
060536 - Lafayette 8.25 140.8 117 135 080725
060537 - Lafayette 5.50 91.8 122 141 080723
060538 - Lafayette 5.50 91.3 120 139 080722
060539 - Lafayette 8.25 143.3 115 133 080720
060540 - Lafayette 5.50 90.7 125 144 080719
060541 - Lafayette 5.50 92.4 123 142 080716
060542 - Lafayette 2.25 46.8 116 137 080715
060543 - Lafayette 8.25 141.8 116 136 080712
060544 - Lafayette 5.50 92.9 116 139 080711
060545 - Lafayette 8.25 143.3 113 137 080704
060546 - Lafayette 5.50 90.2 121 147 080630
060547 - Lafayette 8.25 142.4 116 138 080628
060548 - Lafayette 5.50 91.4 118 138 080625
060549 - Lafayette 2.25 47.9 116 136 080623
060550 - Lafayette 5.50 94.2 112 138 080622
060551 - Lafayette 5.50 94.7 115 133 080621
060552 - Lafayette 2.25 48.3 110 129 080620
060553 - Mt Diablo 7.00 129.4 130 153 080616
060554 - Lafayette 5.50 90.8 120 146 080615
060555 - Lafayette 5.50 91.3 124 144 080614
060556 - Lafayette 5.50 89.7 122 143 080613
060557 - Lafayette 2.76 45.8 120 147 080611
060558 - Lafayette 5.50 90.5 123 145 080609
060559 - Lafayette 5.50 92.7 115 138 080607
060560 - Lafayette 5.50 94.2 118 139 080602
060561 - Lafayette 5.50 96.2 110 202 080507, ref SDS 5 WO8M
060562 -
060563 -
060564 -
060565 -
060566 -
060567 -
060568 -
060569 -
060570 -
0606 -