THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: January 8, 2009 07:00 AM Thursday; Rod Welch

Millie sunitinib #49 treatment IBC 5th relapse.

1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
3...Sunitinib Cyclophosmaide Methotrexate Patient History
4...Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
5...Exercise Hiking Maintain Fitness Strengthen Immune System
6...Case Study on Pateint History Exercising


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS I1 0000. ref SDS H8 0000.
040502 -
040503 -
040504 -
040505 -
040507 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS I1 505G, ref SDS H8 505G.
040904 -
040905 - Background pausing treatment on 081219 for a week for Millie's blood
040906 - counts to recover, and resuming on 081226 with sunitinib and
040907 - cyclophosphamide. ref SDS G4 505G  Today on 090108, treatment with
040908 - sunitinib was continued at full strength, and cyclophosphamide was
040909 - discontinued until blood counts rise above NEUTS 1.00. ref SDS 0 9V4I
040911 -  ..
040912 - Today, IBC rash and nodules in breastbone still possibly improving
040913 - after a few days getting worse, reported on 090105. ref SDS H7 124N
040914 - Examination at UCSF this morning on 090108 found IBC worse than
040915 - observed during examination on 081218 after Millie experienced
040916 - substantial improvement recovering from IBC.  This aligns with
040917 - worsening IBC reported on 081224 and 081225, and then recovery on
040918 - 081226 presented in Millie's letter to the medical team on 081230.
040919 - ref SDS G9 4W7Y  Additionally, on 090103 IBC seemed to get worse again
040920 - for several days, but on 090106 was beginning to respond to treatment
040921 - again, presented in Millie's letter on 090106. ref SDS I0 YO4V
040923 -  ..
040924 - During examination at UCSF, the medical team reviewed findings in CT
040925 - test report for scans on 081230 indicate declining cancer with nodes
040926 - in right axillary stable, and significant decline of lymph adenopathy
040927 - in left and right supraclavicular.
040929 -  ..
040930 - Today, Millie less energetic could not go to the gym for aerobic
040931 - exercise. ref SDS 0 X64F  Did not go hiking at Lafayette nor at the
040932 - Clayton Safeway trail. because the hiking was too difficult, reported
040933 - on 090103, ref SDS H5 OT3L, due to rising side effects of falling
040934 - blood counts that cause fatigue, ref SDS 0 LF8M, from 14 cancer
040935 - treatments beginning on 081226, reported below. ref SDS 0 9I6T
040937 -  ..
040938 - NEUTS patient history of neutropenia from chemotherapy everyday with
040939 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
040941 -  ..
040942 - Neupogen treatments prescribed today by the medical team at UCSF for
040943 - 090109 and 090110 to help maintain blood counts to strengthen Millie's
040944 - immunity system, shown in Millie's letter to the medical team on
040945 - 090109. ref SDS I4 UF3Q
040946 -
040948 -  ..
040949 - Sunitinib Cyclophosmaide Methotrexate Patient History
040950 -
040951 - Follow up ref SDS I1 OE6K, ref SDS H8 OE6K.
040952 -
040954 -        Cycle 1  begin 081128 after 14 treatmenst sunitinib alone
040955 -        Cohort: 3
040957 -        ..
040958 -                                          Cyclophos  Metho
040959 -                               Sunitinib   phamide   trexate
040960 -       Days  Date  Time  Cycle    37.5       50        5
040961 -       =======================================================
040962 -       Follow up ref SDS I1 PA8Y, ref SDS H8 PA8Y.
040963 -
040964 -        1.  081114 0700  Load    37.5         0         0 ... ref SDS 94 OE6K
040965 -        2.  081115 0700  Load    75.0         0         0 ... ref SDS 95 OE6K
040966 -        3.  081116 0700  Load   112.5         0         0 ... ref SDS 96 OE6K
040967 -        4.  081117 0700  Load   150.0         0         0 ... ref SDS 97 OE6K
040968 -        5.  081118 0700  Load   187.5         0         0 ... ref SDS A0 OE6K
040969 -        6.  081119 0700  Load   225.0         0         0 ... ref SDS A2 OE6K
040970 -        7.  081120 0700  Load   263.5         0         0 ... ref SDS A3 OE6K
040971 -        8.  081121 0700  Load   301.0         0         0 ... ref SDS A4 OE6K
040972 -        9.  081122 0700  Load   338.5         0         0 ... ref SDS A5 OE6K
040973 -       10.  081123 0700  Load   376.0         0         0 ... ref SDS A6 OE6K
040974 -       11.  081124 0700  Load   413.5         0         0 ... ref SDS A7 OE6K
040975 -       12.  081125 0700  Load   451.0         0         0 ... ref SDS A8 OE6K
040976 -             ..
040977 -       13.  081126 0700  Load   488.5         0         0 ... ref SDS A9 OE6K
040978 -             ..
040979 -            081126 0820  NEUTS........1.50................... ref SDS B0 PU6K
040981 -             ..
040982 -       14.  081127 0700  Load   526.0         0         0 ... ref SDS B1 OE6K
040983 -       15.  081128 0700  1  1   563.5   1    50    1    5 ... ref SDS B4 OE6K
040984 -       16.  081129 0700  1  2   601.0   2   100    2   10 ... ref SDS B7 OE6K
040985 -       17.  081130 0700  1  3   638.5   3   150    2   10 ... ref SDS B8 OE6K
040986 -       18.  081201 0700  1  4   676.0   4   200    2   10 ... ref SDS B9 OE6K
040987 -       19.  081202 0700  1  5   713.5   5   250    2   10 ... ref SDS C1 OE6K
040988 -             ..
040989 -       20.  081203 0700  1  6   751.0   6   300    2   10 ... ref SDS C3 OE6K
040990 -
040991 -            081203 0735. NEUTS....... 0.624 ...... .......... ref SDS C2 RN5G
040992 -
040993 -                Rate of change per day = 1500 - 624 = 876 / 7
040994 -
040995 -                                       = 120+ per day
040997 -             ..
040998 -       21.  081204 0700  1  7   788.5   7   350    2   10 ... ref SDS C4 OE6K
040999 -             ..
041000 -       22.  081205 0700  1  8   826.0   8   400    3   15 ... ref SDS C5 OE6K
041001 -
041002 -            081205 1300  Neupogen...... 480 mcg  480......... ref SDS C6 KV84
041004 -             ..
041005 -       23.  081206 0700  1  9   863.5   9   450    4   20 ... ref SDS C9 OE6K
041006 -
041007 -            081206 0930  Neupogen...... 480 mcg  960......... ref SDS D0 BI4J
041009 -             ..
041010 -       24.  081207 0700  1 10   901.0  10   500    4   20 ... ref SDS D1 OE6K
041011 -       25.  081208 0700  1 11   938.5  11   550    4   20 ... ref SDS D2 OE6K
041012 -       26.  081209 0700  1 12   976.0  12   600    4   20 ... ref SDS D3 OE6K
041013 -             ..
041014 -       27.  081210 0700  1 13  1013.5  13   650    4   20 ... ref SDS D5 OE6K
041015 -
041016 -            081210 1301. NEUTS....... 1.085 ................. ref SDS D6 QY6H
041018 -             ..
041019 -       28.  081211 0700  1 14  1050.0  14   700    4   20 ... ref SDS D9 OE6K
041020 -             ..
041021 -       29.  081212 0700  1 15  1087.5  15   750    5   25 ... ref SDS E1 OE6K
041022 -
041023 -            081212 1115. NEUTS....... 1.054 ................. ref SDS E2 QY6H
041025 -             ..
041026 -       30.  081213 0700  1 16  1125.0  16   800    6   30 ... ref SDS E4 OE6K
041027 -       31.  081214 0700  1 17  1162.5  17   850    6   30 ... ref SDS E5 OE6K
041028 -       32.  081215 0700  1 18  1200.0  18   900    6   30 ... ref SDS E6 OE6K
041029 -       33.  081216 0700  1 19  1237.5  19   950    6   30 ... ref SDS E7 OE6K
041030 -             ..
041031 -       34.  081217 0700  1 20  1275.0  20  1000    6   30 ... ref SDS E8 OE6K
041032 -       35.  081218 0700  1 21  1312.5  21  1050    canceled.. ref SDS F0 OE6K
041033 -
041034 -            081218 0830. NEUTS....... 0.740 ................. ref SDS F1 QY6H
041036 -             ..
041037 -            081219 0700  2  1  paused until 081226........... ref SDS F3 OE6K
041039 -             ..
041040 -            081219 1130  Neupogen...... 480 mcg 1440 ........ ref SDS F5 UZ7K
041041 -            081220 0900  Neupogen...... 480 mcg 1920 ........ ref SDS F7 UZ7K
041043 -             ..
041044 -       36.  081226 0700  2  1  1350.0  22  1100.............. ref SDS G4 OE6K
041045 -       37.  081227 0700  2  2  1387.5  23  1150.............. ref SDS G6 OE6K
041046 -       38.  081228 0700  2  3  1425.0  24  1200.............. ref SDS G7 OE6K
041047 -       39.  081229 0700  2  4  1462.5  25  1250.............. ref SDS G8 OE6K
041048 -       40.  081230 0700  2  5  1500.0  26  1300.............. ref SDS H0 OE6K
041049 -       41.  081231 0700  2  6  1537.5  27  1350.............. ref SDS H2 OE6K
041050 -       42.  090101 0700  2  7  1575.0  28  1400.............. ref SDS H3 OE6K
041051 -       43.  090102 0700  2  8  1612.5  29  1450.............. ref SDS H4 OE6K
041052 -       44.  090103 0700  2  9  1650.0  30  1500.............. ref SDS H5 OE6K
041053 -       45.  090104 0700  2 10  1687.5  31  1550.............. ref SDS H6 OE6K
041054 -       46.  090105 0700  2 11  1725.0  32  1600.............. ref SDS H7 OE6K
041055 -       47.  090106 0700  2 12  1762.5  33  1650.............. ref SDS H8 OE6K
041056 -       48.  090107 0700  2 13  1800.0  34  1700.............. ref SDS I1 OE6K
041057 -        ..
041058 -       49.  090108 0700  2 14  1837.5  35  1750.............. ref SDS 0 OE6K
041060 -  ..
041061 - Background on recent blood tests is reported on 081218. ref SDS F0
041062 - S18L
041064 -  ..
041065 - On 081230 case study dilemma cancer treatmnets cause low blood counts,
041066 - which prevents getting treatment; not getting treatment incerases
041067 - cancer; UCSF paused treatment for a week and prescribed Neupogen to
041068 - increase blood counts. ref SDS G9 I87N
041069 -
041070 -
041071 -
041072 -
041073 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
050401 -  ..
050402 - Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
050403 -
050404 - Follow up ref SDS I1 LF8M, ref SDS H8 LF8M.
050405 -
050406 - Fatigue is a likely side effect of sunitinib with cyclophosphamide,
050407 - listed in the Consent document reviewed on 081017. ref SDS 76 4G7G
050409 -  ..
050410 - Blood counts NEUTS 0.87 reported for labs today at UCSF, ref SDS I2
050411 - QY6H, show another significant decline from NEUTS 1.710 reported on
050412 - 081226, ref SDS G5 B35J, from getting 14 daily cancer treatments
050413 - starting on 081226, shown by patient history above, ref SDS 0 9I6T,
050414 - has caused significant side effects of fatigue.  Previously, on 081218
050415 - treatment was paused for a week, and the dose for sunitinib was
050416 - proposed to be reduced from 37.5 mg to 25 mg per day, so that Millie
050417 - could recover from low blood counts. ref SDS F2 QW48  The doctor
050418 - reviewed patient history and revised the treatment plan to check blood
050419 - counts on 081226, and prescribed that, if counts recovered to NEUTS
050420 - above 1.00, then sunitinib would continue at 37.5 mg.  Millie reported
050421 - in a letter to the medical team on 081223 initial increased fatigue,
050422 - but after 4 days off treatment (holiday), she experienced increased
050423 - energy. ref SDS G1 BV5V
050425 -  ..
050426 - Today, the doctor prescribed continuing sunitnib at full strength 37.5
050427 - mg.  Cyclophosphamide was paused for a week, and will not be taken
050428 - again until blood counts NEUTS > 1.00, also shown in Millie's letter
050429 - to the medical team on 090109. ref SDS I4 UF3T  A blood test will be
050430 - performed at Kaiser next Friday on 090116; if NEUTS > 1.00
050431 - cyclophsphamide will be continued at reduced dose of 5 days per week,
050432 - instead 7. ref SDS I4 UF3W  This aligns with letter from UCSF today on
050433 - 090108 summarizing instructions from medical team. ref SDS I3 UX5S
050434 - This aligns with Millie's letter to primary care physician at Kaiser
050435 - on 081219. ref SDS F4 SU9Q
050436 -
050437 -            [On 090109 Millie letter to medical team reports blood
050438 -            counts very low again, NEUTS 0.87, confirms UCSF treatment
050439 -            plan on 090108 continues sunitinib at full strenth, and
050440 -            pauses cyclophosphamice until blood counts rise to NEUTS
050441 -            1.00, and then reduces cyclophosphamide from 7 to 5 days a
050442 -            week in order maintain blood counts. ref SDS I4 UF3Q
050444 -  ..
050445 - Today, Millie less energetic could not work out in the gym for aerobic
050446 - exercise. ref SDS 0 X64F, Did not go hiking at Lafayette nor at the
050447 - Clayton Safeway trail, reported below, ref SDS 0 3E4K, because hiking
050448 - was difficult on Millie's legs, reported on 090102, ref SDS H4 6E7G,
050449 - due to rising side effects of fatigue from 14 cancer treatments
050450 - beginning on 081226, shown above, ref SDS 0 9I6T, that are now causing
050451 - blood counts to fall again,
050453 -  ..
050454 - Background on Neupogen treatments and UCSF comments are reported on
050455 - 081207. ref SDS D1 673J
050457 -  ..
050458 - NEUTS blood tests show patient history of treatments with Nuepogen to
050459 - recover from neutropenia caused by getting chemotherapy everyday with
050460 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
050462 -  ..
050463 - Schedule for Neupogen treatments is listed on 081220. ref SDS F7 WJ4O
050465 -  ..
050466 - Feet and toes continue better today, less sensitive to walking that
050467 - was reported during the meeting at UCSF on 081218. ref SDS F2 HM4M
050468 - Subsiding side effects restoring normal use of feet enabled hiking,
050469 - but Millie is tired today, so we did not go hiking, per below.
050470 - ref SDS G7 X64F
050472 -  ..
050473 - Tearing eyes were reported today during the examination.  Tara
050474 - prescribed over-the-counter eye drops.
050476 -  ..
050477 - Joint pain, discomfort, and total ill feeling, commonly associated
050478 - with chemotherapy, reported on 081218, ref SDS F0 E38H, and discussed
050479 - with the medical team at UCSF also on 081218, ref SDS F2 QW7H, has now
050480 - mostly disipated, as a result of the doctor stopping all treatment for
050481 - 1 week, ref SDS F2 QW48, as shown in patient history above.
050482 - ref SDS G7 053F
050484 -  ..
050485 - Interstitional lung disease discussed in the record on 081218,
050486 - ref SDS F0 KM5F, shows no evident symptoms.
050488 -  ..
050489 - Vitals were reported today at the meeting at Kaiser with the primary
050490 - care physician...
050491 -
050492 -                   BP *** ** pulse **
050494 -  ..
050495 - Millie reports continued relief from heartburn with daily treatments
050496 - using Prilosce started on 081208. ref SDS D2 7J6K
050498 -  ..
050499 - Sore throat problem, reported initially on 081218, as having begun
050500 - days earlier, ref SDS F0 2B8M, seems better today today continuing
050501 - relief reported yesterday on 081222. ref SDS F9 TT4O  This increases
050502 - interest in eating food.  Millie had eggs and a baggel for a late
050503 - lunch after returning from the gym.  Swallowing seems much more normal
050504 - now.
050506 -  ..
050507 - Millie reports improved taste from some foods today (e.g., soup),
050508 - cited in study consent documents, reviewed on 081017. ref SDS 76 6T5H
050510 -     ..
050511 -                                   Date
050512 -    Description Adverse Event   Start  Stop     Medication
050513 -    ---------------------------------------------------------
050514 -    Follow up ref SDS I1 MV5H, ref SDS H8 MV5H.
050515 -
050516 -    Diarrhea                    081114 081114   Imodium........ ref SDS 94 LF8M
050517 -    Low pulse                   081120 081120   None........... ref SDS A3 LF8M
050518 -    Low pulse                   081121 081121   None........... ref SDS A4 7G8M
050519 -    BP 144 84 Pulse 48          081121 081121   Hiking......... ref SDS A4 LF8M
050520 -    Joint pain minor            081121 081121   Hiking......... ref SDS A4 LF8M
050521 -    Fatigue minor               081121 081121   Hiking......... ref SDS A4 LF8M
050522 -    Low pulse                   081122 081122   None........... ref SDS A5 7G8M
050523 -    Fatigue minor               081122 081122   Hiking......... ref SDS A5 LF8M
050524 -    Low pulse                   081123 081122   None........... ref SDS A6 7G8M
050525 -    BP 121 74 Pulse 53          081123 081123   Hiking......... ref SDS A6 LF8M
050526 -    Fatigue minor               081123 081122   Hiking......... ref SDS A6 LF8M
050527 -    Joint pain minor            081124 081124   Hiking......... ref SDS A7 LF8M
050528 -    Fatigue minor               081124 081124   Hiking......... ref SDS A7 LF8M
050529 -    Heartburn                   081124 081124   None........... ref SDS A7 HS9K
050530 -    BP 144 78 Pulse 52          081125 081125   Hiking......... ref SDS A8 LF8M
050531 -    Joint pain minor            081125 081125   Hiking......... ref SDS A8 LF8M
050532 -    Fatigue minor               081125 081125   Hiking......... ref SDS A8 LF8M
050533 -    Heartburn                   081125 081125   None........... ref SDS A8 HS9K
050534 -    Heartburn                   081126 081126   None........... ref SDS A9 HS9K
050535 -    Heartburn                   081127 081127   None........... ref SDS B3 HS9K
050536 -    BP 135 73 Pulse 48          081128 081128   Hiking......... ref SDS B4 5X6K
050537 -    Upset stomach               081128 081128   Hiking......... ref SDS B4 T76O
050538 -    BP 140 75 Pulse 50          081129 081129   Hiking......... ref SDS B7 5X6K
050539 -    Heartburn                   081129 081129   None........... ref SDS B7 HS9K
050540 -     ..
050541 -    Fatigue                     081129 081129   Rest........... ref SDS B7 LF8M
050542 -    Fatigue                     081130 081130   Rest........... ref SDS B8 LF8M
050543 -    BP 136 79 Pulse 46          081201 081201   Hiking......... ref SDS B9 5X6K
050544 -    Fatigue                     081201 081201   Rest........... ref SDS B9 LF8M
050545 -    Taste altered               081201 081201   Rest........... ref SDS B9 VP4G
050546 -    BP 141 77 Pulse 46          081202 081202   Aerobics gym... ref SDS C1 5X6K
050547 -    Fatigue                     081202 081202   Rest........... ref SDS C1 LF8M
050548 -    Taste altered               081202 081202   Rest........... ref SDS C1 VP4G
050549 -    BP 138 77 Pulse 48          081203 081203   Hiking......... ref SDS C3 5X6K
050550 -    Fatigue                     081203 081203   Rest........... ref SDS C3 LF8M
050551 -    Taste altered               081203 081203   Rest........... ref SDS C3 VP4G
050552 -    NEUTS (ANC)     0.624       081203 081203   Neupogen.......
050553 -    BP 133 72 Pulse 45          081204 081204   Rest........... ref SDS C4 5X6K
050554 -    Fatigue                     081204 081204   Rest........... ref SDS C4 LF8M
050555 -    Taste altered               081204 081204   Rest........... ref SDS C4 VP4G
050556 -    BP 138 76 Pulse 49          081205 081205   Rest........... ref SDS C5 5X6K
050557 -    Diarrhea                    081205 081114   Imodium........ ref SDS C5 Q67F
050558 -    Fatigue                     081205 081205   Rest........... ref SDS C5 LF8M
050559 -    Taste altered               081205 081205   Rest........... ref SDS C5 VP4G
050560 -    BP *** ** Pulse **          081206 081206   Rest........... ref SDS C9 5X6K
050561 -    Fatigue                     081206 081206   Rest........... ref SDS C9 LF8M
050562 -    BP 128 70 Pulse 53          081207 081207   Hiking......... ref SDS D1 5X6K
050563 -    Fatigue                     081207 081207   Rest........... ref SDS D1 LF8M
050564 -    BP 137 68 Pulse 53          081208 081208   Rest........... ref SDS D2 5X6K
050565 -    Fatigue                     081208 081208   Rest........... ref SDS D2 LF8M
050566 -    BP *** ** Pulse **          081209 081209   Rest........... ref SDS D2 5X6K
050567 -    Fatigue                     081209 081209   Rest........... ref SDS D2 LF8M
050568 -    Heartburn                   081209 081209   Prilosec....... ref SDS D3 7J6K
050569 -    BP 136 70 Pulse 53          081210 081210   Rest........... ref SDS D5 5X6K
050570 -    Fatigue                     081210 081210   Rest........... ref SDS D5 LF8M
050571 -    Heartburn                   081210 081210   Prilosec....... ref SDS D5 7J6K
050572 -    BP *** ** Pulse **          081211 081211   Rest........... ref SDS D9 5X6K
050573 -    Fatigue                     081211 081211   Exercise gym... ref SDS D9 LF8M
050574 -    Heartburn                   081211 081211   Prilosec....... ref SDS D9 7J6K
050575 -    BP 137 76 Pulse 53          081212 081212   Rest........... ref SDS E1 5X6K
050576 -    Fatigue                     081212 081212   Exercise gym... ref SDS E1 LF8M
050577 -    Heartburn                   081212 081212   Prilosec....... ref SDS E1 7J6K
050578 -    BP 147 80 Pulse 51          081213 081213   Rest........... ref SDS E4 5X6K
050579 -    Fatigue                     081213 081213   Exercise gym... ref SDS E4 LF8M
050580 -    BP *** ** Pulse **          081214 081214   Rest........... ref SDS E5 5X6K
050581 -    Fatigue                     081214 081214   Rest........... ref SDS E5 LF8M
050582 -    BP *** ** Pulse **          081215 081215   Rest........... ref SDS E6 5X6K
050583 -    Fatigue                     081215 081215   Rest........... ref SDS E6 LF8M
050584 -    BP 144 79 Pulse 54          081216 081216   Rest........... ref SDS E7 5X6K
050585 -    Fatigue                     081216 081216   Exercise gym... ref SDS E7 LF8M
050586 -     ..
050587 -    Joint pain minor            081216 081216   Rest........... ref SDS E7 E38H
050588 -    BP 137 69 Pulse 63          081217 081217   Rest........... ref SDS E8 5X6K
050589 -    Fatigue                     081217 081217   Rest........... ref SDS E8 LF8M
050590 -    Joint pain minor            081217 081217   Rest........... ref SDS E8 E38H
050591 -    Nosebleed minor             081217 081217   Rest........... ref SDS E8 ZF5F
050592 -     ..
050593 -    BP *** ** Pulse **          081218 081218   Rest........... ref SDS F0 5X6K
050594 -    Fatigue                     081218 081218   Rest........... ref SDS F0 LF8M
050595 -    Joint pain minor            081218 081218   Rest........... ref SDS F0 E38H
050596 -    Nosebleed moderate          081218 081218   Rest........... ref SDS F0 ZF5F
050597 -    Throat pain eating          081218 081218   Eating less.... ref SDS F0 2B8M
050598 -    BP 155 84 Pulse 53          081219 081219   Rest........... ref SDS F3 5X6K
050599 -    Fatigue                     081121 081219   Rest........... ref SDS F3 LF8M
050600 -    Feet toes lesions           081219 081219   Rest........... ref SDS F3 UO8I
050601 -    Joint pain ill feeling      081121 081219   Rest........... ref SDS F3 E38H
050602 -    Throat sore eating          081218 081219   Eating less.... ref SDS F3 TT4O
050603 -    BP 123 69 pulse 53          081220 081220   Rest........... ref SDS F6 5X6K
050604 -    Fatigue                     081121 081220   Rest........... ref SDS F6 LF8M
050605 -    Feet toes lesions           081219 081220   Rest........... ref SDS F6 UO8I
050606 -    Joint pain ill feeling      081121 081220   Rest........... ref SDS F6 E38H
050607 -    Throat sore eating          081218 081220   Eating less.... ref SDS F6 TT4O
050608 -    BP 117 71 pulse 65          081221 081221   Rest........... ref SDS F8 5X6K
050609 -    Fatigue                     081121 081221   Rest........... ref SDS F8 LF8M
050610 -    Feet toes lesions           081219 081221   Rest........... ref SDS F8 UO8I
050611 -    Joint pain ill feeling      081121 081221   Rest........... ref SDS F8 E38H
050612 -    Throat sore eating          081218 081221   Eating less.... ref SDS F8 TT4O
050613 -    BP 117 71 pulse 65          081222 081222   Rest........... ref SDS F9 5X6K
050614 -    Fatigue                     081121 081222   Rest........... ref SDS F9 LF8M
050615 -    Feet toes lesions           081219 081222   Rest........... ref SDS F9 UO8I
050616 -    Joint pain ill feeling      081121 081222   Rest........... ref SDS F9 E38H
050617 -    Throat sore eating          081218 081222   Eating less.... ref SDS F9 TT4O
050618 -    BP 143 68 pulse 65          081223 081223   Rest........... ref SDS F9 5X6K
050619 -    Fatigue more energy         081121 081223   Exercise gym... ref SDS G0 LF8M
050620 -    Feet feel better            081219 081223   Exercise gym... ref SDS G0 UO8I
050621 -    Joint pain subsides         081121 081223   Exercise gym... ref SDS G0 E38H
050622 -    Throat sore improved        081218 081223   Eating normal.. ref SDS G0 TT4O
050623 -    BP *** ** pulse **          081224 081224   Rest........... ref SDS G2 5X6K
050624 -    Fatigue more energy         081121 081224   Exercise gym... ref SDS G2 LF8M
050625 -    Feet feel better            081219 081224   Exercise gym... ref SDS G2 UO8I
050626 -    Joint pain subsides         081121 081224   Exercise gym... ref SDS G2 E38H
050627 -    Throat sore improved        081218 081224   Eating normal.. ref SDS G2 TT4O
050628 -    BP 124 80 pulse 66          081225 081225   Rest........... ref SDS G3 5X6K
050629 -    Fatigue more energy         081121 081225   Activity....... ref SDS G3 LF8M
050630 -    Fatigue more energy         081121 081226   Activity....... ref SDS G4 LF8M
050631 -    BP *** ** pulse **          081227 081227   Rest........... ref SDS G6 5X6K
050632 -    Fatigue more energy         081121 081227   Hiking......... ref SDS G6 LF8M
050633 -    BP *** ** pulse **          081228 081228   Rest........... ref SDS G7 5X6K
050634 -    Fatigue more energy         081121 081228   Rest........... ref SDS G7 LF8M
050635 -    BP *** ** pulse **          081229 081229   Rest........... ref SDS G8 5X6K
050636 -    Fatigue more energy         081121 081229   Rest........... ref SDS G8 LF8M
050637 -    BP *** ** pulse **          081230 081230   Rest........... ref SDS H0 5X6K
050638 -    Diarrhea                    081230 081230   Imodium........ ref SDS H0 KZ9N
050639 -    Fatigue more energy         081121 081230   Rest........... ref SDS H0 LF8M
050640 -    BP *** ** pulse **          081231 081231   Rest........... ref SDS H2 5X6K
050641 -    Fatigue more energy         081121 081231   Rest........... ref SDS H2 LF8M
050642 -    BP *** ** pulse **          090101 090101   Rest........... ref SDS H3 5X6K
050643 -    Fatigue more energy         081121 090101   Hiking......... ref SDS H3 LF8M
050644 -    BP *** ** pulse **          090102 090102   Rest........... ref SDS H4 5X6K
050645 -    Fatigue more energy         081121 090102   Hiking......... ref SDS H4 LF8M
050646 -    BP *** ** pulse **          090103 090103   Rest........... ref SDS H5 5X6K
050647 -    Fatigue less energy         081121 090103   Exercise gym... ref SDS H5 LF8M
050648 -    BP *** ** pulse **          090104 090104   Rest........... ref SDS H6 5X6K
050649 -    Fatigue less energy         081121 090104   Rest........... ref SDS H6 LF8M
050650 -    BP *** ** pulse **          090105 090105   Rest........... ref SDS H7 5X6K
050651 -    Fatigue less energy         081121 090105   Rest........... ref SDS H7 LF8M
050652 -    BP *** ** pulse **          090106 090106   Rest........... ref SDS H8 5X6K
050653 -    Fatigue less energy         081121 090106   Exercise gym... ref SDS H8 LF8M
050654 -    BP *** ** pulse **          090107 090107   Rest........... ref SDS H8 5X6K
050655 -    Fatigue less energy         081121 090107   Rest........... ref SDS I1 LF8M
050656 -    BP *** ** pulse **          090108 090108   Rest........... ref SDS 0 5X6K
050657 -    Fatigue less energy         081121 090108   Rest........... ref SDS 0 LF8M
050658 -    Eyes tearing                090108 090108   Eye drops...... ref SDS 0 518H
050659 -
050660 -
050661 -
0507 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS I1 3E4K, ref SDS H8 3E4K.
060405 -
060406 - Today, Millie less energetic could not work out in the gym for aerobic
060407 - exercise. ref SDS 0 X64F, Did not go hiking at Lafayette nor at the
060408 - flatter Clayton Safeway trail, because hiking was difficult on
060409 - Millie's legs, reported on 090102, ref SDS H4 6E7G, due to rising side
060410 - effects of fatigue from 14 cancer treatments beginning on 081226,
060411 - ref SDS 0 9I6T, that are now causing blood counts to fall again,
060412 - reported above. ref SDS 0 LF8M
060414 -  ..
060415 - NEUTS blood tests show patient history treatments with Nuepogen for
060416 - neutropenia from chemotherapy everyday with cyclophosphamide reported
060417 - in case study on 081205. ref SDS C5 EC5N
060419 -  ..
060420 - On 081110, Millie complained about difficulty lifting herself from a
060421 - full squatting position. ref SDS 90 HX67  For several weeks, she was
060422 - exercising to strengthen legs, and arms, shown by going to the gym on
060423 - 081211. ref SDS D9 3E4K  Rising fatigue now prevents continuing
060424 - exercise.
060425 -
060427 -  ..
060428 - Case Study on Pateint History Exercising
060429 -
060430 - Follow up ref SDS I1 X64F, ref SDS H8 X64F.
060431 -
060432 -                                              +- scm = Sunitinib Cyclophosphmaide Methotrexate
060433 -                                              +- sc  = Sunitinib Cyclophosphmaide
060434 -                           Time     Pulse     |
060435 -    Location        Miles Minutes  Avg Max  Chem  Neupo  Date
060436 -    ----------------------------------------------------------------
060437 -    Concord home                              sc        090108, ref SDS 0 3E4K
060438 -    Concord home                              sc        090107, ref SDS I1 3E4K
060439 -    Concord home (gym)                        sc        090106, ref SDS H8 3E4K
060440 -    Concord home                              sc        090105, ref SDS H7 3E4K
060441 -    Concord home                              sc        090104, ref SDS H6 3E4K
060442 -    Concord home (gym)                        sc        090103, ref SDS H5 3E4K
060443 -    Clayton Safeway  3.00   58.7    83  94    sc        090102, ref SDS H4 3E4K
060444 -    Lafayette        2.75   58.4    87 103    sc        090101, ref SDS H3 3E4K
060445 -    Concord home                              sc        081231, ref SDS H2 3E4K
060446 -    Concord home                              sc        081230, ref SDS H0 3E4K
060447 -    Concord home                              sc        081229, ref SDS G8 3E4K
060448 -    Concord home                              sc        081228, ref SDS G7 3E4K
060449 -    Lafayette        2.75   56.2    90 112    sc        081227, ref SDS G4 3E4K
060450 -    Concord home                              sc        081226, ref SDS G4 3E4K
060451 -    Concord travel                                      081225, ref SDS G3 3E4K
060452 -    Concord home                                        081224, ref SDS G2 3E4K
060453 -    Concord home (gym)                                  081223, ref SDS G0 3E4K
060454 -    Concord home                                        081222, ref SDS F9 3E4K
060455 -    Concord home                                        081221, ref SDS F8 3E4K
060456 -    Concord home                                        081220, ref SDS F6 3E4K
060457 -    Concord home                                        081219, ref SDS F3 3E4K
060458 -    Concord home                              sc        081218, ref SDS F0 3E4K
060459 -    Concord home                              sc        081217, ref SDS E8 3E4K
060460 -    Concord home (gym)                        sc        081216, ref SDS E7 3E4K
060461 -    Concord home                              sc        081215, ref SDS E6 3E4K
060462 -    Concord home                              sc        081214, ref SDS E5 3E4K
060463 -    Concord home (gym)                        scm       081213, ref SDS E4 3E4K
060464 -    Concord home                              scm       081212, ref SDS E1 3E4K
060465 -    Concord home (gym)                        sc        081211, ref SDS D9 3E4K
060466 -    Concord home                              sc        081210, ref SDS D5 3E4K
060467 -    Concord home                              sc        081209, ref SDS D3 3E4K
060468 -    Concord home                              sc        081208, ref SDS D2 3E4K
060469 -    Lafayette        4.75   78.6    95 110    sc        081207, ref SDS D1 3E4K
060470 -    Concord home                              scm       081206, ref SDS C9 3E4K
060471 -    Concord home                              scm       081205, ref SDS C5 3E4K
060472 -    Concord home                              sc        081204, ref SDS C4 3E4K
060473 -    Lafayette        2.75   62.7    90 117    sc        081203, ref SDS C3 3E4K
060474 -    Concord home (gym)                        sc        081202, ref SDS C1 3E4K
060475 -    Lafayette        5.50  102.3    95 122    sc        081201, ref SDS B9 3E4K
060476 -    Concord home                              sc        081130, ref SDS B8 3E4K
060477 -    Lafayette        2.75   56.7    90 115    scm       081129, ref SDS B7 3E4K
060478 -    Lafayette        2.75   46.5   100 128    scm       081128, ref SDS B4 3E4K
060479 -    Lafayette        5.50   93.3   100 122    s         081127, ref SDS B3 3E4K
060480 -    Concord home                              s         081126, ref SDS A9 3E4K
060481 -    Lafayette        4.00   73.7   105 127    s         081125, ref SDS A8 3E4K
060482 -    Lafayette        5.50   91.4   100 129    s         081124, ref SDS A7 3E4K
060483 -    Concord home                              s         081123, ref SDS A6 3E4K
060484 -    Lafayette        5.50   92.8    95 122    s         081122, ref SDS A5 3E4K
060485 -    Lafayette        5.50   94.4    85 112    s         081121, ref SDS A4 3E4K
060486 -    Lafayette        5.50   94.7    90 122    s         081120, ref SDS A3 3E4K
060487 -    San Francisco    1.00   60.0    65  75    s         081119, ref SDS A2 3E4K
060488 -    Lafayette        2.75   49.2    97 130    s         081118, ref SDS A1 3E4K
060489 -    Lafayette        5.50   93.6   115 138    s         081117, ref SDS 98 3E4K
060490 -    Concord home                              s         081116, ref SDS 96 Y68J
060491 -    Concord home                              s         081115, ref SDS 95 EK7I
060492 -    Concord home                              s         081114, ref SDS 94 XW6H
060493 -    Lafayette        5.50   94.2   115 138              081110, ref SDS 90 3E4K
060494 -    Lafayette        2.75   48.4   105 128              081109, ref SDS 89 3E4K
060495 -    Kaiser                                         x    081108, ref SDS 88 UZ7K
060496 -    Kaiser                                         x    081107, ref SDS 87 UZ7K
060497 -    Lafayette        5.50   90.2   120 143              081025, ref SDS 83 3E4K
060498 -    Kaiser                                         x    081025, ref SDS 83 UZ7K
060499 -    Kaiser                                         x    081024, ref SDS 82 UZ7K
060500 -    UCSF                                      c         081023, ref SDS 81 V94O
060501 -    Lafayette        5.50   90.6   115 141              081021, ref SDS 80 3E4K
060502 -    Lafayette        5.50   90.4   110 128              081020, ref SDS 79 3E4K
060503 -    Kaiser                                         x    081018, ref SDS 78 UZ7K
060504 -    Kaiser                                         x    081017, ref SDS 77 UZ7K
060505 -    UCSF                                      e         081016, ref SDS 75 V94O
060506 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 74 3E4K
060507 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 73 3E4K
060508 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 72 3E4K
060509 -    Kaiser                                         x    081011, ref SDS 71 UZ7K
060510 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 70 3E4K
060511 -    Kaiser                                         x    081010, ref SDS 70 UZ7K
060512 -    UCSF                                      e         081009, ref SDS 69 V94O
060513 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 68 3E4K
060514 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 67 3E4K
060515 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 66 3E4K
060516 -    UCSF                                      c         081002, ref SDS 65 V94O
060517 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 64 3E4K
060518 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 64 3E4K
060519 -    Kaiser                                         x    080927, ref SDS 63 UZ7K
060520 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 62 3E4K
060521 -    UCSF                                      c         080925, ref SDS 61 V94O
060522 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 60 3E4K
060523 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 60 3E4K
060524 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 60 3E4K
060525 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 59 3E4K
060526 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 58 3E4K
060527 -    UCSF                                      c         080918, ref SDS 57 V94O
060528 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 58 3E4K
060529 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 56 3E4K
060530 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 55 3E4K
060531 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 54 3E4K
060532 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 53 3E4K
060533 -    UCSF                                      c         080911, ref SDS 52 V94O
060534 -    Lafayette        2.75   46.8   113 140              080909
060535 -    Lafayette        5.50   89.2   117 143              080908
060536 -    Lafayette        5.50   92.1   115 138              080907
060537 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 51 3E4K
060538 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 50 3E4K
060539 -    UCSF                                      c         080904, ref SDS 49 V94O
060540 -    Lafayette        8.25  140.4   116 131              080903
060541 -    Lafayette        5.50   94.9   115 134              080902
060542 -    Kaiser                                         x    080830
060543 -    Kaiser                                         x    080829
060544 -    UCSF                                      c         080828, ref SDS 48 V94O
060545 -    Lafayette        5.50   93.6   120 137              080826
060546 -    Lafayette        5.50   93.2   117 138              080825
060547 -    Lafayette        5.50   93.2   123 136         x    080823
060548 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 47 3E4K
060549 -    UCSF                                      e         080821, ref SDS 46 V94O
060550 -    Lafayette        5.50   94.7   115 137              080820
060551 -    Lafayette        5.50   94.3   115 135              080819
060552 -    Lafayette        8.25  141.7   118 134              080815
060553 -    UCSF                                      e         080814, ref SDS 45 V94O
060554 -    Lafayette        5.50   93.8   120 136              080813
060555 -    Lafayette        5.50   94.4   116 139              080812
060556 -    Lafayette        5.50   94.2   119 133              080810
060557 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 43 3E4K
060558 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 42 3E4K
060559 -    UCSF                                      c         080807, ref SDS 41 V94O
060560 -    Lafayette        8.25  143.7   115 132              080805
060561 -    Concord          7.00  127.6   105 118              080804
060562 -    Lafayette        8.25  143.2   112 134              080802
060563 -    Lafayette        5.50   93.4   115 138              080801
060564 -    Lafayette        5.50   92.2   118 140              080729
060565 -    Lafayette        5.50   92.6   116 137              080728
060566 -    Lafayette        8.25  142.6   114 134              080727
060567 -    Lafayette        5.50   91.5   120 143              080726
060568 -    Lafayette        8.25  140.8   117 135              080725
060569 -    Lafayette        5.50   91.8   122 141              080723
060570 -    Lafayette        5.50   91.3   120 139              080722
060571 -    Lafayette        8.25  143.3   115 133              080720
060572 -    Lafayette        5.50   90.7   125 144              080719
060573 -    Lafayette        5.50   92.4   123 142              080716
060574 -    Lafayette        2.25   46.8   116 137              080715
060575 -    Lafayette        8.25  141.8   116 136              080712
060576 -    Lafayette        5.50   92.9   116 139              080711
060577 -    Lafayette        8.25  143.3   113 137              080704
060578 -    Lafayette        5.50   90.2   121 147              080630
060579 -    Lafayette        8.25  142.4   116 138              080628
060580 -    Lafayette        5.50   91.4   118 138              080625
060581 -    Lafayette        2.25   47.9   116 136              080623
060582 -    Lafayette        5.50   94.2   112 138              080622
060583 -    Lafayette        5.50   94.7   115 133              080621
060584 -    Lafayette        2.25   48.3   110 129              080620
060585 -    Mt Diablo        7.00  129.4   130 153              080616
060586 -    Lafayette        5.50   90.8   120 146              080615
060587 -    Lafayette        5.50   91.3   124 144              080614
060588 -    Lafayette        5.50   89.7   122 143              080613
060589 -    Lafayette        2.76   45.8   120 147              080611
060590 -    Lafayette        5.50   90.5   123 145              080609
060591 -    Lafayette        5.50   92.7   115 138              080607
060592 -    Lafayette        5.50   94.2   118 139              080602
060593 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 19 WO8M
060594 -
060595 -
060596 -
060597 -
060598 -
060599 -
0606 -