THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: December 27, 2008 07:00 AM Saturday; Rod Welch

Millie sunitinib #37 treatment IBC 5th relapse.

1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
3...Sunitinib Cyclophosmaide Methotrexate Patient History
4...Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
5...Exercise Hiking Maintain Fitness Strengthen Immune System
6...Case Study on Pateint History Exercising


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS G2 0000. ref SDS G1 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS G2 505G, ref SDS G1 505G.
040904 -
040905 - Background pausing treatment on 081219 for a week so that Millie's
040906 - blood counts could rise, and resuming 081226 with sunitinib and
040907 - cyclophosphamide. ref SDS G2 505G
040909 -  ..
040910 - Today, IBC rash and nodules in breastbone are seem about the same as
040911 - yesterday, after subsiding from incresses the previous 2 days.
040912 - ref SDS G2 124N
040914 -  ..
040915 - Today Millie more energetic, ref SDS 0 6E7G, decided to try hiking and
040916 - the weather is better, so we did 1 lap at Lafayette. ref SDS 0 X64F
040918 -  ..
040919 - NEUTS patient history of neutropenia from chemotherapy everyday with
040920 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
040922 -  ..
040923 - Neupogen treatments on 081219 and 081220 at Kaiser, ref SDS F6 UZ7K,
040924 - help maintain blood counts to strengthen Millie's immunity system,
040925 - shown in the schedule for Neupogen treatments updated on 081220.
040926 - ref SDS F6 HS5M
040927 -
040929 -  ..
040930 - Sunitinib Cyclophosmaide Methotrexate Patient History
040931 -
040932 - Follow up ref SDS G2 OE6K, ref SDS G1 OE6K.
040933 -
040935 -        Cycle 1  begin 081128 after 14 treatmenst sunitinib alone
040936 -        Cohort: 3
040938 -        ..
040939 -                                          Cyclophos  Metho
040940 -                               Sunitinib   phamide   trexate
040941 -       Days  Date  Time  Cycle    37.5       50        5
040942 -       =======================================================
040943 -       Follow up ref SDS G2 PA8Y, ref SDS G1 PA8Y.
040944 -
040945 -        1.  081114 0700  Load    37.5         0         0 ... ref SDS 94 OE6K
040946 -        2.  081115 0700  Load    75.0         0         0 ... ref SDS 95 OE6K
040947 -        3.  081116 0700  Load   112.5         0         0 ... ref SDS 96 OE6K
040948 -        4.  081117 0700  Load   150.0         0         0 ... ref SDS 97 OE6K
040949 -        5.  081118 0700  Load   187.5         0         0 ... ref SDS A0 OE6K
040950 -        6.  081119 0700  Load   225.0         0         0 ... ref SDS A2 OE6K
040951 -        7.  081120 0700  Load   263.5         0         0 ... ref SDS A3 OE6K
040952 -        8.  081121 0700  Load   301.0         0         0 ... ref SDS A4 OE6K
040953 -        9.  081122 0700  Load   338.5         0         0 ... ref SDS A5 OE6K
040954 -       10.  081123 0700  Load   376.0         0         0 ... ref SDS A6 OE6K
040955 -       11.  081124 0700  Load   413.5         0         0 ... ref SDS A7 OE6K
040956 -       12.  081125 0700  Load   451.0         0         0 ... ref SDS A8 OE6K
040957 -             ..
040958 -       13.  081126 0700  Load   488.5         0         0 ... ref SDS A9 OE6K
040959 -             ..
040960 -            081126 0820  NEUTS........1.50................... ref SDS B0 PU6K
040962 -             ..
040963 -       14.  081127 0700  Load   526.0         0         0 ... ref SDS B1 OE6K
040964 -       15.  081128 0700  1  1   563.5   1    50    1    5 ... ref SDS B4 OE6K
040965 -       16.  081129 0700  1  2   601.0   2   100    2   10 ... ref SDS B7 OE6K
040966 -       17.  081130 0700  1  3   638.5   3   150    2   10 ... ref SDS B8 OE6K
040967 -       18.  081201 0700  1  4   676.0   4   200    2   10 ... ref SDS B9 OE6K
040968 -       19.  081202 0700  1  5   713.5   5   250    2   10 ... ref SDS C1 OE6K
040969 -             ..
040970 -       20.  081203 0700  1  6   751.0   6   300    2   10 ... ref SDS C3 OE6K
040971 -
040972 -            081203 0735. NEUTS....... 0.624 ...... .......... ref SDS C2 RN5G
040973 -
040974 -                Rate of change per day = 1500 - 624 = 876 / 7
040975 -
040976 -                                       = 120+ per day
040978 -             ..
040979 -       21.  081204 0700  1  7   788.5   7   350    2   10 ... ref SDS C4 OE6K
040980 -             ..
040981 -       22.  081205 0700  1  8   826.0   8   400    3   15 ... ref SDS C5 OE6K
040982 -
040983 -            081205 1300  Neupogen...... 480 mcg  480......... ref SDS C6 KV84
040985 -             ..
040986 -       23.  081206 0700  1  9   863.5   9   450    4   20 ... ref SDS C9 OE6K
040987 -
040988 -            081206 0930  Neupogen...... 480 mcg  960......... ref SDS D0 BI4J
040990 -             ..
040991 -       24.  081207 0700  1 10   901.0  10   500    4   20 ... ref SDS D1 OE6K
040992 -       25.  081208 0700  1 11   938.5  11   550    4   20 ... ref SDS D2 OE6K
040993 -       26.  081209 0700  1 12   976.0  12   600    4   20 ... ref SDS D3 OE6K
040994 -             ..
040995 -       27.  081210 0700  1 13  1013.5  13   650    4   20 ... ref SDS D5 OE6K
040996 -
040997 -            081210 1301. NEUTS....... 1.085 ................. ref SDS D6 QY6H
040999 -             ..
041000 -       28.  081211 0700  1 14  1050.0  14   700    4   20 ... ref SDS D9 OE6K
041001 -             ..
041002 -       29.  081212 0700  1 15  1087.5  15   750    5   25 ... ref SDS E1 OE6K
041003 -
041004 -            081212 1115. NEUTS....... 1.054 ................. ref SDS E2 QY6H
041006 -             ..
041007 -       30.  081213 0700  1 16  1125.0  16   800    6   30 ... ref SDS E4 OE6K
041008 -       31.  081214 0700  1 17  1162.5  17   850    6   30 ... ref SDS E5 OE6K
041009 -       32.  081215 0700  1 18  1200.0  18   900    6   30 ... ref SDS E6 OE6K
041010 -       33.  081216 0700  1 19  1237.5  19   950    6   30 ... ref SDS E7 OE6K
041011 -             ..
041012 -       34.  081217 0700  1 20  1275.0  20  1000    6   30 ... ref SDS E8 OE6K
041013 -       35.  081218 0700  1 21  1312.5  21  1050    canceled.. ref SDS F0 OE6K
041014 -
041015 -            081218 0830. NEUTS....... 0.740 ................. ref SDS F1 QY6H
041017 -             ..
041018 -            081219 0700  2  1  paused until 081226........... ref SDS F3 OE6K
041020 -             ..
041021 -            081219 1130  Neupogen...... 480 mcg 1440 ........ ref SDS F4 UZ7K
041022 -            081220 0900  Neupogen...... 480 mcg 1920 ........ ref SDS F6 UZ7K
041024 -             ..
041025 -       36.  081226 0700  2  1  1350.0  22  1100.............. ref SDS G2 OE6K
041026 -       37.  081227 0700  2  2  1387.5  23  1150.............. ref SDS 0 OE6K
041028 -  ..
041029 - Background on recent blood tests is reported on 081218. ref SDS F0
041030 - S18L
041031 -
041032 -        [On 081230 case study dilemma cancer treatmnets cause low blood
041033 -        counts, which prevents getting treatment; not getting treatment
041034 -        incerases cancer; UCSF paused treatment for a week and
041035 -        prescribed Neupogen to increase blood counts. ref SDS G4 I87N
041036 -
041037 -
041038 -
041039 -
041040 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
050401 -  ..
050402 - Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
050403 -
050404 - Follow up ref SDS G2 LF8M, ref SDS G1 LF8M.
050405 -
050406 - Fatigue is a likely side effect of sunitinib with cyclophosphamide,
050407 - listed in the Consent document reviewed on 081017. ref SDS 76 4G7G
050409 -  ..
050410 - Blood counts NEUTS 1.710 reported for labs yesterday at Kaiser on
050411 - 081226, ref SDS G3 B35J increased substantially more than doubling
050412 - from NEUTS 0.740, reported for the lab at UCSF a week ago on 081218,
050413 - ref SDS F1 QY6H, which at that time were causing severe fatigue,
050414 - reported by the medical team during meeting at UCSF on 081218.
050415 - ref SDS F2 WS4J  Cancer treatment was started again yesterday after
050416 - pausing for a week, and getting 2 Neupogen treatments, reported on
050417 - 081220. ref SDS F6 P73J  Substantial increase in blood counts
050418 - accomplishes Doctor Rugo's work plan on 081218. ref SDS F2 BQ8F
050420 -  ..
050421 - Background on Neupogen treatments and UCSF comments are reported on
050422 - 081207. ref SDS D1 673J
050424 -  ..
050425 - NEUTS blood tests show patient history of treatments with Nuepogen to
050426 - recover from neutropenia caused by getting chemotherapy everyday with
050427 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
050429 -  ..
050430 - Schedule for Neupogen treatments is listed on 081220. ref SDS F6 WJ4O
050432 -  ..
050433 - Millie more energetic today, continuing recovery that began on 081223,
050434 - ref SDS F9 6E7G, from severe side effects that prevented hiking for
050435 - several weeks, reported on 081218. ref SDS F0 6E7G  With good weather
050436 - today, Millie went hiking today and did one lap at Lafayette
050437 - reservoir, per below. ref SDS 0 X64F
050439 -  ..
050440 - Feet and toes better today, less sensitive to walking, reported during
050441 - the meeting at UCSF on 081218. ref SDS F2 HM4M  Subsiding side effects
050442 - restoring normal use of feet enabled hiking today, per below.
050443 - ref SDS 0 X64F
050445 -  ..
050446 - Joint pain, discomfort, and total ill feeling, commonly associated
050447 - with chemotherapy, reported on 081218, ref SDS F0 E38H, and discussed
050448 - with the medical team at UCSF also on 081218, ref SDS F2 QW7H, has now
050449 - mostly disipate, as a result of the doctor stopping all treatment for
050450 - 1 week, ref SDS F2 QW48, as shown in patient history above.
050451 - ref SDS 0 053F
050453 -  ..
050454 - Interstitional lung disease discussed in the record on 081218,
050455 - ref SDS F0 KM5F, shows no evident symptoms.
050457 -  ..
050458 - Vitals were reported today at the meeting at Kaiser with the primary
050459 - care physician...
050460 -
050461 -                   BP *** ** pulse **
050463 -  ..
050464 - Millie reports continued relief from heartburn with daily treatments
050465 - using Prilosce started on 081208. ref SDS D2 7J6K
050467 -  ..
050468 - Sore throat problem, reported initially on 081218, as having begun
050469 - days earlier, ref SDS F0 2B8M, seems better today today continuing
050470 - relief reported yesterday on 081222. ref SDS F8 TT4O  This increases
050471 - interest in eating food.  Millie had eggs and a baggel for a late
050472 - lunch after returning from the gym.  Swallowing seems much more normal
050473 - now.
050475 -  ..
050476 - Millie reports improved taste from some foods today (e.g., soup),
050477 - cited in study consent documents, reviewed on 081017. ref SDS 76 6T5H
050479 -     ..
050480 -                                   Date
050481 -    Description Adverse Event   Start  Stop     Medication
050482 -    ---------------------------------------------------------
050483 -    Follow up ref SDS G2 MV5H, ref SDS G1 MV5H.
050484 -
050485 -    Diarrhea                    081114 081114   Imodium........ ref SDS 94 LF8M
050486 -    Low pulse                   081120 081120   None........... ref SDS A3 LF8M
050487 -    Low pulse                   081121 081121   None........... ref SDS A4 7G8M
050488 -    BP 144 84 Pulse 48          081121 081121   Hiking......... ref SDS A4 LF8M
050489 -    Joint pain minor            081121 081121   Hiking......... ref SDS A4 LF8M
050490 -    Fatigue minor               081121 081121   Hiking......... ref SDS A4 LF8M
050491 -    Low pulse                   081122 081122   None........... ref SDS A5 7G8M
050492 -    Fatigue minor               081122 081122   Hiking......... ref SDS A5 LF8M
050493 -    Low pulse                   081123 081122   None........... ref SDS A6 7G8M
050494 -    BP 121 74 Pulse 53          081123 081123   Hiking......... ref SDS A6 LF8M
050495 -    Fatigue minor               081123 081122   Hiking......... ref SDS A6 LF8M
050496 -    Joint pain minor            081124 081124   Hiking......... ref SDS A7 LF8M
050497 -    Fatigue minor               081124 081124   Hiking......... ref SDS A7 LF8M
050498 -    Heartburn                   081124 081124   None........... ref SDS A7 HS9K
050499 -    BP 144 78 Pulse 52          081125 081125   Hiking......... ref SDS A8 LF8M
050500 -    Joint pain minor            081125 081125   Hiking......... ref SDS A8 LF8M
050501 -    Fatigue minor               081125 081125   Hiking......... ref SDS A8 LF8M
050502 -    Heartburn                   081125 081125   None........... ref SDS A8 HS9K
050503 -    Heartburn                   081126 081126   None........... ref SDS A9 HS9K
050504 -    Heartburn                   081127 081127   None........... ref SDS B3 HS9K
050505 -    BP 135 73 Pulse 48          081128 081128   Hiking......... ref SDS B4 5X6K
050506 -    Upset stomach               081128 081128   Hiking......... ref SDS B4 T76O
050507 -    BP 140 75 Pulse 50          081129 081129   Hiking......... ref SDS B7 5X6K
050508 -    Heartburn                   081129 081129   None........... ref SDS B7 HS9K
050509 -     ..
050510 -    Fatigue                     081129 081129   Rest........... ref SDS B7 LF8M
050511 -    Fatigue                     081130 081130   Rest........... ref SDS B8 LF8M
050512 -    BP 136 79 Pulse 46          081201 081201   Hiking......... ref SDS B9 5X6K
050513 -    Fatigue                     081201 081201   Rest........... ref SDS B9 LF8M
050514 -    Taste altered               081201 081201   Rest........... ref SDS B9 VP4G
050515 -    BP 141 77 Pulse 46          081202 081202   Aerobics gym... ref SDS C1 5X6K
050516 -    Fatigue                     081202 081202   Rest........... ref SDS C1 LF8M
050517 -    Taste altered               081202 081202   Rest........... ref SDS C1 VP4G
050518 -    BP 138 77 Pulse 48          081203 081203   Hiking......... ref SDS C3 5X6K
050519 -    Fatigue                     081203 081203   Rest........... ref SDS C3 LF8M
050520 -    Taste altered               081203 081203   Rest........... ref SDS C3 VP4G
050521 -    NEUTS (ANC)     0.624       081203 081203   Neupogen.......
050522 -    BP 133 72 Pulse 45          081204 081204   Rest........... ref SDS C4 5X6K
050523 -    Fatigue                     081204 081204   Rest........... ref SDS C4 LF8M
050524 -    Taste altered               081204 081204   Rest........... ref SDS C4 VP4G
050525 -    BP 138 76 Pulse 49          081205 081205   Rest........... ref SDS C5 5X6K
050526 -    Diarrhea                    081205 081114   Imodium........ ref SDS C5 Q67F
050527 -    Fatigue                     081205 081205   Rest........... ref SDS C5 LF8M
050528 -    Taste altered               081205 081205   Rest........... ref SDS C5 VP4G
050529 -    BP *** ** Pulse **          081206 081206   Rest........... ref SDS C9 5X6K
050530 -    Fatigue                     081206 081206   Rest........... ref SDS C9 LF8M
050531 -    BP 128 70 Pulse 53          081207 081207   Hiking......... ref SDS D1 5X6K
050532 -    Fatigue                     081207 081207   Rest........... ref SDS D1 LF8M
050533 -    BP 137 68 Pulse 53          081208 081208   Rest........... ref SDS D2 5X6K
050534 -    Fatigue                     081208 081208   Rest........... ref SDS D2 LF8M
050535 -    BP *** ** Pulse **          081209 081209   Rest........... ref SDS D2 5X6K
050536 -    Fatigue                     081209 081209   Rest........... ref SDS D2 LF8M
050537 -    Heartburn                   081209 081209   Prilosec....... ref SDS D3 7J6K
050538 -    BP 136 70 Pulse 53          081210 081210   Rest........... ref SDS D5 5X6K
050539 -    Fatigue                     081210 081210   Rest........... ref SDS D5 LF8M
050540 -    Heartburn                   081210 081210   Prilosec....... ref SDS D5 7J6K
050541 -    BP *** ** Pulse **          081211 081211   Rest........... ref SDS D9 5X6K
050542 -    Fatigue                     081211 081211   Exercise gym... ref SDS D9 LF8M
050543 -    Heartburn                   081211 081211   Prilosec....... ref SDS D9 7J6K
050544 -    BP 137 76 Pulse 53          081212 081212   Rest........... ref SDS E1 5X6K
050545 -    Fatigue                     081212 081212   Exercise gym... ref SDS E1 LF8M
050546 -    Heartburn                   081212 081212   Prilosec....... ref SDS E1 7J6K
050547 -    BP 147 80 Pulse 51          081213 081213   Rest........... ref SDS E4 5X6K
050548 -    Fatigue                     081213 081213   Exercise gym... ref SDS E4 LF8M
050549 -    BP *** ** Pulse **          081214 081214   Rest........... ref SDS E5 5X6K
050550 -    Fatigue                     081214 081214   Rest........... ref SDS E5 LF8M
050551 -    BP *** ** Pulse **          081215 081215   Rest........... ref SDS E6 5X6K
050552 -    Fatigue                     081215 081215   Rest........... ref SDS E6 LF8M
050553 -    BP 144 79 Pulse 54          081216 081216   Rest........... ref SDS E7 5X6K
050554 -    Fatigue                     081216 081216   Exercise gym... ref SDS E7 LF8M
050555 -     ..
050556 -    Joint pain minor            081216 081216   Rest........... ref SDS E7 E38H
050557 -    BP 137 69 Pulse 63          081217 081217   Rest........... ref SDS E8 5X6K
050558 -    Fatigue                     081217 081217   Rest........... ref SDS E8 LF8M
050559 -    Joint pain minor            081217 081217   Rest........... ref SDS E8 E38H
050560 -    Nosebleed minor             081217 081217   Rest........... ref SDS E8 ZF5F
050561 -     ..
050562 -    BP *** ** Pulse **          081218 081218   Rest........... ref SDS F0 5X6K
050563 -    Fatigue                     081218 081218   Rest........... ref SDS F0 LF8M
050564 -    Joint pain minor            081218 081218   Rest........... ref SDS F0 E38H
050565 -    Nosebleed moderate          081218 081218   Rest........... ref SDS F0 ZF5F
050566 -    Throat pain eating          081218 081218   Eating less.... ref SDS F0 2B8M
050567 -    BP 155 84 Pulse 53          081219 081219   Rest........... ref SDS F3 5X6K
050568 -    Fatigue                     081121 081219   Rest........... ref SDS F3 LF8M
050569 -    Feet toes lesions           081219 081219   Rest........... ref SDS F3 UO8I
050570 -    Joint pain ill feeling      081121 081219   Rest........... ref SDS F3 E38H
050571 -    Throat sore eating          081218 081219   Eating less.... ref SDS F3 TT4O
050572 -    BP 123 69 pulse 53          081220 081220   Rest........... ref SDS F5 5X6K
050573 -    Fatigue                     081121 081220   Rest........... ref SDS F5 LF8M
050574 -    Feet toes lesions           081219 081220   Rest........... ref SDS F5 UO8I
050575 -    Joint pain ill feeling      081121 081220   Rest........... ref SDS F5 E38H
050576 -    Throat sore eating          081218 081220   Eating less.... ref SDS F5 TT4O
050577 -    BP 117 71 pulse 65          081221 081221   Rest........... ref SDS F7 5X6K
050578 -    Fatigue                     081121 081221   Rest........... ref SDS F7 LF8M
050579 -    Feet toes lesions           081219 081221   Rest........... ref SDS F7 UO8I
050580 -    Joint pain ill feeling      081121 081221   Rest........... ref SDS F7 E38H
050581 -    Throat sore eating          081218 081221   Eating less.... ref SDS F7 TT4O
050582 -    BP 117 71 pulse 65          081222 081222   Rest........... ref SDS F8 5X6K
050583 -    Fatigue                     081121 081222   Rest........... ref SDS F8 LF8M
050584 -    Feet toes lesions           081219 081222   Rest........... ref SDS F8 UO8I
050585 -    Joint pain ill feeling      081121 081222   Rest........... ref SDS F8 E38H
050586 -    Throat sore eating          081218 081222   Eating less.... ref SDS F8 TT4O
050587 -    BP 143 68 pulse 65          081223 081223   Rest........... ref SDS F8 5X6K
050588 -    Fatigue more energy         081121 081223   Exercise gym... ref SDS F9 LF8M
050589 -    Feet feel better            081219 081223   Exercise gym... ref SDS F9 UO8I
050590 -    Joint pain subsides         081121 081223   Exercise gym... ref SDS F9 E38H
050591 -    Throat sore improved        081218 081223   Eating normal.. ref SDS F9 TT4O
050592 -    BP *** ** pulse **          081224 081224   Rest........... ref SDS G0 5X6K
050593 -    Fatigue more energy         081121 081224   Exercise gym... ref SDS G0 LF8M
050594 -    Feet feel better            081219 081224   Exercise gym... ref SDS G0 UO8I
050595 -    Joint pain subsides         081121 081224   Exercise gym... ref SDS G0 E38H
050596 -    Throat sore improved        081218 081224   Eating normal.. ref SDS G0 TT4O
050597 -    BP 124 80 pulse 66          081225 081225   Rest........... ref SDS G1 5X6K
050598 -    Fatigue more energy         081121 081225   Activity....... ref SDS G1 LF8M
050599 -    Fatigue more energy         081121 081226   Activity....... ref SDS G2 LF8M
050600 -    BP *** ** pulse **          081227 081227   Rest........... ref SDS 0 5X6K
050601 -    Fatigue more energy         081121 081227   Hiking......... ref SDS 0 LF8M
050602 -
050603 -
0507 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS G2 3E4K, ref SDS G1 3E4K.
060405 -
060406 - Millie went hiking at Lafayette reservoir, and did 1 lap, 2.75 miles,
060407 - in  56.2 minutes. ref SDS 0 X64F  This was a good time doing a
060408 - difficult hike for the first time in 3 weeks.
060409 -
060410 -        [On 081230 Millie letter to medical team reported increased
060411 -        energy hiking today. ref SDS G4 4W9S
060413 -  ..
060414 - Increased exercise today reflects rising energy from subsiding side
060415 - effects, per above, ref SDS G1 6E7G, after pausing daily treatments
060416 - with cyclophosphamide and sunitinib, also reported yesterday on
060417 - 081223. ref SDS F9 716I
060419 -  ..
060420 - NEUTS blood tests show patient history treatments with Nuepogen for
060421 - neutropenia from chemotherapy everyday with cyclophosphamide reported
060422 - in case study on 081205. ref SDS C5 EC5N
060424 -  ..
060425 - Millie had her 35th treatment with sunitinib on 081218. ref SDS F0
060426 - PA8Y
060428 -  ..
060429 - Sunitinib treatments were paused on 081218 until 081226, reported
060430 - 081218, ref SDS F2 QW48, so that Millie can recover from severe side
060431 - effects, including fatigue, due to very low blood counts. ref SDS F2
060432 - QW49
060434 -  ..
060435 - On 081110, Millie complained about difficulty lifting herself from a
060436 - full squatting position. ref SDS 90 HX67  For several weeks, she was
060437 - exercising to strengthen legs, and arms, shown by going to the gym on
060438 - 081211. ref SDS D9 3E4K  Rising fatigue now prevents continuing
060439 - exercise.
060440 -
060442 -  ..
060443 - Case Study on Pateint History Exercising
060444 -
060445 - Follow up ref SDS G2 X64F, ref SDS G1 X64F.
060446 -
060447 -                                              +- scm = Sunitinib Cyclophosphmaide Methotrexate
060448 -                                              +- sc  = Sunitinib Cyclophosphmaide
060449 -                           Time     Pulse     |
060450 -    Location        Miles Minutes  Avg Max  Chem  Neupo  Date
060451 -    ----------------------------------------------------------------
060452 -    Lafayette        2.75   56.2    90 112    sc        081227, ref SDS D1 3E4K
060453 -    Concord home                              sc        081226, ref SDS G2 3E4K
060454 -    Concord travel                                      081225, ref SDS G1 3E4K
060455 -    Concord home                                        081224, ref SDS G0 3E4K
060456 -    Concord home (gym)                                  081223, ref SDS F9 3E4K
060457 -    Concord home                                        081222, ref SDS F8 3E4K
060458 -    Concord home                                        081221, ref SDS F7 3E4K
060459 -    Concord home                                        081220, ref SDS F5 3E4K
060460 -    Concord home                                        081219, ref SDS F3 3E4K
060461 -    Concord home                              sc        081218, ref SDS F0 3E4K
060462 -    Concord home                              sc        081217, ref SDS E8 3E4K
060463 -    Concord home (gym)                        sc        081216, ref SDS E7 3E4K
060464 -    Concord home                              sc        081215, ref SDS E6 3E4K
060465 -    Concord home                              sc        081214, ref SDS E5 3E4K
060466 -    Concord home (gym)                        scm       081213, ref SDS E4 3E4K
060467 -    Concord home                              scm       081212, ref SDS E1 3E4K
060468 -    Concord home (gym)                        sc        081211, ref SDS D9 3E4K
060469 -    Concord home                              sc        081210, ref SDS D5 3E4K
060470 -    Concord home                              sc        081209, ref SDS D3 3E4K
060471 -    Concord home                              sc        081208, ref SDS D2 3E4K
060472 -    Lafayette        4.75   78.6    95 110    sc        081207, ref SDS D1 3E4K
060473 -    Concord home                              scm       081206, ref SDS C9 3E4K
060474 -    Concord home                              scm       081205, ref SDS C5 3E4K
060475 -    Concord home                              sc        081204, ref SDS C4 3E4K
060476 -    Lafayette        2.75   62.7    90 117    sc        081203, ref SDS C3 3E4K
060477 -    Concord home (gym)                        sc        081202, ref SDS C1 3E4K
060478 -    Lafayette        5.50  102.3    95 122    sc        081201, ref SDS B9 3E4K
060479 -    Concord home                              sc        081130, ref SDS B8 3E4K
060480 -    Lafayette        2.75   56.7    90 115    scm       081129, ref SDS B7 3E4K
060481 -    Lafayette        2.75   46.5   100 128    scm       081128, ref SDS B4 3E4K
060482 -    Lafayette        5.50   93.3   100 122    s         081127, ref SDS B3 3E4K
060483 -    Concord home                              s         081126, ref SDS A9 3E4K
060484 -    Lafayette        4.00   73.7   105 127    s         081125, ref SDS A8 3E4K
060485 -    Lafayette        5.50   91.4   100 129    s         081124, ref SDS A7 3E4K
060486 -    Concord home                              s         081123, ref SDS A6 3E4K
060487 -    Lafayette        5.50   92.8    95 122    s         081122, ref SDS A5 3E4K
060488 -    Lafayette        5.50   94.4    85 112    s         081121, ref SDS A4 3E4K
060489 -    Lafayette        5.50   94.7    90 122    s         081120, ref SDS A3 3E4K
060490 -    San Francisco    1.00   60.0    65  75    s         081119, ref SDS A2 3E4K
060491 -    Lafayette        2.75   49.2    97 130    s         081118, ref SDS A1 3E4K
060492 -    Lafayette        5.50   93.6   115 138    s         081117, ref SDS 98 3E4K
060493 -    Concord home                              s         081116, ref SDS 96 Y68J
060494 -    Concord home                              s         081115, ref SDS 95 EK7I
060495 -    Concord home                              s         081114, ref SDS 94 XW6H
060496 -    Lafayette        5.50   94.2   115 138              081110, ref SDS 90 3E4K
060497 -    Lafayette        2.75   48.4   105 128              081109, ref SDS 89 3E4K
060498 -    Kaiser                                         x    081108, ref SDS 88 UZ7K
060499 -    Kaiser                                         x    081107, ref SDS 87 UZ7K
060500 -    Lafayette        5.50   90.2   120 143              081025, ref SDS 83 3E4K
060501 -    Kaiser                                         x    081025, ref SDS 83 UZ7K
060502 -    Kaiser                                         x    081024, ref SDS 82 UZ7K
060503 -    UCSF                                      c         081023, ref SDS 81 V94O
060504 -    Lafayette        5.50   90.6   115 141              081021, ref SDS 80 3E4K
060505 -    Lafayette        5.50   90.4   110 128              081020, ref SDS 79 3E4K
060506 -    Kaiser                                         x    081018, ref SDS 78 UZ7K
060507 -    Kaiser                                         x    081017, ref SDS 77 UZ7K
060508 -    UCSF                                      e         081016, ref SDS 75 V94O
060509 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 74 3E4K
060510 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 73 3E4K
060511 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 72 3E4K
060512 -    Kaiser                                         x    081011, ref SDS 71 UZ7K
060513 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 70 3E4K
060514 -    Kaiser                                         x    081010, ref SDS 70 UZ7K
060515 -    UCSF                                      e         081009, ref SDS 69 V94O
060516 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 68 3E4K
060517 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 67 3E4K
060518 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 66 3E4K
060519 -    UCSF                                      c         081002, ref SDS 65 V94O
060520 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 64 3E4K
060521 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 64 3E4K
060522 -    Kaiser                                         x    080927, ref SDS 63 UZ7K
060523 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 62 3E4K
060524 -    UCSF                                      c         080925, ref SDS 61 V94O
060525 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 60 3E4K
060526 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 60 3E4K
060527 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 60 3E4K
060528 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 59 3E4K
060529 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 58 3E4K
060530 -    UCSF                                      c         080918, ref SDS 57 V94O
060531 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 58 3E4K
060532 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 56 3E4K
060533 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 55 3E4K
060534 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 54 3E4K
060535 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 53 3E4K
060536 -    UCSF                                      c         080911, ref SDS 52 V94O
060537 -    Lafayette        2.75   46.8   113 140              080909
060538 -    Lafayette        5.50   89.2   117 143              080908
060539 -    Lafayette        5.50   92.1   115 138              080907
060540 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 51 3E4K
060541 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 50 3E4K
060542 -    UCSF                                      c         080904, ref SDS 49 V94O
060543 -    Lafayette        8.25  140.4   116 131              080903
060544 -    Lafayette        5.50   94.9   115 134              080902
060545 -    Kaiser                                         x    080830
060546 -    Kaiser                                         x    080829
060547 -    UCSF                                      c         080828, ref SDS 48 V94O
060548 -    Lafayette        5.50   93.6   120 137              080826
060549 -    Lafayette        5.50   93.2   117 138              080825
060550 -    Lafayette        5.50   93.2   123 136         x    080823
060551 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 47 3E4K
060552 -    UCSF                                      e         080821, ref SDS 46 V94O
060553 -    Lafayette        5.50   94.7   115 137              080820
060554 -    Lafayette        5.50   94.3   115 135              080819
060555 -    Lafayette        8.25  141.7   118 134              080815
060556 -    UCSF                                      e         080814, ref SDS 45 V94O
060557 -    Lafayette        5.50   93.8   120 136              080813
060558 -    Lafayette        5.50   94.4   116 139              080812
060559 -    Lafayette        5.50   94.2   119 133              080810
060560 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 43 3E4K
060561 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 42 3E4K
060562 -    UCSF                                      c         080807, ref SDS 41 V94O
060563 -    Lafayette        8.25  143.7   115 132              080805
060564 -    Concord          7.00  127.6   105 118              080804
060565 -    Lafayette        8.25  143.2   112 134              080802
060566 -    Lafayette        5.50   93.4   115 138              080801
060567 -    Lafayette        5.50   92.2   118 140              080729
060568 -    Lafayette        5.50   92.6   116 137              080728
060569 -    Lafayette        8.25  142.6   114 134              080727
060570 -    Lafayette        5.50   91.5   120 143              080726
060571 -    Lafayette        8.25  140.8   117 135              080725
060572 -    Lafayette        5.50   91.8   122 141              080723
060573 -    Lafayette        5.50   91.3   120 139              080722
060574 -    Lafayette        8.25  143.3   115 133              080720
060575 -    Lafayette        5.50   90.7   125 144              080719
060576 -    Lafayette        5.50   92.4   123 142              080716
060577 -    Lafayette        2.25   46.8   116 137              080715
060578 -    Lafayette        8.25  141.8   116 136              080712
060579 -    Lafayette        5.50   92.9   116 139              080711
060580 -    Lafayette        8.25  143.3   113 137              080704
060581 -    Lafayette        5.50   90.2   121 147              080630
060582 -    Lafayette        8.25  142.4   116 138              080628
060583 -    Lafayette        5.50   91.4   118 138              080625
060584 -    Lafayette        2.25   47.9   116 136              080623
060585 -    Lafayette        5.50   94.2   112 138              080622
060586 -    Lafayette        5.50   94.7   115 133              080621
060587 -    Lafayette        2.25   48.3   110 129              080620
060588 -    Mt Diablo        7.00  129.4   130 153              080616
060589 -    Lafayette        5.50   90.8   120 146              080615
060590 -    Lafayette        5.50   91.3   124 144              080614
060591 -    Lafayette        5.50   89.7   122 143              080613
060592 -    Lafayette        2.76   45.8   120 147              080611
060593 -    Lafayette        5.50   90.5   123 145              080609
060594 -    Lafayette        5.50   92.7   115 138              080607
060595 -    Lafayette        5.50   94.2   118 139              080602
060596 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 19 WO8M
060597 -
060598 -
060599 -
060600 -
060601 -
060602 -
0607 -