THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net
S U M M A R Y
DIARY: November 27, 2008 07:00 AM Thursday;
Rod Welch
Millie sunitinib #14 treatment IBC 5th relapse hiking 6 miles.
1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
........Patient History Sunitinib Loading Dose 14 Days
3...Side Effects Sunitinib Study
4...Exercise Hiking Maintain Fitness Strengthen Immune System
5...Case Study on Pateint History Exercising
..............
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CONTACTS
SUBJECTS
Default Null Subject Account for Blank Record
0403 -
0403 - ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 78 0000. ref SDS 77 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 - ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS 78 505G, ref SDS 77 505G.
040904 -
040905 - On 081113 Millie received sunitinib drugs from UCSF to treat the 5th
040906 - relapse of IBC.
040908 - ..
040909 - Millie began the 14 day "charging" treatment on 081114. ref SDS 63
040910 - EK7I After 14 treatments ending today, Millie has tolerated sunitinib
040911 - well at the prescribed dose. During the meeting yesterday on 081126,
040912 - UCSF prescribed adding chemotherapy treatment with cyclophosphamide
040913 - each day with sunitinib, and also adding 2 treatments of methotrexate
040914 - twice a day for 2 days a week as prescribed in the treatment protocol,
040915 - reviewed on 081017. ref SDS 49 004O These supplemental treatments
040916 - will start tomorrow.
040918 - ..
040919 - Patient History Sunitinib Loading Dose 14 Days
040920 -
040921 - Follow up ref SDS 78 OE6K, ref SDS 77 OE6K.
040922 -
040924 - Cycle 1
040925 - Cohort: 3
040927 - ..
040928 - Sunitinib MG Cyclophos Metho
040929 - Amount Today Cum phamide trexate
040930 - Days Date Time Cycle 25 12.5 Total Total Amnt Total Amnt Total
040931 - --------------------------------------------------------------------
040932 - Follow up ref SDS 75 PA8Y, ref SDS 74 PA8Y.
040933 -
040934 - 1. 081114 0700 1 1 1 37.5 37.5 0 0 0 0 ..... ref SDS 63 OE6K
040935 - 2. 081115 0700 1 1 1 37.5 75.0 0 0 0 0 ..... ref SDS 64 OE6K
040936 - 3. 081116 0700 1 1 1 37.5 112.5 0 0 0 0 ..... ref SDS 65 OE6K
040937 - 4. 081117 0700 1 1 1 37.5 150.0 0 0 0 0 ..... ref SDS 66 OE6K
040938 - 5. 081118 0700 1 1 1 37.5 187.5 0 0 0 0 ..... ref SDS 69 OE6K
040939 - 6. 081119 0700 1 1 1 37.5 225.0 0 0 0 0 ..... ref SDS 71 OE6K
040940 - 7. 081120 0700 1 1 1 37.5 263.5 0 0 0 0 ..... ref SDS 72 OE6K
040941 - 8. 081121 0700 1 1 1 37.5 301.0 0 0 0 0 ..... ref SDS 73 OE6K
040942 - 9. 081122 0700 1 1 1 37.5 338.5 0 0 0 0 ..... ref SDS 74 OE6K
040943 - 10. 081123 0700 1 1 1 37.5 376.0 0 0 0 0 ..... ref SDS 75 OE6K
040944 - 11. 081124 0700 1 1 1 37.5 413.5 0 0 0 0 ..... ref SDS 76 OE6K
040945 - 12. 081125 0700 1 1 1 37.5 451.0 0 0 0 0 ..... ref SDS 77 OE6K
040946 - 13. 081126 0700 1 1 1 37.5 488.5 0 0 0 0 ..... ref SDS 78 OE6K
040947 - 14. 081127 0700 1 1 1 37.5 526.0 0 0 0 0 ..... ref SDS 0 OE6K
040948 -
040949 -
040950 -
040951 -
0410 -
SUBJECTS
Default Null Subject Account for Blank Record
0503 -
050401 - ..
050402 - Side Effects Sunitinib Study
050403 -
050404 - Follow up ref SDS 78 LF8M, ref SDS 77 LF8M.
050405 -
050406 - Sunitinib side effects are listed in the study Consent document,
050407 - reviewed on 081017. ref SDS 49 4G7G
050409 - ..
050410 - Millie feels minor joint pain, ref SDS 49 U18H, and fatigue, side
050411 - effects listed for sunitinib on 081017, ref SDS 49 4G7G, are now
050412 - non-issues for sunitinib.
050414 - ..
050415 - Minor heartburn continues occasionally, as reported on 081024.
050416 - ref SDS 76 HS9K One or two attacks occur while hiking, per below.
050417 - ref SDS 0 HT9G This was reported to the medical team during the
050418 - meeting at UCSF yesterday. Prilosec was prescribed to be taken as
050419 - needed. Kaiser was out of stock after the meeting yesterday, so have
050420 - to wait until tomorrow to begin treatment for heartburn.
050422 - ..
050423 - Energy continues to be high.
050425 - ..
050426 - Millie's record of exercising shows correlation between treatments and
050427 - exercise that indicates mild effects so far. ref SDS 76 X64F She
050428 - plans continued hiking to work through side effects.
050430 - ..
050431 - Blood pressure seems more normal for Millie again today.
050433 - ..
050434 - Date
050435 - Description Adverse Event Start Stop Medication
050436 - ---------------------------------------------------------
050437 - Follow up ref SDS 78 LF8M, ref SDS 77 LF8M.
050438 -
050439 - Diarea 081114 081114 Imodium........ ref SDS 63 LF8M
050440 - Low pulse 081120 081120 None........... ref SDS 72 LF8M
050441 - Low pulse 081121 081121 None........... ref SDS 73 7G8M
050442 - BP 144 84 Pulse 48 081121 081121 Hiking......... ref SDS 73 LF8M
050443 - Joint pain minor 081121 081121 Hiking......... ref SDS 73 LF8M
050444 - Fatigue minor 081121 081121 Hiking......... ref SDS 73 LF8M
050445 - Low pulse 081122 081122 None........... ref SDS 74 7G8M
050446 - Fatigue minor 081122 081122 Hiking......... ref SDS 74 LF8M
050447 - Low pulse 081123 081122 None........... ref SDS 75 7G8M
050448 - BP 121 74 Pulse 53 081123 081123 Hiking......... ref SDS 75 LF8M
050449 - Fatigue minor 081123 081122 Hiking......... ref SDS 75 LF8M
050450 - Joint pain minor 081124 081124 Hiking......... ref SDS 76 LF8M
050451 - Fatigue minor 081124 081124 Hiking......... ref SDS 76 LF8M
050452 - Heartburn 081124 081124 None........... ref SDS 76 HS9K
050453 - BP 144 78 Pulse 52 081125 081125 Hiking......... ref SDS 77 LF8M
050454 - Joint pain minor 081125 081125 Hiking......... ref SDS 77 LF8M
050455 - Fatigue minor 081125 081125 Hiking......... ref SDS 77 LF8M
050456 - Heartburn 081125 081125 None........... ref SDS 77 HS9K
050457 - Heartburn 081126 081126 None........... ref SDS 78 HS9K
050458 - Heartburn 081127 081127 None........... ref SDS 0 HS9K
050459 -
050460 -
050461 -
050462 -
0505 -
SUBJECTS
Default Null Subject Account for Blank Record
0603 -
060401 - ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS 78 3E4K, ref SDS 77 3E4K.
060405 -
060406 - Millie went hiking at Lafayette reservoir, and did 2 laps, about 5.50
060407 - miles in 93 minutes. ref SDS 0 X64F
060409 - ..
060410 - Very crowded at the reservoir today with the Thanksgiving holiday.
060412 - ..
060413 - Millie had her 14th treatment with sunitinib alone this morning at
060414 - 0700. ref SDS 0 PA8Y Tomorrow she starts taking supplemental low dose
060415 - (metronomic) chemotherapy, and so this may increase fatigue.
060417 - ..
060418 - On 081110, Millie complained about diffiuclty lifting herself from a
060419 - full squatting position. ref SDS 61 HX67 She has since been
060420 - exercising to strengthen legs, and arms.
060422 - ..
060423 - This morning Millie did...
060424 -
060425 - Arm presses 3 sets of 10 leaning against bannister.
060426 - Squats 3 sets of 10 vary depth useing bannister for leverage
060428 - ..
060429 - There have been no indications of Cellulitis nor lymphedema that has
060430 - occurred previously with exercising the left arm, reported on 070607.
060431 - ref SDS 3 ZH6I
060433 - ..
060434 - Millie experienced heartburn again today while hiking, as explained on
060435 - 081024. ref SDS 76 HT9G This also occurs while not hiking as reported
060436 - under sunitinib side effects, per above. ref SDS 0 HS9K
060437 -
060439 - ..
060440 - Case Study on Pateint History Exercising
060441 -
060442 - Follow up ref SDS 78 X64F, ref SDS 77 X64F.
060443 -
060444 - +- s = Sunitinib
060445 - +- c = Carboplatin
060446 - +- e = Erbatex cetuximab
060447 - Time Pulse |
060448 - Location Miles Minutes Avg Max Chem Neupo Date
060449 - ----------------------------------------------------------------
060450 - Lafayette 5.50 93.3 100 122 s 081127, ref SDS 0 3E4K
060451 - Concord home s 081126, ref SDS 78 3E4K
060452 - Lafayette 4.00 73.7 105 127 s 081125, ref SDS 77 3E4K
060453 - Lafayette 5.50 91.4 100 129 s 081124, ref SDS 76 3E4K
060454 - Concord home s 081123, ref SDS 75 3E4K
060455 - Lafayette 5.50 92.8 95 122 s 081122, ref SDS 74 3E4K
060456 - Lafayette 5.50 94.4 85 112 s 081121, ref SDS 73 3E4K
060457 - Lafayette 5.50 94.7 90 122 s 081120, ref SDS 72 3E4K
060458 - San Francisco 1.00 60.0 65 75 s 081119, ref SDS 71 3E4K
060459 - Lafayette 2.75 49.2 97 130 s 081118, ref SDS 70 3E4K
060460 - Lafayette 5.50 93.6 115 138 s 081117, ref SDS 67 3E4K
060461 - Concord home s 081116, ref SDS 65 Y68J
060462 - Concord home s 081115, ref SDS 64 EK7I
060463 - Concord home s 081114, ref SDS 63 XW6H
060464 - Lafayette 5.50 94.2 115 138 081110, ref SDS 61 3E4K
060465 - Lafayette 2.75 48.4 105 128 081109, ref SDS 60 3E4K
060466 - Kaiser x 081108, ref SDS 59 UZ7K
060467 - Kaiser x 081107, ref SDS 58 UZ7K
060468 - Lafayette 5.50 90.2 120 143 081025, ref SDS 56 3E4K
060469 - Kaiser x 081025, ref SDS 56 UZ7K
060470 - Kaiser x 081024, ref SDS 55 UZ7K
060471 - UCSF c 081023, ref SDS 54 V94O
060472 - Lafayette 5.50 90.6 115 141 081021, ref SDS 53 3E4K
060473 - Lafayette 5.50 90.4 110 128 081020, ref SDS 52 3E4K
060474 - Kaiser x 081018, ref SDS 51 UZ7K
060475 - Kaiser x 081017, ref SDS 50 UZ7K
060476 - UCSF e 081016, ref SDS 48 V94O
060477 - Lafayette 5.50 90.1 115 154 081014, ref SDS 47 3E4K
060478 - Lafayette 5.50 92.7 115 138 081013, ref SDS 46 3E4K
060479 - Lafayette 8.25 146.4 180 224 081012, ref SDS 45 3E4K
060480 - Kaiser x 081011, ref SDS 44 UZ7K
060481 - Lafayette 5.50 93.3 116 138 081010, ref SDS 43 3E4K
060482 - Kaiser x 081010, ref SDS 43 UZ7K
060483 - UCSF e 081009, ref SDS 42 V94O
060484 - Lafayette 5.50 92.1 113 137 081006, ref SDS 41 3E4K
060485 - Lafayette 2.75 48.5 110 136 x 081004, ref SDS 40 3E4K
060486 - Lafayette 5.50 98.2 117 136 x 081003, ref SDS 39 3E4K
060487 - UCSF c 081002, ref SDS 38 V94O
060488 - Lafayette 5.50 94.7 115 142 080929, ref SDS 37 3E4K
060489 - Lafayette 8.25 150.4 115 135 080928, ref SDS 37 3E4K
060490 - Kaiser x 080927, ref SDS 36 UZ7K
060491 - Lafayette 5.50 90.2 120 140 x 080926, ref SDS 35 3E4K
060492 - UCSF c 080925, ref SDS 34 V94O
060493 - Lafayette 5.50 92.3 116 138 080923, ref SDS 33 3E4K
060494 - Lafayette 5.50 98.4 112 134 080922, ref SDS 33 3E4K
060495 - Lafayette 5.50 98.2 114 137 080921, ref SDS 33 3E4K
060496 - Lafayette 5.50 101.6 110 133 x 080920, ref SDS 32 3E4K
060497 - Lafayette 5.50 89.3 115 144 x 080919, ref SDS 31 3E4K
060498 - UCSF c 080918, ref SDS 30 V94O
060499 - Lafayette 2.75 46.2 117 139 080916, ref SDS 31 3E4K
060500 - Lafayette 5.50 91.8 117 142 080915, ref SDS 29 3E4K
060501 - Clayton Safeway 3.00 62.4 98 118 080914, ref SDS 28 3E4K
060502 - Lafayette 8.25 129.7 123 147 x 080913, ref SDS 27 3E4K
060503 - Lafayette 5.50 88.4 118 146 x 080912, ref SDS 26 3E4K
060504 - UCSF c 080911, ref SDS 25 V94O
060505 - Lafayette 2.75 46.8 113 140 080909
060506 - Lafayette 5.50 89.2 117 143 080908
060507 - Lafayette 5.50 92.1 115 138 080907
060508 - Lafayette 2.75 45.3 120 144 x 080906, ref SDS 24 3E4K
060509 - Lafayette 2.75 56.8 93 120 x 080905, ref SDS 23 3E4K
060510 - UCSF c 080904, ref SDS 22 V94O
060511 - Lafayette 8.25 140.4 116 131 080903
060512 - Lafayette 5.50 94.9 115 134 080902
060513 - Kaiser x 080830
060514 - Kaiser x 080829
060515 - UCSF c 080828, ref SDS 21 V94O
060516 - Lafayette 5.50 93.6 120 137 080826
060517 - Lafayette 5.50 93.2 117 138 080825
060518 - Lafayette 5.50 93.2 123 136 x 080823
060519 - Lafayette 8.25 142.5 110 131 x 080822, ref SDS 20 3E4K
060520 - UCSF e 080821, ref SDS 19 V94O
060521 - Lafayette 5.50 94.7 115 137 080820
060522 - Lafayette 5.50 94.3 115 135 080819
060523 - Lafayette 8.25 141.7 118 134 080815
060524 - UCSF e 080814, ref SDS 18 V94O
060525 - Lafayette 5.50 93.8 120 136 080813
060526 - Lafayette 5.50 94.4 116 139 080812
060527 - Lafayette 5.50 94.2 119 133 080810
060528 - Lafayette 8.25 143.6 114 132 x 080809, ref SDS 16 3E4K
060529 - Lafayette 8.25 141.1 117 135 x 080808, ref SDS 15 3E4K
060530 - UCSF c 080807, ref SDS 14 V94O
060531 - Lafayette 8.25 143.7 115 132 080805
060532 - Concord 7.00 127.6 105 118 080804
060533 - Lafayette 8.25 143.2 112 134 080802
060534 - Lafayette 5.50 93.4 115 138 080801
060535 - Lafayette 5.50 92.2 118 140 080729
060536 - Lafayette 5.50 92.6 116 137 080728
060537 - Lafayette 8.25 142.6 114 134 080727
060538 - Lafayette 5.50 91.5 120 143 080726
060539 - Lafayette 8.25 140.8 117 135 080725
060540 - Lafayette 5.50 91.8 122 141 080723
060541 - Lafayette 5.50 91.3 120 139 080722
060542 - Lafayette 8.25 143.3 115 133 080720
060543 - Lafayette 5.50 90.7 125 144 080719
060544 - Lafayette 5.50 92.4 123 142 080716
060545 - Lafayette 2.25 46.8 116 137 080715
060546 - Lafayette 8.25 141.8 116 136 080712
060547 - Lafayette 5.50 92.9 116 139 080711
060548 - Lafayette 8.25 143.3 113 137 080704
060549 - Lafayette 5.50 90.2 121 147 080630
060550 - Lafayette 8.25 142.4 116 138 080628
060551 - Lafayette 5.50 91.4 118 138 080625
060552 - Lafayette 2.25 47.9 116 136 080623
060553 - Lafayette 5.50 94.2 112 138 080622
060554 - Lafayette 5.50 94.7 115 133 080621
060555 - Lafayette 2.25 48.3 110 129 080620
060556 - Mt Diablo 7.00 129.4 130 153 080616
060557 - Lafayette 5.50 90.8 120 146 080615
060558 - Lafayette 5.50 91.3 124 144 080614
060559 - Lafayette 5.50 89.7 122 143 080613
060560 - Lafayette 2.76 45.8 120 147 080611
060561 - Lafayette 5.50 90.5 123 145 080609
060562 - Lafayette 5.50 92.7 115 138 080607
060563 - Lafayette 5.50 94.2 118 139 080602
060564 - Lafayette 5.50 96.2 110 202 080507, ref SDS 5 WO8M
060565 -
060566 -
060567 -
060568 -
060569 -
060570 -
0606 -