THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net
S U M M A R Y
DIARY: November 25, 2008 07:00 AM Tuesday;
Rod Welch
Millie sunitinib #12 IBC 5th relapse hiking6 miles.
1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
........Patient History Sunitinib Loading Dose 14 Days
3...Side Effects Sunitinib Study
4...Exercise Hiking Maintain Fitness Strengthen Immune System
5...Case Study on Pateint History Exercising
..............
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CONTACTS
SUBJECTS
Default Null Subject Account for Blank Record
0403 -
0403 - ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 76 0000. ref SDS 75 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040507 -
040509 - ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS 76 505G.
040904 -
040905 - On 081113 Millie received sunitinib drugs from UCSF to treat the 5th
040906 - relapse of IBC.
040908 - ..
040909 - Millie began the 14 day "charging" treatment on 081114. ref SDS 63
040910 - EK7I After 14 treatments, if Millie tolerates sunitinib at the
040911 - prescribed dose, then she begins adding 2 chemotherapy drugs once a
040912 - day for 2 days a week as prescribed in the treatment protocol,
040913 - reviewed on 081017. ref SDS 49 004O
040915 - ..
040916 - Patient History Sunitinib Loading Dose 14 Days
040917 -
040918 - Follow up ref SDS 76 OE6K, ref SDS 75 OE6K.
040919 -
040921 - Cycle 1
040922 - Cohort: 3
040924 - ..
040925 - Sunitinib MG Cyclophos Metho
040926 - Amount Today Cum phamide trexate
040927 - Days Date Time Cycle 25 12.5 Total Total Amnt Total Amnt Total
040928 - --------------------------------------------------------------------
040929 - Follow up ref SDS 75 PA8Y, ref SDS 74 PA8Y.
040930 -
040931 - 1. 081114 0700 1 1 1 37.5 37.5 0 0 0 0 ..... ref SDS 63 OE6K
040932 - 2. 081115 0700 1 1 1 37.5 75.0 0 0 0 0 ..... ref SDS 64 OE6K
040933 - 3. 081116 0700 1 1 1 37.5 112.5 0 0 0 0 ..... ref SDS 65 OE6K
040934 - 4. 081117 0700 1 1 1 37.5 150.0 0 0 0 0 ..... ref SDS 66 OE6K
040935 - 5. 081118 0700 1 1 1 37.5 187.5 0 0 0 0 ..... ref SDS 69 OE6K
040936 - 6. 081119 0700 1 1 1 37.5 225.0 0 0 0 0 ..... ref SDS 71 OE6K
040937 - 7. 081120 0700 1 1 1 37.5 263.5 0 0 0 0 ..... ref SDS 72 OE6K
040938 - 8. 081121 0700 1 1 1 37.5 301.0 0 0 0 0 ..... ref SDS 73 OE6K
040939 - 9. 081122 0700 1 1 1 37.5 338.5 0 0 0 0 ..... ref SDS 74 OE6K
040940 - 10. 081123 0700 1 1 1 37.5 376.0 0 0 0 0 ..... ref SDS 75 OE6K
040941 - 11. 081124 0700 1 1 1 37.5 413.5 0 0 0 0 ..... ref SDS 76 OE6K
040942 - 12. 081125 0700 1 1 1 37.5 451.0 0 0 0 0 ..... ref SDS 0 OE6K
040943 -
040944 -
040945 -
040946 -
0410 -
SUBJECTS
Default Null Subject Account for Blank Record
0503 -
050401 - ..
050402 - Side Effects Sunitinib Study
050403 -
050404 - Follow up ref SDS 76 LF8M, ref SDS 75 LF8M.
050405 -
050406 - Sunitinib side effects are listed in the study Consent document,
050407 - reviewed on 081017. ref SDS 49 4G7G
050409 - ..
050410 - Today, Millie reports minor joint pain, ref SDS 49 U18H, and fatigue,
050411 - side effects listed for sunitinib on 081017, ref SDS 49 4G7G, have
050412 - become non-issues.
050414 - ..
050415 - Minor heartburn continues occasionally, as reported on 081024.
050416 - ref SDS 76 HS9K Heartburn occurred again today during the hike at
050417 - Lafayette, per below. ref SDS 0 HT9G
050419 - ..
050420 - Energy is increased today shown by vigorous work out in the Gym, then
050421 - hiking 4 miles today, per below. ref SDS 0 3E4K
050423 - ..
050424 - Millie's record of exercising shows correlation between treatments and
050425 - exercise that indicates mild effects so far. ref SDS 76 X64F She
050426 - plans continued hiking to work through side effects.
050428 - ..
050429 - Blood pressure seems more normal for Millie again today.
050431 - ..
050432 - Blood pressure 144 78 and pulse 52 today shows continued lessening of
050433 - sunitinib side effects of high blood pressure, also listed on 081017.
050434 - ref SDS 49 C78M Reflects improvement while hiking today, ref SDS 0
050435 - X64F, recovering from generally a 30 point drop in patient profile for
050436 - pulse while hiking on 081121. ref SDS 73 X64F
050438 - ..
050439 - Millie also has side effects from Neupogen; but nothing for several
050440 - weeks since she stopped treatments pending evaluation with new
050441 - sunitinib treatments, last reported on 081120. ref SDS 72 SB8I
050443 - ..
050444 - Date
050445 - Description Adverse Event Start Stop Medication
050446 - ---------------------------------------------------------
050447 - Follow up ref SDS 75 LF8M, ref SDS 74 LF8M.
050448 -
050449 - Diarea 081114 081114 Imodium........ ref SDS 63 LF8M
050450 - Low pulse 081120 081120 None........... ref SDS 72 LF8M
050451 - Low pulse 081121 081121 None........... ref SDS 73 7G8M
050452 - BP 144 84 Pulse 48 081121 081121 Hiking......... ref SDS 73 LF8M
050453 - Joint pain minor 081121 081121 Hiking......... ref SDS 73 LF8M
050454 - Fatigue minor 081121 081121 Hiking......... ref SDS 73 LF8M
050455 - Low pulse 081122 081122 None........... ref SDS 74 7G8M
050456 - Fatigue minor 081122 081122 Hiking......... ref SDS 74 LF8M
050457 - Low pulse 081123 081122 None........... ref SDS 75 7G8M
050458 - BP 121 74 Pulse 53 081123 081123 Hiking......... ref SDS 75 LF8M
050459 - Fatigue minor 081123 081122 Hiking......... ref SDS 75 LF8M
050460 - Joint pain minor 081124 081124 Hiking......... ref SDS 76 LF8M
050461 - Fatigue minor 081124 081124 Hiking......... ref SDS 76 LF8M
050462 - Heartburn 081124 081124 None........... ref SDS 76 HS9K
050463 - BP 144 78 Pulse 52 081125 081125 Hiking......... ref SDS 0 LF8M
050464 - Joint pain minor 081125 081125 Hiking......... ref SDS 0 LF8M
050465 - Fatigue minor 081125 081125 Hiking......... ref SDS 0 LF8M
050466 - Heartburn 081125 081125 None........... ref SDS 0 HS9K
050467 -
050468 -
050469 -
050470 -
0505 -
SUBJECTS
Default Null Subject Account for Blank Record
0603 -
060401 - ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS 76 3E4K, ref SDS 75 3E4K.
060405 -
060406 - Millie went to the gym this morning at 0800, and did aerobics for 60
060407 - minutes. She reported a vigorous work out, pulse reached 131.
060409 - ..
060410 - Millie went hiking at Lafayette reservoir, and did 1.5 laps, about
060411 - 4.00 miles in 73 minutes. ref SDS 0 X64F Previously on 081118 Millie
060412 - worked out in the gym, and the hiked 1 lap at Lafayette, about 2.75
060413 - miles. ref SDS 70 3E4K
060415 - ..
060416 - Millie experienced heartburn again today while hiking, as explained
060417 - yesterday on 081024. ref SDS 76 HT9G This also occurs while not
060418 - hiking as reported under sunitinib side effects, per above.
060419 - ref SDS 0 HS9K
060421 - ..
060422 - Millie has not had another attack of Cellulitis and lymphedema since
060423 - going to the emergency care unit on 080409. ref SDS 4 0001 There was
060424 - a slight flare up on 080520. ref SDS 6 OU5J Even with double
060425 - workouts today, per above, ref SDS 0 3E4K, there are no signs of
060426 - recurrence.
060428 - ..
060429 - Millie had her 12th treatment with sunitinib this morning at 0700.
060430 - ref SDS 75 PA8Y
060432 - ..
060433 - On 081110, Millie complained about diffiuclty lifting herself from a
060434 - full squatting position. ref SDS 61 HX67 She has since been
060435 - exercising to strengthen legs, and arms.
060437 - ..
060438 - This morning Millie did...
060439 -
060440 - Arm presses 3 sets of 10 leaning against bannister.
060441 - Squats 3 sets of 10 vary depth useing bannister for leverage
060443 - ..
060444 - There have been no indications of Cellulitis nor lymphedema that has
060445 - occurred previously with exercising the left arm, reported on 070607.
060446 - ref SDS 3 ZH6I
060447 -
060449 - ..
060450 - Case Study on Pateint History Exercising
060451 -
060452 - Follow up ref SDS 76 X64F, ref SDS 75 X64F.
060453 -
060454 - +- s = Sunitinib
060455 - +- c = Carboplatin
060456 - +- e = Erbatex cetuximab
060457 - Time Pulse |
060458 - Location Miles Minutes Avg Max Chem Neupo Date
060459 - ----------------------------------------------------------------
060460 - Lafayette 4.00 73.7 105 127 s 081125, ref SDS 0 3E4K
060461 - Lafayette 5.50 91.4 100 129 s 081124, ref SDS 76 3E4K
060462 - Concord home s 081123, ref SDS 75 3E4K
060463 - Lafayette 5.50 92.8 95 122 s 081122, ref SDS 74 3E4K
060464 - Lafayette 5.50 94.4 85 112 s 081121, ref SDS 73 3E4K
060465 - Lafayette 5.50 94.7 90 122 s 081120, ref SDS 72 3E4K
060466 - San Francisco 1.00 60.0 65 75 s 081119, ref SDS 71 3E4K
060467 - Lafayette 2.75 49.2 97 130 s 081118, ref SDS 70 3E4K
060468 - Lafayette 5.50 93.6 115 138 s 081117, ref SDS 67 3E4K
060469 - Concord home s 081116, ref SDS 65 Y68J
060470 - Concord home s 081115, ref SDS 64 EK7I
060471 - Concord home s 081114, ref SDS 63 XW6H
060472 - Lafayette 5.50 94.2 115 138 081110, ref SDS 61 3E4K
060473 - Lafayette 2.75 48.4 105 128 081109, ref SDS 60 3E4K
060474 - Kaiser x 081108, ref SDS 59 UZ7K
060475 - Kaiser x 081107, ref SDS 58 UZ7K
060476 - Lafayette 5.50 90.2 120 143 081025, ref SDS 56 3E4K
060477 - Kaiser x 081025, ref SDS 56 UZ7K
060478 - Kaiser x 081024, ref SDS 55 UZ7K
060479 - UCSF c 081023, ref SDS 54 V94O
060480 - Lafayette 5.50 90.6 115 141 081021, ref SDS 53 3E4K
060481 - Lafayette 5.50 90.4 110 128 081020, ref SDS 52 3E4K
060482 - Kaiser x 081018, ref SDS 51 UZ7K
060483 - Kaiser x 081017, ref SDS 50 UZ7K
060484 - UCSF e 081016, ref SDS 48 V94O
060485 - Lafayette 5.50 90.1 115 154 081014, ref SDS 47 3E4K
060486 - Lafayette 5.50 92.7 115 138 081013, ref SDS 46 3E4K
060487 - Lafayette 8.25 146.4 180 224 081012, ref SDS 45 3E4K
060488 - Kaiser x 081011, ref SDS 44 UZ7K
060489 - Lafayette 5.50 93.3 116 138 081010, ref SDS 43 3E4K
060490 - Kaiser x 081010, ref SDS 43 UZ7K
060491 - UCSF e 081009, ref SDS 42 V94O
060492 - Lafayette 5.50 92.1 113 137 081006, ref SDS 41 3E4K
060493 - Lafayette 2.75 48.5 110 136 x 081004, ref SDS 40 3E4K
060494 - Lafayette 5.50 98.2 117 136 x 081003, ref SDS 39 3E4K
060495 - UCSF c 081002, ref SDS 38 V94O
060496 - Lafayette 5.50 94.7 115 142 080929, ref SDS 37 3E4K
060497 - Lafayette 8.25 150.4 115 135 080928, ref SDS 37 3E4K
060498 - Kaiser x 080927, ref SDS 36 UZ7K
060499 - Lafayette 5.50 90.2 120 140 x 080926, ref SDS 35 3E4K
060500 - UCSF c 080925, ref SDS 34 V94O
060501 - Lafayette 5.50 92.3 116 138 080923, ref SDS 33 3E4K
060502 - Lafayette 5.50 98.4 112 134 080922, ref SDS 33 3E4K
060503 - Lafayette 5.50 98.2 114 137 080921, ref SDS 33 3E4K
060504 - Lafayette 5.50 101.6 110 133 x 080920, ref SDS 32 3E4K
060505 - Lafayette 5.50 89.3 115 144 x 080919, ref SDS 31 3E4K
060506 - UCSF c 080918, ref SDS 30 V94O
060507 - Lafayette 2.75 46.2 117 139 080916, ref SDS 31 3E4K
060508 - Lafayette 5.50 91.8 117 142 080915, ref SDS 29 3E4K
060509 - Clayton Safeway 3.00 62.4 98 118 080914, ref SDS 28 3E4K
060510 - Lafayette 8.25 129.7 123 147 x 080913, ref SDS 27 3E4K
060511 - Lafayette 5.50 88.4 118 146 x 080912, ref SDS 26 3E4K
060512 - UCSF c 080911, ref SDS 25 V94O
060513 - Lafayette 2.75 46.8 113 140 080909
060514 - Lafayette 5.50 89.2 117 143 080908
060515 - Lafayette 5.50 92.1 115 138 080907
060516 - Lafayette 2.75 45.3 120 144 x 080906, ref SDS 24 3E4K
060517 - Lafayette 2.75 56.8 93 120 x 080905, ref SDS 23 3E4K
060518 - UCSF c 080904, ref SDS 22 V94O
060519 - Lafayette 8.25 140.4 116 131 080903
060520 - Lafayette 5.50 94.9 115 134 080902
060521 - Kaiser x 080830
060522 - Kaiser x 080829
060523 - UCSF c 080828, ref SDS 21 V94O
060524 - Lafayette 5.50 93.6 120 137 080826
060525 - Lafayette 5.50 93.2 117 138 080825
060526 - Lafayette 5.50 93.2 123 136 x 080823
060527 - Lafayette 8.25 142.5 110 131 x 080822, ref SDS 20 3E4K
060528 - UCSF e 080821, ref SDS 19 V94O
060529 - Lafayette 5.50 94.7 115 137 080820
060530 - Lafayette 5.50 94.3 115 135 080819
060531 - Lafayette 8.25 141.7 118 134 080815
060532 - UCSF e 080814, ref SDS 18 V94O
060533 - Lafayette 5.50 93.8 120 136 080813
060534 - Lafayette 5.50 94.4 116 139 080812
060535 - Lafayette 5.50 94.2 119 133 080810
060536 - Lafayette 8.25 143.6 114 132 x 080809, ref SDS 16 3E4K
060537 - Lafayette 8.25 141.1 117 135 x 080808, ref SDS 15 3E4K
060538 - UCSF c 080807, ref SDS 14 V94O
060539 - Lafayette 8.25 143.7 115 132 080805
060540 - Concord 7.00 127.6 105 118 080804
060541 - Lafayette 8.25 143.2 112 134 080802
060542 - Lafayette 5.50 93.4 115 138 080801
060543 - Lafayette 5.50 92.2 118 140 080729
060544 - Lafayette 5.50 92.6 116 137 080728
060545 - Lafayette 8.25 142.6 114 134 080727
060546 - Lafayette 5.50 91.5 120 143 080726
060547 - Lafayette 8.25 140.8 117 135 080725
060548 - Lafayette 5.50 91.8 122 141 080723
060549 - Lafayette 5.50 91.3 120 139 080722
060550 - Lafayette 8.25 143.3 115 133 080720
060551 - Lafayette 5.50 90.7 125 144 080719
060552 - Lafayette 5.50 92.4 123 142 080716
060553 - Lafayette 2.25 46.8 116 137 080715
060554 - Lafayette 8.25 141.8 116 136 080712
060555 - Lafayette 5.50 92.9 116 139 080711
060556 - Lafayette 8.25 143.3 113 137 080704
060557 - Lafayette 5.50 90.2 121 147 080630
060558 - Lafayette 8.25 142.4 116 138 080628
060559 - Lafayette 5.50 91.4 118 138 080625
060560 - Lafayette 2.25 47.9 116 136 080623
060561 - Lafayette 5.50 94.2 112 138 080622
060562 - Lafayette 5.50 94.7 115 133 080621
060563 - Lafayette 2.25 48.3 110 129 080620
060564 - Mt Diablo 7.00 129.4 130 153 080616
060565 - Lafayette 5.50 90.8 120 146 080615
060566 - Lafayette 5.50 91.3 124 144 080614
060567 - Lafayette 5.50 89.7 122 143 080613
060568 - Lafayette 2.76 45.8 120 147 080611
060569 - Lafayette 5.50 90.5 123 145 080609
060570 - Lafayette 5.50 92.7 115 138 080607
060571 - Lafayette 5.50 94.2 118 139 080602
060572 - Lafayette 5.50 96.2 110 202 080507, ref SDS 5 WO8M
060573 -
060574 -
060575 -
060576 -
060577 -
060578 -
0606 -