THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: December 17, 2008 07:00 AM Wednesday; Rod Welch

Millie sunitinib #34 treatment IBC 5th relapse recovering well.

1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
3...Sunitinib Cyclophosmaide Methotrexate Patient History
4...Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
5...Exercise Hiking Maintain Fitness Strengthen Immune System
6...Case Study on Pateint History Exercising


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS E8 0000. ref SDS E7 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS E8 505G, ref SDS E7 505G.
040904 -
040905 - Background on starting treatment is reported in the record on 081214.
040906 - ref SDS E6 505G
040908 -  ..
040909 - Millie continues with sunitinib and cyclophosphmaide; methotrexate
040910 - will not be taken again until next Friday on 081219.
040912 -  ..
040913 - Millie had good response after 19 treatments with sunitinib, reported
040914 - on 081202. ref SDS C1 AS6U  At that time, the rate of improvement
040915 - seemed to have slowed, also reported on 081202. ref SDS C1 AT4Q
040917 -  ..
040918 - Concern about slow improvement and possibly another relapse was
040919 - reported again 2 days ago on 081215 ref SDS E7 F656  At that time, IBC
040920 - nodules in the breastbone area seemed more numerous and in some cases
040921 - larger, and some have scabs, i.e., have become noticably more "angry."
040922 - ref SDS E7 F66X   Worry and doubt about prospects were informed by the
040923 - lab at Kaiser on 081210 reporting the cancer marker CA 15-3 197,
040924 - ref SDS D7 A16M, soared to more than double previously high levels
040925 - compared to patient history the past 7 years.
040927 -  ..
040928 - Good news today, after 34 treatments with sunitinib, 20 treatments
040929 - with cyclophosphamide, and 6 with methotrexate, ref SDS 0 MF5H, there
040930 - now seems further and substantial reduction of IBC rash to a point
040931 - barely visible, except for the left arm.  The left arm shows good
040932 - improvement reducing intensity of red coloration.  IBC nodules cited
040933 - two days ago on 081215 seem today less pronounced and "hilly." though
040934 - still very evident.
040936 -  ..
040937 - Significant recovery from IBC after just 1 cycle with the sunitinib
040938 - protocol, plus the initial 14 day loading dose of sunitinib alone,
040939 - seems similar to improvement reported on 050520 after 2 cycles with
040940 - Taxotere and capecitabine (Xeloda). ref SDS E3 025H  At that time, on
040941 - 050520 severe side effects required temporarily stopping treatments
040942 - beginning on 050514, ref SDS E2 RU9M; on 050520 treatment dose for
040943 - capecitabine (Xeloda) reduced to reduce side effects. ref SDS E3 NT3I
040945 -             ..
040946 -            [On 081217 Millie reported progress to UCSF. ref SDS E9
040947 -            YJ4V
040949 -  ..
040950 - Significant improvement observed today reducing IBC rash to near
040951 - invisibility therefore seems starkely conflicting with cancer marker
040952 - CA 15-3 197 in the lab at Kaiser on 081210. ref SDS D7 A16M  Soaring
040953 - cancer marker may be reconciled in part by the separate CT test for
040954 - the neck on 081107, and submitted separately on 081113 after meeting
040955 - with the medical team.  Review at that time on 081113 shows findings
040956 - of extensive adenopathy in the right supraclavicular never previously
040957 - reported. ref SDS 94 HW8M
040959 -  ..
040960 - Continued reduction of IBC rash subsiding with the sunitinib protocol
040961 - should lower CA 15-3 in the blood test tomorrow at UCSF on 081218,
040962 - unless cancer has spread internally, which will be reviewd by the CT
040963 - test scheduled on 081230, reported on 081210. ref SDS D8 H48N
040965 -  ..
040966 - Uncertainty about the future, including prospects for the vacation to
040967 - Europe planned in April - May time frame seem a little brighter today.
040969 -  ..
040970 - NEUTs blood tests show patient history neutropenia from chemotherapy
040971 - everyday with cyclophosphamide reported in case study on 081205.
040972 - ref SDS C6 EC5N
040974 -  ..
040975 - Schedule for Neupogen treatments is listed on 081206. ref SDS D1 HS5M
040976 -
040978 -  ..
040979 - Sunitinib Cyclophosmaide Methotrexate Patient History
040980 -
040981 - Follow up ref SDS E8 OE6K, ref SDS E7 OE6K.
040982 -
040984 -        Cycle 1  begin 081128 after 14 treatmenst sunitinib alone
040985 -        Cohort: 3
040987 -        ..
040988 -                                          Cyclophos  Metho
040989 -                               Sunitinib   phamide   trexate
040990 -       Days  Date  Time  Cycle    37.5       50        5
040991 -       =======================================================
040992 -       Follow up ref SDS E8 PA8Y, ref SDS E7 PA8Y.
040993 -
040994 -        1.  081114 0700  Load    37.5         0         0 ... ref SDS 95 OE6K
040995 -        2.  081115 0700  Load    75.0         0         0 ... ref SDS 96 OE6K
040996 -        3.  081116 0700  Load   112.5         0         0 ... ref SDS 97 OE6K
040997 -        4.  081117 0700  Load   150.0         0         0 ... ref SDS 98 OE6K
040998 -        5.  081118 0700  Load   187.5         0         0 ... ref SDS A1 OE6K
040999 -        6.  081119 0700  Load   225.0         0         0 ... ref SDS A3 OE6K
041000 -        7.  081120 0700  Load   263.5         0         0 ... ref SDS A4 OE6K
041001 -        8.  081121 0700  Load   301.0         0         0 ... ref SDS A5 OE6K
041002 -        9.  081122 0700  Load   338.5         0         0 ... ref SDS A6 OE6K
041003 -       10.  081123 0700  Load   376.0         0         0 ... ref SDS A7 OE6K
041004 -       11.  081124 0700  Load   413.5         0         0 ... ref SDS A8 OE6K
041005 -       12.  081125 0700  Load   451.0         0         0 ... ref SDS A9 OE6K
041006 -             ..
041007 -       13.  081126 0700  Load   488.5         0         0 ... ref SDS B0 OE6K
041008 -             ..
041009 -            081126 0820  NEUTS........1.50................... ref SDS B1 PU6K
041011 -             ..
041012 -       14.  081127 0700  Load   526.0         0         0 ... ref SDS B2 OE6K
041013 -       15.  081128 0700  1  1   563.5   1    50    1    5 ... ref SDS B5 OE6K
041014 -       16.  081129 0700  1  2   601.0   2   100    2   10 ... ref SDS B8 OE6K
041015 -       17.  081130 0700  1  3   638.5   3   150    2   10 ... ref SDS B9 OE6K
041016 -       18.  081201 0700  1  4   676.0   4   200    2   10 ... ref SDS C0 OE6K
041017 -       19.  081202 0700  1  5   713.5   5   250    2   10 ... ref SDS C2 OE6K
041018 -             ..
041019 -       20.  081203 0700  1  6   751.0   6   300    2   10 ... ref SDS C4 OE6K
041020 -
041021 -            081203 0735. NEUTS....... 0.624 ...... .......... ref SDS C3 RN5G
041022 -
041023 -                Rate of change per day = 1500 - 624 = 876 / 7
041024 -
041025 -                                       = 120+ per day
041027 -             ..
041028 -       21.  081204 0700  1  7   788.5   7   350    2   10 ... ref SDS C5 OE6K
041029 -             ..
041030 -       22.  081205 0700  1  8   826.0   8   400    3   15 ... ref SDS C6 OE6K
041031 -
041032 -            081205 1300  Neupogen...... 480 mcg.............. ref SDS C7 KV84
041034 -             ..
041035 -       23.  081206 0700  1  9   863.5   9   450    4   20 ... ref SDS D0 OE6K
041036 -
041037 -            081206 0930  Neupogen...... 480 mcg.............. ref SDS D1 BI4J
041039 -             ..
041040 -       24.  081207 0700  1 10   901.0  10   500    4   20 ... ref SDS D2 OE6K
041041 -       25.  081208 0700  1 11   938.5  11   550    4   20 ... ref SDS D3 OE6K
041042 -       26.  081209 0700  1 12   976.0  12   600    4   20 ... ref SDS D4 OE6K
041043 -             ..
041044 -       27.  081210 0700  1 13  1013.5  13   650    4   20 ... ref SDS D6 OE6K
041045 -
041046 -            081210 1301. NEUTS....... 1.085 ................. ref SDS D7 QY6H
041048 -             ..
041049 -       28.  081211 0700  1 14  1050.0  14   700    4   20 ... ref SDS E0 OE6K
041050 -             ..
041051 -       29.  081212 0700  1 15  1087.5  15   750    5   25 ... ref SDS E2 OE6K
041052 -
041053 -            081212 1115. NEUTS....... 1.054 ................. ref SDS E3 QY6H
041055 -             ..
041056 -       30.  081213 0700  1 16  1125.0  16   800    6   30 ... ref SDS E5 OE6K
041057 -       31.  081214 0700  1 17  1162.5  17   850    6   30 ... ref SDS E6 OE6K
041058 -       32.  081215 0700  1 18  1200.0  18   900    6   30 ... ref SDS E7 OE6K
041059 -       33.  081216 0700  1 19  1237.5  19   950    6   30 ... ref SDS E8 OE6K
041060 -             ..
041061 -       34.  081217 0700  1 20  1275.0  20  1000    6   30 ... ref SDS 0 OE6K
041063 -  ..
041064 - Millie's blood test on 081210 indicates ANC 1085, ref SDS D7 QY6H,
041065 - increased about 400 points from the test on 081203.  Follow up test on
041066 - 081212 showed minor decline ANC 1054 (NEUTS 1.054). ref SDS E3 QY6H
041067 - As a result, Kaiser cancelled Neupogen treatments scheduled for 081212
041068 - and 081213. ref SDS E4 UZ7K
041070 -  ..
041071 - This will be evaluated again on 081218 when Millie gets a blood test
041072 - at UCSF to start the next cycle of sunitinib treatment.
041073 -
041074 -
041075 -
041076 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
050401 -  ..
050402 - Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
050403 -
050404 - Follow up ref SDS E8 LF8M, ref SDS E7 LF8M.
050405 -
050406 - Fatigue is a likely side effect of sunitinib with cyclophosphamide,
050407 - listed in the Consent document reviewed on 081017. ref SDS 77 4G7G
050409 -  ..
050410 - Low blood counts NEUTS 1.054 reported for the lab on 081212 at Kaiser,
050411 - ref SDS E3 QY6H, may reflect rising fatigue.
050413 -  ..
050414 - Background on Neupogen treatments and UCSF comments are reported on
050415 - 081207. ref SDS D2 673J
050417 -  ..
050418 - NEUTs blood tests show patient history treatments with Nuepogen for
050419 - neutropenia from chemotherapy everyday with cyclophosphamide reported
050420 - in case study on 081205. ref SDS C6 EC5N
050422 -  ..
050423 - Millie tired, but seems more energetic today.  She had several outside
050424 - activities - going to a cancer support group meeting, and then
050425 - stopping on the way home to get a picture framed.  This evening she
050426 - played bridge, and was pleased to win, saying the cards fell her way.
050427 - She did not like bickering and pettiness displayed by others, and has
050428 - decided not to continue with this group.
050430 -  ..
050431 - Millie has experienced rising joint pain general ill feeling, weakness
050432 - that increases when she stands and moves by walking; going to the gym
050433 - has been difficult, but she talks today about increasing work outs at
050434 - the gym in order to maintain flexibility, strength, and stamina.
050436 -  ..
050437 - Feet sore causing pain and discomfort walking from multiple lesions on
050438 - toes worsening from yesterday on 081216, ref SDS E8 HY8M, beginning
050439 - about a week ago, and gradually increased that makes walking very
050440 - difficult, and further precludes hiking, as shown in patient history
050441 - below. ref SDS 0 X64F
050443 -  ..
050444 - Nose bleed has begun the past few days, evident only from minor blood
050445 - from blowing her nose.  Nosebleed is listed as a less likely side
050446 - effect of the sunitinib protocol, reviewed on 081017. ref SDS 77 QL4O
050447 -
050448 -        [On 081218 labs at UCSF for examination starting 2nd cycle
050449 -        of sunitinib protocol show CBC blood counts again very low,
050450 -        ref SDS F1 075H, with platelets 67, ref SDS F1 7Z6N,
050451 -        attributed for causing new sunitinib side effect of
050452 -        nosebleed, ref SDS F2 GF4S, and NEUTS 0.74 have again fallen
050453 -        substantially, ref SDS F1 QY6H; as a result treatment
050454 -        regimen changed; all treatment was paused for 7 days until
050455 -        081226; Methotrexate ended entirely; consideration will be
050456 -        made to reduce dose for sunitinib. ref SDS F2 GF4V
050458 -  ..
050459 - In addition to low blood counts, review on 081112 for the the CT test
050460 - on 081107 showed findings of worsening Interstitional Lung disease,
050461 - ref SDS 92 TS4J, which is a side effect of cetuximab and
050462 - cyclophosphamide.  Millie had 97 treatments with cetuximab, which
050463 - ended on 081023. ref SDS 82 V94O  She has had 16 low dose treatments
050464 - with cyclophosphamide, ref SDS E5 AG5G, since starting on 081128.
050465 - ref SDS B5 VR57
050467 -  ..
050468 - The doctor indicated in a call on 081210 that the rate of progression
050469 - of Interstitional Lung disease indicated by current testing on 081107
050470 - does not pose a serious threat to Millie's longevity. ref SDS D8 H46M
050472 -  ..
050473 - Vitals were reported today...
050474 -
050475 -                   BP 137 69 Pulse 63
050477 -  ..
050478 - Millie reports continued relief from heartburn with daily treatments
050479 - using Prilosce started on 081208. ref SDS D3 7J6K
050481 -  ..
050482 - Millie reports improved taste from some foods today (e.g., soup),
050483 - cited in study consent documents, reviewed on 081017. ref SDS 77 6T5H
050484 -
050486 -     ..
050487 -                                   Date
050488 -    Description Adverse Event   Start  Stop     Medication
050489 -    ---------------------------------------------------------
050490 -    Follow up ref SDS E8 MV5H, ref SDS E7 MV5H.
050491 -
050492 -    Diarrhea                    081114 081114   Imodium........ ref SDS 95 LF8M
050493 -    Low pulse                   081120 081120   None........... ref SDS A4 LF8M
050494 -    Low pulse                   081121 081121   None........... ref SDS A5 7G8M
050495 -    BP 144 84 Pulse 48          081121 081121   Hiking......... ref SDS A5 LF8M
050496 -    Joint pain minor            081121 081121   Hiking......... ref SDS A5 LF8M
050497 -    Fatigue minor               081121 081121   Hiking......... ref SDS A5 LF8M
050498 -    Low pulse                   081122 081122   None........... ref SDS A6 7G8M
050499 -    Fatigue minor               081122 081122   Hiking......... ref SDS A6 LF8M
050500 -    Low pulse                   081123 081122   None........... ref SDS A7 7G8M
050501 -    BP 121 74 Pulse 53          081123 081123   Hiking......... ref SDS A7 LF8M
050502 -    Fatigue minor               081123 081122   Hiking......... ref SDS A7 LF8M
050503 -    Joint pain minor            081124 081124   Hiking......... ref SDS A8 LF8M
050504 -    Fatigue minor               081124 081124   Hiking......... ref SDS A8 LF8M
050505 -    Heartburn                   081124 081124   None........... ref SDS A8 HS9K
050506 -    BP 144 78 Pulse 52          081125 081125   Hiking......... ref SDS A9 LF8M
050507 -    Joint pain minor            081125 081125   Hiking......... ref SDS A9 LF8M
050508 -    Fatigue minor               081125 081125   Hiking......... ref SDS A9 LF8M
050509 -    Heartburn                   081125 081125   None........... ref SDS A9 HS9K
050510 -    Heartburn                   081126 081126   None........... ref SDS B0 HS9K
050511 -    Heartburn                   081127 081127   None........... ref SDS B4 HS9K
050512 -    BP 135 73 Pulse 48          081128 081128   Hiking......... ref SDS B5 5X6K
050513 -    Upset stomach               081128 081128   Hiking......... ref SDS B5 T76O
050514 -    BP 140 75 Pulse 50          081129 081129   Hiking......... ref SDS B8 5X6K
050515 -    Heartburn                   081129 081129   None........... ref SDS B8 HS9K
050516 -    Fatigue                     081129 081129   Rest........... ref SDS B8 LF8M
050517 -    Fatigue                     081130 081130   Rest........... ref SDS B9 LF8M
050518 -    BP 136 79 Pulse 46          081201 081201   Hiking......... ref SDS C0 5X6K
050519 -    Fatigue                     081201 081201   Rest........... ref SDS C0 LF8M
050520 -    Taste altered               081201 081201   Rest........... ref SDS C0 VP4G
050521 -    BP 141 77 Pulse 46          081202 081202   Aerobics gym... ref SDS C2 5X6K
050522 -    Fatigue                     081202 081202   Rest........... ref SDS C2 LF8M
050523 -    Taste altered               081202 081202   Rest........... ref SDS C2 VP4G
050524 -    BP 138 77 Pulse 48          081203 081203   Hiking......... ref SDS C4 5X6K
050525 -    Fatigue                     081203 081203   Rest........... ref SDS C4 LF8M
050526 -    Taste altered               081203 081203   Rest........... ref SDS C4 VP4G
050527 -    NEUTS (ANC)     0.624       081203 081203   Neupogen.......
050528 -    BP 133 72 Pulse 45          081204 081204   Rest........... ref SDS C5 5X6K
050529 -    Fatigue                     081204 081204   Rest........... ref SDS C5 LF8M
050530 -    Taste altered               081204 081204   Rest........... ref SDS C5 VP4G
050531 -    BP 138 76 Pulse 49          081205 081205   Rest........... ref SDS C6 5X6K
050532 -    Diarrhea                    081205 081114   Imodium........ ref SDS C6 Q67F
050533 -    Fatigue                     081205 081205   Rest........... ref SDS C6 LF8M
050534 -    Taste altered               081205 081205   Rest........... ref SDS C6 VP4G
050535 -    BP *** ** Pulse **          081206 081206   Rest........... ref SDS D0 5X6K
050536 -    Fatigue                     081206 081206   Rest........... ref SDS D0 LF8M
050537 -    BP 128 70 Pulse 53          081207 081207   Hiking......... ref SDS D2 5X6K
050538 -    Fatigue                     081207 081207   Rest........... ref SDS D2 LF8M
050539 -    BP 137 68 Pulse 53          081208 081208   Rest........... ref SDS D3 5X6K
050540 -    Fatigue                     081208 081208   Rest........... ref SDS D3 LF8M
050541 -    BP *** ** Pulse **          081209 081209   Rest........... ref SDS D3 5X6K
050542 -    Fatigue                     081209 081209   Rest........... ref SDS D3 LF8M
050543 -    Heartburn                   081209 081209   Prilosec....... ref SDS D4 7J6K
050544 -    BP 136 70 Pulse 53          081210 081210   Rest........... ref SDS D6 5X6K
050545 -    Fatigue                     081210 081210   Rest........... ref SDS D6 LF8M
050546 -    Heartburn                   081210 081210   Prilosec....... ref SDS D6 7J6K
050547 -    BP *** ** Pulse **          081211 081211   Rest........... ref SDS E0 5X6K
050548 -    Fatigue                     081211 081211   Exercise gym... ref SDS E0 LF8M
050549 -    Heartburn                   081211 081211   Prilosec....... ref SDS E0 7J6K
050550 -    BP 137 76 Pulse 53          081212 081212   Rest........... ref SDS E2 5X6K
050551 -    Fatigue                     081212 081212   Exercise gym... ref SDS E2 LF8M
050552 -    Heartburn                   081212 081212   Prilosec....... ref SDS E2 7J6K
050553 -    BP 147 80 Pulse 51          081213 081213   Rest........... ref SDS E5 5X6K
050554 -    Fatigue                     081213 081213   Exercise gym... ref SDS E5 LF8M
050555 -    BP *** ** Pulse **          081214 081214   Rest........... ref SDS E6 5X6K
050556 -    Fatigue                     081214 081214   Rest........... ref SDS E6 LF8M
050557 -    BP *** ** Pulse **          081215 081215   Rest........... ref SDS E7 5X6K
050558 -    Fatigue                     081215 081215   Rest........... ref SDS E7 LF8M
050559 -    BP 144 79 Pulse 54          081216 081216   Rest........... ref SDS E8 5X6K
050560 -    Fatigue                     081216 081216   Exercise gym... ref SDS E8 LF8M
050561 -    Joint pain minor            081216 081216   Rest........... ref SDS E8 E38H
050562 -    BP 137 69 Pulse 63          081217 081217   Rest........... ref SDS 0 5X6K
050563 -    Fatigue                     081217 081217   Rest........... ref SDS 0 LF8M
050564 -    Joint pain minor            081217 081217   Rest........... ref SDS 0 E38H
050565 -    Feet toes lesions sore      081218 081217   Rest........... ref SDS 0 IU6N
050566 -    Nosebleed minor             081217 081217   Rest........... ref SDS 0 ZF5F
050567 -
050568 -
050569 -
050570 -
0506 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS E8 3E4K, ref SDS E7 3E4K.
060405 -
060406 - Millie more energetic today.  She did not go hiking because today is a
060407 - cancer support group meeting.  The weather remains very cold, which
060408 - curtails outside activity.
060410 -  ..
060411 - Decreased exercise reflects low energy from continuing side effects
060412 - of daily treatments with cyclophosphamide and sunitinib, per above.
060413 - ref SDS 0 LF8M
060415 -  ..
060416 - General feeling is loss of energy, reflected by low blood counts
060417 - reported on 081212, ref SDS E3 075H, and with NEUTS at 1054.
060418 - ref SDS E3 QY6H
060419 -
060420 -        [On 081218 labs at UCSF for examination starting 2nd cycle
060421 -        of sunitinib protocol show CBC blood counts again very low,
060422 -        ref SDS F1 075H, with platelets 67, ref SDS F1 7Z6N,
060423 -        attributed for causing new sunitinib side effect of
060424 -        nosebleed, ref SDS F2 GF4S, and NEUTS 0.74 have again fallen
060425 -        substantially, ref SDS F1 QY6H; as a result treatment
060426 -        regimen changed; all treatment was paused for 7 days until
060427 -        081226; Methotrexate ended entirely; consideration will be
060428 -        made to reduce dose for sunitinib. ref SDS F2 GF4V
060430 -  ..
060431 - Glenna reported in a telephone call on 081203 that other patients
060432 - treated with the sunitinib protocol also experience fatigue.
060433 - ref SDS C4 XN43
060435 -  ..
060436 - NEUTs blood tests show patient history treatments with Nuepogen for
060437 - neutropenia from chemotherapy everyday with cyclophosphamide reported
060438 - in case study on 081205. ref SDS C6 EC5N
060440 -  ..
060441 - Millie had her 33nd treatment with sunitinib this morning at 0700.
060442 - ref SDS E8 PA8Y  This is the 19th day of the 1st cycle that includes
060443 - sunitinib and cyclophosphmaide.  Millie does not get treatment with
060444 - methotrexate again until next Friday, 081219.
060446 -  ..
060447 - On 081110, Millie complained about difficulty lifting herself from a
060448 - full squatting position. ref SDS 91 HX67  She has since been
060449 - exercising to strengthen legs, and arms, shown today by going to the
060450 - gym. ref SDS E0 3E4K
060452 -  ..
060453 - Millie went to the gym this morning and did aerobics.
060454 -
060456 -  ..
060457 - Case Study on Pateint History Exercising
060458 -
060459 - Follow up ref SDS E8 X64F, ref SDS E7 X64F.
060460 -
060461 -                                              +- scm = Sunitinib Cyclophosphmaide Methotrexate
060462 -                                              +- sc  = Sunitinib Cyclophosphmaide
060463 -                           Time     Pulse     |
060464 -    Location        Miles Minutes  Avg Max  Chem  Neupo  Date
060465 -    ----------------------------------------------------------------
060466 -    Concord home                              sc        081217, ref SDS 0 3E4K
060467 -    Concord home (gym)                        sc        081216, ref SDS E8 3E4K
060468 -    Concord home                              sc        081215, ref SDS E7 3E4K
060469 -    Concord home                              sc        081214, ref SDS E6 3E4K
060470 -    Concord home (gym)                        scm       081213, ref SDS E5 3E4K
060471 -    Concord home                              scm       081212, ref SDS E2 3E4K
060472 -    Concord home (gym)                        sc        081211, ref SDS E0 3E4K
060473 -    Concord home                              sc        081210, ref SDS D6 3E4K
060474 -    Concord home                              sc        081209, ref SDS D4 3E4K
060475 -    Concord home                              sc        081208, ref SDS D3 3E4K
060476 -    Lafayette        4.75   78.6    95 110    sc        081207, ref SDS D2 3E4K
060477 -    Concord home                              scm       081206, ref SDS D0 3E4K
060478 -    Concord home                              scm       081205, ref SDS C6 3E4K
060479 -    Concord home                              sc        081204, ref SDS C5 3E4K
060480 -    Lafayette        2.75   62.7    90 117    sc        081203, ref SDS C4 3E4K
060481 -    Concord home (gym)                        sc        081202, ref SDS C2 3E4K
060482 -    Lafayette        5.50  102.3    95 122    sc        081201, ref SDS C0 3E4K
060483 -    Concord home                              sc        081130, ref SDS B9 3E4K
060484 -    Lafayette        2.75   56.7    90 115    scm       081129, ref SDS B8 3E4K
060485 -    Lafayette        2.75   46.5   100 128    scm       081128, ref SDS B5 3E4K
060486 -    Lafayette        5.50   93.3   100 122    s         081127, ref SDS B4 3E4K
060487 -    Concord home                              s         081126, ref SDS B0 3E4K
060488 -    Lafayette        4.00   73.7   105 127    s         081125, ref SDS A9 3E4K
060489 -    Lafayette        5.50   91.4   100 129    s         081124, ref SDS A8 3E4K
060490 -    Concord home                              s         081123, ref SDS A7 3E4K
060491 -    Lafayette        5.50   92.8    95 122    s         081122, ref SDS A6 3E4K
060492 -    Lafayette        5.50   94.4    85 112    s         081121, ref SDS A5 3E4K
060493 -    Lafayette        5.50   94.7    90 122    s         081120, ref SDS A4 3E4K
060494 -    San Francisco    1.00   60.0    65  75    s         081119, ref SDS A3 3E4K
060495 -    Lafayette        2.75   49.2    97 130    s         081118, ref SDS A2 3E4K
060496 -    Lafayette        5.50   93.6   115 138    s         081117, ref SDS 99 3E4K
060497 -    Concord home                              s         081116, ref SDS 97 Y68J
060498 -    Concord home                              s         081115, ref SDS 96 EK7I
060499 -    Concord home                              s         081114, ref SDS 95 XW6H
060500 -    Lafayette        5.50   94.2   115 138              081110, ref SDS 91 3E4K
060501 -    Lafayette        2.75   48.4   105 128              081109, ref SDS 90 3E4K
060502 -    Kaiser                                         x    081108, ref SDS 89 UZ7K
060503 -    Kaiser                                         x    081107, ref SDS 88 UZ7K
060504 -    Lafayette        5.50   90.2   120 143              081025, ref SDS 84 3E4K
060505 -    Kaiser                                         x    081025, ref SDS 84 UZ7K
060506 -    Kaiser                                         x    081024, ref SDS 83 UZ7K
060507 -    UCSF                                      c         081023, ref SDS 82 V94O
060508 -    Lafayette        5.50   90.6   115 141              081021, ref SDS 81 3E4K
060509 -    Lafayette        5.50   90.4   110 128              081020, ref SDS 80 3E4K
060510 -    Kaiser                                         x    081018, ref SDS 79 UZ7K
060511 -    Kaiser                                         x    081017, ref SDS 78 UZ7K
060512 -    UCSF                                      e         081016, ref SDS 76 V94O
060513 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 75 3E4K
060514 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 74 3E4K
060515 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 73 3E4K
060516 -    Kaiser                                         x    081011, ref SDS 72 UZ7K
060517 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 71 3E4K
060518 -    Kaiser                                         x    081010, ref SDS 71 UZ7K
060519 -    UCSF                                      e         081009, ref SDS 70 V94O
060520 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 69 3E4K
060521 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 68 3E4K
060522 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 67 3E4K
060523 -    UCSF                                      c         081002, ref SDS 66 V94O
060524 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 65 3E4K
060525 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 65 3E4K
060526 -    Kaiser                                         x    080927, ref SDS 64 UZ7K
060527 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 63 3E4K
060528 -    UCSF                                      c         080925, ref SDS 62 V94O
060529 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 61 3E4K
060530 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 61 3E4K
060531 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 61 3E4K
060532 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 60 3E4K
060533 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 59 3E4K
060534 -    UCSF                                      c         080918, ref SDS 58 V94O
060535 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 59 3E4K
060536 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 57 3E4K
060537 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 56 3E4K
060538 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 55 3E4K
060539 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 54 3E4K
060540 -    UCSF                                      c         080911, ref SDS 53 V94O
060541 -    Lafayette        2.75   46.8   113 140              080909
060542 -    Lafayette        5.50   89.2   117 143              080908
060543 -    Lafayette        5.50   92.1   115 138              080907
060544 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 52 3E4K
060545 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 51 3E4K
060546 -    UCSF                                      c         080904, ref SDS 50 V94O
060547 -    Lafayette        8.25  140.4   116 131              080903
060548 -    Lafayette        5.50   94.9   115 134              080902
060549 -    Kaiser                                         x    080830
060550 -    Kaiser                                         x    080829
060551 -    UCSF                                      c         080828, ref SDS 49 V94O
060552 -    Lafayette        5.50   93.6   120 137              080826
060553 -    Lafayette        5.50   93.2   117 138              080825
060554 -    Lafayette        5.50   93.2   123 136         x    080823
060555 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 48 3E4K
060556 -    UCSF                                      e         080821, ref SDS 47 V94O
060557 -    Lafayette        5.50   94.7   115 137              080820
060558 -    Lafayette        5.50   94.3   115 135              080819
060559 -    Lafayette        8.25  141.7   118 134              080815
060560 -    UCSF                                      e         080814, ref SDS 46 V94O
060561 -    Lafayette        5.50   93.8   120 136              080813
060562 -    Lafayette        5.50   94.4   116 139              080812
060563 -    Lafayette        5.50   94.2   119 133              080810
060564 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 44 3E4K
060565 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 43 3E4K
060566 -    UCSF                                      c         080807, ref SDS 42 V94O
060567 -    Lafayette        8.25  143.7   115 132              080805
060568 -    Concord          7.00  127.6   105 118              080804
060569 -    Lafayette        8.25  143.2   112 134              080802
060570 -    Lafayette        5.50   93.4   115 138              080801
060571 -    Lafayette        5.50   92.2   118 140              080729
060572 -    Lafayette        5.50   92.6   116 137              080728
060573 -    Lafayette        8.25  142.6   114 134              080727
060574 -    Lafayette        5.50   91.5   120 143              080726
060575 -    Lafayette        8.25  140.8   117 135              080725
060576 -    Lafayette        5.50   91.8   122 141              080723
060577 -    Lafayette        5.50   91.3   120 139              080722
060578 -    Lafayette        8.25  143.3   115 133              080720
060579 -    Lafayette        5.50   90.7   125 144              080719
060580 -    Lafayette        5.50   92.4   123 142              080716
060581 -    Lafayette        2.25   46.8   116 137              080715
060582 -    Lafayette        8.25  141.8   116 136              080712
060583 -    Lafayette        5.50   92.9   116 139              080711
060584 -    Lafayette        8.25  143.3   113 137              080704
060585 -    Lafayette        5.50   90.2   121 147              080630
060586 -    Lafayette        8.25  142.4   116 138              080628
060587 -    Lafayette        5.50   91.4   118 138              080625
060588 -    Lafayette        2.25   47.9   116 136              080623
060589 -    Lafayette        5.50   94.2   112 138              080622
060590 -    Lafayette        5.50   94.7   115 133              080621
060591 -    Lafayette        2.25   48.3   110 129              080620
060592 -    Mt Diablo        7.00  129.4   130 153              080616
060593 -    Lafayette        5.50   90.8   120 146              080615
060594 -    Lafayette        5.50   91.3   124 144              080614
060595 -    Lafayette        5.50   89.7   122 143              080613
060596 -    Lafayette        2.76   45.8   120 147              080611
060597 -    Lafayette        5.50   90.5   123 145              080609
060598 -    Lafayette        5.50   92.7   115 138              080607
060599 -    Lafayette        5.50   94.2   118 139              080602
060600 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 20 WO8M
060601 -
060602 -
060603 -
060604 -
060605 -
060606 -
0607 -