THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: January 9, 2009 07:00 AM Friday; Rod Welch

Millie sunitinib #50 treatment IBC 5th relapse.

1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
3...Sunitinib Cyclophosmaide Methotrexate Patient History
4...Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
5...Exercise Hiking Maintain Fitness Strengthen Immune System
6...Case Study on Pateint History Exercising


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS I1 0000. ref SDS I0 0000.
040502 -
040503 -
040504 -
040505 -
040507 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS I1 505G, ref SDS I0 505G.
040904 -
040905 - Background pausing treatment on 081219 for a week for Millie's blood
040906 - counts to recover, and resuming on 081226 with sunitinib and
040907 - cyclophosphamide. ref SDS G3 505G  Yesterday on 090108 treatment with
040908 - sunitinib was continued at full strength, and cyclophosphamide was
040909 - discontinued until blood counts rise above NEUTS 1.00, and then
040910 - cyclophosphamide will reduced from 7 to 5 days a week. ref SDS I1 9V4I
040911 -
040912 -        [On 090109 Millie letter to medical team reports blood
040913 -        counts very low again, NEUTS 0.87, confirms UCSF treatment
040914 -        plan on 090108 continues sunitinib at full strenth, and
040915 -        pauses cyclophosphamice until blood counts rise to NEUTS
040916 -        1.00, and then reduces cyclophosphamide from 7 to 5 days a
040917 -        week in order maintain blood counts. ref SDS I4 UF3Q
040919 -  ..
040920 - Today, IBC rash and nodules in breastbone still possibly improving
040921 - after a few days getting worse, reported on 090105. ref SDS H6 124N
040922 - Examination at UCSF yesterday on 090108 found IBC worse than observed
040923 - during examination on 081218 after Millie experienced substantial
040924 - improvement recovering from IBC.  This aligns with worsening IBC
040925 - reported on 081224 and 081225, and then recovery on 081226 presented
040926 - in Millie's letter to the medical team on 081230. ref SDS G8 4W7Y
040927 - Additionally, on 090103 IBC seemed to get worse again for several
040928 - days, but on 090106 was beginning to respond to treatment again,
040929 - presented in Millie's letter on 090106. ref SDS H9 YO4V
040931 -  ..
040932 - Today, Millie less energetic could not go to the gym for aerobic
040933 - exercise. ref SDS 0 X64F  Did not go hiking at Lafayette nor at the
040934 - Clayton Safeway trail. because the hiking was too difficult, reported
040935 - on 090103, ref SDS 0 OT3L, due to rising side effects of falling blood
040936 - counts that cause fatigue, ref SDS 0 LF8M, from 15 cancer treatments
040937 - beginning on 081226, reported below. ref SDS 0 9I6T
040939 -  ..
040940 - NEUTS patient history of neutropenia from chemotherapy everyday with
040941 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
040943 -  ..
040944 - Neupogen treatments prescribed today by the medical team at UCSF for
040945 - 090109, ref SDS I5 UZ7K, and 090110 to help maintain blood counts to
040946 - strengthen Millie's immunity system, shown in Millie's letter to the
040947 - medical team on 090109. ref SDS I4 UF3Q
040948 -
040950 -  ..
040951 - Sunitinib Cyclophosmaide Methotrexate Patient History
040952 -
040953 - Follow up ref SDS I1 OE6K, ref SDS I0 OE6K.
040954 -
040956 -        Cycle 1  begin 081128 after 14 treatmenst sunitinib alone
040957 -        Cohort: 3
040959 -        ..
040960 -                                          Cyclophos  Metho
040961 -                               Sunitinib   phamide   trexate
040962 -       Days  Date  Time  Cycle    37.5       50        5
040963 -       =======================================================
040964 -       Follow up ref SDS I1 PA8Y, ref SDS I0 PA8Y.
040965 -
040966 -        1.  081114 0700  Load    37.5         0         0 ... ref SDS 94 OE6K
040967 -        2.  081115 0700  Load    75.0         0         0 ... ref SDS 95 OE6K
040968 -        3.  081116 0700  Load   112.5         0         0 ... ref SDS 96 OE6K
040969 -        4.  081117 0700  Load   150.0         0         0 ... ref SDS 97 OE6K
040970 -        5.  081118 0700  Load   187.5         0         0 ... ref SDS A0 OE6K
040971 -        6.  081119 0700  Load   225.0         0         0 ... ref SDS A2 OE6K
040972 -        7.  081120 0700  Load   263.5         0         0 ... ref SDS A3 OE6K
040973 -        8.  081121 0700  Load   301.0         0         0 ... ref SDS A4 OE6K
040974 -        9.  081122 0700  Load   338.5         0         0 ... ref SDS A5 OE6K
040975 -       10.  081123 0700  Load   376.0         0         0 ... ref SDS A6 OE6K
040976 -       11.  081124 0700  Load   413.5         0         0 ... ref SDS A7 OE6K
040977 -       12.  081125 0700  Load   451.0         0         0 ... ref SDS A8 OE6K
040978 -             ..
040979 -       13.  081126 0700  Load   488.5         0         0 ... ref SDS A9 OE6K
040980 -             ..
040981 -            081126 0820  NEUTS........1.50................... ref SDS B0 PU6K
040983 -             ..
040984 -       14.  081127 0700  Load   526.0         0         0 ... ref SDS B1 OE6K
040985 -       15.  081128 0700  1  1   563.5   1    50    1    5 ... ref SDS B4 OE6K
040986 -       16.  081129 0700  1  2   601.0   2   100    2   10 ... ref SDS B7 OE6K
040987 -       17.  081130 0700  1  3   638.5   3   150    2   10 ... ref SDS B8 OE6K
040988 -       18.  081201 0700  1  4   676.0   4   200    2   10 ... ref SDS B9 OE6K
040989 -       19.  081202 0700  1  5   713.5   5   250    2   10 ... ref SDS C1 OE6K
040990 -             ..
040991 -       20.  081203 0700  1  6   751.0   6   300    2   10 ... ref SDS C3 OE6K
040992 -
040993 -            081203 0735. NEUTS....... 0.624 ...... .......... ref SDS C2 RN5G
040994 -
040995 -                Rate of change per day = 1500 - 624 = 876 / 7
040996 -
040997 -                                       = 120+ per day
040999 -             ..
041000 -       21.  081204 0700  1  7   788.5   7   350    2   10 ... ref SDS C4 OE6K
041001 -             ..
041002 -       22.  081205 0700  1  8   826.0   8   400    3   15 ... ref SDS C5 OE6K
041003 -
041004 -            081205 1300  Neupogen...... 480 mcg  480......... ref SDS C6 KV84
041006 -             ..
041007 -       23.  081206 0700  1  9   863.5   9   450    4   20 ... ref SDS C9 OE6K
041008 -
041009 -            081206 0930  Neupogen...... 480 mcg  960......... ref SDS D0 BI4J
041011 -             ..
041012 -       24.  081207 0700  1 10   901.0  10   500    4   20 ... ref SDS D1 OE6K
041013 -       25.  081208 0700  1 11   938.5  11   550    4   20 ... ref SDS D2 OE6K
041014 -       26.  081209 0700  1 12   976.0  12   600    4   20 ... ref SDS D3 OE6K
041015 -             ..
041016 -       27.  081210 0700  1 13  1013.5  13   650    4   20 ... ref SDS D5 OE6K
041017 -
041018 -            081210 1301. NEUTS....... 1.085 ................. ref SDS D6 QY6H
041020 -             ..
041021 -       28.  081211 0700  1 14  1050.0  14   700    4   20 ... ref SDS D9 OE6K
041022 -             ..
041023 -       29.  081212 0700  1 15  1087.5  15   750    5   25 ... ref SDS E1 OE6K
041024 -
041025 -            081212 1115. NEUTS....... 1.054 ................. ref SDS E2 QY6H
041027 -             ..
041028 -       30.  081213 0700  1 16  1125.0  16   800    6   30 ... ref SDS E4 OE6K
041029 -       31.  081214 0700  1 17  1162.5  17   850    6   30 ... ref SDS E5 OE6K
041030 -       32.  081215 0700  1 18  1200.0  18   900    6   30 ... ref SDS E6 OE6K
041031 -       33.  081216 0700  1 19  1237.5  19   950    6   30 ... ref SDS E7 OE6K
041032 -             ..
041033 -       34.  081217 0700  1 20  1275.0  20  1000    6   30 ... ref SDS E8 OE6K
041034 -       35.  081218 0700  1 21  1312.5  21  1050    canceled.. ref SDS F0 OE6K
041035 -
041036 -            081218 0830. NEUTS....... 0.740 ................. ref SDS F1 QY6H
041038 -             ..
041039 -            081219 0700  2  1  paused until 081226........... ref SDS F3 OE6K
041041 -             ..
041042 -            081219 1130  Neupogen...... 480 mcg 1440 ........ ref SDS F4 UZ7K
041043 -            081220 0900  Neupogen...... 480 mcg 1920 ........ ref SDS F6 UZ7K
041045 -             ..
041046 -       36.  081226 0700  2  1  1350.0  22  1100.............. ref SDS G3 OE6K
041047 -       37.  081227 0700  2  2  1387.5  23  1150.............. ref SDS G5 OE6K
041048 -       38.  081228 0700  2  3  1425.0  24  1200.............. ref SDS G6 OE6K
041049 -       39.  081229 0700  2  4  1462.5  25  1250.............. ref SDS G7 OE6K
041050 -       40.  081230 0700  2  5  1500.0  26  1300.............. ref SDS G9 OE6K
041051 -       41.  081231 0700  2  6  1537.5  27  1350.............. ref SDS H1 OE6K
041052 -       42.  090101 0700  2  7  1575.0  28  1400.............. ref SDS H2 OE6K
041053 -       43.  090102 0700  2  8  1612.5  29  1450.............. ref SDS H3 OE6K
041054 -       44.  090103 0700  2  9  1650.0  30  1500.............. ref SDS H4 OE6K
041055 -       45.  090104 0700  2 10  1687.5  31  1550.............. ref SDS H5 OE6K
041056 -       46.  090105 0700  2 11  1725.0  32  1600.............. ref SDS H6 OE6K
041057 -       47.  090106 0700  2 12  1762.5  33  1650.............. ref SDS H7 OE6K
041058 -       48.  090107 0700  2 13  1800.0  34  1700.............. ref SDS I0 OE6K
041059 -             ..
041060 -       49.  090108 0700  2 14  1837.5  35  1750.............. ref SDS I1 OE6K
041061 -             ..
041062 -       50.  090109 0700  3  1  1875.0..paused................ ref SDS 0 OE6K
041064 -  ..
041065 - Background on blood tests is reported on 081218. ref SDS F0 S18L
041067 -  ..
041068 - On 081230 case study dilemma cancer treatmnets cause low blood counts,
041069 - which prevents getting treatment; not getting treatment incerases
041070 - cancer; UCSF paused treatment for a week and prescribed Neupogen to
041071 - increase blood counts. ref SDS G8 I87N
041072 -
041073 -
041074 -
041075 -
041076 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
050401 -  ..
050402 - Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
050403 -
050404 - Follow up ref SDS I1 LF8M, ref SDS I0 LF8M.
050405 -
050406 - Fatigue is a likely side effect of sunitinib with cyclophosphamide,
050407 - listed in the Consent document reviewed on 081017. ref SDS 76 4G7G
050409 -  ..
050410 - Blood counts NEUTS 0.87 reported for labs on 090108 at UCSF,
050411 - ref SDS I2 QY6H, show another significant decline from NEUTS 1.710
050412 - reported on 081226, ref SDS G4 B35J, from getting 15 daily cancer
050413 - treatments starting on 081226, shown by patient history above,
050414 - ref SDS 0 9I6T, has caused significant side effects of fatigue.
050415 - Hopefully, pausing cyclophosphamide prescribed by medical team at UCSF
050416 - yesterday on 090108, ref SDS I1 9V4I, will enable blood counts to
050417 - increase so that treatment with sunitinib can continue at full
050418 - strength, explained in Millie's letter to the medical team today on
050419 - 090109. ref SDS I4 UF3T  A blood test will be performed at Kaiser next
050420 - Friday on 090116; if NEUTS > 1.00 cyclophsphamide will be continued at
050421 - reduced dose of 5 days per week, instead 7. ref SDS I4 UF3W  This
050422 - aligns with letter from UCSF yesterday on 090108 summarizing
050423 - instructions from medical team. ref SDS I3 UX5S
050425 -  ..
050426 - Today, Millie less energetic could not work out in the gym for aerobic
050427 - exercise. ref SDS 0 X64F, Did not go hiking at Lafayette nor at the
050428 - Clayton Safeway trail, reported below, ref SDS 0 3E4K, because hiking
050429 - was difficult on Millie's legs, reported on 090102, ref SDS H3 6E7G,
050430 - due to rising side effects of fatigue from 15 cancer treatments
050431 - beginning on 081226, shown above, ref SDS 0 9I6T, that are now causing
050432 - blood counts to fall again, per above. ref SDS 0 6M7G
050434 -  ..
050435 - Background on Neupogen treatments and UCSF comments are reported on
050436 - 081207. ref SDS D1 673J
050438 -  ..
050439 - NEUTS blood tests show patient history of treatments with Nuepogen to
050440 - recover from neutropenia caused by getting chemotherapy everyday with
050441 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
050443 -  ..
050444 - Schedule for Neupogen treatments is listed on 081220. ref SDS F6 WJ4O
050446 -  ..
050447 - Feet and toes continue better today, less sensitive to walking that
050448 - was reported during the meeting at UCSF on 081218. ref SDS F2 HM4M
050449 - Subsiding side effects restoring normal use of feet enabled hiking,
050450 - but Millie is tired today, so we did not go hiking, per below.
050451 - ref SDS G6 X64F
050453 -  ..
050454 - Tearing eyes were reported today during the examination.  Tara
050455 - prescribed over-the-counter eye drops.
050457 -  ..
050458 - Joint pain, discomfort, and total ill feeling, commonly associated
050459 - with chemotherapy, reported on 081218, ref SDS F0 E38H, and discussed
050460 - with the medical team at UCSF also on 081218, ref SDS F2 QW7H, has now
050461 - mostly disipated, as a result of the doctor stopping all treatment for
050462 - 1 week, ref SDS F2 QW48, as shown in patient history above.
050463 - ref SDS G6 053F
050465 -  ..
050466 - Interstitional lung disease discussed in the record on 081218,
050467 - ref SDS F0 KM5F, shows no evident symptoms.
050469 -  ..
050470 - Vitals were reported today at the meeting at Kaiser with the primary
050471 - care physician...
050472 -
050473 -                   BP *** ** pulse **
050475 -  ..
050476 - Millie reports continued relief from heartburn with daily treatments
050477 - using Prilosce started on 081208. ref SDS D2 7J6K
050479 -  ..
050480 - Sore throat problem, reported initially on 081218, as having begun
050481 - days earlier, ref SDS F0 2B8M, seems better today today continuing
050482 - relief reported yesterday on 081222. ref SDS F8 TT4O  This increases
050483 - interest in eating food.  Millie had eggs and a baggel for a late
050484 - lunch after returning from the gym.  Swallowing seems much more normal
050485 - now.
050487 -  ..
050488 - Millie reports improved taste from some foods today (e.g., soup),
050489 - cited in study consent documents, reviewed on 081017. ref SDS 76 6T5H
050491 -     ..
050492 -                                   Date
050493 -    Description Adverse Event   Start  Stop     Medication
050494 -    ---------------------------------------------------------
050495 -    Follow up ref SDS I1 MV5H, ref SDS I0 MV5H.
050496 -
050497 -    Diarrhea                    081114 081114   Imodium........ ref SDS 94 LF8M
050498 -    Low pulse                   081120 081120   None........... ref SDS A3 LF8M
050499 -    Low pulse                   081121 081121   None........... ref SDS A4 7G8M
050500 -    BP 144 84 Pulse 48          081121 081121   Hiking......... ref SDS A4 LF8M
050501 -    Joint pain minor            081121 081121   Hiking......... ref SDS A4 LF8M
050502 -    Fatigue minor               081121 081121   Hiking......... ref SDS A4 LF8M
050503 -    Low pulse                   081122 081122   None........... ref SDS A5 7G8M
050504 -    Fatigue minor               081122 081122   Hiking......... ref SDS A5 LF8M
050505 -    Low pulse                   081123 081122   None........... ref SDS A6 7G8M
050506 -    BP 121 74 Pulse 53          081123 081123   Hiking......... ref SDS A6 LF8M
050507 -    Fatigue minor               081123 081122   Hiking......... ref SDS A6 LF8M
050508 -    Joint pain minor            081124 081124   Hiking......... ref SDS A7 LF8M
050509 -    Fatigue minor               081124 081124   Hiking......... ref SDS A7 LF8M
050510 -    Heartburn                   081124 081124   None........... ref SDS A7 HS9K
050511 -    BP 144 78 Pulse 52          081125 081125   Hiking......... ref SDS A8 LF8M
050512 -    Joint pain minor            081125 081125   Hiking......... ref SDS A8 LF8M
050513 -    Fatigue minor               081125 081125   Hiking......... ref SDS A8 LF8M
050514 -    Heartburn                   081125 081125   None........... ref SDS A8 HS9K
050515 -    Heartburn                   081126 081126   None........... ref SDS A9 HS9K
050516 -    Heartburn                   081127 081127   None........... ref SDS B3 HS9K
050517 -    BP 135 73 Pulse 48          081128 081128   Hiking......... ref SDS B4 5X6K
050518 -    Upset stomach               081128 081128   Hiking......... ref SDS B4 T76O
050519 -    BP 140 75 Pulse 50          081129 081129   Hiking......... ref SDS B7 5X6K
050520 -    Heartburn                   081129 081129   None........... ref SDS B7 HS9K
050521 -     ..
050522 -    Fatigue                     081129 081129   Rest........... ref SDS B7 LF8M
050523 -    Fatigue                     081130 081130   Rest........... ref SDS B8 LF8M
050524 -    BP 136 79 Pulse 46          081201 081201   Hiking......... ref SDS B9 5X6K
050525 -    Fatigue                     081201 081201   Rest........... ref SDS B9 LF8M
050526 -    Taste altered               081201 081201   Rest........... ref SDS B9 VP4G
050527 -    BP 141 77 Pulse 46          081202 081202   Aerobics gym... ref SDS C1 5X6K
050528 -    Fatigue                     081202 081202   Rest........... ref SDS C1 LF8M
050529 -    Taste altered               081202 081202   Rest........... ref SDS C1 VP4G
050530 -    BP 138 77 Pulse 48          081203 081203   Hiking......... ref SDS C3 5X6K
050531 -    Fatigue                     081203 081203   Rest........... ref SDS C3 LF8M
050532 -    Taste altered               081203 081203   Rest........... ref SDS C3 VP4G
050533 -    NEUTS (ANC)     0.624       081203 081203   Neupogen.......
050534 -    BP 133 72 Pulse 45          081204 081204   Rest........... ref SDS C4 5X6K
050535 -    Fatigue                     081204 081204   Rest........... ref SDS C4 LF8M
050536 -    Taste altered               081204 081204   Rest........... ref SDS C4 VP4G
050537 -    BP 138 76 Pulse 49          081205 081205   Rest........... ref SDS C5 5X6K
050538 -    Diarrhea                    081205 081114   Imodium........ ref SDS C5 Q67F
050539 -    Fatigue                     081205 081205   Rest........... ref SDS C5 LF8M
050540 -    Taste altered               081205 081205   Rest........... ref SDS C5 VP4G
050541 -    BP *** ** Pulse **          081206 081206   Rest........... ref SDS C9 5X6K
050542 -    Fatigue                     081206 081206   Rest........... ref SDS C9 LF8M
050543 -    BP 128 70 Pulse 53          081207 081207   Hiking......... ref SDS D1 5X6K
050544 -    Fatigue                     081207 081207   Rest........... ref SDS D1 LF8M
050545 -    BP 137 68 Pulse 53          081208 081208   Rest........... ref SDS D2 5X6K
050546 -    Fatigue                     081208 081208   Rest........... ref SDS D2 LF8M
050547 -    BP *** ** Pulse **          081209 081209   Rest........... ref SDS D2 5X6K
050548 -    Fatigue                     081209 081209   Rest........... ref SDS D2 LF8M
050549 -    Heartburn                   081209 081209   Prilosec....... ref SDS D3 7J6K
050550 -    BP 136 70 Pulse 53          081210 081210   Rest........... ref SDS D5 5X6K
050551 -    Fatigue                     081210 081210   Rest........... ref SDS D5 LF8M
050552 -    Heartburn                   081210 081210   Prilosec....... ref SDS D5 7J6K
050553 -    BP *** ** Pulse **          081211 081211   Rest........... ref SDS D9 5X6K
050554 -    Fatigue                     081211 081211   Exercise gym... ref SDS D9 LF8M
050555 -    Heartburn                   081211 081211   Prilosec....... ref SDS D9 7J6K
050556 -    BP 137 76 Pulse 53          081212 081212   Rest........... ref SDS E1 5X6K
050557 -    Fatigue                     081212 081212   Exercise gym... ref SDS E1 LF8M
050558 -    Heartburn                   081212 081212   Prilosec....... ref SDS E1 7J6K
050559 -    BP 147 80 Pulse 51          081213 081213   Rest........... ref SDS E4 5X6K
050560 -    Fatigue                     081213 081213   Exercise gym... ref SDS E4 LF8M
050561 -    BP *** ** Pulse **          081214 081214   Rest........... ref SDS E5 5X6K
050562 -    Fatigue                     081214 081214   Rest........... ref SDS E5 LF8M
050563 -    BP *** ** Pulse **          081215 081215   Rest........... ref SDS E6 5X6K
050564 -    Fatigue                     081215 081215   Rest........... ref SDS E6 LF8M
050565 -    BP 144 79 Pulse 54          081216 081216   Rest........... ref SDS E7 5X6K
050566 -    Fatigue                     081216 081216   Exercise gym... ref SDS E7 LF8M
050567 -     ..
050568 -    Joint pain minor            081216 081216   Rest........... ref SDS E7 E38H
050569 -    BP 137 69 Pulse 63          081217 081217   Rest........... ref SDS E8 5X6K
050570 -    Fatigue                     081217 081217   Rest........... ref SDS E8 LF8M
050571 -    Joint pain minor            081217 081217   Rest........... ref SDS E8 E38H
050572 -    Nosebleed minor             081217 081217   Rest........... ref SDS E8 ZF5F
050573 -     ..
050574 -    BP *** ** Pulse **          081218 081218   Rest........... ref SDS F0 5X6K
050575 -    Fatigue                     081218 081218   Rest........... ref SDS F0 LF8M
050576 -    Joint pain minor            081218 081218   Rest........... ref SDS F0 E38H
050577 -    Nosebleed moderate          081218 081218   Rest........... ref SDS F0 ZF5F
050578 -    Throat pain eating          081218 081218   Eating less.... ref SDS F0 2B8M
050579 -    BP 155 84 Pulse 53          081219 081219   Rest........... ref SDS F3 5X6K
050580 -    Fatigue                     081121 081219   Rest........... ref SDS F3 LF8M
050581 -    Feet toes lesions           081219 081219   Rest........... ref SDS F3 UO8I
050582 -    Joint pain ill feeling      081121 081219   Rest........... ref SDS F3 E38H
050583 -    Throat sore eating          081218 081219   Eating less.... ref SDS F3 TT4O
050584 -    BP 123 69 pulse 53          081220 081220   Rest........... ref SDS F5 5X6K
050585 -    Fatigue                     081121 081220   Rest........... ref SDS F5 LF8M
050586 -    Feet toes lesions           081219 081220   Rest........... ref SDS F5 UO8I
050587 -    Joint pain ill feeling      081121 081220   Rest........... ref SDS F5 E38H
050588 -    Throat sore eating          081218 081220   Eating less.... ref SDS F5 TT4O
050589 -    BP 117 71 pulse 65          081221 081221   Rest........... ref SDS F7 5X6K
050590 -    Fatigue                     081121 081221   Rest........... ref SDS F7 LF8M
050591 -    Feet toes lesions           081219 081221   Rest........... ref SDS F7 UO8I
050592 -    Joint pain ill feeling      081121 081221   Rest........... ref SDS F7 E38H
050593 -    Throat sore eating          081218 081221   Eating less.... ref SDS F7 TT4O
050594 -    BP 117 71 pulse 65          081222 081222   Rest........... ref SDS F8 5X6K
050595 -    Fatigue                     081121 081222   Rest........... ref SDS F8 LF8M
050596 -    Feet toes lesions           081219 081222   Rest........... ref SDS F8 UO8I
050597 -    Joint pain ill feeling      081121 081222   Rest........... ref SDS F8 E38H
050598 -    Throat sore eating          081218 081222   Eating less.... ref SDS F8 TT4O
050599 -    BP 143 68 pulse 65          081223 081223   Rest........... ref SDS F8 5X6K
050600 -    Fatigue more energy         081121 081223   Exercise gym... ref SDS F9 LF8M
050601 -    Feet feel better            081219 081223   Exercise gym... ref SDS F9 UO8I
050602 -    Joint pain subsides         081121 081223   Exercise gym... ref SDS F9 E38H
050603 -    Throat sore improved        081218 081223   Eating normal.. ref SDS F9 TT4O
050604 -    BP *** ** pulse **          081224 081224   Rest........... ref SDS G1 5X6K
050605 -    Fatigue more energy         081121 081224   Exercise gym... ref SDS G1 LF8M
050606 -    Feet feel better            081219 081224   Exercise gym... ref SDS G1 UO8I
050607 -    Joint pain subsides         081121 081224   Exercise gym... ref SDS G1 E38H
050608 -    Throat sore improved        081218 081224   Eating normal.. ref SDS G1 TT4O
050609 -    BP 124 80 pulse 66          081225 081225   Rest........... ref SDS G2 5X6K
050610 -    Fatigue more energy         081121 081225   Activity....... ref SDS G2 LF8M
050611 -    Fatigue more energy         081121 081226   Activity....... ref SDS G3 LF8M
050612 -    BP *** ** pulse **          081227 081227   Rest........... ref SDS G5 5X6K
050613 -    Fatigue more energy         081121 081227   Hiking......... ref SDS G5 LF8M
050614 -    BP *** ** pulse **          081228 081228   Rest........... ref SDS G6 5X6K
050615 -    Fatigue more energy         081121 081228   Rest........... ref SDS G6 LF8M
050616 -    BP *** ** pulse **          081229 081229   Rest........... ref SDS G7 5X6K
050617 -    Fatigue more energy         081121 081229   Rest........... ref SDS G7 LF8M
050618 -    BP *** ** pulse **          081230 081230   Rest........... ref SDS G9 5X6K
050619 -    Diarrhea                    081230 081230   Imodium........ ref SDS G9 KZ9N
050620 -    Fatigue more energy         081121 081230   Rest........... ref SDS G9 LF8M
050621 -    BP *** ** pulse **          081231 081231   Rest........... ref SDS H1 5X6K
050622 -    Fatigue more energy         081121 081231   Rest........... ref SDS H1 LF8M
050623 -    BP *** ** pulse **          090101 090101   Rest........... ref SDS H2 5X6K
050624 -    Fatigue more energy         081121 090101   Hiking......... ref SDS H2 LF8M
050625 -    BP *** ** pulse **          090102 090102   Rest........... ref SDS H3 5X6K
050626 -    Fatigue more energy         081121 090102   Hiking......... ref SDS H3 LF8M
050627 -    BP *** ** pulse **          090103 090103   Rest........... ref SDS H4 5X6K
050628 -    Fatigue less energy         081121 090103   Exercise gym... ref SDS H4 LF8M
050629 -    BP *** ** pulse **          090104 090104   Rest........... ref SDS H5 5X6K
050630 -    Fatigue less energy         081121 090104   Rest........... ref SDS H5 LF8M
050631 -    BP *** ** pulse **          090105 090105   Rest........... ref SDS H6 5X6K
050632 -    Fatigue less energy         081121 090105   Rest........... ref SDS H6 LF8M
050633 -    BP *** ** pulse **          090106 090106   Rest........... ref SDS H7 5X6K
050634 -    Fatigue less energy         081121 090106   Exercise gym... ref SDS H7 LF8M
050635 -    BP *** ** pulse **          090107 090107   Rest........... ref SDS H7 5X6K
050636 -    Fatigue less energy         081121 090107   Rest........... ref SDS I0 LF8M
050637 -    BP *** ** pulse **          090108 090108   Rest........... ref SDS I1 5X6K
050638 -    Fatigue less energy         081121 090108   Rest........... ref SDS I1 LF8M
050639 -    Eyes tearing                090108 090108   Eye drops...... ref SDS I1 518H
050640 -    BP *** ** pulse **          090109 090109   Rest........... ref SDS 0 5X6K
050641 -    Fatigue less energy         081121 090109   Rest........... ref SDS 0 LF8M
050642 -    Eyes tearing                090108 090109   Eye drops...... ref SDS 0 518H
050643 -
050644 -
050645 -
0507 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS I1 3E4K, ref SDS I0 3E4K.
060405 -
060406 - Today, Millie less energetic could not work out in the gym for aerobic
060407 - exercise. ref SDS 0 X64F, Did not go hiking at Lafayette nor at the
060408 - flatter Clayton Safeway trail, because hiking was difficult on
060409 - Millie's legs, reported on 090102, ref SDS H3 6E7G, due to rising side
060410 - effects of fatigue from 15 cancer treatments beginning on 081226,
060411 - ref SDS 0 9I6T, that are now causing blood counts to fall again,
060412 - reported above. ref SDS 0 LF8M
060414 -  ..
060415 - NEUTS blood tests show patient history treatments with Nuepogen for
060416 - neutropenia from chemotherapy everyday with cyclophosphamide reported
060417 - in case study on 081205. ref SDS C5 EC5N
060419 -  ..
060420 - On 081110, Millie complained about difficulty lifting herself from a
060421 - full squatting position. ref SDS 90 HX67  For several weeks, she was
060422 - exercising to strengthen legs, and arms, shown by going to the gym on
060423 - 081211. ref SDS D9 3E4K  Rising fatigue now prevents continuing
060424 - exercise.
060425 -
060427 -  ..
060428 - Case Study on Pateint History Exercising
060429 -
060430 - Follow up ref SDS I1 X64F, ref SDS I0 X64F.
060431 -
060432 -                                              +- scm = Sunitinib Cyclophosphmaide Methotrexate
060433 -                                              +- sc  = Sunitinib Cyclophosphmaide
060434 -                           Time     Pulse     |
060435 -    Location        Miles Minutes  Avg Max  Chem  Neupo  Date
060436 -    ----------------------------------------------------------------
060437 -    Concord home                              s         090109, ref SDS 0 3E4K
060438 -    Concord home                              sc        090108, ref SDS I1 3E4K
060439 -    Concord home                              sc        090107, ref SDS I0 3E4K
060440 -    Concord home (gym)                        sc        090106, ref SDS H7 3E4K
060441 -    Concord home                              sc        090105, ref SDS H6 3E4K
060442 -    Concord home                              sc        090104, ref SDS H5 3E4K
060443 -    Concord home (gym)                        sc        090103, ref SDS H4 3E4K
060444 -    Clayton Safeway  3.00   58.7    83  94    sc        090102, ref SDS H3 3E4K
060445 -    Lafayette        2.75   58.4    87 103    sc        090101, ref SDS H2 3E4K
060446 -    Concord home                              sc        081231, ref SDS H1 3E4K
060447 -    Concord home                              sc        081230, ref SDS G9 3E4K
060448 -    Concord home                              sc        081229, ref SDS G7 3E4K
060449 -    Concord home                              sc        081228, ref SDS G6 3E4K
060450 -    Lafayette        2.75   56.2    90 112    sc        081227, ref SDS G4 3E4K
060451 -    Concord home                              sc        081226, ref SDS G3 3E4K
060452 -    Concord travel                                      081225, ref SDS G2 3E4K
060453 -    Concord home                                        081224, ref SDS G1 3E4K
060454 -    Concord home (gym)                                  081223, ref SDS F9 3E4K
060455 -    Concord home                                        081222, ref SDS F8 3E4K
060456 -    Concord home                                        081221, ref SDS F7 3E4K
060457 -    Concord home                                        081220, ref SDS F5 3E4K
060458 -    Concord home                                        081219, ref SDS F3 3E4K
060459 -    Concord home                              sc        081218, ref SDS F0 3E4K
060460 -    Concord home                              sc        081217, ref SDS E8 3E4K
060461 -    Concord home (gym)                        sc        081216, ref SDS E7 3E4K
060462 -    Concord home                              sc        081215, ref SDS E6 3E4K
060463 -    Concord home                              sc        081214, ref SDS E5 3E4K
060464 -    Concord home (gym)                        scm       081213, ref SDS E4 3E4K
060465 -    Concord home                              scm       081212, ref SDS E1 3E4K
060466 -    Concord home (gym)                        sc        081211, ref SDS D9 3E4K
060467 -    Concord home                              sc        081210, ref SDS D5 3E4K
060468 -    Concord home                              sc        081209, ref SDS D3 3E4K
060469 -    Concord home                              sc        081208, ref SDS D2 3E4K
060470 -    Lafayette        4.75   78.6    95 110    sc        081207, ref SDS D1 3E4K
060471 -    Concord home                              scm       081206, ref SDS C9 3E4K
060472 -    Concord home                              scm       081205, ref SDS C5 3E4K
060473 -    Concord home                              sc        081204, ref SDS C4 3E4K
060474 -    Lafayette        2.75   62.7    90 117    sc        081203, ref SDS C3 3E4K
060475 -    Concord home (gym)                        sc        081202, ref SDS C1 3E4K
060476 -    Lafayette        5.50  102.3    95 122    sc        081201, ref SDS B9 3E4K
060477 -    Concord home                              sc        081130, ref SDS B8 3E4K
060478 -    Lafayette        2.75   56.7    90 115    scm       081129, ref SDS B7 3E4K
060479 -    Lafayette        2.75   46.5   100 128    scm       081128, ref SDS B4 3E4K
060480 -    Lafayette        5.50   93.3   100 122    s         081127, ref SDS B3 3E4K
060481 -    Concord home                              s         081126, ref SDS A9 3E4K
060482 -    Lafayette        4.00   73.7   105 127    s         081125, ref SDS A8 3E4K
060483 -    Lafayette        5.50   91.4   100 129    s         081124, ref SDS A7 3E4K
060484 -    Concord home                              s         081123, ref SDS A6 3E4K
060485 -    Lafayette        5.50   92.8    95 122    s         081122, ref SDS A5 3E4K
060486 -    Lafayette        5.50   94.4    85 112    s         081121, ref SDS A4 3E4K
060487 -    Lafayette        5.50   94.7    90 122    s         081120, ref SDS A3 3E4K
060488 -    San Francisco    1.00   60.0    65  75    s         081119, ref SDS A2 3E4K
060489 -    Lafayette        2.75   49.2    97 130    s         081118, ref SDS A1 3E4K
060490 -    Lafayette        5.50   93.6   115 138    s         081117, ref SDS 98 3E4K
060491 -    Concord home                              s         081116, ref SDS 96 Y68J
060492 -    Concord home                              s         081115, ref SDS 95 EK7I
060493 -    Concord home                              s         081114, ref SDS 94 XW6H
060494 -    Lafayette        5.50   94.2   115 138              081110, ref SDS 90 3E4K
060495 -    Lafayette        2.75   48.4   105 128              081109, ref SDS 89 3E4K
060496 -    Kaiser                                         x    081108, ref SDS 88 UZ7K
060497 -    Kaiser                                         x    081107, ref SDS 87 UZ7K
060498 -    Lafayette        5.50   90.2   120 143              081025, ref SDS 83 3E4K
060499 -    Kaiser                                         x    081025, ref SDS 83 UZ7K
060500 -    Kaiser                                         x    081024, ref SDS 82 UZ7K
060501 -    UCSF                                      c         081023, ref SDS 81 V94O
060502 -    Lafayette        5.50   90.6   115 141              081021, ref SDS 80 3E4K
060503 -    Lafayette        5.50   90.4   110 128              081020, ref SDS 79 3E4K
060504 -    Kaiser                                         x    081018, ref SDS 78 UZ7K
060505 -    Kaiser                                         x    081017, ref SDS 77 UZ7K
060506 -    UCSF                                      e         081016, ref SDS 75 V94O
060507 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 74 3E4K
060508 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 73 3E4K
060509 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 72 3E4K
060510 -    Kaiser                                         x    081011, ref SDS 71 UZ7K
060511 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 70 3E4K
060512 -    Kaiser                                         x    081010, ref SDS 70 UZ7K
060513 -    UCSF                                      e         081009, ref SDS 69 V94O
060514 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 68 3E4K
060515 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 67 3E4K
060516 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 66 3E4K
060517 -    UCSF                                      c         081002, ref SDS 65 V94O
060518 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 64 3E4K
060519 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 64 3E4K
060520 -    Kaiser                                         x    080927, ref SDS 63 UZ7K
060521 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 62 3E4K
060522 -    UCSF                                      c         080925, ref SDS 61 V94O
060523 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 60 3E4K
060524 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 60 3E4K
060525 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 60 3E4K
060526 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 59 3E4K
060527 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 58 3E4K
060528 -    UCSF                                      c         080918, ref SDS 57 V94O
060529 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 58 3E4K
060530 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 56 3E4K
060531 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 55 3E4K
060532 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 54 3E4K
060533 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 53 3E4K
060534 -    UCSF                                      c         080911, ref SDS 52 V94O
060535 -    Lafayette        2.75   46.8   113 140              080909
060536 -    Lafayette        5.50   89.2   117 143              080908
060537 -    Lafayette        5.50   92.1   115 138              080907
060538 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 51 3E4K
060539 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 50 3E4K
060540 -    UCSF                                      c         080904, ref SDS 49 V94O
060541 -    Lafayette        8.25  140.4   116 131              080903
060542 -    Lafayette        5.50   94.9   115 134              080902
060543 -    Kaiser                                         x    080830
060544 -    Kaiser                                         x    080829
060545 -    UCSF                                      c         080828, ref SDS 48 V94O
060546 -    Lafayette        5.50   93.6   120 137              080826
060547 -    Lafayette        5.50   93.2   117 138              080825
060548 -    Lafayette        5.50   93.2   123 136         x    080823
060549 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 47 3E4K
060550 -    UCSF                                      e         080821, ref SDS 46 V94O
060551 -    Lafayette        5.50   94.7   115 137              080820
060552 -    Lafayette        5.50   94.3   115 135              080819
060553 -    Lafayette        8.25  141.7   118 134              080815
060554 -    UCSF                                      e         080814, ref SDS 45 V94O
060555 -    Lafayette        5.50   93.8   120 136              080813
060556 -    Lafayette        5.50   94.4   116 139              080812
060557 -    Lafayette        5.50   94.2   119 133              080810
060558 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 43 3E4K
060559 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 42 3E4K
060560 -    UCSF                                      c         080807, ref SDS 41 V94O
060561 -    Lafayette        8.25  143.7   115 132              080805
060562 -    Concord          7.00  127.6   105 118              080804
060563 -    Lafayette        8.25  143.2   112 134              080802
060564 -    Lafayette        5.50   93.4   115 138              080801
060565 -    Lafayette        5.50   92.2   118 140              080729
060566 -    Lafayette        5.50   92.6   116 137              080728
060567 -    Lafayette        8.25  142.6   114 134              080727
060568 -    Lafayette        5.50   91.5   120 143              080726
060569 -    Lafayette        8.25  140.8   117 135              080725
060570 -    Lafayette        5.50   91.8   122 141              080723
060571 -    Lafayette        5.50   91.3   120 139              080722
060572 -    Lafayette        8.25  143.3   115 133              080720
060573 -    Lafayette        5.50   90.7   125 144              080719
060574 -    Lafayette        5.50   92.4   123 142              080716
060575 -    Lafayette        2.25   46.8   116 137              080715
060576 -    Lafayette        8.25  141.8   116 136              080712
060577 -    Lafayette        5.50   92.9   116 139              080711
060578 -    Lafayette        8.25  143.3   113 137              080704
060579 -    Lafayette        5.50   90.2   121 147              080630
060580 -    Lafayette        8.25  142.4   116 138              080628
060581 -    Lafayette        5.50   91.4   118 138              080625
060582 -    Lafayette        2.25   47.9   116 136              080623
060583 -    Lafayette        5.50   94.2   112 138              080622
060584 -    Lafayette        5.50   94.7   115 133              080621
060585 -    Lafayette        2.25   48.3   110 129              080620
060586 -    Mt Diablo        7.00  129.4   130 153              080616
060587 -    Lafayette        5.50   90.8   120 146              080615
060588 -    Lafayette        5.50   91.3   124 144              080614
060589 -    Lafayette        5.50   89.7   122 143              080613
060590 -    Lafayette        2.76   45.8   120 147              080611
060591 -    Lafayette        5.50   90.5   123 145              080609
060592 -    Lafayette        5.50   92.7   115 138              080607
060593 -    Lafayette        5.50   94.2   118 139              080602
060594 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 19 WO8M
060595 -
060596 -
060597 -
060598 -
060599 -
060600 -
0607 -