THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: January 10, 2009 07:00 AM Saturday; Rod Welch

Millie sunitinib #51 treatment IBC 5th relapse.

1...Summary/Objective
2...Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
3...Sunitinib Cyclophosmaide Methotrexate Patient History
4...Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
5...Exercise Hiking Maintain Fitness Strengthen Immune System
6...Case Study on Pateint History Exercising


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS I6 0000. ref SDS I1 0000.
040502 -
040503 -
040504 -
040505 -
040507 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Sunitinib Metronomic Treatment Loading Dose Clinical Study UCSF
040902 -
040903 - Follow up ref SDS I6 505G, ref SDS I1 505G.
040904 -
040905 - Background pausing treatment on 081219 for a week enabled Millie's
040906 - blood counts to recover, and resumed on 081226 with sunitinib and
040907 - cyclophosphamide. ref SDS G3 505G  On 081230 case study dilemma cancer
040908 - treatmnets cause low blood counts, which prevents getting treatment;
040909 - not getting treatment incerases cancer; UCSF paused treatment for a
040910 - week and prescribed Neupogen to increase blood counts. ref SDS G8 I87N
040911 - On 090108 treatment with sunitinib was continued at full strength, and
040912 - cyclophosphamide was discontinued until blood counts rise above NEUTS
040913 - 1.00, and then cyclophosphamide will reduced from 7 to 5 days a week.
040914 - ref SDS I1 9V4I
040916 -  ..
040917 - Today, IBC rash seems to be improving; rate of improvement for IBC
040918 - nodules in breastbone seems slower following examination at UCSF on
040919 - 090108 that found IBC worse, reported in Millie's letter to the
040920 - medical team on 090109, ref SDS I5 UE6R, than observed during
040921 - examination on 081218 after Millie experienced substantial improvement
040922 - recovering from IBC. ref SDS F2 VD4F  This aligns with worsening IBC
040923 - reported on 081224 and 081225, and then recovery on 081226 presented
040924 - in Millie's letter to the medical team on 081230. ref SDS G8 4W7Y
040925 - Earlier on 081202 the rate of improvement recovering from IBC seemed
040926 - to slower, ref SDS C0 AT4Q, like today.  Additionally, on 090103 IBC
040927 - seemed to get worse again for several days, but on 090106 was
040928 - beginning to respond to treatment, presented in Millie's letter on
040929 - 090106. ref SDS H9 YO4V  This record of uneven response to treatment
040930 - may reflect in part difficulty maintaining consistent levels of
040931 - sunitinib treatment, due to low blood counts caused in part by
040932 - chemotherapy cyclophosphamide and Methotrexate.  On 081218
040933 - Methotrexate was ended, and cyclophosphamide was paused along with
040934 - sunitinib. ref SDS F2 QW48  On 090108 cyclophosphamide was again
040935 - paused, and sunitinib was continued at full dose, shown in Millie's
040936 - letter on 090109 to the medical team. ref SDS I5 UF3T
040938 -  ..
040939 - Today, Millie tried hiking Lafayette reservoir.  Chronic fatigue from
040940 - past cancer treatments, reported on 090103, ref SDS I6 OT3L, made
040941 - hiking very difficult today, reported below, ref SDS 0 3E4K, caused by
040942 - side effects of low blood counts, ref SDS 0 LF8M, from 16 cancer
040943 - treatments beginning on 081226, reported below. ref SDS 0 9I6T
040945 -  ..
040946 - NEUTS patient history of neutropenia from chemotherapy everyday with
040947 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
040949 -  ..
040950 - Neupogen treatments prescribed on 090108 by the medical team at UCSF
040951 - for 090109 and 090110, help maintain blood counts to strengthen
040952 - Millie's immunity system, shown in Millie's letter to the medical team
040953 - on 090109. ref SDS I5 UF3Q  Today, Millie had the 2nd treatment at
040954 - Kaiser. ref SDS I7 P73J
040955 -
040957 -  ..
040958 - Sunitinib Cyclophosmaide Methotrexate Patient History
040959 -
040960 - Follow up ref SDS I6 OE6K, ref SDS I1 OE6K.
040961 -
040963 -        Cycle 1  begin 081128 after 14 treatmenst sunitinib alone
040964 -        Cohort: 3
040966 -        ..
040967 -                                          Cyclophos  Metho
040968 -                               Sunitinib   phamide   trexate
040969 -       Days  Date  Time  Cycle    37.5       50        5
040970 -       =======================================================
040971 -       Follow up ref SDS I6 PA8Y, ref SDS I1 PA8Y.
040972 -
040973 -        1.  081114 0700  Load    37.5         0         0 ... ref SDS 94 OE6K
040974 -        2.  081115 0700  Load    75.0         0         0 ... ref SDS 95 OE6K
040975 -        3.  081116 0700  Load   112.5         0         0 ... ref SDS 96 OE6K
040976 -        4.  081117 0700  Load   150.0         0         0 ... ref SDS 97 OE6K
040977 -        5.  081118 0700  Load   187.5         0         0 ... ref SDS A0 OE6K
040978 -        6.  081119 0700  Load   225.0         0         0 ... ref SDS A2 OE6K
040979 -        7.  081120 0700  Load   263.5         0         0 ... ref SDS A3 OE6K
040980 -        8.  081121 0700  Load   301.0         0         0 ... ref SDS A4 OE6K
040981 -        9.  081122 0700  Load   338.5         0         0 ... ref SDS A5 OE6K
040982 -       10.  081123 0700  Load   376.0         0         0 ... ref SDS A6 OE6K
040983 -       11.  081124 0700  Load   413.5         0         0 ... ref SDS A7 OE6K
040984 -       12.  081125 0700  Load   451.0         0         0 ... ref SDS A8 OE6K
040985 -             ..
040986 -       13.  081126 0700  Load   488.5         0         0 ... ref SDS A9 OE6K
040987 -             ..
040988 -            081126 0820  NEUTS........1.50................... ref SDS B0 PU6K
040990 -             ..
040991 -       14.  081127 0700  Load   526.0         0         0 ... ref SDS B1 OE6K
040992 -       15.  081128 0700  1  1   563.5   1    50    1    5 ... ref SDS B4 OE6K
040993 -       16.  081129 0700  1  2   601.0   2   100    2   10 ... ref SDS B7 OE6K
040994 -       17.  081130 0700  1  3   638.5   3   150    2   10 ... ref SDS B8 OE6K
040995 -       18.  081201 0700  1  4   676.0   4   200    2   10 ... ref SDS B9 OE6K
040996 -       19.  081202 0700  1  5   713.5   5   250    2   10 ... ref SDS C1 OE6K
040997 -             ..
040998 -       20.  081203 0700  1  6   751.0   6   300    2   10 ... ref SDS C3 OE6K
040999 -
041000 -            081203 0735. NEUTS....... 0.624 ...... .......... ref SDS C2 RN5G
041001 -
041002 -                Rate of change per day = 1500 - 624 = 876 / 7
041003 -
041004 -                                       = 120+ per day
041006 -             ..
041007 -       21.  081204 0700  1  7   788.5   7   350    2   10 ... ref SDS C4 OE6K
041008 -             ..
041009 -       22.  081205 0700  1  8   826.0   8   400    3   15 ... ref SDS C5 OE6K
041010 -
041011 -            081205 1300  Neupogen...... 480 mcg  480......... ref SDS C6 KV84
041013 -             ..
041014 -       23.  081206 0700  1  9   863.5   9   450    4   20 ... ref SDS C9 OE6K
041015 -
041016 -            081206 0930  Neupogen...... 480 mcg  960......... ref SDS D0 BI4J
041018 -             ..
041019 -       24.  081207 0700  1 10   901.0  10   500    4   20 ... ref SDS D1 OE6K
041020 -       25.  081208 0700  1 11   938.5  11   550    4   20 ... ref SDS D2 OE6K
041021 -       26.  081209 0700  1 12   976.0  12   600    4   20 ... ref SDS D3 OE6K
041022 -             ..
041023 -       27.  081210 0700  1 13  1013.5  13   650    4   20 ... ref SDS D5 OE6K
041024 -
041025 -            081210 1301. NEUTS....... 1.085 ................. ref SDS D6 QY6H
041027 -             ..
041028 -       28.  081211 0700  1 14  1050.0  14   700    4   20 ... ref SDS D9 OE6K
041029 -             ..
041030 -       29.  081212 0700  1 15  1087.5  15   750    5   25 ... ref SDS E1 OE6K
041031 -
041032 -            081212 1115. NEUTS....... 1.054 ................. ref SDS E2 QY6H
041034 -             ..
041035 -       30.  081213 0700  1 16  1125.0  16   800    6   30 ... ref SDS E4 OE6K
041036 -       31.  081214 0700  1 17  1162.5  17   850    6   30 ... ref SDS E5 OE6K
041037 -       32.  081215 0700  1 18  1200.0  18   900    6   30 ... ref SDS E6 OE6K
041038 -       33.  081216 0700  1 19  1237.5  19   950    6   30 ... ref SDS E7 OE6K
041039 -             ..
041040 -       34.  081217 0700  1 20  1275.0  20  1000    6   30 ... ref SDS E8 OE6K
041041 -       35.  081218 0700  1 21  1312.5  21  1050    canceled.. ref SDS F0 OE6K
041042 -
041043 -            081218 0830. NEUTS....... 0.740 ................. ref SDS F1 QY6H
041045 -             ..
041046 -            081219 0700  2  1  paused until 081226........... ref SDS F3 OE6K
041048 -             ..
041049 -            081219 1130  Neupogen...... 480 mcg 1440 ........ ref SDS F4 UZ7K
041050 -            081220 0900  Neupogen...... 480 mcg 1920 ........ ref SDS F6 UZ7K
041052 -             ..
041053 -       36.  081226 0700  2  1  1350.0  22  1100.............. ref SDS G3 OE6K
041054 -       37.  081227 0700  2  2  1387.5  23  1150.............. ref SDS G5 OE6K
041055 -       38.  081228 0700  2  3  1425.0  24  1200.............. ref SDS G6 OE6K
041056 -       39.  081229 0700  2  4  1462.5  25  1250.............. ref SDS G7 OE6K
041057 -       40.  081230 0700  2  5  1500.0  26  1300.............. ref SDS G9 OE6K
041058 -       41.  081231 0700  2  6  1537.5  27  1350.............. ref SDS H1 OE6K
041059 -       42.  090101 0700  2  7  1575.0  28  1400.............. ref SDS H2 OE6K
041060 -       43.  090102 0700  2  8  1612.5  29  1450.............. ref SDS H3 OE6K
041061 -       44.  090103 0700  2  9  1650.0  30  1500.............. ref SDS H4 OE6K
041062 -       45.  090104 0700  2 10  1687.5  31  1550.............. ref SDS H5 OE6K
041063 -       46.  090105 0700  2 11  1725.0  32  1600.............. ref SDS H6 OE6K
041064 -       47.  090106 0700  2 12  1762.5  33  1650.............. ref SDS H7 OE6K
041065 -       48.  090107 0700  2 13  1800.0  34  1700.............. ref SDS I0 OE6K
041066 -             ..
041067 -       49.  090108 0700  2 14  1837.5  35  1750.............. ref SDS I1 OE6K
041068 -             ..
041069 -       50.  090109 0700  3  1  1875.0..paused................ ref SDS I6 OE6K
041070 -             ..
041071 -       51.  090110 0700  3  2  1910.5..paused................ ref SDS 0 OE6K
041072 -
041073 -
041074 -
041075 -
041076 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
050401 -  ..
050402 - Side Effects Sunitinib Study with Cyclophosphamide Methotrexate
050403 -
050404 - Follow up ref SDS I6 LF8M, ref SDS I1 LF8M.
050405 -
050406 - Fatigue is a likely side effect of sunitinib with cyclophosphamide,
050407 - listed in the Consent document reviewed on 081017. ref SDS 76 4G7G
050409 -  ..
050410 - Blood counts NEUTS 0.87 reported for labs on 090108 at UCSF,
050411 - ref SDS I2 QY6H, show another significant decline from NEUTS 1.710
050412 - reported on 081226, ref SDS G4 B35J, from getting 16 daily cancer
050413 - treatments starting on 081226, shown by patient history above,
050414 - ref SDS 0 9I6T, has caused significant side effects of fatigue.
050415 - Hopefully, Neupogen treatments yesterday and today, ref SDS 0 RG7J,
050416 - and pausing cyclophosphamide prescribed by medical team at UCSF on
050417 - 090108, ref SDS I1 9V4I, will enable blood counts to increase so that
050418 - treatment with sunitinib can continue at full strength, explained in
050419 - Millie's letter to the medical team yesterday on 090109. ref SDS I5
050420 - UF3T  A blood test will be performed at Kaiser next Friday on 090116;
050421 - if NEUTS > 1.00 cyclophsphamide will be continued at reduced dose of 5
050422 - days per week, instead 7. ref SDS I5 UF3W  This aligns with letter
050423 - from UCSF on 090108 summarizing instructions from medical team.
050424 - ref SDS I4 UX5S
050426 -  ..
050427 - Millie tried hiking at Lafayette Reservoir today and did 1 lap about 3
050428 - miles, ref SDS 0 X64F  This hike was difficult because Millie's legs,
050429 - are very tired, reported below, ref SDS 0 3E4K, cited previously on
050430 - 090102, ref SDS H3 6E7G, due to side effects of fatigue from 16 cancer
050431 - treatments beginning on 081226, shown above, ref SDS 0 9I6T, that are
050432 - now causing blood counts to fall again, per above. ref SDS 0 6M7G
050434 -  ..
050435 - Background on Neupogen treatments and UCSF comments are reported on
050436 - 081207. ref SDS D1 673J
050438 -  ..
050439 - NEUTS blood tests show patient history of treatments with Nuepogen to
050440 - recover from neutropenia caused by getting chemotherapy everyday with
050441 - cyclophosphamide reported in case study on 081205. ref SDS C5 EC5N
050443 -  ..
050444 - Schedule for Neupogen treatments is listed in another record today on
050445 - 090110. ref SDS I7 HS5M
050447 -  ..
050448 - Neupogen treatments prescribed on 090108 by the medical team at UCSF
050449 - for 090109 and 090110, help maintain blood counts to strengthen
050450 - Millie's immunity system, shown in Millie's letter to the medical team
050451 - on 090109. ref SDS I5 UF3Q  Today, Millie had the 2nd treatment at
050452 - Kaiser. ref SDS I7 P73J
050454 -  ..
050455 - Feet and toes continue better today, less sensitive to walking that
050456 - was reported during the meeting at UCSF on 081218. ref SDS F2 HM4M
050457 - Subsiding side effects restoring normal use of feet enabled hiking
050458 - today for the first time in several weeks, per below. ref SDS 0 X64F
050460 -  ..
050461 - Tearing eyes reported during examination on 090108; Tara, ref SDS I3
050462 - XB3M, prescribed over-the-counter eye drops.  This was evident during
050463 - the hike today.
050465 -  ..
050466 - Joint pain, discomfort, and total ill feeling, commonly associated
050467 - with chemotherapy, reported on 081218, ref SDS F0 E38H, and discussed
050468 - with the medical team at UCSF also on 081218, ref SDS F2 QW7H, has now
050469 - mostly disipated, as a result of the doctor stopping all treatment for
050470 - 1 week, ref SDS F2 QW48, as shown in patient history above.
050471 - ref SDS G6 053F
050473 -  ..
050474 - Interstitional lung disease discussed in the record on 081218,
050475 - ref SDS F0 KM5F, shows no evident symptoms.
050477 -  ..
050478 - Vitals were reported today at the meeting at Kaiser with the primary
050479 - care physician...
050480 -
050481 -                   BP *** ** pulse **
050483 -  ..
050484 - Millie reports continued relief from heartburn with daily treatments
050485 - using Prilosce started on 081208. ref SDS D2 7J6K
050487 -  ..
050488 - Sore throat problem, reported initially on 081218, as having begun
050489 - days earlier, ref SDS F0 2B8M, seems better today today continuing
050490 - relief reported yesterday on 081222. ref SDS F8 TT4O  This increases
050491 - interest in eating food.  Millie had eggs and a baggel for a late
050492 - lunch after returning from the gym.  Swallowing seems much more normal
050493 - now.
050495 -  ..
050496 - Millie reports improved taste from some foods today (e.g., soup),
050497 - cited in study consent documents, reviewed on 081017. ref SDS 76 6T5H
050499 -     ..
050500 -                                   Date
050501 -    Description Adverse Event   Start  Stop     Medication
050502 -    ---------------------------------------------------------
050503 -    Follow up ref SDS I6 MV5H, ref SDS I1 MV5H.
050504 -
050505 -    Diarrhea                    081114 081114   Imodium........ ref SDS 94 LF8M
050506 -    Low pulse                   081120 081120   None........... ref SDS A3 LF8M
050507 -    Low pulse                   081121 081121   None........... ref SDS A4 7G8M
050508 -    BP 144 84 Pulse 48          081121 081121   Hiking......... ref SDS A4 LF8M
050509 -    Joint pain minor            081121 081121   Hiking......... ref SDS A4 LF8M
050510 -    Fatigue minor               081121 081121   Hiking......... ref SDS A4 LF8M
050511 -    Low pulse                   081122 081122   None........... ref SDS A5 7G8M
050512 -    Fatigue minor               081122 081122   Hiking......... ref SDS A5 LF8M
050513 -    Low pulse                   081123 081122   None........... ref SDS A6 7G8M
050514 -    BP 121 74 Pulse 53          081123 081123   Hiking......... ref SDS A6 LF8M
050515 -    Fatigue minor               081123 081122   Hiking......... ref SDS A6 LF8M
050516 -    Joint pain minor            081124 081124   Hiking......... ref SDS A7 LF8M
050517 -    Fatigue minor               081124 081124   Hiking......... ref SDS A7 LF8M
050518 -    Heartburn                   081124 081124   None........... ref SDS A7 HS9K
050519 -    BP 144 78 Pulse 52          081125 081125   Hiking......... ref SDS A8 LF8M
050520 -    Joint pain minor            081125 081125   Hiking......... ref SDS A8 LF8M
050521 -    Fatigue minor               081125 081125   Hiking......... ref SDS A8 LF8M
050522 -    Heartburn                   081125 081125   None........... ref SDS A8 HS9K
050523 -    Heartburn                   081126 081126   None........... ref SDS A9 HS9K
050524 -    Heartburn                   081127 081127   None........... ref SDS B3 HS9K
050525 -    BP 135 73 Pulse 48          081128 081128   Hiking......... ref SDS B4 5X6K
050526 -    Upset stomach               081128 081128   Hiking......... ref SDS B4 T76O
050527 -    BP 140 75 Pulse 50          081129 081129   Hiking......... ref SDS B7 5X6K
050528 -    Heartburn                   081129 081129   None........... ref SDS B7 HS9K
050529 -     ..
050530 -    Fatigue                     081129 081129   Rest........... ref SDS B7 LF8M
050531 -    Fatigue                     081130 081130   Rest........... ref SDS B8 LF8M
050532 -    BP 136 79 Pulse 46          081201 081201   Hiking......... ref SDS B9 5X6K
050533 -    Fatigue                     081201 081201   Rest........... ref SDS B9 LF8M
050534 -    Taste altered               081201 081201   Rest........... ref SDS B9 VP4G
050535 -    BP 141 77 Pulse 46          081202 081202   Aerobics gym... ref SDS C1 5X6K
050536 -    Fatigue                     081202 081202   Rest........... ref SDS C1 LF8M
050537 -    Taste altered               081202 081202   Rest........... ref SDS C1 VP4G
050538 -    BP 138 77 Pulse 48          081203 081203   Hiking......... ref SDS C3 5X6K
050539 -    Fatigue                     081203 081203   Rest........... ref SDS C3 LF8M
050540 -    Taste altered               081203 081203   Rest........... ref SDS C3 VP4G
050541 -    NEUTS (ANC)     0.624       081203 081203   Neupogen.......
050542 -    BP 133 72 Pulse 45          081204 081204   Rest........... ref SDS C4 5X6K
050543 -    Fatigue                     081204 081204   Rest........... ref SDS C4 LF8M
050544 -    Taste altered               081204 081204   Rest........... ref SDS C4 VP4G
050545 -    BP 138 76 Pulse 49          081205 081205   Rest........... ref SDS C5 5X6K
050546 -    Diarrhea                    081205 081114   Imodium........ ref SDS C5 Q67F
050547 -    Fatigue                     081205 081205   Rest........... ref SDS C5 LF8M
050548 -    Taste altered               081205 081205   Rest........... ref SDS C5 VP4G
050549 -    BP *** ** Pulse **          081206 081206   Rest........... ref SDS C9 5X6K
050550 -    Fatigue                     081206 081206   Rest........... ref SDS C9 LF8M
050551 -    BP 128 70 Pulse 53          081207 081207   Hiking......... ref SDS D1 5X6K
050552 -    Fatigue                     081207 081207   Rest........... ref SDS D1 LF8M
050553 -    BP 137 68 Pulse 53          081208 081208   Rest........... ref SDS D2 5X6K
050554 -    Fatigue                     081208 081208   Rest........... ref SDS D2 LF8M
050555 -    BP *** ** Pulse **          081209 081209   Rest........... ref SDS D2 5X6K
050556 -    Fatigue                     081209 081209   Rest........... ref SDS D2 LF8M
050557 -    Heartburn                   081209 081209   Prilosec....... ref SDS D3 7J6K
050558 -    BP 136 70 Pulse 53          081210 081210   Rest........... ref SDS D5 5X6K
050559 -    Fatigue                     081210 081210   Rest........... ref SDS D5 LF8M
050560 -    Heartburn                   081210 081210   Prilosec....... ref SDS D5 7J6K
050561 -    BP *** ** Pulse **          081211 081211   Rest........... ref SDS D9 5X6K
050562 -    Fatigue                     081211 081211   Exercise gym... ref SDS D9 LF8M
050563 -    Heartburn                   081211 081211   Prilosec....... ref SDS D9 7J6K
050564 -    BP 137 76 Pulse 53          081212 081212   Rest........... ref SDS E1 5X6K
050565 -    Fatigue                     081212 081212   Exercise gym... ref SDS E1 LF8M
050566 -    Heartburn                   081212 081212   Prilosec....... ref SDS E1 7J6K
050567 -    BP 147 80 Pulse 51          081213 081213   Rest........... ref SDS E4 5X6K
050568 -    Fatigue                     081213 081213   Exercise gym... ref SDS E4 LF8M
050569 -    BP *** ** Pulse **          081214 081214   Rest........... ref SDS E5 5X6K
050570 -    Fatigue                     081214 081214   Rest........... ref SDS E5 LF8M
050571 -    BP *** ** Pulse **          081215 081215   Rest........... ref SDS E6 5X6K
050572 -    Fatigue                     081215 081215   Rest........... ref SDS E6 LF8M
050573 -    BP 144 79 Pulse 54          081216 081216   Rest........... ref SDS E7 5X6K
050574 -    Fatigue                     081216 081216   Exercise gym... ref SDS E7 LF8M
050575 -     ..
050576 -    Joint pain minor            081216 081216   Rest........... ref SDS E7 E38H
050577 -    BP 137 69 Pulse 63          081217 081217   Rest........... ref SDS E8 5X6K
050578 -    Fatigue                     081217 081217   Rest........... ref SDS E8 LF8M
050579 -    Joint pain minor            081217 081217   Rest........... ref SDS E8 E38H
050580 -    Nosebleed minor             081217 081217   Rest........... ref SDS E8 ZF5F
050581 -     ..
050582 -    BP *** ** Pulse **          081218 081218   Rest........... ref SDS F0 5X6K
050583 -    Fatigue                     081218 081218   Rest........... ref SDS F0 LF8M
050584 -    Joint pain minor            081218 081218   Rest........... ref SDS F0 E38H
050585 -    Nosebleed moderate          081218 081218   Rest........... ref SDS F0 ZF5F
050586 -    Throat pain eating          081218 081218   Eating less.... ref SDS F0 2B8M
050587 -    BP 155 84 Pulse 53          081219 081219   Rest........... ref SDS F3 5X6K
050588 -    Fatigue                     081121 081219   Rest........... ref SDS F3 LF8M
050589 -    Feet toes lesions           081219 081219   Rest........... ref SDS F3 UO8I
050590 -    Joint pain ill feeling      081121 081219   Rest........... ref SDS F3 E38H
050591 -    Throat sore eating          081218 081219   Eating less.... ref SDS F3 TT4O
050592 -    BP 123 69 pulse 53          081220 081220   Rest........... ref SDS F5 5X6K
050593 -    Fatigue                     081121 081220   Rest........... ref SDS F5 LF8M
050594 -    Feet toes lesions           081219 081220   Rest........... ref SDS F5 UO8I
050595 -    Joint pain ill feeling      081121 081220   Rest........... ref SDS F5 E38H
050596 -    Throat sore eating          081218 081220   Eating less.... ref SDS F5 TT4O
050597 -    BP 117 71 pulse 65          081221 081221   Rest........... ref SDS F7 5X6K
050598 -    Fatigue                     081121 081221   Rest........... ref SDS F7 LF8M
050599 -    Feet toes lesions           081219 081221   Rest........... ref SDS F7 UO8I
050600 -    Joint pain ill feeling      081121 081221   Rest........... ref SDS F7 E38H
050601 -    Throat sore eating          081218 081221   Eating less.... ref SDS F7 TT4O
050602 -    BP 117 71 pulse 65          081222 081222   Rest........... ref SDS F8 5X6K
050603 -    Fatigue                     081121 081222   Rest........... ref SDS F8 LF8M
050604 -    Feet toes lesions           081219 081222   Rest........... ref SDS F8 UO8I
050605 -    Joint pain ill feeling      081121 081222   Rest........... ref SDS F8 E38H
050606 -    Throat sore eating          081218 081222   Eating less.... ref SDS F8 TT4O
050607 -    BP 143 68 pulse 65          081223 081223   Rest........... ref SDS F8 5X6K
050608 -    Fatigue more energy         081121 081223   Exercise gym... ref SDS F9 LF8M
050609 -    Feet feel better            081219 081223   Exercise gym... ref SDS F9 UO8I
050610 -    Joint pain subsides         081121 081223   Exercise gym... ref SDS F9 E38H
050611 -    Throat sore improved        081218 081223   Eating normal.. ref SDS F9 TT4O
050612 -    BP *** ** pulse **          081224 081224   Rest........... ref SDS G1 5X6K
050613 -    Fatigue more energy         081121 081224   Exercise gym... ref SDS G1 LF8M
050614 -    Feet feel better            081219 081224   Exercise gym... ref SDS G1 UO8I
050615 -    Joint pain subsides         081121 081224   Exercise gym... ref SDS G1 E38H
050616 -    Throat sore improved        081218 081224   Eating normal.. ref SDS G1 TT4O
050617 -    BP 124 80 pulse 66          081225 081225   Rest........... ref SDS G2 5X6K
050618 -    Fatigue more energy         081121 081225   Activity....... ref SDS G2 LF8M
050619 -    Fatigue more energy         081121 081226   Activity....... ref SDS G3 LF8M
050620 -    BP *** ** pulse **          081227 081227   Rest........... ref SDS G5 5X6K
050621 -    Fatigue more energy         081121 081227   Hiking......... ref SDS G5 LF8M
050622 -    BP *** ** pulse **          081228 081228   Rest........... ref SDS G6 5X6K
050623 -    Fatigue more energy         081121 081228   Rest........... ref SDS G6 LF8M
050624 -    BP *** ** pulse **          081229 081229   Rest........... ref SDS G7 5X6K
050625 -    Fatigue more energy         081121 081229   Rest........... ref SDS G7 LF8M
050626 -    BP *** ** pulse **          081230 081230   Rest........... ref SDS G9 5X6K
050627 -    Diarrhea                    081230 081230   Imodium........ ref SDS G9 KZ9N
050628 -    Fatigue more energy         081121 081230   Rest........... ref SDS G9 LF8M
050629 -    BP *** ** pulse **          081231 081231   Rest........... ref SDS H1 5X6K
050630 -    Fatigue more energy         081121 081231   Rest........... ref SDS H1 LF8M
050631 -    BP *** ** pulse **          090101 090101   Rest........... ref SDS H2 5X6K
050632 -    Fatigue more energy         081121 090101   Hiking......... ref SDS H2 LF8M
050633 -    BP *** ** pulse **          090102 090102   Rest........... ref SDS H3 5X6K
050634 -    Fatigue more energy         081121 090102   Hiking......... ref SDS H3 LF8M
050635 -    BP *** ** pulse **          090103 090103   Rest........... ref SDS H4 5X6K
050636 -    Fatigue less energy         081121 090103   Exercise gym... ref SDS H4 LF8M
050637 -    BP *** ** pulse **          090104 090104   Rest........... ref SDS H5 5X6K
050638 -    Fatigue less energy         081121 090104   Rest........... ref SDS H5 LF8M
050639 -    BP *** ** pulse **          090105 090105   Rest........... ref SDS H6 5X6K
050640 -    Fatigue less energy         081121 090105   Rest........... ref SDS H6 LF8M
050641 -    BP *** ** pulse **          090106 090106   Rest........... ref SDS H7 5X6K
050642 -    Fatigue less energy         081121 090106   Exercise gym... ref SDS H7 LF8M
050643 -    BP *** ** pulse **          090107 090107   Rest........... ref SDS H7 5X6K
050644 -    Fatigue less energy         081121 090107   Rest........... ref SDS I0 LF8M
050645 -    BP *** ** pulse **          090108 090108   Rest........... ref SDS I1 5X6K
050646 -    Fatigue less energy         081121 090108   Rest........... ref SDS I1 LF8M
050647 -    Eyes tearing                090108 090108   Eye drops...... ref SDS I1 518H
050648 -    BP *** ** pulse **          090109 090109   Rest........... ref SDS I6 5X6K
050649 -    Fatigue less energy         081121 090109   Rest........... ref SDS I6 LF8M
050650 -    Eyes tearing                090108 090109   Eye drops...... ref SDS I6 518H
050651 -    BP *** ** pulse **          090110 090110   Rest........... ref SDS 0 5X6K
050652 -    Fatigue less energy         081121 090110   Hiking......... ref SDS 0 LF8M
050653 -    Eyes tearing                090108 090110   Eye drops...... ref SDS 0 518H
050654 -
050655 -
050656 -
0507 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Exercise Hiking Maintain Fitness Strengthen Immune System
060403 -
060404 - Follow up ref SDS I6 3E4K, ref SDS I1 3E4K.
060405 -
060406 - Today, Millie tried hiking at Lafayette reservoir and did 1 lap in
060407 - about 59 minutes. ref SDS 0 X64F  Hiking was difficult on Millie's
060408 - legs, reported previously on 090102, ref SDS H3 6E7G, due to rising
060409 - side effects of fatigue from 16 cancer treatments beginning on 081226,
060410 - ref SDS 0 9I6T, that are now causing blood counts to fall again.
060411 - Neupogen treatments yesterday and today, and pausing cyclophosphamide
060412 - may enable blood counts and energy to rise, per above. ref SDS 0 LF8M
060414 -  ..
060415 - NEUTS blood tests show patient history treatments with Nuepogen for
060416 - neutropenia from chemotherapy everyday with cyclophosphamide reported
060417 - in case study on 081205. ref SDS C5 EC5N
060419 -  ..
060420 - On 081110, Millie complained about difficulty lifting herself from a
060421 - full squatting position. ref SDS 90 HX67  For several weeks, she was
060422 - exercising to strengthen legs, and arms, shown by going to the gym on
060423 - 081211. ref SDS D9 3E4K  Rising fatigue now prevents continuing
060424 - exercise.
060425 -
060427 -  ..
060428 - Case Study on Pateint History Exercising
060429 -
060430 - Follow up ref SDS I6 X64F, ref SDS I1 X64F.
060431 -
060432 -                                              +- scm = Sunitinib Cyclophosphmaide Methotrexate
060433 -                                              +- sc  = Sunitinib Cyclophosphmaide
060434 -                           Time     Pulse     |
060435 -    Location        Miles Minutes  Avg Max  Chem  Neupo  Date
060436 -    ----------------------------------------------------------------
060437 -    Lafayette        2.75   58.9    85 105    s         090110, ref SDS 0 3E4K
060438 -    Concord home                              s         090109, ref SDS I6 3E4K
060439 -    Concord home                              sc        090108, ref SDS I1 3E4K
060440 -    Concord home                              sc        090107, ref SDS I0 3E4K
060441 -    Concord home (gym)                        sc        090106, ref SDS H7 3E4K
060442 -    Concord home                              sc        090105, ref SDS H6 3E4K
060443 -    Concord home                              sc        090104, ref SDS H5 3E4K
060444 -    Concord home (gym)                        sc        090103, ref SDS H4 3E4K
060445 -    Clayton Safeway  3.00   58.7    83  94    sc        090102, ref SDS H3 3E4K
060446 -    Lafayette        2.75   58.4    87 103    sc        090101, ref SDS H2 3E4K
060447 -    Concord home                              sc        081231, ref SDS H1 3E4K
060448 -    Concord home                              sc        081230, ref SDS G9 3E4K
060449 -    Concord home                              sc        081229, ref SDS G7 3E4K
060450 -    Concord home                              sc        081228, ref SDS G6 3E4K
060451 -    Lafayette        2.75   56.2    90 112    sc        081227, ref SDS G5 3E4K
060452 -    Concord home                              sc        081226, ref SDS G3 3E4K
060453 -    Concord travel                                      081225, ref SDS G2 3E4K
060454 -    Concord home                                        081224, ref SDS G1 3E4K
060455 -    Concord home (gym)                                  081223, ref SDS F9 3E4K
060456 -    Concord home                                        081222, ref SDS F8 3E4K
060457 -    Concord home                                        081221, ref SDS F7 3E4K
060458 -    Concord home                                        081220, ref SDS F5 3E4K
060459 -    Concord home                                        081219, ref SDS F3 3E4K
060460 -    Concord home                              sc        081218, ref SDS F0 3E4K
060461 -    Concord home                              sc        081217, ref SDS E8 3E4K
060462 -    Concord home (gym)                        sc        081216, ref SDS E7 3E4K
060463 -    Concord home                              sc        081215, ref SDS E6 3E4K
060464 -    Concord home                              sc        081214, ref SDS E5 3E4K
060465 -    Concord home (gym)                        scm       081213, ref SDS E4 3E4K
060466 -    Concord home                              scm       081212, ref SDS E1 3E4K
060467 -    Concord home (gym)                        sc        081211, ref SDS D9 3E4K
060468 -    Concord home                              sc        081210, ref SDS D5 3E4K
060469 -    Concord home                              sc        081209, ref SDS D3 3E4K
060470 -    Concord home                              sc        081208, ref SDS D2 3E4K
060471 -    Lafayette        4.75   78.6    95 110    sc        081207, ref SDS D1 3E4K
060472 -    Concord home                              scm       081206, ref SDS C9 3E4K
060473 -    Concord home                              scm       081205, ref SDS C5 3E4K
060474 -    Concord home                              sc        081204, ref SDS C4 3E4K
060475 -    Lafayette        2.75   62.7    90 117    sc        081203, ref SDS C3 3E4K
060476 -    Concord home (gym)                        sc        081202, ref SDS C1 3E4K
060477 -    Lafayette        5.50  102.3    95 122    sc        081201, ref SDS B9 3E4K
060478 -    Concord home                              sc        081130, ref SDS B8 3E4K
060479 -    Lafayette        2.75   56.7    90 115    scm       081129, ref SDS B7 3E4K
060480 -    Lafayette        2.75   46.5   100 128    scm       081128, ref SDS B4 3E4K
060481 -    Lafayette        5.50   93.3   100 122    s         081127, ref SDS B3 3E4K
060482 -    Concord home                              s         081126, ref SDS A9 3E4K
060483 -    Lafayette        4.00   73.7   105 127    s         081125, ref SDS A8 3E4K
060484 -    Lafayette        5.50   91.4   100 129    s         081124, ref SDS A7 3E4K
060485 -    Concord home                              s         081123, ref SDS A6 3E4K
060486 -    Lafayette        5.50   92.8    95 122    s         081122, ref SDS A5 3E4K
060487 -    Lafayette        5.50   94.4    85 112    s         081121, ref SDS A4 3E4K
060488 -    Lafayette        5.50   94.7    90 122    s         081120, ref SDS A3 3E4K
060489 -    San Francisco    1.00   60.0    65  75    s         081119, ref SDS A2 3E4K
060490 -    Lafayette        2.75   49.2    97 130    s         081118, ref SDS A1 3E4K
060491 -    Lafayette        5.50   93.6   115 138    s         081117, ref SDS 98 3E4K
060492 -    Concord home                              s         081116, ref SDS 96 Y68J
060493 -    Concord home                              s         081115, ref SDS 95 EK7I
060494 -    Concord home                              s         081114, ref SDS 94 XW6H
060495 -    Lafayette        5.50   94.2   115 138              081110, ref SDS 90 3E4K
060496 -    Lafayette        2.75   48.4   105 128              081109, ref SDS 89 3E4K
060497 -    Kaiser                                         x    081108, ref SDS 88 UZ7K
060498 -    Kaiser                                         x    081107, ref SDS 87 UZ7K
060499 -    Lafayette        5.50   90.2   120 143              081025, ref SDS 83 3E4K
060500 -    Kaiser                                         x    081025, ref SDS 83 UZ7K
060501 -    Kaiser                                         x    081024, ref SDS 82 UZ7K
060502 -    UCSF                                      c         081023, ref SDS 81 V94O
060503 -    Lafayette        5.50   90.6   115 141              081021, ref SDS 80 3E4K
060504 -    Lafayette        5.50   90.4   110 128              081020, ref SDS 79 3E4K
060505 -    Kaiser                                         x    081018, ref SDS 78 UZ7K
060506 -    Kaiser                                         x    081017, ref SDS 77 UZ7K
060507 -    UCSF                                      e         081016, ref SDS 75 V94O
060508 -    Lafayette        5.50   90.1   115 154              081014, ref SDS 74 3E4K
060509 -    Lafayette        5.50   92.7   115 138              081013, ref SDS 73 3E4K
060510 -    Lafayette        8.25  146.4   180 224              081012, ref SDS 72 3E4K
060511 -    Kaiser                                         x    081011, ref SDS 71 UZ7K
060512 -    Lafayette        5.50   93.3   116 138              081010, ref SDS 70 3E4K
060513 -    Kaiser                                         x    081010, ref SDS 70 UZ7K
060514 -    UCSF                                      e         081009, ref SDS 69 V94O
060515 -    Lafayette        5.50   92.1   113 137              081006, ref SDS 68 3E4K
060516 -    Lafayette        2.75   48.5   110 136         x    081004, ref SDS 67 3E4K
060517 -    Lafayette        5.50   98.2   117 136         x    081003, ref SDS 66 3E4K
060518 -    UCSF                                      c         081002, ref SDS 65 V94O
060519 -    Lafayette        5.50   94.7   115 142              080929, ref SDS 64 3E4K
060520 -    Lafayette        8.25  150.4   115 135              080928, ref SDS 64 3E4K
060521 -    Kaiser                                         x    080927, ref SDS 63 UZ7K
060522 -    Lafayette        5.50   90.2   120 140         x    080926, ref SDS 62 3E4K
060523 -    UCSF                                      c         080925, ref SDS 61 V94O
060524 -    Lafayette        5.50   92.3   116 138              080923, ref SDS 60 3E4K
060525 -    Lafayette        5.50   98.4   112 134              080922, ref SDS 60 3E4K
060526 -    Lafayette        5.50   98.2   114 137              080921, ref SDS 60 3E4K
060527 -    Lafayette        5.50  101.6   110 133         x    080920, ref SDS 59 3E4K
060528 -    Lafayette        5.50   89.3   115 144         x    080919, ref SDS 58 3E4K
060529 -    UCSF                                      c         080918, ref SDS 57 V94O
060530 -    Lafayette        2.75   46.2   117 139              080916, ref SDS 58 3E4K
060531 -    Lafayette        5.50   91.8   117 142              080915, ref SDS 56 3E4K
060532 -    Clayton Safeway  3.00   62.4    98 118              080914, ref SDS 55 3E4K
060533 -    Lafayette        8.25  129.7   123 147         x    080913, ref SDS 54 3E4K
060534 -    Lafayette        5.50   88.4   118 146         x    080912, ref SDS 53 3E4K
060535 -    UCSF                                      c         080911, ref SDS 52 V94O
060536 -    Lafayette        2.75   46.8   113 140              080909
060537 -    Lafayette        5.50   89.2   117 143              080908
060538 -    Lafayette        5.50   92.1   115 138              080907
060539 -    Lafayette        2.75   45.3   120 144         x    080906, ref SDS 51 3E4K
060540 -    Lafayette        2.75   56.8    93 120         x    080905, ref SDS 50 3E4K
060541 -    UCSF                                      c         080904, ref SDS 49 V94O
060542 -    Lafayette        8.25  140.4   116 131              080903
060543 -    Lafayette        5.50   94.9   115 134              080902
060544 -    Kaiser                                         x    080830
060545 -    Kaiser                                         x    080829
060546 -    UCSF                                      c         080828, ref SDS 48 V94O
060547 -    Lafayette        5.50   93.6   120 137              080826
060548 -    Lafayette        5.50   93.2   117 138              080825
060549 -    Lafayette        5.50   93.2   123 136         x    080823
060550 -    Lafayette        8.25  142.5   110 131         x    080822, ref SDS 47 3E4K
060551 -    UCSF                                      e         080821, ref SDS 46 V94O
060552 -    Lafayette        5.50   94.7   115 137              080820
060553 -    Lafayette        5.50   94.3   115 135              080819
060554 -    Lafayette        8.25  141.7   118 134              080815
060555 -    UCSF                                      e         080814, ref SDS 45 V94O
060556 -    Lafayette        5.50   93.8   120 136              080813
060557 -    Lafayette        5.50   94.4   116 139              080812
060558 -    Lafayette        5.50   94.2   119 133              080810
060559 -    Lafayette        8.25  143.6   114 132         x    080809, ref SDS 43 3E4K
060560 -    Lafayette        8.25  141.1   117 135         x    080808, ref SDS 42 3E4K
060561 -    UCSF                                      c         080807, ref SDS 41 V94O
060562 -    Lafayette        8.25  143.7   115 132              080805
060563 -    Concord          7.00  127.6   105 118              080804
060564 -    Lafayette        8.25  143.2   112 134              080802
060565 -    Lafayette        5.50   93.4   115 138              080801
060566 -    Lafayette        5.50   92.2   118 140              080729
060567 -    Lafayette        5.50   92.6   116 137              080728
060568 -    Lafayette        8.25  142.6   114 134              080727
060569 -    Lafayette        5.50   91.5   120 143              080726
060570 -    Lafayette        8.25  140.8   117 135              080725
060571 -    Lafayette        5.50   91.8   122 141              080723
060572 -    Lafayette        5.50   91.3   120 139              080722
060573 -    Lafayette        8.25  143.3   115 133              080720
060574 -    Lafayette        5.50   90.7   125 144              080719
060575 -    Lafayette        5.50   92.4   123 142              080716
060576 -    Lafayette        2.25   46.8   116 137              080715
060577 -    Lafayette        8.25  141.8   116 136              080712
060578 -    Lafayette        5.50   92.9   116 139              080711
060579 -    Lafayette        8.25  143.3   113 137              080704
060580 -    Lafayette        5.50   90.2   121 147              080630
060581 -    Lafayette        8.25  142.4   116 138              080628
060582 -    Lafayette        5.50   91.4   118 138              080625
060583 -    Lafayette        2.25   47.9   116 136              080623
060584 -    Lafayette        5.50   94.2   112 138              080622
060585 -    Lafayette        5.50   94.7   115 133              080621
060586 -    Lafayette        2.25   48.3   110 129              080620
060587 -    Mt Diablo        7.00  129.4   130 153              080616
060588 -    Lafayette        5.50   90.8   120 146              080615
060589 -    Lafayette        5.50   91.3   124 144              080614
060590 -    Lafayette        5.50   89.7   122 143              080613
060591 -    Lafayette        2.76   45.8   120 147              080611
060592 -    Lafayette        5.50   90.5   123 145              080609
060593 -    Lafayette        5.50   92.7   115 138              080607
060594 -    Lafayette        5.50   94.2   118 139              080602
060595 -    Lafayette        5.50   96.2   110 202              080507, ref SDS 19 WO8M
060596 -
060597 -
060598 -
060599 -
060600 -
060601 -
0607 -