CONTACTS 

SUBJECTS
Cetuximab 12th Cycle 3rd Treatment 18th Total Treatment Chemotherapy

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS B4 0000. ref SDS B0 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Background on Millie's treatment in the clinical study is reported on
040902 - 080508. ref SDS 93 TZ8I
040904 -    ..
040905 -   Taxotere Capecitabine 2nd Relapse IBC Treatment After Mastectomy
040906 -
040907 -   Follow up ref SDS B4 X33O, ref SDS B0 X33O.
040908 -
040909 -   Millie had left mastectomy on 051021.  Biopsy at that time reported
040910 -   no findings of cancer.  Approximately 8 months later on 060707 the
040911 -   doctor diagnosed IBC relapse and prescribed treatment. ref SDS 3
040912 -   PF3O
040913 -
040914 -    1.  Cycle 09 and 01 ................... 060721, ref SDS 4 407N
040915 -    2.  Cycle 10 and 02 ................... 060814, ref SDS 6 LY6O
040916 -    3.  Cycle 11 and 03 ................... 060908, ref SDS 6 407N
040917 -    4.  Cycle 12 and 04 ................... 060929, ref SDS 6 407N
040918 -    5.  Cycle 13 and 05 ................... 061020, ref SDS 7 407N
040919 -    6.  Cycle 14 and 06 ................... 061110, ref SDS 8 407N
040920 -    7.  Cycle 15 and 07 ................... 061201, ref SDS 9 407N
040922 -    ..
040923 -   Cetuxiab Alone Clinical Study
040924 -
040925 -   Follow up ref SDS B4 356I, ref SDS B0 356I.
040926 -
040927 -                   Total    Cetuximab
040928 -    8.  Cycle 01 and 08 and 01 01.......... 070201, ref SDS 11 SG8I
040929 -    9.  Cycle 01 and 08 and 02 02.......... 070208, ref SDS 12 SG8I
040930 -   10.  Cycle 01 and 08 and 03 03.......... 070215, ref SDS 13 SG8I
040931 -   11.  Cycle 01 and 08 and 04 04.......... 070222, ref SDS 14 SG8I
040932 -   12.  Cycle 02 and 09 and 01 05.......... 070301, ref SDS 15 SG8I
040933 -   13.  Cycle 02 and 09 and 02 06.......... 070308, ref SDS 17 7T3H
040934 -   14.  Cycle 02 and 09 and 03 07.......... 070315, ref SDS 18 7T3H
040935 -   15.  Cycle 02 and 09 and 04 08.......... 070322, ref SDS 19 7T3H
040936 -   16.  Cycle 03 and 10 and 01 09.......... 070329, ref SDS 20 7T3H
040937 -   17.  Cycle 03 and 10 and 02 10.......... 070405, ref SDS 21 7T3H
040938 -   18.  Cycle 03 and 10 and 03 11.......... 070412, ref SDS 22 7T3H
040939 -   19.  Cycle 03 and 10 and 04 12.......... 070419, ref SDS 23 7T3H
040940 -   20.  Cycle 04 and 11 and 01 13.......... 070426, ref SDS 24 7T3H
040941 -   21.  Cycle 04 and 11 and 02 14.......... 070503, ref SDS 25 7T3H
040942 -   22.  Cycle 04 and 11 and 03 15.......... 070510, ref SDS 26 7T3H
040943 -   23.  Cycle 04 and 11 and 04 16.......... 070517, ref SDS 27 7T3H
040944 -   24.  Cycle 05 and 12 and 01 17.......... 070524, ref SDS 28 7T3H
040945 -   25.  Cycle 05 and 12 and 02 18.......... 070531, ref SDS 29 7T3H
040946 -   26.  Cycle 05 and 12 and 03 19.......... 070607, ref SDS 30 7T3H
040947 -   27.  Cycle 05 and 12 and 04 20.......... 070614, ref SDS 31 0001
040948 -   28.  Cycle 06 and 13 and 01 21.......... 070621, ref SDS 32 0001
040949 -   29.  Cycle 06 and 13 and 02 22.......... 070628, ref SDS 33 0001
040950 -   30.  Cycle 06 and 13 and 03 23.......... 070705, ref SDS 34 0001
040951 -   31.  Cycle 06 and 13 and 04 24.......... 070712, ref SDS 34 0001
040952 -   32.  Cycle 07 and 14 and 01 25.......... 070719, ref SDS 35 0001
040953 -   33.  Cycle 07 and 14 and 02 26.......... 070726, ref SDS 33 0001
040954 -   34.  Cycle 07 and 14 and 03 27.......... 070802, ref SDS 34 0001
040955 -   35.  Cycle 07 and 14 and 04 28.......... 070809, ref SDS 36 0001
040956 -   36.  Cycle 08 and 15 and 01 29.......... 070816, ref SDS 37 0001
040957 -   37.  Cycle 08 and 15 and 02 30.......... 070823, ref SDS 38 0001
040958 -   38.  Cycle 08 and 15 and 03 31.......... 070830, ref SDS 38 0001
040959 -   39.  Cycle 08 and 15 and 04 32.......... 070906, ref SDS 39 0001
040960 -   40.  Cycle 09 and 16 and 01 33.......... 070920, ref SDS 40 0001
040961 -   41.  Cycle 09 and 16 and 02 34.......... 070927, ref SDS 41 0001
040962 -   42.  Cycle 09 and 16 and 03 35.......... 071004, ref SDS 42 0001
040963 -   43.  Cycle 09 and 16 and 04 36.......... 071011, ref SDS 43 0001
040964 -   44.  Cycle 10 and 17 and 01 37.......... 071018, ref SDS 44 0001
040965 -   45.  Cycle 10 and 17 and 02 38.......... 071025, ref SDS 45 0001
040966 -   46.  Cycle 10 and 17 and 03 39.......... 071101, ref SDS 31 0001
040967 -   47.  Cycle 10 and 17 and 04 40.......... 071108, ref SDS 46 0001
040968 -   48.  Cycle 11 and 18 and 01 41.......... 071115, ref SDS 47 0001
040969 -   49.  Cycle 11 and 18 and 02 42.......... 071122, ref SDS 33 0001
040970 -   50.  Cycle 11 and 18 and 03 43.......... 071129, ref SDS 49 0001
040971 -   51.  Cycle 11 and 18 and 04 44.......... 071206, ref SDS 50 0001
040972 -   52.  Cycle 12 and 19 and 01 45.......... 071213, ref SDS 53 0001
040973 -   53.  Cycle 12 and 19 and 02 46.......... 071220, ref SDS 56 0001
040974 -   54.  Cycle 12 and 19 and 03 47.......... 071227, ref SDS 57 0001
040975 -   55.  Cycle 12 and 19 and 04 48.......... 080103, ref SDS 58 0001
040976 -   56.  Cycle 13 and 20 and 01 49.......... 080110, ref SDS 61 0001
040977 -   57.  Cycle 13 and 20 and 02 50.......... 080117, ref SDS 62 0001
040978 -   58.  Cycle 13 and 20 and 03 51.......... 080124, ref SDS 63 0001
040979 -   59.  Cycle 13 and 20 and 04 52.......... 080131, ref SDS 65 0001
040980 -   60.  Cycle 14 and 21 and 01 53.......... 080207, ref SDS 69 0001
040981 -   61.  Cycle 14 and 21 and 02 54.......... 080214, ref SDS 70 0001
040982 -   62.  Cycle 14 and 21 and 03 55.......... 080221, ref SDS 34 0001
040983 -   63.  Cycle 14 and 21 and 04 56.......... 080228, ref SDS 75 0001
040984 -   64.  Cycle 15 and 22 and 01 57 01  00... 080306, ref SDS 78 TZ8I
040985 -
040987 -    ..
040988 -   Cetuxiab with Carboplatin Clinical Study 2nd Arm
040989 -
040990 -   Follow up ref SDS B4 5B6J, ref SDS B0 5B6J.
040991 -
040992 -   On 080207 doctor reports IBC may be spreading. ref SDS 68 GH5H
040993 -   Follow up examination on 080219 Doctor Rugo diagnosed progression of
040994 -   disease. ref SDS 88 3J4I  Photographs show spread of IBC rash,
040995 -
040996 -             2nd
040997 -             Arm              Cetuximab Carboplatin
040998 -   65.  Cycle 01 15 and 22 and 02 58 02  01... 080313, ref SDS 79 TZ8I
040999 -   66.  Cycle 01 15 and 22 and 03 59 03  01... 080320, ref SDS 80 TZ8I
041000 -   67.  Cycle 01 15 and 22 and 04 60 04  01... 080327, ref SDS 81 TZ8I
041001 -   68.  Cycle 02 16 and 23 and 01 61 05  02... 080403, ref SDS 82 TZ8I
041002 -   69.  Cycle 02 16 and 23 and 02 62 06  03... 080410, ref SDS 85 TZ8I
041003 -   70.  Cycle 02 16 and 23 and 03 63 07  03... 080417, ref SDS 87 TZ8I
041004 -   71.  Cycle 02 16 and 23 and 04 64 08  03... 080424, ref SDS 89 TZ8I
041005 -   72.  Cycle 03 17 and 24 and 01 65 09  04... 080501, ref SDS 91 5B6J
041006 -   73.  Cycle 03 17 and 24 and 02 66 10  05... 080508, ref SDS 93 5B6J
041007 -   74.  Cycle 03 17 and 24 and 03 67 11  05... 080515, ref SDS 94 5B6J
041008 -   75.  Cycle 03 17 and 24 and 04 68 12  05... 080522, ref SDS 95 5B6J
041009 -   76.  Cycle 04 18 and 25 and 01 69 13  06... 080529, ref SDS 98 5B6J
041010 -   77.  Cycle 04 18 and 25 and 02 70 14  07... 080605, ref SDS 99 5B6J
041011 -   78.  Cycle 04 18 and 25 and 03 71 15  08... 080612, ref SDS A2 5B6J
041012 -   79.  Cycle 04 18 and 25 and 04 72 16  08... 080619, ref SDS A5 5B6J
041013 -   80.  Cycle 05 19 and 26 and 01 73 17  09... 080626, ref SDS B0 5B6J
041014 -   81.  Cycle 05 19 and 26 and 02 74 18  10... 080703, ref SDS B4 5B6J
041015 -   82.  Cycle 05 19 and 26 and 03 75 19  11... 080710, ref SDS 0 5B6J
041017 -  ..
041018 - Today is the 3rd treatment of the 5th cycle with cetuximab and
041019 - Carboplatin together.  This is the 19th treatment overall with
041020 - cetuximab on the 2nd arm of the clinical study, but is only the 11th
041021 - treatment with Carboplatin due to low blood counts.
041022 -
041023 -
041024 -
041025 -
041026 -
0411 -

SUBJECTS
Default Null Subject Account for Blank Record

0503 -
0504 - 0800
050501 -  ..
050502 - Labs Blood Test New Power Port Huber Needle Configured Kaiser
050503 - Power Port Huber Needle Configured Kaiser Surgeon Effective at UCSF
050504 -
050505 - Follow up ref SDS B4 FW5N, ref SDS B0 FW5N.
050506 -
050507 - Adding Carboplatin to the treatment protocol now requires weekly blood
050508 - tests to determine if the immune system is strong enough for safe
050509 - chemotherapy treatment, reported on 070201, ref SDS 11 XR40, and citing
050510 - the clinical study protocol received from UCSF on 070116. ref SDS 10
050511 - 5U7Z
050513 -  ..
050514 - Catherine was Millie's nurse today.
050516 -  ..
050517 - Catherine received Millie's letter, ref DIP 1 0001, sent yesterday on
050518 - 080709, ref SDS B6 FK6F, reporting surgery the day before on Tuesday,
050519 - to replace the port catheter with a new Power Port. ref SDS B5 0001
050521 -  ..
050522 - Catherine used the Huber needle pre-configured with stitches by Doctor
050523 - Riley-Paull during surgery.  The port worked perfectly today,
050524 - reflecting testing at Kaiser on Tuesday, 080708. ref SDS B5 6F4I
050525 - Blood flowed generously, with no problems.  Catherine will coordinate
050526 - with the medical staff on removing stitches after Millie's treatment
050527 - today, as planned by the surgeon at Kaiser. ref SDS B5 LI5K
050529 -             ..
050530 -            [...below, UCSF receives Kaiser certificate explaining
050531 -            Power Port was tested ready for use. ref SDS 0 MZ8G
050533 -             ..
050534 -            [On 080717 Millie letter to Kaiser commending the surgeon
050535 -            on successful Power Port surgery and accessing the Power
050536 -            Port for Millie's treatment at UCSF 2 days later,
050537 -            ref SDS B9 EF5I; and requesting name of anesthesiologist
050538 -            who did great work. ref SDS B9 623X
050540 -             ..
050541 -            [On 080911 UCSF used similar procedure to configure Huber
050542 -            needle accessing Power Port for Millie's treatment to be
050543 -            used later at Kaiser for a CT test. ref SDS C1 OY4J
050544 -
050545 -
050547 -  ..
050548 - During treatment, Catherine submitted results of the test.
050549 -
050564 -     ..
050565 -    Log#:                   080710 08:10
050566 -    <----------------------- U C S F -----------------------> <-------------  Kaiser -------------->
050567 -    Type                 Results   Units        Normal        ACRO   Type            Units        Normal
050568 -     ..
050569 -    CBC with DIFF & PLT CT                                     CBCD
050570 -     ..
050571 -    WBC COUNT               7.4    x10E9/L     3.4  -   10     WBC   WBC x10-3        K/uL     3.4  -  10.0
050572 -    RBC COUNT      L        3.74   x10E12/L      4  -   5.2    RBC   RBC x10-6        M/uL    3.60  -  5.70
050573 -    HEMOGLOBIN             12.7    g/dL         12  -   15.5   HGB   Hemoglobin       g/dL    11.5  -  15.0
050574 -    HEMATOCRIT             36.8    PERCENT      36  -   46     HCT   Hematocrit       %       34.0  -  46.0
050575 -    MCV                    98      fL           80  -   100    MCV   MCV              fL      80.0  -  100.0
050576 -    MCH                    34.0    pg           26  -   34     MCH
050577 -    MCHC                   34.6    g/dL         31  -   36     MCHC
050578 -    PLATELETS             173      x10E9/L     140  -  450     PLT   Plt x10-3        K/uL     140  -  400
050579 -
050580 -        Performed at Mt Zion Clinic Lab, 1600 Divisadero, San
050581 -        Francisco, CA  94115
050582 -    ..
050583 -     (NEUTS x 1000 = ANC for Kaiser)
050584 -    NEUTS         L         5.12   x10E9/L     1.8  -  6.8     N-A   ANC                      1500
050585 -    Neutrophils    Not Reported                                      Neutrophils       %        50  -  70
050587 -     ..
050588 -    LYMPHS                  1.52   x10E9/L     0.9  -  2.9     L-A   Lymphocytes       %        20  -  50
050589 -    MONOS                   0.37   x10E9/L     0.1  -  0.6     M-A   Monocyte          %         0  -  11
050590 -    EOS                     0.32   x10E9/L       0  -  0.4     E-A   Esoinophils       %         1  -  5
050591 -    BASOS                   0.05   x10E9/L       0  -  0.1     B-A   Basophil          %         0  -  2
050592 -
050594 -  ..
050595 - Missing Blood Tests Previous Lab on 080526
050596 -
050597 - Follow up ref SDS B4 TW3O.
050598 -
050599 - Catherine reviewed labs on 080626 reporting tests were omitted
050600 - compared to prior tests, ref SDS B0 HS7I, following up review last
050601 - week on 080703. ref SDS B4 TW3O
050603 -  ..
050604 - She feels the test on 080626 correctly applies Chemotherapy Orders
050605 - issued on 080626. ref SDS B0 PWPW  Previous labs may have included
050606 - tests that were ordered my mistake.  Catherine advised that Brigid and
050607 - Doctor Rugo are both out of the office today.  She proposed discussing
050608 - scope of labs with the medical team in 2 weeks when we meet to start
050609 - the next cycle.
050610 -
050611 -
050613 -  ..
050614 - NEUTS Improve UCSF Prescribed Neupogen Treatment on Sunday
050615 -
050616 - Follow up ref SDS B4 PU6K, ref SDS B0 PU6K.
050617 -
050618 - Blood counts increased significantly again for the 3rd consecutive
050619 - week shown by the Lab report today with NEUTS 5.12, ref SDS 0 QY6H,
050620 - compared with NEUTS 2.90 last week on 080703, ref SDS B4 QY6H
050621 - Significant rise in blood counts with weekly Carboplatin chemotherapy
050622 - treatments, reflects getting 2 treatments with Neupogen last week at
050623 - the Kaiser Infusion Clinic, and aligns with Brigid's instructions
050624 - during the meeting at UCSF on 080626, ref SDS A9 QJ4H, even though
050625 - Chemotherapy Orders to do not prescribe Neupogen. ref SDS B0 PWSY
050627 -  ..
050628 - Catherine advised that Doctor Rugo and Brigid are both out of the
050629 - office today.  She feels Millie's 3 successive weeks of rising blood
050630 - counts to far above the save level for treatment could support cost
050631 - containment and avoiding side effects, reported on 080629, ref SDS B3
050632 - 6Q5J, by avoiding one or both Neupogen treatments this week.  Since
050633 - there is no medical professional to consult on Millie's case,
050634 - Catherine recommended continuing with 2 Neupogen treatments this week,
050635 - i.e., tomororw and Saturday, following the prescription during the
050636 - meeting on 080626. ref SDS A9 QJ4H
050638 -  ..
050639 - Side effects of Neupogen reported on 080628, ref SDS B1 6Q5J, and
050640 - again on 080629, ref SDS B3 6Q5J, have been less severe the past week
050641 - even though Neupogen treatments have continued at 2 per week.
050642 -
050643 -     [On 080713 Millie reported recurrence of Neupogen side effects.
050644 -     ref SDS B7 RM99
050645 -
050646 -
050647 -
050648 -
0507 -

SUBJECTS
Default Null Subject Account for Blank Record

0603 -
060401 -  ..
060402 - Xray Needed for Power Port UCSF Coordinates with Kaiser
060403 - Power Port Surgery Certification Required Kaiser Submit to UCSF
060404 -
060405 - Follow up ref SDS B4 MZ8G, ref SDS B0 MZ8G.
060406 -
060407 - Surgery at Kaiser this past Tuesday on 080708 replaced the port
060408 - catheter with a Power Port. ref SDS B5 0001
060410 -  ..
060411 - Millie submitted the certificate from Kaiser reporting that the Power
060412 - Port implanted on 080708 was tested successfully, ref SDS B5 BF4K, as
060413 - requested by UCSF on 080626. ref SDS B0 MZ9L
060415 -  ..
060416 - On 080627 Millie coordinated with the primary care physician at Kaiser
060417 - notifying that UCSF needs a "certificate" from the surgeon.  The
060418 - primary care physician in the Oncology Department at Kaiser notified
060419 - the surgeon to prepare a "certificate" stating Power Port has been
060420 - tested and found suitable for use at UCSF.  On 080708 surgery was
060421 - performed for the Power Port; the surgeon was reminded to submit a
060422 - "certificate" on suitability for use at UCSF.  The surgoen was
060423 - annoyed, noting there is no medical documentation for "certificates."
060424 - ref SDS B5 O65F
060426 -  ..
060427 - Catherine clarified today that UCSF needs the xray report showing
060428 - placement of the Power Port. ref SDS B5 O67N  UCSF management called
060429 - Kaiser during Millie's treatment today.  The Kaiser Surgery department
060430 - coordinated submission of the xray report via fax to the Infusion
060431 - Clinic at UCSF. ref SDS B5 UY3I  Catherine filed the Kaiser xray
060432 - report in Millie's medical chart at UCSF.  The certificate was
060433 - evidently not needed.
060435 -  ..
060436 - Millie reviewed documentation on the Power Port with instructions for
060437 - use, received from Kaiser on 080708. ref SDS B5 DZ5O
060439 -  ..
060440 - Catherine assisted Millie in filling out the Power Port identification
060441 - card received in the packet on 080708. ref SDS B5 PPRR
060443 -  ..
060444 - Catherine made copies of instructions for use, including guidance on
060445 - the back of the ID card showing flushing volumes to maintain the Power
060446 - Port for optimal flow, as shown in the record on 080708. ref SDS B5
060447 - EM3L
060448 -
060450 -  ..
0605 -
0606 -
0607 - 1245
0608 -
060801 - Millie's treatment was stretched out today due to heavy volume of
060802 - patients.  Another nurse assisted to disconnect the treatment IV for
060803 - Carboplatin and flush the port, per Bard protocol, reported on 080708,
060804 - ref SDS B5 XJ6S, while Catherine was tending other patients.
060806 -  ..
060807 - Catherine advised that she got approval to remove stitches holding the
060808 - Huber needle in the Power Port.
060810 -  ..
060811 - Catherine removed the several bandages to expose the Huber needle, and
060812 - the stitches.  She used a specially sealed set of scissors and
060813 - tweesers to carefully remove the stitches.  They came looses easily
060814 - and without discomfort to Millie, in the manner explained by the
060815 - surgeon at Kaiser on 080708. ref SDS B5 LI5K
060817 -  ..
060818 - Catherine remarked on excellent work by the surgeon.  She said
060819 - sometimes an incision of this kind is longer than needed, or there
060820 - might be 2 incisions where only one is needed, and this extends
060821 - discomfort from recovery and healing time for the patient.  Catherine
060822 - noted only a single small incision, and that the new Power Port seems
060823 - to have been slid into place an inch or so from the site of the port
060824 - catheter that was removed.
060826 -  ..
060827 - Millie asked about removing the surgical tape covering the incision
060828 - wound for implanting the Power Port during surgery on Tuesday, 080708.
060829 - ref SDS B5 436J
060831 -  ..
060832 - Catherine explained the tape may fall off over the next week, and if
060833 - not, she will inspect the incision wound and decide about removing the
060834 - tape at that time.
060835 -
060836 -     [On 080717 Catherine examined the wound and noted good progress
060837 -     healing; decided to leave the surgical tape in place another week.
060838 -     ref SDS B8 IL3L
060840 -      ..
060841 -     [On 080719 as a result of complications from CT test on 080718
060842 -     causing bleeding throught surgical wound, Julie in Kaiser Infusion
060843 -     Clinic removed the original surgical tape from the Power Port
060844 -     incision wound; inspection shows healing, but possible compromise
060845 -     with slight gap from the bleeding; fresh surgical tape was placed
060846 -     to dress the wound. ref SDS C0 LD87
060848 -  ..
060849 - Catherine placed a large square bandage over the area, including the
060850 - adhesion tape over the incison wound.  She seemed to say Millie can
060851 - remove the large bandage in a day or so, but should leave the tape in
060852 - place that was placed by the surgeon until next week.  She said this
060853 - tape is designed to wear off naturally, and so may begin to curl in a
060854 - few days, but leave it in place until treatment next Thursday.
060855 - Catherine will remove it at that time.
060856 -
060857 -
060858 -
060859 -
060860 -
060861 -
060862 -
060863 -
060864 -
060865 -
060866 -
060867 -
0609 -