THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: April 5, 2007 08:30 AM Thursday; Rod Welch

Millie at UCSF 3rd cycle 2nd treatment Cetuximab for IBC relapse.

1...Summary/Objective
2...Clinic Examination Orientation Starting Treatment Cetuximab
3...Breast Examination Likely IBC 2 Scenarios Spreading Intensity Declines
4...Emotional Roller Coaster Endemic Cancer Treatment and Coordination
5...Cetuximab Prognosis IBC May Subside for 10 Months Before Progressing
6...Prognosis Disease May Subside 10 Months or More Before Progression
7...Progresssion of Disease May be Delayed for 10 Months or More
8...Measureable Disease Photographs IBC Rash Improving
9...IBC Rash Improved Measurable Disease Photographs Tape Measure
10...Side Effects Medicated After Weekly Examinations
11...Infusion Clinic for Cetuximab Treatent
..........Taxotere Capecitabine
..........Cetuxiab Clinical Study
12...Nurses Notes...
13...Side Effects Minimal...
14...Schedule Weekly Treatments Continue on Thursdays
15...Preparation for Treatment Required One (1) Attempt to Connect Port
16...Blood Draws 7 Vials for Clinical Study Research
17...Benadryl Reduce Side Effects Cetuximab Chemotherapy Treatment
18...Cetuximab Full Dose Blood Counts on Targets Treatment 1 Hour
19...Vitals Show Patient Stable
20...Energy Normal Stable After Treatment Cetuximab Support Drugs


..............
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CONTACTS 

SUBJECTS
Treatment Cetuximab 2nd Treatment 3rd Cycle Chemotherapy 10th Cycle

1103 -
1103 -    ..
1104 - Summary/Objective
1105 -
110501 - Follow up ref SDS 34 0000. ref SDS 30 0000.
110502 -
110503 - Treatment at O830 in the Infusion Clinic. ref SDS 0 1M6H  There was no
110504 - meeting in the Breast Care Center today because examinations occur
110505 - every other treatment, and today is the 2nd treatment of the cycle.
110506 - Treatment Brigid prescribed reducing the dose of Benadryl has been
110507 - successful elminating side effects of "restless legs. ref SDS 0 F77K
110508 - Difficulty sleeping has also disappated with increasing good news of
110509 - effective treatment. ref SDS 0 NG3I  Energy continues to increase.
110510 - ref SDS 0 CA4K  Millie took a nap for a few hours after getting home
110511 - from treatment today. ref SDS 0 BB7G
110512 -
110513 -
110514 -
110515 -
110517 -  ..
1106 -
1107 -
1108 - Progress
1109 -
110901 - Clinic Examination Orientation Starting Treatment Cetuximab
110902 -
110903 - Follow up ref SDS 34 407N, ref SDS 30 407N.
110905 -  ..
110906 - Agenda...
110907 -
110908 -    1.  Infusion Clinic........................... ref SDS 0 1M6H
110909 -    2.  Side effects.............................. ref SDS 0 QU8K
110910 -
110911 -
110912 -
110913 -
1110 -

SUBJECTS
Breast Examination Not Performed in Breast Care Clinic Prior to Trea

1903 -
190401 -  ..
190402 - Breast Examination Likely IBC 2 Scenarios Spreading Intensity Declines
190403 -
190404 - Follow up ref SDS 34 FO6H, ref SDS 30 FO6H.
190405 -
190406 - There was no examination today.
190407 -
190408 -
190409 -
1905 -

SUBJECTS
Emotional Health Not Reviewed Examination Breast Care Clinic Prior t

2503 -
250401 -  ..
250402 - Emotional Roller Coaster Endemic Cancer Treatment and Coordination
250403 -
250404 - Follow up ref SDS 34 6A7J, ref SDS 30 6A7J.
250405 -
250406 - There was no examination today.
250407 -
250408 -
2505 -

SUBJECTS
Prognosis Reviewed During Examination Breast Care Clinic Prior to Tr

3003 -
300401 -  ..
300402 - Cetuximab Prognosis IBC May Subside for 10 Months Before Progressing
300403 - Prognosis Disease May Subside 10 Months or More Before Progression
300404 - Progresssion of Disease May be Delayed for 10 Months or More
300405 -
300406 - Follow up ref SDS 34 6A9H, ref SDS 30 6A9H.
300407 -
300408 - There was no examination today.
300409 -
300410 -
300411 -
300412 -
3005 -

SUBJECTS
Measurable Disease Not Reviewed No Examination Breast Care Clinic Pr

3503 -
350401 -  ..
350402 - Measureable Disease Photographs IBC Rash Improving
350403 - IBC Rash Improved Measurable Disease Photographs Tape Measure
350404 -
350405 - Follow up ref SDS 34 6T6M, ref SDS 30 6T6M.
350406 -
350407 - There was no examination today.
350408 -
350409 -
350410 -
350411 -
3505 -

SUBJECTS
Side Effects Not Reviewed No Examination Breast Care Clinic Prior to

4003 -
400401 -  ..
400402 - Side Effects Medicated After Weekly Examinations
400403 -
400404 - Follow up ref SDS 34 FO66, ref SDS 30 FO66.
400405 -
400406 - There was no examination today.
400407 -
400408 -
400409 -
4005 -

SUBJECTS
Cetuximab 3rd Cycle 2nd Treatment 10th Total Treatment Chemotherapy

4603 -
4604 - 0830
460501 -  ..
460502 - Infusion Clinic for Cetuximab Treatent
460503 -
460504 - Follow up ref SDS 34 1M6H, ref SDS 30 1M6H.
460505 -
460506 - Millie received 10th overall and 2nd treatment of 3rd cycle with
460507 - Cetuximab, starting from 070201, ref SDS 15 G68I, and the 17th
460508 - treatment for 3rd relapse of IBC, beginning on 060721. ref SDS 4 407N
460510 -  ..
460511 - Catherine was the nurse today.
460513 -           ..
460514 -          Taxotere Capecitabine
460515 -
460516 -          Follow up ref SDS 34 PR8Q, ref SDS 30 PR8Q.
460517 -
460518 -                   Relapse Treatments
460519 -
460520 -      1.  Cycle 09 and 01 ................... 060721, ref SDS 4 407N
460521 -      2.  Cycle 10 and 02 ................... 060814, ref SDS 7 LY6O
460522 -      3.  Cycle 11 and 03 ................... 060908, ref SDS 8 407N
460523 -      4.  Cycle 12 and 04 ................... 060929, ref SDS 9 407N
460524 -      5.  Cycle 13 and 05 ................... 061020, ref SDS 10 407N
460525 -      6.  Cycle 14 and 06 ................... 061110, ref SDS 11 407N
460526 -      7.  Cycle 15 and 07 ................... 061201, ref SDS 12 407N
460528 -           ..
460529 -          Cetuxiab Clinical Study
460530 -
460531 -          Follow up ref SDS 34 7T3H, ref SDS 30 7T3H.
460532 -
460533 -                   Total    Cetuximab
460534 -      8.  Cycle 01 and 08 and 01 01.......... 070201, ref SDS 15 SG8I
460535 -      9.  Cycle 01 and 08 and 02 02.......... 070208, ref SDS 17 SG8I
460536 -     10.  Cycle 01 and 08 and 03 03.......... 070215, ref SDS 18 SG8I
460537 -     11.  Cycle 01 and 08 and 04 04.......... 070222, ref SDS 21 7T3H
460538 -     12.  Cycle 02 and 09 and 01 05.......... 070301, ref SDS 24 7T3H
460539 -     13.  Cycle 02 and 09 and 02 06.......... 070308, ref SDS 27 7T3H
460540 -     14.  Cycle 02 and 09 and 03 07.......... 070315, ref SDS 29 7T3H
460541 -     15.  Cycle 02 and 09 and 04 08.......... 070322, ref SDS 30 7T3H
460542 -     16.  Cycle 03 and 10 and 01 09.......... 070329, ref SDS 34 7T3H
460543 -     17.  Cycle 03 and 10 and 02 10.......... 070405, ref SDS 0 7T3H
460545 -  ..
460546 - Nurses Notes...
460557 -  ..
460558 - Why is the visit number constant in Nurse's Notes, and yet seems to
460559 - vary in the schedule received from Nola last week? ref SDS 29 159O
460561 -     ..
460562 -    UCSF Log Time...
460563 -
460564 -                   Blood
460565 -                    Test   Infusion
460566 -
460567 -          In.......          0830
460568 -          Out......          1130
460569 -          Visit....      Min  2.5  Hours  Total 3 Hours
460571 -      ..
460572 -     Pain Assessment...
460573 -
460574 -          x
460575 -          0123456789 10
460576 -
460577 -     <923k
460578 -     Administration Site:  Right Port Catheter
460579 -     Needle Size:          20 G 1"
460580 -     Blood Return Good:    Yes
460582 -      ..
460583 -     Remind patient to call MD if temp > 101 F, Shaking Chills
460584 -
460585 -            This protocol differs from Kaiser requirements, reported on
460586 -            041202. ref SDS 1 IX9N
460587 -
460588 -
460589 -
460590 -
4606 -

SUBJECTS
Side Effects Infusion Clinic UCSF Consultation Treatment Cetuximab A

5903 -
5904 - 0840
590501 -  ..
590502 - Side Effects Minimal...
590503 -
590504 - Follow up ref SDS 34 QU8K, ref SDS 30 QU8K.
590506 -  ..
590507 - Nurse's notes report side effects...
590508 -
590509 -        1.  Rash acne-like...... ref SDS 34 SK9O
590510 -
590511 -               Minimal facial rash continues from 070208 around the
590512 -               nose and chin, ref SDS 17 QU8K; treatment effective with
590513 -               medication prescribed on 070222. ref SDS 21 FO66
590515 -             ..
590516 -        2.  Dry skin face, chest arm...... ref SDS 34 JS6M
590517 -
590518 -               Background on notice and treatments prescribed reported
590519 -               on 070322. ref SDS 30 JS6M  Medical team commented
590520 -               during examination on 070329, how well Millie looks.
590521 -               ref SDS 33 N49K  The next day on 070330, the primary
590522 -               care physician at Kaiser commented similarly, during
590523 -               follow up examination. ref SDS 36 N49K  This indicates
590524 -               UCSF examinations by Catherine in the Infusion Clinic,
590525 -               and by Brigid in the Breast Care Center has been timely,
590526 -               thorough, and effective prescribing Curel on 070301,
590527 -               ref SDS 23 5V73, and later Aquaphor on 070322.
590528 -               ref SDS 30 JS6M
590530 -             ..
590531 -        3.  Rash on right chest....... ref SDS 34 KU3L
590532 -
590533 -               Examination of right chest observes various blemishes.
590534 -               Nurses's Notes today say no rash noted above the port,
590535 -               continuing observations the last several weeks reported
590536 -               on 070329. ref SDS 34 KU3L  On 070330 examination at
590537 -               Kaiser showed significantly increased intensity of rash
590538 -               on upper left arm, ref SDS 36 N19J, and a similar new
590539 -               rash above the right breast and below the colar bone.
590540 -               ref SDS 36 583G  Rash on the upper right chest was
590541 -               previously reported in Nurse's Notes on 070315 during
590542 -               treatment at UCSF. ref SDS 29 KU3L  Kaiser diagnosed
590543 -               Cellulitis possibly complications of lymphedema, citing
590544 -               elevated temperature, and possibly triggered by
590545 -               patient's increased exercise that overtaxed the system.
590546 -               ref SDS 36 7C7F  Keflex antibiotics was prescribed,
590547 -               ref SDS 36 474O; about 3 hours later self-examination
590548 -               showed these erruptive rash conditions had subsided, and
590549 -               so Keflex treatment was not performed. ref SDS 36 KZ6L
590550 -               Examination today finding no evidence of rash on the
590551 -               upper right chest and below the collar bone aligns with
590552 -               patient history of erratic rash, rather than advancing
590553 -               IBC. ref SDS 14 5N6L
590555 -             ..
590556 -        4.  Rash right arm............... ref SDS 34 LI4M
590557 -
590558 -               Catherine does not comment on this issue in Nurse's
590559 -               Notes today.  Examination by the medical team on 070329
590560 -               found no evidence of disease in the right arm.
590561 -               ref SDS 33 H15M
590563 -             ..
590564 -        5.  Restless legs side effect Benedryl...... ref SDS 34 F77K
590565 -
590566 -               This was resolved on 070329 by Brigid changing the
590567 -               chemotherapy order to reduce the dose of Benadryl
590568 -               pre-treatment. ref SDS 33 MF4N
590570 -             ..
590571 -        6.  Sleeping difficulty................. ref SDS 34 NG3I
590572 -
590573 -               This problem has subsided as worry and doubt have been
590574 -               reduced by continuing favorable reports showing response
590575 -               to treatment, discussed with the medical team during
590576 -               examination on 070329. ref SDS 33 Y642
590577 -
590579 -             ..
590580 -        7.  Lymphedema Cellulitis Complications...... ref SDS 34 SU6L
590581 -
590582 -               Lymphedema continues relatively controlled with major
590583 -               swelling in the left arm, measured this morning before
590584 -               treatment 11.25, and shown by the study on 060509.
590585 -               ref SDS 2 HO7F  There is no evident association with
590586 -               cetuximab treatments.  Proximate cause was left breast
590587 -               mastectomy with removal of lymph nodes in the left
590588 -               axillary, complicated by exercise to strengthen the
590589 -               immune system for resisting cancer, and by cat bites
590590 -               that flow from engaging pets for qualify of life,
590591 -               reported in the case study on 070130. ref SDS 14 VX6F
590593 -                ..
590594 -               Increased intensity of rash on the upper left arm was
590595 -               reported on 070330 during examination at Kaiser by
590596 -               primary care physician. ref SDS 36 N19J   This was bone,
590597 -               ref SDS 36 583G; these dramatic changes in diagnosed
590598 -               without biopsy as complications of lymphedema causing
590599 -               Cellulitis with elevated temperature, and possibly
590600 -               triggered by patient's increased exercise that overtaxed
590601 -               the system. ref SDS 36 7C7F  Keflex antibiotics was
590602 -               prescribed, ref SDS 36 474O; about 3 hours later
590603 -               self-examination showed these erruptive rash conditions
590604 -               had subsided, and so Keflex treatment was not performed.
590605 -               ref SDS 36 KZ6L   Today, there is no evidence of
590606 -               increased rash intensity of the upper left arm.
590607 -
590609 -             ..
590610 -        8.  Tired, fatigued - pulmonary emoblism... ref SDS 34 FG3N
590611 -
590612 -               Fatigue, shortness of breath and other symptoms of
590613 -               pulmonary embolism were presented during meeting on
590614 -               070130, ref SDS 14 CV5L, citing case study listed on
590615 -               060722. ref SDS 5 ZV41
590617 -                ..
590618 -               Energy that seemed to be declining leading up to
590619 -               treatment on 070301, ref SDS 24 CA4K, has continued to
590620 -               rise back to normal, as reported last week on 070322.
590621 -               ref SDS 30 CA4K  Millie continues working out in the
590622 -               gym, and has started hiking the trail at Lafayette
590623 -               Reservoir again, as reported to the medical team during
590624 -               examination on 070329. ref SDS 33 E44L  Increased
590625 -               exercise in the morning on 070330 may have triggered
590626 -               symptoms of Cellulitis diagnosed during examination
590627 -               later in the afternoon on 070330. ref SDS 36 7C7F
590629 -             ..
590630 -        9.  Heavy chest - shortness of breathing..... ref SDS 34 UL6L
590631 -
590632 -               Patient history was reported to UCSF on 070130.
590633 -               ref SDS 14 RT6I
590634 -
590635 -               Condition seems improved, tracking continuing higher
590636 -               energy, per above. ref SDS 0 CA4K
590637 -
590639 -             ..
590640 -       10.  Cough - clearing throat............... ref SDS 34 8N4G
590641 -
590642 -               This condition occassionally increases noticably with
590643 -               episodes of mild, contined cough and clearing throat, as
590644 -               reported to the doctor on 070130. ref SDS 14 RT6I
590645 -
590647 -             ..
590648 -       11.  Dry hands and feet................ ref SDS 34 UM32
590649 -
590650 -               Dry hands and feet seem much improved since ending
590651 -               treatment with Taxotere and capecitiabine on 061201.
590652 -
590654 -             ..
590655 -       12.  Eyes tearing...................... ref SDS 34 HM9G
590656 -
590657 -               This seems improved since ending treatment with Taxoter
590658 -               and capecitabine on 061201.
590659 -
590661 -             ..
590662 -       13.  Nausea and vomitting................. ref SDS 34 D19M
590663 -
590664 -               Problems with Taxotere and capecitabine reported on
590665 -               061110, ref SDS 11 D19M, did not occur this past week
590666 -               after treatment with cetuximab.  As a result, there was
590667 -               no pre-treatment with Decadron today, per below.
590668 -               ref SDS 30 G57I
590670 -             ..
590671 -       14.  Sores in mouth................... ref SDS 34 KW4R
590672 -
590673 -               None yet, cleaning mouth carefully to avoid problem.
590674 -
590675 -
590676 -
590677 -
5907 -

SUBJECTS
Schedule Treatment Weekly Thursday 0800 4 Week Cycles Clinical Study

6503 -
650401 -  ..
650402 - Schedule Weekly Treatments Continue on Thursdays
650403 -
650404 - Follow up ref SDS 34 QK6L, ref SDS 30 QK6L.
650406 -  ..
650407 - Millie's next treatment is scheduled for 070412 0800, reported by Nola
650408 - on 070315. ref SDS 29 159O
650409 -
650410 -
650411 -
650412 -
6505 -

SUBJECTS
Port Catheter IV Connection Prepare for Drip Treatment 1 Try Require

7203 -
7204 - 0850
720501 -  ..
720502 - Preparation for Treatment Required One (1) Attempt to Connect Port
720503 -
720504 - Follow up ref SDS 34 EB7J, ref SDS 30 EB7J.
720506 -  ..
720507 - The nurse connected the IV tubes to the port....
720509 -       ..
720510 -      Interlink System Vented Paclitaxel set
720512 -  ..
720513 - Like last week and earlier on 070301, there were no problems getting
720514 - blood to flow from the port, ref SDS 24 EB7J, as occurred on 070222,
720515 - ref SDS 20 DC5W, and earlier on 070201. ref SDS 15 DC5W
720517 -  ..
720518 - The nurse flushed the port with saline.
720519 -
720520 -
720521 -
720522 -
7206 -

SUBJECTS
Blood Draws None Today 7 Vials Clinical Study Research Cetuximab Dru

7903 -
790401 -  ..
790402 - Blood Draws 7 Vials for Clinical Study Research
790403 -
790404 - Follow up ref SDS 34 O56V, ref SDS 30 O56V.
790405 -
790406 - Blood draws for the clinical study occur only to start a new cycle; so
790407 - there were no blood draws today during the 2nd treatment of cycle 3.
790408 -
790409 -
790410 -
790411 -
790412 -
7905 -

SUBJECTS
Benadryl Pre-treatment Prepares Patient for Cetuximab Chemotherapy A

8503 -
8504 - 0900
850501 -  ..
850502 - Benadryl Reduce Side Effects Cetuximab Chemotherapy Treatment
850503 -
850504 - Follow up ref SDS 34 DC7J, ref SDS 30 DC7J.
850505 -
850506 - Benadryl (diphenhydramine) started.   50 MG....... ref SDS 30 IJ41
850507 -
850508 -        Purpose reported on 060721. ref SDS 4 DC7J
850510 -  ..
850511 - Chemotherpay order calls for Benadryl (diphenhydramine) pre-treatment
850512 - 30 - 60 minutes prior to cetuximab infusion, shown below. ref SDS 0
850513 - IJ41
850514 -
850516 -  ..
8506 -
8507 -
8508 - 0915
8509 -
850901 - Benedryl completed equipment beeps.
850903 -  ..
850904 - Millie reported that decreasing the dose of Benadryl pre-treatment to
850905 - 25 mg completely eliminated previous problems of "restless legs," per
850906 - above. ref SDS 34 F77K
850907 -
850908 -
850910 -  ..
8510 -
8511 -
8512 -
8513 -
851301 - Decadron (dexamethasone) IV pre-treatment........ ref SDS 30 FM4M
851302 -
851303 - On 070208 Decadron was not given because Millie did not experience
851304 - side effects of nausea and vomitting after treatment with cetuximab on
851305 - 070201. ref SDS 17 G57I  Since this favorable condition continues, per
851306 - above, ref SDS 30 D19M, Decadron was not given again today.
851307 -
851309 -  ..
8514 -
8515 -
8516 -
851601 - Decadron completed -- not reported.
851602 -
851603 -
851604 -
851605 -
8517 -

SUBJECTS
Cetuximab 3rd Cycle 2nd Treatment Clinical Study Drug Trial Treatmen

9403 -
9404 - 0920
940501 -  ..
940502 - Cetuximab Full Dose Blood Counts on Targets Treatment 1 Hour
940503 -
940504 - Follow up ref SDS 34 4N5M, ref SDS 30 4N5M.
940506 -  ..
940507 - Cetuximab started.
940508 -
940509 -           Verify chemotherapy order for 070208.
940511 -  ..
940512 - Chemotherapy order calls for cetuximab to start 30 - 60 minutes after
940513 - Beyadryl pre-tretment. ref SDS 30 IJ41
940515 -  ..
940516 - Chemotherapy Orders...
940517 -
940523 -    Auth#                                     Stor BCC LOC
940524 -    Visit:  12575738             DOS 20070201
940526 -     ..
940527 -    Date:  20070201
940529 -     ..
940530 -    Study Order for CC#05752:  Phase II Trial of Cetuximab alone and
940531 -    in combination with Carboplatin in ER-negative, PR-negative,
940532 -    HER2-negative Nonoverexpressing Metastatic Breast Cancers
940534 -     ..
940535 -    Dates to be given:  070201
940536 -    Arm 1:Cetuximab alone
940538 -     ..
940539 -    Diagnosis:  breast cancer
940541 -     ..
940542 -    ICD-9 codes: 174.9
940543 -    Allergies  NKDA
940545 -     ..
940546 -    Pre-medications 30 - 60 minutes prior to cetuximab infusion
940548 -     ..
940549 -    3. Diphenhydramine 25 mg IV or  [illegible writing]
940550 -
940551 -       Benadryl........... ref SDS 30 DC7J
940552 -
940553 -       Earlier this morning, Brigid changed the Chemotherapy Order
940554 -       reducing Diphenhydramine (Benadryl) from 50 mg to 25 mg in order
940555 -       to reduce side effects of "restless legs," per above.
940556 -       ref SDS 34 F77K
940558 -        ..
940559 -       This was effective, reported above. ref SDS 34 7R6H
940561 -     ..
940562 -    4. Dexamethasone (??) 10 mg IB or 20 mg IV [handwritten ???]
940563 -
940564 -       Further premed TBD [barely legible handwriting??]
940566 -     ..
940567 -    Medication:  (plan to give weekly ********STUDY SUPPLY**********
940569 -     ..
940570 -    5. Cetuximab (Erbitux) (loading dose)
940571 -
940572 -              400 mg/m [squared] = 684 mg IV over 120 minutes for
940573 -              first dose x 1
940574 -
940575 -       dose on dcte 20070201   Maximum infusion rate is 5 ml/minute
940576 -       (concentration 2 mg/ml)
940578 -     ..
940579 -    6. Cetuximab (Erbitux) (maintenance dose)
940580 -
940581 -              250 mg/m [squared] = 428 mg IV (or ____ mg/m[squared] =
940582 -              ____mg) IV over 60 or ____ minutes.
940583 -
940584 -       Maximum infusion rate is 5 ml/minute (concentration 2 mg/ml)
940585 -       Infuse once weekly for 8 weeks.  First dose to be given on date
940586 -       20070201.
940588 -        ..
940589 -       Cetuximab is administered undiluted through a low protien
940590 -       binding 0.22 micro in-line filter.  Use NS solution to flush the
940591 -       line at the end of the infusion.
940593 -        ..
940594 -       ARM 2:  Administer carboplatin of vital signs are unremarkable
940595 -       one hour after cetuximab infusion.
940597 -        ..
940598 -       Vital signs at baseline, upon cetuximab completion and one hour
940599 -       after cetuximab.
940600 -
940601 -       ****please note start and stop times****
940603 -        ..
940604 -       Laboratory work:
940605 -
940606 -          See carboplatin orders
940608 -        ..
940609 -       x  Notify MD for dose modifications if patient has severe
940610 -          acne in form rash
940611 -
940612 -          CBC with differential and platletes every 4 weeks
940613 -          Creatinine and magnesium every 4 weeks
940614 -          BUN AST Alk phos Alt Total bilrubin, electrolyes every 8
940615 -          weeks.  If levels are outside of normal laboratory values
940616 -          notify Brigid NP  (MD/RN) at 415 443 4730
940618 -        ..
940619 -       x  Physician has discussed risks/benefits of therapy with the
940620 -          patient.  Signed consent obtained.
940621 -
940622 -
940623 -          Yes  No   O2 by nasal cannula at 2 liters/min prn for chest
940624 -          pain or SOB
940626 -           ..
940627 -          Yes  No   Diphenhydramine 50 mg IV prn x1 for urticaria
940628 -          [barely legible], pruritis SOB
940630 -           ..
940631 -          Yes  No   Hydrocortizone 100 mg IV prn x1 for urticaria
940632 -          [barely legible], pruritis SOB
940634 -           ..
940635 -          Yes  No   Albuterol inhaler 2-4 puffs prn SOB or chest
940636 -          tightness
940638 -           ..
940639 -          Yes  No   Epinephrine 1x1000 (1 mg/ml) 0.3 mg IV prn
940640 -          anaphylaxis
940642 -           ..
940643 -          Breast CC05752 Cetuximab doc 20061024
940644 -          Approved 20060615
940646 -           ..
940647 -          Physician signature [Hope Rugo]
940649 -           ..
940650 -          Provider#  35313
940652 -           ..
940653 -          Date:  20010131
940654 -
940656 -  ..
9407 -
9408 -
9409 - 1020
9410 -
941001 - Cetuximab treatment completed.
941002 -
941003 - Millie had a 1 hour rest and observation period, required by the
941004 - protocol. ref SDS 30 G679
941005 -
941006 -
941007 -
941009 -  ..
9411 -
9412 -
9413 - 1130
9414 -
941401 - Diane disconnected the IV tubes.
941403 -  ..
941404 - She inserted Herceptin to flush the port.
941406 -  ..
941407 - She then removed the needle from the port, and swabbed the needle
941408 - wound, and placed a temporary bandage.
941409 -
941410 -
941411 -
941412 -
941413 -
9415 -

SUBJECTS
Vitals Blood Pressure Pulse Temperature Sa02 Weight Infusion Treatme

A103 -
A104 - 0900
A10501 -  ..
A10502 - Vitals Show Patient Stable
A10503 -
A10504 - Follow up ref SDS 34 AW4L, ref SDS 30 AW4L.
A10505 -
A10506 -                    Blood
A10507 -    Date   Time     Pressure   Pulse  Temprtr  Weight   So2
A10508 -
A10509 -        [On 070329 followed up. ref SDS 33 XU6M
A10511 -     ..
A10512 -    070405 1130..... 133  75     55     36.2c            97
A10513 -    070405 1030..... 114  69     57     36.4c            99
A10514 -    070405 0900..... 128  78     54     36.5c           100
A10515 -    070329 1140..... 125  74     53     36.8c            98
A10516 -    070329 1045..... 125  72     53         c           100
A10517 -    070329 0900..... 141  76     60     36.6c            99
A10518 -    070322 1055..... 118  71     55     37.0c            97
A10519 -    070322 1015..... 120  69     57     37.1c            98
A10520 -    070322 0900..... 130  70     56     36.0c            98
A10521 -    070315 1300..... 119  75     58     36.2c            98
A10522 -    070315 1150..... 137  73     52     36.5c            99
A10523 -    070315 0945..... 143  85     60     36.4c            97
A10524 -    070308 1100..... 144  87     70     36.0c            98
A10525 -    070301 1645..... 125  62     90 *   36.4c
A10526 -    070301 1505..... 112  69     86 *   36.6c            98
A10527 -    070222 1145..... 115  73     58     36.3c   147      98
A10528 -    070222 1045..... 100  60     56     36.6c   147      98
A10529 -    070222 0930..... 117  63     68     36.2c   147      97
A10530 -    070215 1200..... 106  66     61     37.0c   147      97
A10531 -    070215 1055.....  96  61     64     37.0c   147      94
A10532 -    070215 0930..... 100  64     66     36.7c   147      98
A10533 -    070208 0920..... 143  70     59     36.5c   147      98
A10534 -    070201 1330..... 136  74     66             148      94
A10535 -    070201 1220..... 110  65     62     36.3c   148      96
A10536 -    070201 1000..... 132  80     65     36.9c   148      99
A10537 -    061201 1534..... 123  76     76     97.5    150
A10538 -    061110 1534..... 136  83     73     97.0    150      98
A10539 -    061020 1534..... 140  79     67     99.8    151      97
A10540 -    060929 1452..... 141  78     66     98.3    149
A10541 -    060908 1335..... 139  79     73     98.1    149
A10542 -    060814 1610..... 139  80     59     98.2    151
A10543 -    060722 1440..... 142  74     67     98.1    149
A10544 -    060711.......... 172  87     54     97.5    147
A10545 -    060623.......... 141  87     71     98.0    147
A10546 -    060428.......... 129  73     80     99.4    149
A10547 -    060217.......... 153  81     61     98.6    150
A10548 -    050916.......... 120  80     80     98.5
A10549 -
A10550 -  *  Need vitals taken twice to verify atypical diagnostics.
A10551 -
A10552 -
A10553 -
A10554 -
A106 -

SUBJECTS
Energy Normal Stable Alert Drive Home After Treatment Tired Sleep 2
Cetuximab Chemotherapy Treatments Cancer IBC

AE04 -
AE05 - 1130
AE0601 -  ..
AE0602 - Energy Normal Stable After Treatment Cetuximab Support Drugs
AE0603 -
AE0604 - Follow up ref SDS 34 F54N, ref SDS 30 F54N.
AE0606 -  ..
AE0607 - On 060724 diary side effects for cetuximab chemotherapy treatment on
AE0608 - clinical study drug trial. ref SDS 6 YP4I
AE0610 -  ..
AE0611 - Millie was alert after treatment again today, and not wobbly nor
AE0612 - disoriented.  She was able to drive home without side effects of
AE0613 - treatment.
AE0615 -  ..
AE0616 - After arriving home about 1215, Millie had a light lunch, and then
AE0617 - took a nap from about 1300 until about 1500.  This may relate to side
AE0618 - effects from cetuximab treatments that cause fatigue, reported on
AE0619 - 070116. ref SDS 13 O64M
AE0620 -
AE0621 -
AE0622 -
AE0623 -
AE0624 -
AE0625 -
AE0626 -
AE07 -