THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: August 14, 2006 04:00 PM Monday; Rod Welch

Millie at Kaiser 10th cycle Xeloda Taxotere IBC relapse.

1...Summary/Objective
2...Schedule Next Treatment Change to Mondays Side Effects Experiment
3...Blood Counts Good Dose Chemotherapy Taxol Normal
4...ACN 6972 Well Above 1500 Criteria for Blood Counts Approve Treatment
5...ANC Blood Count Formula Clarified Patient Meets Test for Treatment
6...CA 15-3 87 No Change Not Tested with Current Blood Test for Chemo
7...Preparation for Treatment Required One (1) Attempt to Connect Port
8...Taxotere Full Dose Blood Counts on Targets
9...Vitals Show Patient Stable
10...Pharmacist Orders Capecitabine Decadron Instructions
11...Tired Wobbly After Treatment Taxotere Support Drugs


..............
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CONTACTS 

SUBJECTS
10th Cycle Treatment Taxotere Xeloda Capacitibine Chemotherapy Treat

0503 -
0503 -    ..
0504 - Summary/Objective
0505 -
050501 - Follow up ref SDS 84 0000, ref SDS 79 0000.
050502 -
050503 - Millie's blood count was well above criteria for treatment.
050504 - ref SDS 0 P560  For some reason Kaiser did not perform CA 15-3 needed
050505 - to assess changing treatment protocol based on trend analysis.  Diana
050506 - ordered the test, which can be performed sometime this week.
050507 - ref SDS 0 2N5J
050508 -
050509 -    [On 060817 CA 15-3 73 dramatic improvement, reversing 6 month rise
050510 -    of cancer marker, now falling back below critical 80 level,
050511 -    ref SDS 85 TS5O; supports observation impression on 060808 that IBC
050512 -    red rash subsiding and breaking up, ref SDS 83 VO6G, further
050513 -    reported on 060817, ref SDS 85 NU6L, evidence patient experiencing
050514 -    delayed response to treatment under scenario #1, developed on
050515 -    060808. ref SDS 83 J16O
050516 -
050517 -
050518 -
050520 -  ..
0506 -
0507 -
0508 - Progress
0509 -
050901 - When Millie registered at the counter today for treatment in the
050902 - Oncology Department, the attendant handed her an envelope with the
050903 - packet of documents that Arlette printed from Kaiser's records.  This
050904 - follows up planning on 060810, when Arlette offered to prepare
050905 - documents for 2nd opinion review. ref SDS 84 U76O
050906 -
050907 -     [On 060819 organize Kaiser's documents to facilitate 2nd opinion
050908 -     review by UCSF. ref SDS 86 LK4M
050910 -      ..
050911 -     [On 061011 commend Kaiser and Arlette for extra work providing a
050912 -     packet of documents to facilitate 2nd opinion review by UCSF,
050913 -     reducing the cost by 30%, which saved the customer $200.
050914 -     ref SDS 87 QY4I
050916 -  ..
050917 - Received treatment to begin 10th cycle overall of chemotherapy with
050918 - Taxotere and Xeloda, and 2nd cycle of treatment for 3rd relapse of
050919 - IBC, planned by the primary care physician on 060711. ref SDS 78 PF3O
050920 - Scheduling and treatment were reviewed by the backup doctor on 060808
050921 - due to rising IBC symptoms after 1st cycle, and decision was made to
050922 - continue treatment plan with Taxotere and Xeloda. ref SDS 83 N96O  The
050923 - 1st cycle (9th overall) was performed on regular schedule at Kaiser on
050924 - 060721. ref SDS 79 407N  Work today was deferred from the regular
050925 - schedule for the 2nd cycle to treat relapse due to low blood counts on
050926 - 060810. ref SDS 84 5K4F
050928 -  ..
050929 - Diana said the blood counts are good today.  This was confirmed by the
050930 - report showing counts are well above requirements for treatment.
050931 - ref SDS 0 P560
050933 -  ..
050934 - Millie had a blood draw on Sunday, 060813, per planning on 060810.
050935 - ref SDS 84 CN7I
050936 -
050939 -
050940 -
050941 -
050942 -
050943 -
0510 -

SUBJECTS
Schedule Treatment Regular 3-week Cycle on Monday 060904 Labor Day E

0803 -
080401 -  ..
080402 - Schedule Next Treatment Change to Mondays Side Effects Experiment
080403 -
080404 - Follow up ref SDS 79 QK6L.
080405 -
080406 - The original plan was for treatments on Friday, to fit Millie's
080407 - schedule of having Friday and Monday off-work, which gives time to
080408 - recover from ill feelings caused by Taxotere, reported on 060721,
080409 - ref SDS 79 QK6L, and citing case study on side effects reported on
080410 - 050422. ref SDS 52 JY3N
080411 -
080412 -     [On 060817 followed up. ref SDS 85 7Q8H
080414 -  ..
080415 - Diana said that she cannot change the schedule back to Friday, because
080416 - that day is already booked.  Extra effort would be needed to support
080417 - patient requirements.  The nurse was also concerned that advancing
080418 - treatment 3 days from Monday to Friday would not be enough time for
080419 - blood counts to recover, as occurred on 060810, ref SDS 84 5K4F, and
080420 - this would require getting approval of the doctor or cause another
080421 - delay.  She said that delaying the next treatment to the following
080422 - Friday would, also, require the nursing staff to get approval of the
080423 - doctor for allowing chemotherapy to be diluted across a greater time
080424 - span which reduces theraputic benefits to the patient.  These choices
080425 - to support the patient are stressful for the nursing staff, as
080426 - explained on 060810, ref SDS 84 NW9K
080428 -  ..
080429 - Diana proposed that Millie experiment and try treatments on Monday,
080430 - and indicted that if this turns out to be inconvenient, then another
080431 - nurse can consider making the effort to adjust the schedule to fit the
080432 - patient's requirements by switching back to Friday.
080434 -  ..
080435 - Millie agreed.
080437 -  ..
080438 - As a result, Diana submitted the following schedule...
080439 -
080440 -       060903 1330.... Blood Draw
080441 -       060904 1330.... Chemotherapy Taxotere 11th Cycle
080443 -  ..
080444 - Actually, this is Labor Day, a holiday.  Sounded like Diana went
080445 - ahead and scheduled the work on this day to align with treatment on
080446 - Mondays, and further scheduled Millie to get a blood draw the day
080447 - before on 060903 to evaluate ready for treatment.
080448 -
080449 -
080450 -
080451 -
080452 -
080453 -
080454 -
0805 -

SUBJECTS
Blood Tests Chemotherapy White Cell Count Good 10th Cycle Taxotere C

1203 -
120401 -  ..
120402 - Blood Counts Good Dose Chemotherapy Taxol Normal
120403 -
120404 - Follow up ref SDS 84 Q659, ref SDS 79 Q659.
120406 -  ..
120407 - Diana submitted the report showing...
120408 -
120409 -    Patient   Provider  Category   View      FR Date   To Date
120415 -     ..
120416 -    Procedure              Results             Reference Range
120417 -
120420 -
120421 -                  ** Marina Way South **
120423 -     ..
120424 -    Test Name            Value Unit     <-------- RANGE-------->
120425 -    @CBC
120426 -    WBC x 10-3               8.4 K/uL           3.5   -     12.5
120427 -    RBC x 10-6              4.08 M/uL           3.60  -      5.70
120428 -    Hemoglobin              13.2 g/dL          11.5   -     15.0
120429 -    Hematocrit              38.2 %             34.0   -     46.0
120430 -    MCV                       94 fL            80.0   -    100.0
120431 -    RDW                     14.3 %             11.9   -     14.3
120432 -    Plt x10-3              248   K/uL         140     -    400
120433 -     ..
120434 -    Neutrophils               83 %             50     -     70
120435 -    Lymphocytes     L         16 %             20     -     50
120436 -    Monocyte                   0 %              0     -     11
120437 -    Eosinophils                0 %              1     -      5
120438 -    Basophil                   0 %              0     -      2
120439 -     ..
120440 -    Bands             No Report  %              0     -      5
120442 -     ..
120443 -    CA 15-3           No Report  U/mL          -<     -     39
120445 -     ..
120446 -    Alkaline Phos     No Report  U/L           38     -    126
120447 -    Bili, Tot Adult   No Report  mg/dL        0.2     -    1.3
120448 -    Creatinine        No Report  mg/dL        0.6     -    1.2
120449 -    AST (SGOT       H No Report  U/L           14     -     36
120450 -    ALT (SGPT         No Report  U/L           11     -     66
120452 -     ..
120453 -    RBC Morphology    No Report
120454 -    Poikilocytosis  * No Report
120455 -    Anisocytosis    * No Report
120456 -    Schistocytes    * No Report
120457 -    PLT Estimate      No Report
120458 -    PLT Morphology    No Report
120459 -
120460 -
120461 -
120462 -
1205 -

SUBJECTS
Absolute Neutrophils Count ANC Formula Clarified Composite Blood Tes

1503 -
150401 -  ..
150402 - ACN 6972 Well Above 1500 Criteria for Blood Counts Approve Treatment
150403 - ANC Blood Count Formula Clarified Patient Meets Test for Treatment
150404 -
150405 - Formula for ANC, from record on 050128. ref SDS 44 TZ3N
150407 -  ..
150408 - Calculation from 060810 yielded 1376. ref SDS 84 9C5N
150410 -  ..
150411 - Diana clarified the formula for ANC
150413 -  ..
150414 - She said bands are added to neutrophis to get the total number for
150415 - calculating with WBC.
150416 -
150417 -                  WBC               =   8.4........ ref SDS 0 0N7Q
150418 -                  Neutrophils       =   0.83....... ref SDS 0 8W7S
150419 -                  Bands             -   0.......... ref SDS 0 2Q5O
150421 -             ..
150422 -            ANC = 8.4 x 1000 x (0.83 + 0) = 6972
150423 -
150424 -               [On 070301 research on neutropenia explains
150425 -               calcualtion of ANC at Kaiser and NEUTS at UCSF.
150426 -               ref SDS 88 516G
150427 -
150428 -
150429 -
150430 -
1505 -

SUBJECTS
CA 15-3 87 No Change Not Tested with Current Blood Test for Chemo

1703 -
170401 -  ..
170402 - CA 15-3 87 No Change Not Tested with Current Blood Test for Chemo
170403 -
170404 - Follow up ref SDS 84 2N5J, ref SDS 79 2N5J.
170406 -  ..
170407 - Last test was reported on 060810. ref SDS 84 2N5J
170409 -  ..
170410 - For some reason CA 15-3 was not performed for this blood test.
170411 - ref SDS 84 564H
170413 -  ..
170414 - Diana ordered another CA 15-3 test which Millie can get tomorrow to
170415 - assess efficacy of treatment, reported on 060810. ref SDS 84 5T9J
170416 - This test will support review on 060821 by Doctor Benz at UCSF.
170417 -
170418 -    [On 060817 CA 15-3 73 dramatic improvement, reversing 6 month rise
170419 -    of cancer marker, now falling back below critical 80 level,
170420 -    ref SDS 85 TS5O; supports observation impression on 060808 that IBC
170421 -    red rash subsiding and breaking up, ref SDS 83 VO6G, further
170422 -    reported on 060817, ref SDS 85 NU6L, evidence patient experiencing
170423 -    delayed response to treatment under scenario #1, developed on
170424 -    060808. ref SDS 83 J16O
170425 -
170426 -
170427 -
170428 -
1705 -

SUBJECTS
Port Connection Prepare for Treatment 1 Try Required Diana Excellent

2003 -
2004 - 1417
200501 -  ..
200502 - Preparation for Treatment Required One (1) Attempt to Connect Port
200503 - -----------------------------
200504 - Follow up ref SDS 79 EB7J, ref SDS 69 EB7J.
200506 -  ..
200507 - Julie did the administration again with Diana to verify Millie gets
200508 - the correct treatment.
200510 -  ..
200511 - Millie explained having taken Decadron tablets according to the
200512 - prescription to take two tablets twice a day, per instructions on
200513 - 050415. ref SDS 51 8U4O
200515 -  ..
200516 - Decadron was given by Diana again before treatment today, and Millie
200517 - will take another dose of Decadron tomorrow as part of chemotherapy
200518 - treatment today.
200519 -
200520 -        Generic name:  dexamethasone
200521 -
200522 -              http://www.tirgan.com/decadron.htm
200524 -         ..
200525 -        Description and purpose of Decadron is reported in the record
200526 -        on 060721. ref SDS 79 4I4Q
200528 -  ..
200529 - Compazine - Diana gave Millie a pill prior to treatment that reduces
200530 - nausea rather than as a drip treatment to avoid allergic reaction.
200531 -
200532 -        Generic name:  Prochlorperazine
200533 -
200534 -        Purpose of Compazine is reported on 060721. ref SDS 79 WD4M
200536 -  ..
200537 - Ativan - was not part of treatment today, previously given on 060721.
200538 - ref SDS 79 FZ5M
200539 -
200540 -        Generic name:  benzodiazepines
200541 -
200542 -        Purpose of Atiman reported on 060721. ref SDS 79 NF6K
200543 -
200544 -
200545 -
200547 -  ..
2006 -
2007 -
2008 - 1609
2009 -
200901 - Diana connected the IV tubes to the port....
200903 -       ..
200904 -      Interlink System Vented Paclitaxel set
200906 -  ..
200907 - This was done without incident, very professional and competent.
200908 -
200909 -
200910 -
2010 -

SUBJECTS
Benadryl Drip Treatment Prepares Patient for Chemotherapy Avoid Feve

2203 -
2204 - 1416
220501 -  ..
220502 - Benadryl started.
220503 -
220504 -              http://www.oncolink.org/treatment/article.cfm?c=2&s=10&id=150
220505 -
220506 -        Generic name:  diphenhydramine
220507 -
220508 -        Purpose reported on 060721. ref SDS 79 DC7J
220509 -
220510 -
220512 -  ..
2206 -
2207 -
2208 - 1629
2209 -
220901 - Benedryl completed.
220902 -
220903 -
220904 -
220905 -
2210 -

SUBJECTS
Taxotere 102 MG Drip Treatment 10th Cycle Taxotere Capecitiabine (Xe

2503 -
2504 - 1633
250501 -  ..
250502 - Taxotere Full Dose Blood Counts on Targets
250503 -
250504 - Follow up ref SDS 79 4N5M, ref SDS 69 4N5M.
250506 -  ..
250507 - Taxotere started - 102 MG.
250509 -  ..
250510 - There was no patient evaulation process today, which fits the
250511 - procedure the first time Millie was treated with Taxotere on 020610,
250512 - ref SDS 2 MR5I; later, on 050415 Kaiser performed patient evaluation
250513 - of side effects for Taxotere treatment. ref SDS 51 4333
250514 -
250515 -
250516 -
250518 -  ..
2506 -
2507 -
2508 - 1732
2509 -
250901 - Equipment beeped indicating treatment is over.
250902 -
250903 - Taxotere treatment completed.
250905 -  ..
250906 - Diana disconnected the IV tubes.
250908 -  ..
250909 - She inserted Herceptin to flush the port.
250911 -  ..
250912 - She then removed the needle from the port, and swabbed the needle
250913 - wound, and placed a temporary bandage.
250914 -
250915 -
250916 -
250917 -
250918 -
2510 -

SUBJECTS
Vitals Blood Pressure Pulse Temperature Taxotere 102 MG Drip Treatme

2803 -
2804 - 1440
280501 -  ..
280502 - Vitals Show Patient Stable
280503 -
280504 - Follow up ref SDS 79 AW4L.
280505 -
280506 - Diana took vitals before starting Benedryl drip treatment...
280507 -
280508 -                    Blood
280509 -    Date   Time     Pressure   Pulse  Temprtr  Weight
280511 -     ..
280512 -    060814 1610..... 139  80     59     98.2
280513 -    060722 1440..... 142  74     67     98.1
280514 -    060711.......... 172  87     54     97.5    147
280515 -    060623.......... 141  87     71     98.0    147
280516 -    060428.......... 129  73     80     99.4    149
280517 -    060217.......... 153  81     61     98.6    150
280518 -    050916.......... 120  80     80     98.5
280519 -
280520 -
280521 -
280522 -
2806 -

SUBJECTS
Pharmacist Orders Capecitabine Decadron Instructions Dose Capecitabi

3303 -
3304 - 1420
330501 -  ..
330502 - Pharmacist Orders Capecitabine Decadron Instructions
330503 -
330504 - Follow up ref SDS 79 TZ4I, ref SDS 78 N96O.
330505 -
330506 - Zan called Millie at home, and advised that he has placed an order
330507 - for Millie's medication.
330508 -
330510 -  ..
3306 -
3307 -
3308 - 1522
3309 -
330901 - Arrived at hospial.  Millie went to the pharmacy on the 2nd floor and
330902 - purchased the drugs ordered by Zan earlier today.
330903 -
330904 -
330905 -
330906 -
330907 -
3310 -

SUBJECTS
Tired Wobbly Alert to Drive Home Asleep by 1910 Today after Treatmen

3703 -
3704 - 1733
370501 -  ..
370502 - Tired Wobbly After Treatment Taxotere Support Drugs
370503 -
370504 - Follow up ref SDS 79 F54N, ref SDS 69 F54N.
370505 -
370506 - Millie was a little disoriented after treatment today.  She was not
370507 - treated with Ativan, as was done on 060721, ref SDS 79 F54N, and so
370508 - Mil was alert enough to drive home.
370510 -  ..
370511 - On 060724 diary side effects for 2nd phase taking Taxotere and
370512 - capecitabine (Xeloda). ref SDS 80 QX8K
370513 -
370514 -
370516 -  ..
3706 -
3707 -
3708 - 1802
3709 -
370901 - Fixed a salad for Millie.  Millie ate, and was asleep by 1830.
370902 -
370904 -  ..
3710 -
3711 -
3712 - 1910
3713 -
371301 - Woke Millie up and she took the 1.5 Xeloda tablets starting treatment
371302 - today, per Zan's instructions on 060721. ref SDS 79 J492
371303 -
371304 -
371305 -
371306 -
3714 -