CONTACTS 

SUBJECTS
Meeting UCSF Infusion Clinic Agenda Cetuximab Carboplatin 2nd Arm Cl

1003 -
1003 -    ..
1004 - Summary/Objective
1005 -
100501 - Follow up ref SDS 53 0000. ref SDS 51 0000.
100502 -
100503 -
100504 -
100505 -
100506 -
100508 -  ..
1006 -
1007 -
1008 - Progress
1009 -
100901 - The first treatment on the clinical study began on 070201 with
100902 - cetuximab alone, ref SDS 4 G68I, and continued for 14 cycles.
100904 -  ..
100905 - Today is the 2nd treatment of the 2nd cycle with cetuximab and
100906 - Carboplatin together.  This is the 6th treatment overall with
100907 - cetuximab and the 3rd treatment overall with Carboplatin starting the
100908 - 2nd cycle of the 2nd arm for the clinical study.
100910 -  ..
100911 - Catherine is out sick today, and Diane is not working, because she
100912 - worked Sunday, and so takes today off.
100914 -  ..
100915 - Talked to Stephanie.  She cannot access Catherine's email to review
100916 - the record.  Explained background of treatment for Cellulitis and
100917 - lymphedema in Emergency at Kaiser in Walnut Creek yesterday due to
100918 - high temperature of 101.9. ref SDS 56 V45J
100920 -  ..
100921 - Stephanie took Millie's temparature and found 98.4, showing continued
100922 - recovery, as reported late last night after getting home. ref SDS 56
100923 - M46X
100925 -  ..
100926 - Millie rolled her sleeve up enough for Stephanie to observe
100927 - continuing, and possibly expanding IBC rash on the lower left arm.
100928 - This was evident from rash crossing over the lines Doctor Pujol drew
100929 - to show the spread of Cellulitis at that time last night about 2045 at
100930 - the Kaiser hospital in Walnut Creek. ref SDS 56 M93M
100931 -
100932 -        [On 080410 examination at home about 1700 shows arm nearly
100933 -        normal, no signs of Cellulitis rash. ref SDS 58 V45J
100935 -  ..
100936 - Stephanie drew blood, and will include blood cultures, since getting
100937 - data from Kaiser has been problematic in the past.
100938 -
100939 -
100940 -
1010 -

SUBJECTS
Blood Tests Labs Infusion Clinic Evaluate Safe Chemotherapy 1st Trea

2003 -
200401 -  ..
200402 - Labs Blood Test
200403 -
200404 - Follow up ref SDS 53 FW5N, ref SDS 51 FW5N.
200405 -
200406 - Adding Carboplatin to the treatment protocol now requires weekly blood
200407 - tests to determine if the immune system is strong enough for safe
200408 - chemotherapy treatment, reported on 070201, ref SDS 4 XR40, and citing
200409 - the clinical study protocol received from UCSF on 070116. ref SDS 3
200410 - 5U7Z
200412 -  ..
200413 - During treatment, Catherine submitted results of the test.
200414 -
200429 -     ..
200430 -    Log#:                   080410 08:30
200431 -    <----------------------- U C S F -----------------------> <-------------  Kaiser -------------->
200432 -    Type                 Results   Units        Normal        ACRO   Type            Units        Normal
200433 -     ..
200434 -    CBC with DIFF & PLT CT                                     CBCD
200435 -     ..
200436 -    WBC COUNT               9.0    x10E9/L     3.4  -   10     WBC   WBC x10-3        K/uL     3.4  -  10.0
200437 -    RBC COUNT               4.19   x10E12/L      4  -   5.2    RBC   RBC x10-6        M/uL    3.60  -  5.70
200438 -    HEMOGLOBIN             13.4    g/dL         12  -   15.5   HGB   Hemoglobin       g/dL    11.5  -  15.0
200439 -    HEMATOCRIT             39.0    PERCENT      36  -   46     HCT   Hematocrit       %       34.0  -  46.0
200440 -    MCV                    93      fL           80  -   100    MCV   MCV              fL      80.0  -  100.0
200441 -    MCH                    31.9    pg           26  -   34     MCH
200442 -    MCHC                   34.3    g/dL         31  -   36     MCHC
200443 -    PLATELETS             166      x10E9/L     140  -  450     PLT   Plt x10-3        K/uL     140  -  400
200444 -    ..
200445 -     (NEUTS x 1000 = ANC for Kaiser)
200446 -    NEUTS         H         6.85   x10E9/L     1.8  -  6.8     N-A   ANC                      1500
200447 -
200448 -        Blood counts increased significantly today, e.g., NEUTS 6.85,
200449 -        compared with NEUTS 1.34 last week on 080403, ref SDS 53 QY6H,
200450 -        as a result of taking 1 treatment with Neupogen prescribed by
200451 -        Doctor Rugo on 080403. ref SDS 52 6Y9K
200453 -     ..
200454 -    LYMPHS                  1.29   x10E9/L     0.9  -  2.90    L-A   Lymphocytes       %        20  -  50
200455 -    MONOS                   0.74   x10E9/L     0.2  -  0.80    M-A   Monocyte          %         0  -  11
200456 -    EOS                     0.06   x10E9/L       0  -  0.40    E-A   Esoinophils       %         1  -  5
200457 -    BASOS                   0.07   x10E9/L       0  -  0.10    B-A   Basophil          %         0  -  2
200458 -                                                                                                 0  -  5
200459 -     ..
200460 -    <----------------------- U C S F -----------------------> <-------------  Kaiser -------------->
200461 -    Type                 Results   Units        Normal        ACRO   Type            Units        Normal
200462 -    PT            H        23.0    s          12.0  -  14.1    PT    PT, patient       sec     8.9  -  11.1
200463 -    INL NRM Ratio H         2.0                0.9  -  1.1     INR   INR                       2.0  -  3.0
200465 -     ..
200466 -    ELECTROLYTE PANEL                                          LYTE
200467 -    SODIUM        L       132      mmol/L      134  -  143     NA    Sodium            mEq/L   137  -  145
200468 -    POTASSIUM               3.9    mmol/L      3.4  -  4.9     K     Potassium         mEq/L   3.5  -  5.3
200469 -    CHLORIDE              100      mmol/L       98  -  107     CL
200470 -    CARBON DIOX TOTAL L    18      mmol/L       23  -  32      CO2
200471 -    ANION GAP              14                    3  -  14      ANGA
200472 -     ..
200473 -    MAGNESIUM               1.9    mg/dL       1.8  -  2.3     MG    Magnesium         mg/dL   1.6  -  2.3
200474 -
200476 -  ..
200477 - Millie received the rest of the report for the blood test on 080403
200478 - which shows CA 15-3 66 at that time.  Posted this to the prior report
200479 - on 080403. ref SDS 53 A16M
200480 -
200481 -        [On 080904 case study neutropenia Millie's patient history.
200482 -        ref SDS 59 8O7I
200483 -
200484 -
200485 -
200486 -
200487 -
200488 -
2005 -

SUBJECTS
Absolute Neutrophils Count ANC 6850 Above 1500 NEUTS 6.85 Above 1.5

3103 -
3104 - 0952
310501 -  ..
310502 - NEUTS 6.85 UCSF Approves Treatment Cetuximab and Carboplatin
310503 -
310504 - Follow up ref SDS 53 T38F.
310505 -
310506 - Stephanie advised that the doctor approved Millie getting treatment
310507 - today with both cetuximab and Carboplatin, since her blood counts are
310508 - very high, ref SDS 0 QY6H, and her temperature is normal.
310510 -  ..
310511 - This reflects continued recovery from Cellulitis treated in the
310512 - Emergency Room department at Kaiser yesterday, and as reported to UCSF
310513 - in a letter earlier this morning. ref SDS 57 WS5G
310515 -  ..
310516 - High blood counts resulted in not requiring Neupogen treatment this
310517 - week.
310518 -
310519 -
310520 -
3106 -

SUBJECTS
Default Null Subject Account for Blank Record

4103 -
410401 -  ..
410402 - Magnesium 1.9 Blood Test Today Shows Effective Treatment Last Week
410403 -
410404 - Follow up ref SDS 53 RW6F, ref SDS 32 4F9G.
410406 -  ..
410407 - The blood test last week on 080403 was done a day later and on 080404
410408 - Brigid reported Magnesium 1.5, which is below the target range,
410409 - ref SDS 54 OP61, and the doctor ordered treatment to increase blood
410410 - counts with "Magnesium Replacement." ref SDS 54 OP6U
410412 -  ..
410413 - On 080405 Kaiser sold Millie over-the-counter pills with both Calcium
410414 - and Magnesium, and Millie took these pills according to instructions
410415 - on the bottle. ref SDS 55 J23S
410417 -  ..
410418 - The report on Magnesium 1.9 for the blood test this morning shows
410419 - increase to the target range, per above. ref SDS 53 CP6J  This
410420 - indicates successful treatment on 080405. ref SDS 55 J24F
410421 -
410422 -
410423 -
410424 -
410425 -
410426 -
410427 -
410428 -
410429 -
4105 -