THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net
S U M M A R Y
DIARY: July 3, 2008 08:00 AM Thursday;
Rod Welch
Millie 2nd treatment 5th cycle cetuximab Carboplatin 4th relapse IBC.
1...Summary/Objective
...Taxotere Capecitabine 2nd Relapse IBC Treatment After Mastectomy
...Cetuxiab Alone Clinical Study
...Cetuxiab with Carboplatin Clinical Study 2nd Arm
2...Schedule Weekly Treatments Continue on Thursdays
3...Labs Blood Test
4...Missing Blood Tests Previous Lab on 080526
5...NEUTS Improve UCSF Prescribed Neupogen Treatment on Sunday
6...Power Port Surgery Certification Required Kaiser Submit to UCSF
..............
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CONTACTS
SUBJECTS
Cetuximab 12th Cycle 3rd Treatment 18th Total Treatment Chemotherapy
0403 -
0403 - ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS B1 0000. ref SDS A6 0000.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 - ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Background on Millie's treatment in the clinical study is reported on
040902 - 080508. ref SDS 94 TZ8I
040904 - ..
040905 - Taxotere Capecitabine 2nd Relapse IBC Treatment After Mastectomy
040906 -
040907 - Follow up ref SDS B1 X33O, ref SDS A6 X33O.
040908 -
040909 - Millie had left mastectomy on 051021. Biopsy at that time reported
040910 - no findings of cancer. Approximately 8 months later on 060707 the
040911 - doctor diagnosed IBC relapse and prescribed treatment. ref SDS 3
040912 - PF3O
040913 -
040914 - 1. Cycle 09 and 01 ................... 060721, ref SDS 4 407N
040915 - 2. Cycle 10 and 02 ................... 060814, ref SDS 6 LY6O
040916 - 3. Cycle 11 and 03 ................... 060908, ref SDS 6 407N
040917 - 4. Cycle 12 and 04 ................... 060929, ref SDS 6 407N
040918 - 5. Cycle 13 and 05 ................... 061020, ref SDS 7 407N
040919 - 6. Cycle 14 and 06 ................... 061110, ref SDS 8 407N
040920 - 7. Cycle 15 and 07 ................... 061201, ref SDS 9 407N
040922 - ..
040923 - Cetuxiab Alone Clinical Study
040924 -
040925 - Follow up ref SDS B1 356I, ref SDS A6 356I.
040926 -
040927 - Total Cetuximab
040928 - 8. Cycle 01 and 08 and 01 01.......... 070201, ref SDS 11 SG8I
040929 - 9. Cycle 01 and 08 and 02 02.......... 070208, ref SDS 12 SG8I
040930 - 10. Cycle 01 and 08 and 03 03.......... 070215, ref SDS 13 SG8I
040931 - 11. Cycle 01 and 08 and 04 04.......... 070222, ref SDS 14 SG8I
040932 - 12. Cycle 02 and 09 and 01 05.......... 070301, ref SDS 15 SG8I
040933 - 13. Cycle 02 and 09 and 02 06.......... 070308, ref SDS 17 7T3H
040934 - 14. Cycle 02 and 09 and 03 07.......... 070315, ref SDS 18 7T3H
040935 - 15. Cycle 02 and 09 and 04 08.......... 070322, ref SDS 19 7T3H
040936 - 16. Cycle 03 and 10 and 01 09.......... 070329, ref SDS 20 7T3H
040937 - 17. Cycle 03 and 10 and 02 10.......... 070405, ref SDS 21 7T3H
040938 - 18. Cycle 03 and 10 and 03 11.......... 070412, ref SDS 22 7T3H
040939 - 19. Cycle 03 and 10 and 04 12.......... 070419, ref SDS 23 7T3H
040940 - 20. Cycle 04 and 11 and 01 13.......... 070426, ref SDS 24 7T3H
040941 - 21. Cycle 04 and 11 and 02 14.......... 070503, ref SDS 25 7T3H
040942 - 22. Cycle 04 and 11 and 03 15.......... 070510, ref SDS 26 7T3H
040943 - 23. Cycle 04 and 11 and 04 16.......... 070517, ref SDS 27 7T3H
040944 - 24. Cycle 05 and 12 and 01 17.......... 070524, ref SDS 28 7T3H
040945 - 25. Cycle 05 and 12 and 02 18.......... 070531, ref SDS 29 7T3H
040946 - 26. Cycle 05 and 12 and 03 19.......... 070607, ref SDS 30 7T3H
040947 - 27. Cycle 05 and 12 and 04 20.......... 070614, ref SDS 31 0001
040948 - 28. Cycle 06 and 13 and 01 21.......... 070621, ref SDS 32 0001
040949 - 29. Cycle 06 and 13 and 02 22.......... 070628, ref SDS 33 0001
040950 - 30. Cycle 06 and 13 and 03 23.......... 070705, ref SDS 34 0001
040951 - 31. Cycle 06 and 13 and 04 24.......... 070712, ref SDS 34 0001
040952 - 32. Cycle 07 and 14 and 01 25.......... 070719, ref SDS 35 0001
040953 - 33. Cycle 07 and 14 and 02 26.......... 070726, ref SDS 33 0001
040954 - 34. Cycle 07 and 14 and 03 27.......... 070802, ref SDS 34 0001
040955 - 35. Cycle 07 and 14 and 04 28.......... 070809, ref SDS 36 0001
040956 - 36. Cycle 08 and 15 and 01 29.......... 070816, ref SDS 37 0001
040957 - 37. Cycle 08 and 15 and 02 30.......... 070823, ref SDS 38 0001
040958 - 38. Cycle 08 and 15 and 03 31.......... 070830, ref SDS 38 0001
040959 - 39. Cycle 08 and 15 and 04 32.......... 070906, ref SDS 39 0001
040960 - 40. Cycle 09 and 16 and 01 33.......... 070920, ref SDS 40 0001
040961 - 41. Cycle 09 and 16 and 02 34.......... 070927, ref SDS 41 0001
040962 - 42. Cycle 09 and 16 and 03 35.......... 071004, ref SDS 42 0001
040963 - 43. Cycle 09 and 16 and 04 36.......... 071011, ref SDS 43 0001
040964 - 44. Cycle 10 and 17 and 01 37.......... 071018, ref SDS 44 0001
040965 - 45. Cycle 10 and 17 and 02 38.......... 071025, ref SDS 45 0001
040966 - 46. Cycle 10 and 17 and 03 39.......... 071101, ref SDS 31 0001
040967 - 47. Cycle 10 and 17 and 04 40.......... 071108, ref SDS 46 0001
040968 - 48. Cycle 11 and 18 and 01 41.......... 071115, ref SDS 47 0001
040969 - 49. Cycle 11 and 18 and 02 42.......... 071122, ref SDS 33 0001
040970 - 50. Cycle 11 and 18 and 03 43.......... 071129, ref SDS 49 0001
040971 - 51. Cycle 11 and 18 and 04 44.......... 071206, ref SDS 50 0001
040972 - 52. Cycle 12 and 19 and 01 45.......... 071213, ref SDS 53 0001
040973 - 53. Cycle 12 and 19 and 02 46.......... 071220, ref SDS 56 0001
040974 - 54. Cycle 12 and 19 and 03 47.......... 071227, ref SDS 57 0001
040975 - 55. Cycle 12 and 19 and 04 48.......... 080103, ref SDS 58 0001
040976 - 56. Cycle 13 and 20 and 01 49.......... 080110, ref SDS 61 0001
040977 - 57. Cycle 13 and 20 and 02 50.......... 080117, ref SDS 62 0001
040978 - 58. Cycle 13 and 20 and 03 51.......... 080124, ref SDS 63 0001
040979 - 59. Cycle 13 and 20 and 04 52.......... 080131, ref SDS 65 0001
040980 - 60. Cycle 14 and 21 and 01 53.......... 080207, ref SDS 69 0001
040981 - 61. Cycle 14 and 21 and 02 54.......... 080214, ref SDS 70 0001
040982 - 62. Cycle 14 and 21 and 03 55.......... 080221, ref SDS 34 0001
040983 - 63. Cycle 14 and 21 and 04 56.......... 080228, ref SDS 75 0001
040984 - 64. Cycle 15 and 22 and 01 57 01 00... 080306, ref SDS 78 TZ8I
040986 - ..
040987 - Cetuxiab with Carboplatin Clinical Study 2nd Arm
040988 -
040989 - Follow up ref SDS B1 5B6J, ref SDS A6 5B6J.
040990 -
040991 - On 080207 doctor reports IBC may be spreading. ref SDS 68 GH5H
040992 - Follow up examination on 080219 Doctor Rugo diagnosed progression of
040993 - disease. ref SDS 89 3J4I Photographs show spread of IBC rash,
040994 -
040995 - 2nd
040996 - Arm Cetuximab Carboplatin
040997 - 65. Cycle 01 15 and 22 and 02 58 02 01... 080313, ref SDS 79 TZ8I
040998 - 66. Cycle 01 15 and 22 and 03 59 03 01... 080320, ref SDS 80 TZ8I
040999 - 67. Cycle 01 15 and 22 and 04 60 04 01... 080327, ref SDS 81 TZ8I
041000 - 68. Cycle 02 16 and 23 and 01 61 05 02... 080403, ref SDS 82 TZ8I
041001 - 69. Cycle 02 16 and 23 and 02 62 06 03... 080410, ref SDS 85 TZ8I
041002 - 70. Cycle 02 16 and 23 and 03 63 07 03... 080417, ref SDS 87 TZ8I
041003 - 71. Cycle 02 16 and 23 and 04 64 08 03... 080424, ref SDS 90 TZ8I
041004 - 72. Cycle 03 17 and 24 and 01 65 09 04... 080501, ref SDS 92 5B6J
041005 - 73. Cycle 03 17 and 24 and 02 66 10 05... 080508, ref SDS 94 5B6J
041006 - 74. Cycle 03 17 and 24 and 03 67 11 05... 080515, ref SDS 95 5B6J
041007 - 75. Cycle 03 17 and 24 and 04 68 12 05... 080522, ref SDS 96 5B6J
041008 - 76. Cycle 04 18 and 25 and 01 69 13 06... 080529, ref SDS 99 5B6J
041009 - 77. Cycle 04 18 and 25 and 02 70 14 07... 080605, ref SDS A0 5B6J
041010 - 78. Cycle 04 18 and 25 and 03 71 15 08... 080612, ref SDS A3 5B6J
041011 - 79. Cycle 04 18 and 25 and 04 72 16 08... 080619, ref SDS A6 5B6J
041012 - 80. Cycle 05 19 and 26 and 01 73 17 09... 080626, ref SDS B1 5B6J
041013 - 81. Cycle 05 19 and 26 and 02 74 18 10... 080703, ref SDS 0 5B6J
041015 - ..
041016 - Today is the 2nd treatment of the 5th cycle with cetuximab and
041017 - Carboplatin together. This is the 18th treatment overall with
041018 - cetuximab on the 2nd arm of the clinical study, but is only the 10th
041019 - treatment with Carboplatin due to low blood counts.
041021 - ..
041022 - Catherine was Millie's nurse today, because she is coming in now at
041023 - 0800.
041024 -
041025 -
041026 -
0411 -
SUBJECTS
Default Null Subject Account for Blank Record
0903 -
090401 - ..
090402 - Schedule Weekly Treatments Continue on Thursdays
090403 -
090404 - Follow up ref SDS B1 IK7H, ref SDS 99 IK7H.
090405 -
090406 - Nola submitted UCSF schedule for Millie's treatment on 080731 which
090407 - was missing from the schedule submitted last week on 080626.
090408 - ref SDS B1 2F9N
090409 -
090410 -
090411 -
090412 -
0905 -
SUBJECTS
Default Null Subject Account for Blank Record
1003 -
1004 - 0800
100501 - ..
100502 - Labs Blood Test
100503 -
100504 - Follow up ref SDS B1 FW5N, ref SDS A6 FW5N.
100505 -
100506 - Adding Carboplatin to the treatment protocol now requires weekly blood
100507 - tests to determine if the immune system is strong enough for safe
100508 - chemotherapy treatment, reported on 070201, ref SDS 11 XR40, and citing
100509 - the clinical study protocol received from UCSF on 070116. ref SDS 10
100510 - 5U7Z
100512 - ..
100513 - During treatment, Catherine submitted results of the test.
100514 -
100529 - ..
100530 - Log#: 080703 08:10
100531 - <----------------------- U C S F -----------------------> <------------- Kaiser -------------->
100532 - Type Results Units Normal ACRO Type Units Normal
100533 - ..
100534 - CBC with DIFF & PLT CT CBCD
100535 - ..
100536 - WBC COUNT 5.5 x10E9/L 3.4 - 10 WBC WBC x10-3 K/uL 3.4 - 10.0
100537 - RBC COUNT L 3.90 x10E12/L 4 - 5.2 RBC RBC x10-6 M/uL 3.60 - 5.70
100538 - HEMOGLOBIN 13.4 g/dL 12 - 15.5 HGB Hemoglobin g/dL 11.5 - 15.0
100539 - HEMATOCRIT 38.0 PERCENT 36 - 46 HCT Hematocrit % 34.0 - 46.0
100540 - MCV 98 fL 80 - 100 MCV MCV fL 80.0 - 100.0
100541 - MCH H 34.3 pg 26 - 34 MCH
100542 - MCHC 35.2 g/dL 31 - 36 MCHC
100543 - PLATELETS 193 x10E9/L 140 - 450 PLT Plt x10-3 K/uL 140 - 400
100544 -
100545 - Performed at Mt Zion Clinic Lab, 1600 Divisadero, San
100546 - Francisco, CA 94115
100547 - ..
100548 - (NEUTS x 1000 = ANC for Kaiser)
100549 - NEUTS L 2.90 x10E9/L 1.8 - 6.8 N-A ANC 1500
100550 - Neutrophils Not Reported Neutrophils % 50 - 70
100552 - ..
100553 - LYMPHS 1.84 x10E9/L 0.9 - 2.9 L-A Lymphocytes % 20 - 50
100554 - MONOS 0.43 x10E9/L 0.1 - 0.6 M-A Monocyte % 0 - 11
100555 - EOS 0.23 x10E9/L 0 - 0.4 E-A Esoinophils % 1 - 5
100556 - BASOS 0.09 x10E9/L 0 - 0.1 B-A Basophil % 0 - 2
100557 -
100558 -
100559 -
100561 - ..
100562 - Missing Blood Tests Previous Lab on 080526
100563 -
100564 - Catherine reviewed the labs on 080626 reporting tests were omitted
100565 - compared to prior tests. ref SDS B1 HS7I
100567 - ..
100568 - There was discussion that tests missing for the blood test on 080626
100569 - are not required in the orders for blood work in Millie's Chemotherapy
100570 - Orders. ref SDS B1 PWPW Correlating labs with Chemotherapy Orders
100571 - presents continuing challenge, reported on 080423. ref SDS 88 798Q
100572 -
100573 - [On 080724 labs starting cycle 6 included Protein Total and
100574 - Calcium, which were missing from lab starting cycle 5 on
100575 - 080529, ref SDS B3 GT9I, and continue to omit Glucose and
100576 - Albumin, also, omitted for lab on 080529. ref SDS B3 PT5X
100578 - ..
100579 - [On 080724 labs starting cycle 6 included Protein Total and
100580 - Calcium, ref SDS B3 GT9I, which were missing from lab
100581 - starting cycle 5 on 080626, ref SDS B1 SE9J, and continue
100582 - to omit Glucose and Albumin, ref SDS B3 PT5X, also, omitted
100583 - for the lab on 080626. ref SDS B1 HS7I
100584 -
100586 - ..
100587 - NEUTS Improve UCSF Prescribed Neupogen Treatment on Sunday
100588 -
100589 - Follow up ref SDS B1 PU6K, ref SDS A6 PU6K.
100590 -
100591 - Blood counts increased significantly again this week shown by the
100592 - report today with NEUTS 2.90, ref SDS 0 QY6H, compared with NEUTS 1.80
100593 - last week on 080626, ref SDS B1 QY6H Significant rise in blood counts
100594 - despite treatment with Carboplatin chemotherapy last week, reflects
100595 - getting 2 treatments with Neupogen last week at the Kaiser Infusion
100596 - Clinic, and aligns with Brigid's instructions during the meeting at
100597 - UCSF on 080626, ref SDS B0 QJ4H, even though Chemotherapy Orders to do
100598 - not prescribe Neupogen. ref SDS B1 PWSY
100600 - ..
100601 - On 080628 Laura at Kaiser requested Chemotherapy Orders documenting
100602 - UCSF prescription for Neupogen treatments at Kaiser. ref SDS B2 QQ9I
100603 - This request was submitted to UCSF in Millie's letter on 080702.
100605 - ..
100606 - There was no blood test ordered today for Magnesium to follow up the
100607 - treatment last week on 080626 when Magnesium tested too low.
100608 - ref SDS B1 PR5K
100609 -
100610 -
100611 -
100612 -
100613 -
1007 -
SUBJECTS
Default Null Subject Account for Blank Record
1103 -
110401 - ..
110402 - Power Port Surgery Certification Required Kaiser Submit to UCSF
110403 -
110404 - Follow up ref SDS B1 MZ8G.
110405 -
110406 - Surger to implant a Power Port is scheduled for 080708.
110407 -
110408 -
110409 -
110410 -
110411 -
110412 -
110413 -
110414 -
1105 -