THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: December 6, 2002 02:30 PM Friday; Rod Welch

Millie meeting doctor at Kaiser on progress treating breast cancer.

1...Summary/Objective
2...Schedule Evaluation Meeting for 030117
3...Recovery Progress CA 15-3 Cancer Marker Rises Above Target Level
4...CA 15-3 Cancer Marker Above Target Level Progress Toward Recovery
5...PET Scan Scheduled for January
6...Urination Frequency Side Effect Chemotherapy, Indication of Diabetes
7...Swelling Along Left Side Below Arm Area Likely Lymph Node Drainage
8...Breast Firmness Results from Surgery Scar Tissue and Radiation


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CONTACTS 

SUBJECTS
CA 15-3 Blood Tests Show 36 Significant Drop into 30s
CA 15-3 Trend Rising from 33 to 41 Will be Reviewed During Follow Up

1304 -
1304 -    ..
1305 - Summary/Objective
1306 -
130601 - Follow up ref SDS 41 0000, ref SDS 40 0000.
130602 -
130603 - The doctor advanced the schedule for a PET scan test to 021218, and
130604 - ordered another blood test to evaluate recovery following completion
130605 - of chemotherapy.  Tests will be reviewed during a meeting with the
130606 - doctor on 030109 to assess further treatment decisions based on trends
130607 - in CA 15-3. ref SDS 0 KVDE  Swelling under the arm, ref SDS 0 KW5F,
130608 - and firmness in the breast appear to be normal side effects of
130609 - treatment. ref SDS 0 SG7J  A blood test for diabetes was taken based
130610 - on increased urination. ref SDS 0 KV6F
130611 -
130612 -
130613 -
130614 -
130615 -
130617 -  ..
1307 -
1308 -
1309 - Progress
1310 -
131001 - Schedule Evaluation Meeting for 030117
131002 - Recovery Progress CA 15-3 Cancer Marker Rises Above Target Level
131003 - CA 15-3 Cancer Marker Above Target Level Progress Toward Recovery
131004 -
131005 - Follow up ref SDS 41 SQ5I, ref SDS 40 SQ5I.
131006 -
131007 - The doctor advised that cancer treatment concluded on 021204 with
131008 - completion of phase II using Taxotere, ref SDS 41 0001, following
131009 - radiation, and phase I treatment that began in April, reported on
131010 - 020423. ref SDS 20 0001
131012 -  ..
131013 - Millie asked about the trend of CA 15-3 test results over the past
131014 - three months that increased from 33 to 41. ref SDS 41 F48G
131015 -
131016 -          021202......... 41 H?............ 021204, ref SDS 41 SP5G
131017 -          021102......... 36 H?............ 021113, ref SDS 40 Y65I
131018 -          021023......... 33 H?............ 021023, ref SDS 39 SQ5I
131019 -       *  020930......... 33 H?..29........ 021002, ref SDS 38 SQ5I
131020 -          020917......... 36 H?............ 020924, ref SDS 37 SQ5I
131021 -          020717......... 59 H?............ 020726, ref SDS 36 YN5K
131022 -          020629......... 75 H ............ 020705, ref SDS 34 UX6I
131023 -          020608........  67 H ............ 020614, ref SDS 30 0001
131024 -          020603........ 108 H ............ 020607, ref SDS 28 X67F
131025 -          020511........ 117 H ............ 020603, ref SDS 27 PJ4J
131026 -          020419......... 81 H ............ 020430, ref SDS 23 7N5H
131027 -          020321......... 85 H ............ 020405, ref SDS 13 6T8K
131029 -  ..
131030 - The doctor said he would be disturbed by a trend upward, and indicated
131031 - the current results over the past two months rising in two reports
131032 - from an all-time low for Millie of 33 to now 41 does not show a trend.
131033 - He explained that CA 15-3 varies in the body, so variance is not
131034 - disturbing.
131035 -
131036 -      [On 030109 CA 15-3 dropped to 37 showing improvement on reversing
131037 -      the trend over the past 2 months. ref SDS 44 SM6M
131039 -       ..
131040 -      [On 030508 the doctor submits ASCO guidance showing CA 15-3 not
131041 -      recommended to diagnose cancer, applied for guidance showing
131042 -      recurrence when treatment fails. ref SDS 45 M28G
131044 -       ..
131045 -      [On 030606 patient concerned about rising trend of CA 15-3.
131046 -      ref SDS 46 NE7L
131048 -       ..
131049 -      [On 050729 doctor orders additional chemotherapy treatments based
131050 -      on sudden 25% rise of CA 15-3, after reaching all-time low.
131051 -      ref SDS 48 Y44G
131053 -  ..
131054 - Millie explained having injured a toe recently, and asked if that
131055 - could influence variance in CA 1503?
131057 -  ..
131058 - The doctor said that trauma to a toe is not typically associated with
131059 - variance in CA 15-3.
131061 -  ..
131062 - Millie advised that recently there have been small ridges or bumps
131063 - appearing on her finger nails; she asked if this could account for
131064 - variance in CA 15-3?
131065 -
131066 -     [On 050809 save side effect occurs after 5th cycle of treatment
131067 -     with Taxotere and capecitiabine (Xeloda). ref SDS 49 6X81
131069 -  ..
131070 - The doctor said that this condition is often a side effect from
131071 - chemotherapy with Taxotere, and does not influence variance in CA
131072 - 15-3.
131074 -  ..
131075 - The doctor looked at the Kaiser computer in the examination room and
131076 - printed additional information showing Kaiser changed the method of
131077 - computing CA 15-3 a few months ago that now gives slightly higher
131078 - readings.  He noted the report that several months ago on 020930, when
131079 - Millie had a CA 15-3 test result of 33, under the prior system the
131080 - reading would have been 29, well below the target level of 31 that
131081 - indicates normal.
131083 -  ..
131084 - The doctor indicated more tests are needed to establish a trend.
131086 -  ..
131087 - The doctor scheduled a PET scan, and scheduled a meeting with Millie
131088 - for 030109 to review results of the test, per below. ref SDS 0 LK5L
131090 -  ..
131091 - Prior to the meeting, Millie will have another blood test to obtain
131092 - another CA 15-3 level that can be discussed during the meeting on
131093 - 030109.
131094 -
131095 -      [On 030109 CA 15-3 dropped to 37 showing improvement on reversing
131096 -      the trend over the past 2 months. ref SDS 44 SM6M
131097 -
131098 -
131099 -
131100 -
1312 -

SUBJECTS
PET Scan Planned to Evaluate Condition Following Completion of Phase
PET Scan Scheduled for 030110 to Evaluate Condition Following Phase 2

1504 -
150501 -  ..
150502 - PET Scan Scheduled for January
150503 -
150504 - Millie asked about scheduling a Pet Scan which was planned during the
150505 - meeting on 020924? ref SDS 37 IF4J.
150507 -  ..
150508 - The doctor said that in light of rising CA 15-3 test results, per
150509 - above, ref SDS 0 SM6M, he feels that the PET scan test schedule should
150510 - be advanced from January.  He wants this done as soon as possible.
150512 -  ..
150513 - After meeting with the doctor, Millie went to the nuclear medicine
150514 - department downstairs in the hospital and submitted documents received
150515 - from the doctor for scheduling the PET scan test so that results are
150516 - available for a follow up meeting with the doctor next month on
150517 - 030117.
150518 -
150519 -     [On 021210 PET scan test scheduled for 021218. ref SDS 42 0001
150520 -
150521 -
150522 -
150523 -
150524 -
150525 -
1506 -

SUBJECTS
Urination Increased Frequency Side Effect Chemotherapy May Indicate D

1603 -
160401 -  ..
160402 - Urination Frequency Side Effect Chemotherapy, Indication of Diabetes
160403 -
160404 - Millie reported increased urination and loss of control,
160405 - incontenance.
160407 -  ..
160408 - The doctor said this is a side effect of chemotherapy; it can also
160409 - indicate diabetes.
160411 -  ..
160412 - The doctor schedule a blood test for diabetes.
160413 -
160414 -     [On 050729 same urinary problem reported after 5 cycles of
160415 -     treatment with Taxotere and capecitabine (Xeloda). ref SDS 48 VT3O
160417 -  ..
160418 - After the meeting we went to the labatory and a blood test sample was
160419 - taken.
160420 -
160421 -
160422 -
1605 -

SUBJECTS
Swelling Left Side Under Left Arm Likely Caused by Draining Lymph Nod

1803 -
180401 -  ..
180402 - Swelling Along Left Side Below Arm Area Likely Lymph Node Drainage
180403 -
180404 - Millie reported some occassional mild discomfort from new swelling
180405 - below the left arm pit where lymph nodes were removed during surgery
180406 - on 020312. ref SDS 8 7V61  This is a new development since the report
180407 - on 020726 that swelling and discomfort had ended after treatment with
180408 - Taxotere. ref SDS 36 YO52
180410 -  ..
180411 - The doctor examined Millie.  He advised that some swelling is expected
180412 - at this time from lymph drainage to this area as a result of removal
180413 - of cancerous lymph nodes during surgery on 020312. ref SDS 8 Q78M
180415 -  ..
180416 - The doctor commented that the degree of swelling is very minor, barely
180417 - detectable by sight and by feel comparing the left side with the right
180418 - side.  He indicated this condition does not show more than is expected
180419 - following surgery to remove lymph nodes.
180421 -  ..
180422 - The doctor feels continued rise in CA 15-3, per above, ref SDS 0 5E6L,
180423 - and the return of lumps under the arm requires monitoring now that the
180424 - 2nd phase of cheomotherapy ended a few days ago on 021204. ref SDS 41
180425 - 0001
180427 -  ..
180428 - The doctor indicated that overall, treatment with Taxotere seems to
180429 - have improved Millie's condition, and that the PET scan test in a few
180430 - weeks will provide further evidence on deciding whether more
180431 - treatment is required.
180433 -  ..
180434 - Millie said she feels great; she is back on the job and maintaining a
180435 - normal exercise schedule of hikng and workouts at the gym.  Even
180436 - though treatment has ended, Millie will continue to get CA 15-3
180437 - testing and other tests to evaluate response to treatment.
180438 -
180439 -     [On 030109 findings of PET test on 021218 seems to indicate
180440 -     favorably that swelling under left arm reported on 020520 is no
180441 -     longer visible. ref SDS 44 GJ55
180443 -      ..
180444 -     [On 030109 findings of PET test on 021228 citing evidence of "new
180445 -     mild diffuse increased uptakes at the region of the left axilla"
180446 -     may reflect reports today of occassional mild discomfort from new
180447 -     swelling under the left arm, ref SDS 44 L66M, which analyst's
180448 -     "impression" says are likely secondary to post-radiation changes,
180449 -     suggesting not cancerous. ref SDS 44 GJ69
180450 -
180451 -
180452 -
180453 -
180454 -
1805 -

SUBJECTS
Breast Firmness About Surgery and Radiation Area Typical Result
Radiation Treatment Completed Chemotherapy Schedule Phase II Called L

2004 -
200501 -  ..
200502 - Breast Firmness Results from Surgery Scar Tissue and Radiation
200503 -
200504 - Follow up ref SDS 37 0J7H.
200505 -
200506 - The doctor examined the surgery and radiation areas on the breast and
200507 - observed firmness from thickened, stiff skin following completion of
200508 - radiation treatment on 020910, reported in the record on 020924.
200509 - ref SDS 37 0J7H  These conditions were not reported during
200510 - examination at that time on 020924.
200512 -  ..
200513 - He feels today that this new condition reflects scar tissue from
200514 - surgery 9 months ago on 020312, ref SDS 8 0001, and reaction to
200515 - radiation treatments that ended 3 months ago on 020910.  The doctor
200516 - noted that in some women the entire breast becomes firm.  In Millie's
200517 - case firmness is localized to the area of surgery and radiation
200518 - treatment.
200519 -
200520 -     [On 021218 Millie met with radiologist for examination following
200521 -     completion of radiation treatments. ref SDS 43 0001
200523 -      ..
200524 -     [On 030109 PET scan test on 021218 received from the doctor and
200525 -     describes new mild diffuse increased uptakes at the region of the
200526 -     left axilla, left upper chest wall, and left supraclavicular
200527 -     regions. ref SDS 44 L66M
200529 -      ..
200530 -     [On 030109 the doctor observed red rash and stiff skin on left
200531 -     breast. ref SDS 44 KW5F
200533 -      ..
200534 -     [On 030606 patient requests emergency meeting for doctor to
200535 -     examine sudden severe inflammation and rash on left breast; a
200536 -     week later the doctor finds rash has subsided, ref SDS 46 7C6W,
200537 -     but observed skin firmness in the left breast, attributed to
200538 -     side effects of surgery and radiation treatments. ref SDS 46
200539 -     O16M
200541 -      ..
200542 -     [On 030710 CT test reports similar findings of skin thickening
200543 -     on left breast may be side effects of radiation therapy, and
200544 -     also notes that the same symptoms occur with "known breast
200545 -     cancer," ref SDS 47 VM7I; patient requests further testing with
200546 -     biopsy; Kaiser defers testing for cancer on grounds symptoms
200547 -     are most likely side effects of radiation treatment in 2002.
200548 -     ref SDS 47 T64L
200549 -
200550 -
200551 -
200552 -
200553 -
200554 -
200555 -
2006 -