THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rod@welchco.com


S U M M A R Y


DIARY: September 25, 1999 10:58 AM Saturday; Rod Welch

Received report from Doctor Boulris on knee examination at Kaiser.

1...Summary/Objective
2...Report Clarifies Issues, Need Review of Med History, New Treatments
3...Left Knee Has Greater Wear, Why is Pain in Right Knee Comparable?
4...Cortisone, Synvisc Possible Treatment Options
5...Glucosamine May Improve Osteoarthritis, Need Prescribed Usage
6...Avoid Swelling - Medicate Prior to Activity; Use Neoprene Brace
7...Knee Replacement Strong Possibility in Future
8...Debridement Interim Alternative to Knee Replacement


..............
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CONTACTS 
0201 - Kaiser Permanente                                                                                                                                                  
020101 - Dr. Craig M. Boulris, M.D.; Orthopedic Surgeon  
020102 - Orthopedic Department                                                                                                                                            

SUBJECTS
Medical, Kaiser                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
Exam 990910 Knee Treatments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
Decisions Shared                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
Questions, Suggestions                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
Report Omits Medical History, New Therapies                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0807 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0807 -    ..
0808 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
0809 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
080901 - Follow up ref SDS 77 0000, ref SDS 76 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
080902 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
080903 - Craig submitted an excellent report that helps formulate treatment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
080904 - plans under Kaiser's partnership procedure.  Email can help avoid                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
080905 - delay in submitting medical history that hampered review.  Need                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
080906 - clarification on using Glucosamine.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
080907 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
080908 -     [On 990927 requested clarifications. ref SDS 78 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
080910 -      ..
080911 -     [On 990928 Craig received the letter. ref SDS 79 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
080913 -      ..
080914 -     [On 991008 submitted request for response. ref SDS 81 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
080916 -      ..
080917 -     [On 991011 received response from Craig. ref SDS 82 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
080918 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
080919 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
080921 -  ..
0810 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0811 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0812 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
081301 -  ..
081302 - Report Clarifies Issues, Need Review of Med History, New Treatments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081303 - 
081304 - Received report, ref DRT 1 0001, from Craig for the meeting on 990910,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
081305 - ref SDS 68 0001, per request. ref SDS 68 3555                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081306 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081307 - The report does not cite the letter, ref DIP 1 0001, prepared on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
081308 - 990913, ref SDS 71 7728, which explains understandings from the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
081309 - meeting on 990910. ref SDS 68 0001  This occurred because it was not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
081310 - forwarded until 990916, ref SDS 74 0001, and Craig's letter was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
081311 - evidently dictated three days earlier, on 990913, even though it was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081312 - not transcribed until 990921, ref DRT 1 3420, and received on 990925.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
081314 -  ..
081315 - These are coordination issues discussed on 990915. ref SDS 73 0001                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
081317 -  ..
081318 - Once communications with Kaiser are mobilized we should be able to get                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
081319 - everyone in sync with partnership goals reviewed on 990625.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
081320 - ref SDS 43 4185  Email can improve this record that required 15 days                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
081321 - to deliver mail a distance of 2 miles.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
081323 -  ..
081324 - As a result of Craig not receiving the letter on 990913...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
081325 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081326 -      1.  The report does not cite medical history reported on 990625.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
081327 -          ref SDS 43 5152, requested in a letter to Craig on 990913.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081328 -          ref DIP 1 4224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
081329 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081330 -          This reflects practice reported on 990910. ref SDS 68 9130                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081331 -          Medical history is not a life and death issue in this case,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081332 -          however, it is always good management to review background.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081334 -           ..
081335 -          Medical history should be cited, or else explain why not in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081336 -          this case.  It should not require life and death issues to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
081337 -          take a look at the record. ref SDS 43 5152                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081339 -     ..
081340 -    [On 991011 Craig says he reviewed the record. ref SDS 82 2303]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
081342 -           ..
081343 -      2.  The report does not review all eight (8) of the treatments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
081344 -          submitted for consideration, which was a goal of the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
081345 -          examination 990910, cited in patient history on 990625.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
081346 -          ref SDS 43 5400                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
081348 -           ..
081349 -          The report relates possible use of injectables which include                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
081350 -          cortisone, hydriodic acid, Synvisc.  The pros and cons of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
081351 -          these were all discussed with the patient. ref DRT 1 3955                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
081353 -           ..
081354 -          Need review of all eight (8) published remedies brought                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
081355 -          forward by the patient for comment. ref OF 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
081357 -     ..
081358 -    [On 991011 Craig says he reviewed the article, but does not comment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
081359 -    on all of the therapies because they are not all relevant.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
081360 -    ref SDS 82 2304]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081361 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081363 -  ..
081364 - Left Knee Has Greater Wear, Why is Pain in Right Knee Comparable?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
081365 - 
081366 - The left knee is reviewed in detail. ref DRT 1 2376                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081367 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081368 - Doctor Boulris says in particular...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081369 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081370 -        His radiographs show mild to moderate arthritis of the left                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
081371 -        knee with diminution of the medial joint space in particular                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
081372 -        with some calcification in the meniscal area.  There are some                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081373 -        early osteophytes which are formed on the femoral condyles.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
081374 -        ref DRT 1 TK4G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
081376 -  ..
081377 - This aligns with understandings from the meeting on 990910, after                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
081378 - getting an xray.  Craig and I looked at the xray film together, and it                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
081379 - seemed to show the joint space narrower on the inside of the left                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
081380 - knee, where calcification and osteophytes occur that give the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
081381 - impression the upper femoral bone is now extending into the space                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
081382 - where cartilage was removed in the 1974 knee surgery. ref SDS 68 OE68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
081383 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081385 -  ..
081386 - The right knee has less explanation. ref DRT 1 0720                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081388 -  ..
081389 - The report does not recognize that pain in the right knee is currently                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
081390 - as severe as the left, shown on 990910. ref SDS 68 1224                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
081392 -  ..
081393 - Graphics prepared during the meeting to analyse conditions that can                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
081394 - account for comparable pain in both knees, are not included nor cited                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
081395 - in the report. ref SDS 68 7872                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081396 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081397 -     Need professional opinion on comparable knee pain.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
081398 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081399 -     Failure to review comparable experience in both knees which have                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
081400 -     evident different physical states, may overlook a common cause                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
081401 -     that is not evident, but requires inquiry.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
081403 -      ..
081404 -     If not, say we don't have a good explanation at this time.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
081406 -    ..
081407 -   [On 991011 craig responded, essentially saying the cause of pain in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
081408 -   the right knee is unknown. ref SDS 82 3088]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
081409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081410 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
081411 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0815 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Synvisc Injection Therapy                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
Cortisone                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
1204 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
120501 -  ..
120502 - Cortisone, Synvisc Possible Treatment Options                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120503 - 
120504 - The report recommends using cortisone and Synvisc. ref DRT 1 3955                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
120505 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120506 -      a.  Cortisone was explained on 990910 as pain relief that does                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120507 -          not treat deterioration causing pain. ref SDS 68 5394                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120509 -           ..
120510 -          Initial goal is to treat deterioration, not pain, per se.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120511 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120512 -             [On 990927 notified Craig of plan to avoid using                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
120513 -             cortisone, and try initially glucosamine. ref SDS 78 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
120515 -              ..
120516 -             [On 991011 Craig says he uses cortisone and it is the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120517 -             standard of care nationally. ref SDS 82 3955]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120519 -           ..
120520 -      b.  The record on 990910 shows that Synvisc was expressly                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120521 -          not recommended. ref SDS 68 7802                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120523 -           ..
120524 -          Further review may have adjusted the original opinion, and in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
120525 -          that case it would be helpful to report information that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
120526 -          supports this change.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120528 -           ..
120529 -          Were colleagues consulted, other experts?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120531 -           ..
120532 -          Did Craig see the report on Synvisc, ref OF 4 5672, submitted                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
120533 -          on 990731? ref SDS 56 0001                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
120535 -           ..
120536 -          Is the record on 990910 incorrect? ref SDS 68 7802  If so,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
120537 -          say that.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120538 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120539 -             [On 991011 Craig confirmed recommendation to use Synvisc                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
120540 -             (which is Hyaluronic Acid injection treatment).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
120541 -             ref SDS 82 3942]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120543 -           ..
120544 -      c.  Synvisc in a series of three injections is proposed, after                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120545 -          use of cortisone. ref DRT 1 3955                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120547 -           ..
120548 -          Injectables are discussed in a general way.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120550 -           ..
120551 -          Need to review application relative to Kaiser's experience,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120552 -          and report by vendor, ref OF 4 5678, reviewed on 990719,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
120553 -          ref SDS 53 4628, and submitted to Kaiser on 990731.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120554 -          ref SDS 56 0001                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120555 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120556 -             [On 990927 requested response to these action items.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120557 -             ref SDS 78 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120559 -              ..
120560 -             [On 990928 notified Kathy that her submission of Synvisc                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
120561 -             on 990719, has been favorably reviewed. ref SDS 80 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
120563 -              ..
120564 -             [On 991011 Craig does not address issue, merely says                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120565 -             success of Synvisc has not been as high as he would like.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120566 -             ref SDS 82 3942]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120568 -              ..
120569 -             [On 991125 notified Steve about Synvisc. ref SDS 85 7654]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120570 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120571 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120572 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120573 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120574 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
1206 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Glucosamine Chronditrin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
Glucosamine Chondoten Recommended for Arthritis in Knee by Doctor Bou                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
1604 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
160501 -  ..
160502 - Glucosamine May Improve Osteoarthritis, Need Prescribed Usage                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160503 - 
160504 - Glucosamine is the medication that may slow or reverse loss of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160505 - cartilage, ref DRT 1 5200, commonly called osteoarthritis.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
160506 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160507 - It has been combined with Chondroitin sulfate, and efficacy of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160508 - Chondroitin sulfate is somewhat more questionable                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
160509 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160510 -      This is the preferred initial effort to reduce ware and replace                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
160511 -      cartilage, discussed on 990910. ref SDS 68 5628                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
160513 -       ..
160514 -      Need a clearer prescription on dosage?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
160516 -       ..
160517 -      Reporting that efficacy is questionable does not really disclose                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
160518 -      whether to use both, or not.  From recollection Craig seemed to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
160519 -      indicate on 990910 that Glucosamine should be taken by itself,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
160520 -      but the record is unclear, ref SDS 68 5628, so an express                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
160521 -      recommendation should be made by the doctor.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
160522 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160523 -          [On 990927 requested more specific prescription for using                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160524 -          Glucosamine and Chrondriton. ref SDS 78 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
160526 -           ..
160527 -          [On 991011 research on the web indicates that Chontroitin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160528 -          with Glucosamine repairs cartilage. ref SDS 82 5933]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
160530 -           ..
160531 -          [On 991026 Don Harms, tennis friend, reports good results                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160532 -          using Glucosamine with Chondroitin for 6 months. ref SDS 84                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
160533 -          3392]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160535 -           ..
160536 -          [On 991125 notified Steve about this research. ref SDS 85                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
160537 -          0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160539 -           ..
160540 -          [On 000121 Jeanne Bradley at Kaiser submitted guidance on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160541 -          dosage. ref SDS 86 1680                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160543 -           ..
160544 -          [On 030807 case study shows personal history using liquid                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160545 -          Glucosamine Chondroiten and clincial research. ref SDS 87                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
160546 -          FN9N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
160548 -           ..
160549 -          [On 040529 0248 report that Glucosamine Chondroitin in liquid                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
160550 -          form relieved knee pain from hiking 3 - 10 miles per day.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
160551 -          ref SDS 88 MN9P                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160553 -           ..
160554 -          [On 050421 received inquiry on the Internet about working                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160555 -          with Doctor Boulris at kaiser, ref SDS 89 EU5I, reported good                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
160556 -          results solving knee pain with Glucosamine Chondroitin.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
160557 -          ref SDS 89 5A7W                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
160559 -           ..
160560 -          [On 090306 0800 NIH of Complementary and Alternative Medicine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
160561 -          (CAM) study found Glucosamine Chondroiten not effective for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
160562 -          mild osteoarthritis (OA), further found this treatment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160563 -          provides significant relief for patients suffering severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
160564 -          knee pain. ref SDS 90 8Q8G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
160566 -       ..
160567 -      Possibly instructions come with purchasing the medication;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160568 -      however, typically doctors prescribe dosage, for how long, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
160569 -      indicate conditions to monitor for adjusting continued use.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
160571 -       ..
160572 -      Any side effects to anticipate and take precautions to minimize?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
160574 -       ..
160575 -      Is the dosage the same for humans as for dogs and horses, noted                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
160576 -      on 990910? ref SDS 68 5628  Are these applications marketed                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
160577 -      separately, so this is not an issue?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
160579 -       ..
160580 -      Is there a reason to defer treatment until after cortisone and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
160581 -      Synvisc, which seem to have a higher priority in the report?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
160583 -       ..
160584 -      Is medication taken concurrent with activity like tennis that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
160585 -      stresses the target area, or, should such activity be avoided                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
160586 -      for a period to permit recovery of cartilage to occur?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
160588 -       ..
160589 -      Is there a web site to review?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
160590 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160591 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
160592 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
1606 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Premedicate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
Motrin, Tylenol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
Neoprene Brace                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
1805 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
180601 -  ..
180602 - Avoid Swelling - Medicate Prior to Activity; Use Neoprene Brace                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
180603 - 
180604 - The report recommends Tylenol medication prior to activity so                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
180605 - that swelling is reduced. ref DRT 1 4088                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
180606 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180607 - On 990910 Motrin also avoids swelling. ref SDS 68 7161                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
180609 -       ..
180610 -      Craig explained during the meeting why it is helpful to prevent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
180611 -      swelling, when the goal is to prevent damage to the knee that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
180612 -      causes swelling.  However, I do not remember the answer, and it                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
180613 -      would be helpful to understand it. ref SDS 68 6808                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
180615 -       ..
180616 -      The report does not cover this point.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
180618 -       ..
180619 -      If he has time, he might confirm the reasoning on why swelling                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
180620 -      needs to be avoided. ref SDS 0 4524                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
180621 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180622 -          [On 990927 requested clarification of this point.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
180623 -          ref SDS 78 0001]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180624 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180625 -          [On 991011 Craig says Tylonol for pain relief is the standard                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
180626 -          of care nationally.  He does not explain why it is useful to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
180627 -          prevent swelling. ref SDS 82 3955]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
180628 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180630 -  ..
180631 - Craig mentions wearing a neoprene knee brace to keep the knee warm,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
180632 - ref DRT 1 4088, which was discussed on 990910, but not included in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
180633 - the record due to oversight, i.e., a mistake.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
180634 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180635 -      Getting a report fixed a mistake, which is the purpose of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
180636 -      "reporting," explained in POIMS. ref OF 5 2300                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
180638 -       ..
180639 -      I have used this type of brace, and gave it up because there was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
180640 -      no evident impact, in that it did not seem to relieve pain.  I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
180641 -      actually had a period of a few years with no pain in either knee,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
180642 -      so that may have led to abandoning this procedure.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
180644 -       ..
180645 -      I am not sure why keeping the knee warm is helpful.  Is it that a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
180646 -      cold condition is brittle and so is subject to greater injury                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
180647 -      during activity?  That is a normal warm up issue, so maybe we are                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
180648 -      enhancing normal warm up because of greater exposure than normal.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
180650 -       ..
180651 -      [On 991011 Craig says neoprene brace keeps knee warm but does not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
180652 -      explain why this is useful. ref SDS 82 9588]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
180653 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180654 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180655 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
180656 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
1807 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Debridement, Arthroscopic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
Knee Replacement                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
2004 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
200501 -  ..
200502 - Knee Replacement Strong Possibility in Future                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
200503 - Debridement Interim Alternative to Knee Replacement                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
200504 - 
200505 - The report reviews potential requirement for knee replacement in 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
200506 - years, ref DRT 1 3844, as shown in the record on 990910. ref SDS 68                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200507 - 9733                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
200509 -  ..
200510 - The report relates discussion on the possibility of a debridement of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
200511 - the knee arthroscopically to try to temporize the need for a total                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
200512 - knee replacement. ref DRT 1 5200                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
200513 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200514 -     I do not recall this discussion on 990910, so this is another                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
200515 -     correction and clarification of the record.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200517 -      ..
200518 -     This appears to be the arthroscopic surgery work performed on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
200519 -     881011, which is part of the medical history reported on 990625.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
200520 -     ref SDS 43 5152  Possibly Craig had a chance to review the record,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
200521 -     per work on 990915, ref SDS 73 4524, and this prompted inclusion                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
200522 -     in the report.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
200524 -      ..
200525 -     The prior work on 881011 was performed because I got to the point                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
200526 -     that I could not walk.  There was constant pain in the left knee,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
200527 -     as reported on 880922. ref SDS 1 3299  Following the operation,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
200528 -     Jim reported finding torn material in the knee, ref SDS 2 6800,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
200529 -     which may have accounted for severe pain.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
200531 -      ..
200532 -     That is not the condition now.  Want to work toward avoiding it                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
200533 -     through cartilage repalcement therapies, such as Synvisc and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
200534 -     Glucosamine, reviewed in Craig's report, or any of the other 8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
200535 -     remedies submitted for review, per request 2, above. ref SDS 0                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
200536 -     6734                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
200537 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200538 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200539 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200540 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200541 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200542 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200543 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
200544 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
2006 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
Distribution. . . . See "CONTACTS"