THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rod@welchco.com


S U M M A R Y


DIARY: October 17, 2013 10:00 AM Thursday; Rod Welch

VA meeting Doctor Egan on LDL lower with exercise, hike Half Dome in Yosemite.

1...Summary/Objective
2...Lab Review Shows Elevated T Bilirubin and Cholesterol
3...Side Effects Rosuvastatin Persistant Conflict Patient Profile
4...Bilirubin Rises 25% Well Above Protocol Range Chronic Hyperbilirubinemia
5...Hyperbilirubinemia Chronic Bilirubin Rises 40% Above Protocol Range
6...Hyperlipidemia Not Controlled Cholesterol Elevated Despite Exercise
7...Cholesterol Elevated Despite Exercise Discuss Clinical Trial
8...Clinical Trial Considered Lower Cholesterol Without Statin Drugs
9...Hiking Increase and Half Dome Lower Cholesterol with Lower Weight
10...Medical Chart Progress Notes Meeting 130304


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CONTACTS 

SUBJECTS
VA Doctor Patient Partnership Effective Productive Examination Docto                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
3403 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
3403 -    ..
3404 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
3405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340501 - Follow up ref SDS 29 0000. ref SDS 26 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
340502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340503 - Good progress with Doctor Patient partnership productive meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
340504 - relying on agenda. ref SDS 0 D95H  Doctor concerned about chronic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
340505 - hyperbilirubinemia with T Bilirubin rising 40% above target, reflects                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
340506 - intollerance for statin drugs to control cholesterol (hyperlipidemia).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340507 - ref SDS 0 KV5G  Doctor ordered consult with SF VA Medical Center for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
340508 - participation clinical trials using new agents to control cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
340509 - that avoid severe side effects. ref SDS 0 VY6H  Patient continuing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
340510 - active physically hiking Half Dome and 1200 miles with further weight                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
340511 - loss past 5 months makes CAD asymptomatic and stable, so no further                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
340512 - testing required at this time. ref SDS 0 KU9N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340513 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340514 -            [On 131103 1739 received letter from SFVA schedule meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
340515 -            on 131120 1000, to develop clinical trial care for lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340516 -            cholesterol. ref SDS 34 Q27Z                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340518 -             ..
340519 -            [On 140430 0900 submit agenda to Doctor Egan with copy to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
340520 -            Doctor Sandhu for follow up meeting. ref SDS 37 HY6O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
340521 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340522 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340523 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340524 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340526 -  ..
3406 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
3407 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
3408 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340801 - Lab Review Shows Elevated T Bilirubin and Cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340802 - Side Effects Rosuvastatin Persistant Conflict Patient Profile                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
340803 - Bilirubin Rises 25% Well Above Protocol Range Chronic Hyperbilirubinemia                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
340804 - Hyperbilirubinemia Chronic Bilirubin Rises 40% Above Protocol Range                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
340805 - 
340806 - Follow up ref SDS 29 D95H, ref SDS 26 TS7I.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
340807 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340808 - Doctor Egan indicated he received the agenda submitted yesterday                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
340809 - on 131016 1632. ref SDS 32 TW9H  During the meeting he was aware of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
340810 - issues presented in links provided in the agenda.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
340812 -  ..
340813 - Reviewed labs on 131015 0724. ref SDS 31 KK9M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
340815 -  ..
340816 - Discussed Bilirubin increasing 25% to 1.7, 40% above target range,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
340817 - shown in the record on 131015 0724, ref SDS 31 015M, rather than                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340818 - falling within target range, compared to 1.3 on prior lab 5 months ago                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340819 - on 130529 0818. ref SDS 28 1Y9G  Since Rosuvastatin was ended on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340820 - 121206 0900, ref SDS 20 OS5L, this record may indicate Rosuvastatin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
340821 - did not elevate Bilirubin; or, alternatively, that chronic dysfunction                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
340822 - of liver has occurred taking Rosuvastatin that cannot be reversabed,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
340823 - or that recovery will be long term.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
340825 -             ..
340826 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
340827 -            assessment report doctor concerned about chronic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
340828 -            hyperbilirubinemia. ref SDS 0 PSXT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340830 -  ..
340831 - Background on Rosuvastatin causing elevated Total Bilirubin with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
340832 - severe side effects is reported in the record on...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
340833 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340834 -             121130............................ ref SDS 19 ER4K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
340835 -             121206............................ ref SDS 20 NI9L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
340837 -  ..
340838 - Doctor Egan seemed to indicate today that elevated T Bilirubin 1.7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
340839 - does not signal treatable issue, because symptoms have mostly                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340840 - subsided, as reported in the record on 121206 0900. ref SDS 20 I05F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
340842 -  ..
340843 - The doctor explained that patient history showing continuing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
340844 - intermittant and mild peripheral neuropathy, reported in patient                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
340845 - history since prior meeting at VA on 130603, see case study on 120101                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
340846 - 0900, ref SDS 10 X14N, suggests intervention is not required at this                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
340847 - time to improve recovery after ending Rosuvastatin last year on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340848 - 121206. ref SDS 20 OS5L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340849 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340850 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
340851 -            assessment report doctor concerned about chronic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
340852 -            hyperbilirubinemia. ref SDS 0 PSXT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
340854 -  ..
340855 - Persistant side effects from statin medications present complex                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340856 - patient profile for lowering cholesterol.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
340857 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340858 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340859 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340860 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
340861 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
3409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
VA Cardiology Examination Cholesterol Hyperlipidemia LDL 248 Despite                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
7603 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
760401 -  ..
760402 - Hyperlipidemia Not Controlled Cholesterol Elevated Despite Exercise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760403 - Cholesterol Elevated Despite Exercise Discuss Clinical Trial                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
760404 - Clinical Trial Considered Lower Cholesterol Without Statin Drugs                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
760405 - 
760406 - Follow up ref SDS 29 D95H.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
760407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760408 - Lab on 131015, showing cholesterol remained high, 131015 0724,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
760409 - ref SDS 31 BE6O, conflict with increased exercise and weight loss,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
760410 - discussed in the letter to the medical team yesterday on 131016 1632.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760411 - ref SDS 32 IW57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760412 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760413 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
760414 -            assessment report patient status CAD stable, asymptomatic.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760415 -            hyperlipidemia not controlled. ref SDS 0 T24N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
760417 -  ..
760418 - On 130603 0930 Medical Chart Progress Notes show Lipitor also called                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760419 - ATORVASTATIN is listed in prescribed medications and status is "hold."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
760420 - ref SDS 29 YH7I  This reflects patient history suffering severe side                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
760421 - effects with statin medications, reported during the meeting 5 months                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760422 - ago on 121206 0900. ref SDS 20 I05F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
760424 -  ..
760425 - Discussed clinical trials again for "targeted" drugs that lower                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760426 - cholesterol with less adverse side effects suffered the past year with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
760427 - statin technologies.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760428 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760429 -            [On 131103 1739 received letter from SFVA schedule meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
760430 -            on 131120 1000, to develop clinical trial care for lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
760431 -            cholesterol. ref SDS 34 Q27Z                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
760433 -  ..
760434 - Anacetrapib cholesterol treatment reported on 101117 1018. ref SDS 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
760435 - U75H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760437 -  ..
760438 - ClinicalTrials.gov Identifier.................. NCT01252953                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
760439 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760440 - ...for Anacetrapib is shown on Internet at...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
760441 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760442 -              http://clinicaltrials.gov/show/NCT01252953                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
760444 -  ..
760445 - VA requirements and procedures for clinical trials is shown at...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
760446 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760447 -              http://www.research.va.gov/resources/ord_admin/clinical_trials/#.Ua0zC0A3uAw                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
760449 -  ..
760450 - VA guidance for patients volunteering for clinical trials...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
760451 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760452 -              http://www.research.va.gov/programs/csp/participation.cfm#.Ua00M0A3uAw                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
760453 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760455 -  ..
760456 - Anacetrapib cholesterol treatment does not seem listed on CSP active                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760457 - studies...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
760458 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760459 -              http://www.research.va.gov/programs/csp/studies.cfm#.Ua01FUA3uAw                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
760461 -  ..
760462 - Amgen and Regeneron are developing medicines that cut cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
760463 - through a new strategy, by blocking a protein called PCSK9, reported                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760464 - on 120325 1312. ref SDS 12 GG5I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760466 -  ..
760467 - Article published by Reuters reported on 131015 new cholesterol drug                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760468 - by Regeneron and Sanofi (evidently joint venture project)...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
760469 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760470 -        Alirocumab cuts LDL-C by 47.2 pct                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
760471 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760472 -        Patients taking alirocumab started out with a low 75-milligram                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760473 -        dose every two weeks, but this was increased to 150 milligrams                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760474 -        at week 12 if their LDL levels at week eight were above 70.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
760475 -        Most patients, however, remained on the low dose throughout                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
760476 -        the study because they got their LDL levels below that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
760477 -        threshold - an aggressive LDL target - by the eighth week.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
760479 -         ..
760480 -        "It shows that a low dose, when used as a monotherapy, can be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760481 -        quite effective," Yancopoulos said, noting that no worrisome                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
760482 -        side effects were seen in the study nor in earlier trials.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
760484 -         ..
760485 -        Self-injection bi-weekly, seems better than taking a pill                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
760486 -        everyday.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
760487 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760488 -              http://www.reuters.com/article/2013/10/16/us-regeneron-sanofi-cholesterol-idUSBRE99F04220131016                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
760490 -  ..
760491 - Since cholesterol 321, and LDL 249 are well above targets for LDL 70,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760492 - set in the record on 110309 0900. ref SDS 6 ZM98  Doctor Egan will                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
760493 - make referral to San Francisco VA Medical Center for evaluating                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760494 - patient participation in clinical trial of treatments and medications                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760495 - to lower cholesterol with minimal side effects.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760496 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760497 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
760498 -            assessment report patient status hyperlipidemia not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
760499 -            controlled, ref SDS 0 PSXT; Doctor Egan makes referral to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
760500 -            SF VA Medical Center for consult on participation clinical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760501 -            trials, ref SDS 0 EU9F, with experimental agents such as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
760502 -            AMG 145 and REGN 727 to resolve multiple statin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
760503 -            intolerances. ref SDS 0 CN4H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
760505 -             ..
760506 -            [On 131121 0930 discussed with San Francisco VA Medical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
760507 -            Center participating in clinical trial for PCSK9 as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
760508 -            alternative to statin drug treatment to manage cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760509 -            for reducing CVD risk of atherosclerosis. ref SDS 35 1P5M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
760511 -             ..
760512 -            [On 131121 0930 VA Progress Notes in medical chart report                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
760513 -            consideration for patient to participate in clinical trial                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760514 -            testing PCSK9 drugs to manage cholesterol for lowering CVD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
760515 -            risk through regression of atherosclerosis. ref SDS 35 Q17I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
760516 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760517 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760518 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760519 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760520 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
760521 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
7606 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
VA Cardiology Examination Patient Active Physically Half Dome Hike 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
AA03 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
AA0401 -  ..
AA0402 - Hiking Increase and Half Dome Lower Cholesterol with Lower Weight                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
AA0403 - 
AA0404 - Follow up ref SDS 29 KU9N.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
AA0405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0406 - Doctor Egan was pleased with patient excellent health recovering from                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
AA0407 - heart surgery on 091022 0700, ref SDS 2 PQWU, through exercise and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
AA0408 - weight loss evident recently hiking Half Dome in Yosemite on 130918                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
AA0409 - 0620, ref SDS 30 0001, and hiking 1200 miles past 5 months, reported                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
AA0410 - in the letter yesterday on 131016 1632. ref SDS 32 IW4O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
AA0412 -  ..
AA0413 - Discussed doing another treadmill stress test to evaluate patient                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
AA0414 - health based on record of exercise in combination with lab showing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
AA0415 - elevated cholesterol, reported on 131015 0724. ref SDS 31 BE6O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
AA0417 -  ..
AA0418 - Doctor Egan noted the treadmill stress ordered by Doctor Lee, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
AA0419 - performed at the VA on 090916, was based on a 5-year period of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
AA0420 - routinely experiencing chest pain hiking the first hill at Lafayette                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
AA0421 - Reservoir 4 - 6 times per week, and finally worsening to continuous                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
AA0422 - chest pain hiking the entire 3 mile route at the reservoir for 3 days                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
AA0423 - prior to meeting with Doctor Lee on 090908.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
AA0425 -  ..
AA0426 - The doctor indicated the situation is different and more favorable                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
AA0427 - now.  At this time, 4 years after heart surgery to correct the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
AA0428 - original problem reported on 090908, ref SDS 1 MY4N, the patient has                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
AA0429 - not suffered chest pain with increased physical activity, most                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
AA0430 - recently hiking about 1200 miles the past 5 months, and climbing Half                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
AA0431 - Dome on 130918, presented in the letter to the VA on 131016 1632.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
AA0432 - ref SDS 32 IW57                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
AA0434 -  ..
AA0435 - The doctor advised that since the patient is very active physically,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
AA0436 - and is asymptomatic, there is no need for further testing despite                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
AA0437 - elevated cholesterol in the lipid lab test on 131015 0724. ref SDS 31                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
AA0438 - BE6O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
AA0440 -             ..
AA0441 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
AA0442 -            report patient completed Half Dome hike and remains active                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
AA0443 -            physically, ref SDS 0 TX4G, assessment report patient                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
AA0444 -            status CAD stable, asymptomatic. ref SDS 0 T24N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
AA0446 -  ..
AA0447 - Scheduled next meeting in 6 months.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
AA0448 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0449 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0450 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0451 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0452 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0453 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA0454 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
AA05 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
VA Cardiology Medical Chart Progress Notes Examination Investigate C                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B703 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70401 -  ..
B70402 - Medical Chart Progress Notes Meeting 130304                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70403 - 
B70404 - Follow up ref SDS 29 TF5O, ref SDS 26 TF5O.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70406 -    1.  LOCAL TITLE: Cardiology 10501                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70407 -        STANDARD TITLE: CARDIOLOGY NOTE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70408 -        DATE OF NOTE: OCT 17, 2013@08:44 ENTRY DATE: OCT 17, 2013@08:44:02                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70409 -        AUTHOR: EGAN,JAMES EXP COSIGNER:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70410 -        URGENCY:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70411 -        STATUS: COMPLETED                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
B70415 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70416 -    2.  ...68 year old MALE followed in Cardiology Clinic for problems                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70417 -        including                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70418 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70419 -        1.  CAD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70421 -                 ..
B70422 -            a)  Angina, class II- III 10/2/09                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70424 -                 ..
B70425 -            b)  Abnormal TMST, relatively low work load 9/16/09                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70427 -                 ..
B70428 -            c)  CABGx4v 10/22/09 SFVA (LIMA-->LAD, SVG-->diag,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70429 -                SVG-->Ramus,SVG-->PDA).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70431 -             ..
B70432 -        2.  Hyperlipidemia intolerant simvastatin, atorvastatin,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70433 -            rosuvastatin.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
B70435 -             ..
B70436 -        3.  Achalasia, S/P laparoscopic myotomy with fundoplication at                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70437 -            the San Francisco VA December 2009.  Subsequently recurrent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70438 -            stricture.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70440 -             ..
B70441 -        4.  PACs with exercise on ETT 4/6/11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70443 -         ..
B70444 -    3.  Background                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70445 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70446 -        ...[Doctor Egan enters in Progress for the meeting today,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70447 -        assessment and work plan from prior meeting on 121206...]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70449 -         ..
B70450 -        The patient was last seen in clinic on 6/3/13 , A&P as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70451 -        follow:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70452 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70453 -        1.  ASSESSMENT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70455 -                 ..
B70456 -            1)  CAD. Stable, asymptomatic.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70458 -                 ..
B70459 -            2)  Hyperlipidemia.  not in control                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70461 -                 ..
B70462 -            3)  PACs with exercise on ETT 4/6/11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70464 -              ..
B70465 -         2.  PLAN                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70466 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70467 -             1)  Current medications reconciled.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70468 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70469 -             2)  Prolonged discussion of appropriate approach to his                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70470 -                 hyperlipidemia.  Given past left should pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70471 -                 attributed to simvastatin and possible lightheadedness                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70472 -                 and paresthesias with rosuvastatin, atorvastatin seems                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70473 -                 a reasonable choice.  Discussed potential interaction                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70474 -                 with omeprazole and increased risk of myopathy.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70475 -                 Prefers to make an attempt with atorva and failing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70476 -                 that research participation in clinical trials of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70477 -                 newer agents.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70479 -                  ..
B70480 -             3)  Rx atorvastatin 40 mg daily                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70482 -                  ..
B70483 -             4)  CMP, Lipids in early October following climb of Half Dome.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70484 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70485 -        2.  /es/ James Egan, MD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70486 -            Staff Physician, Cardiology                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70487 -            Signed:  2013 06 03 1022 PDT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70488 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70490 -         ..
B70491 -    4.  Current Patient Status on 131017 1000 PDT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70492 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70493 -        Eventually discontinued atorvastatin, felt it was limiting his                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70494 -        exercise capability.  Completed his Half Dome hike 9/28/13.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70495 -        Now hiking 11 miles in 160 minutes, 1200 miles over the last 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70496 -        months.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70498 -  ..
B70499 - Lipitor (atorvastatin) deferred due to adverse side effects aligns                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70500 - with report to medical team on submitted yesterday on 131016 1632.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70501 - ref SDS 32 IW5J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70503 -  ..
B70504 - Exercise increase and weight loss with concomitant improved health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70505 - aligns with report to medical team submitted yesterday on 131016 1632,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70506 - ref SDS 32 IW57, and discussed during the meeting, above. ref SDS 0                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70507 - KU9N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70509 -  ..
B70510 - Reference to Half Dome relates to report today hiking Half Dome on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70511 - 130918 0620. ref SDS 30 0001  The doctor entered 130928, which is off                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70512 - by 10 days, but there was a lot discussed during the meeting.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70514 -  ..
B70515 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70516 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70517 -        Seen today with Kathy, as prior.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70519 -         ..
B70520 -        Feeling well in every respect, Half Dome hike was challenging                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70521 -        but successful.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70523 -  ..
B70524 - Aligns with the record hiking Half Dome on 130918 0620, ref SDS 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
B70525 - QE4L, submitted with the agenda yesterday on 131016 1632, ref SDS 32                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70526 - IW4O, and discussed during the meeting. ref SDS 0 KU9N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70528 -  ..
B70529 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70530 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70531 -        No symptoms suggestive of angina, remains very active                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70532 -        physically.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70534 -         ..
B70535 -        Concerned with ongoing elevation in LDL, has been researching                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70536 -        experimental agents such as AMG 145 and REGN 727 and would be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70537 -        interested in participating in a clinical trial if one were                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70538 -        available to him, given multiple statin intolerances.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70540 -  ..
B70541 - Progress Notes report multiple statin intolerances, above, ref SDS 0                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70542 - JM5L, and aligns with discussion during the meeting, above.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70543 - ref SDS 0 179N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70544 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70545 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70546 -            assessment report patient status hyperlipidemia not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70547 -            controlled, ref SDS 0 PSXT; Doctor Egan makes referral to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70548 -            SF VA Medical Center for consult on participation clinical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70549 -            trials, ref SDS 0 EU9F, with experimental agents such as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70550 -            AMG 145 and REGN 727 to resolve multiple statin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70551 -            intolerances. ref SDS 0 CN4H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70553 -             ..
B70554 -            [On 131103 1739 received letter from SFVA schedule meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70555 -            on 131120 1000, to develop clinical trial care for lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70556 -            cholesterol. ref SDS 34 Q27Z                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70558 -  ..
B70559 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70560 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70561 -        No history of dizziness, lightheadedness or syncope.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70562 -        Occasional mild paresthesias of right foot.  No palpitations.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70564 -         ..
B70565 -    5.  PAST MEDICAL HISTORY:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70566 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70567 -        Computerized Problem List is the source for the following:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70568 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70569 -            1.  Dizziness * (ICD-9-CM 780.4) 09/06/12 Egan, James                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70571 -                 ..
B70572 -            2.  Paresthesia * (ICD-9-CM 782.0) 09/06/12 Egan, James                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70574 -                 ..
B70575 -            3.  Vitamin D Deficiency 08/03/11 Sandhu, Harkesh                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70577 -                 ..
B70578 -            4.  Postsurgical Aortocoronary Bypass Status (ICD-9-CM                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70579 -                V45.81) 03/09/11 Egan, James                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70581 -                 ..
B70582 -            5.  Esophageal Stricture 03/05/10 LEE,RANDALL E.......                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70584 -                 ..
B70585 -            6.  Screening for Malignant Neoplasms of colon 02/02/10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70586 -                LEE,RANDALL E (ICD-9-CM V76.51)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70588 -                 ..
B70589 -            7.  Coronary Atherosclerosis (unspecified type 02/02/10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70590 -                LEE,RANDALL E vessel, native or graft) (ICD-9-CM 41                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70592 -                 ..
B70593 -            8.  Coronary Artery Bypass using Venous and 01/04/10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70594 -                SANDHU,HARKESH Arterial Grafts (Single Vein Graft),                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70595 -                Onset 10/00/09 done at vasf                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70597 -  ..
B70598 - CABG was performed at VA San Francisco Medical Center on 091022.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70599 - ref SDS 16 PQWU                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70601 -  ..
B70602 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70603 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70604 -            9.  Surgical Thoracoscopy with Esophagomyotomy 01/04/10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70605 -                SANDHU,HARKESH (Heller Type), Onset 12/16/09 at vasf                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70607 -                 ..
B70608 -           10.  Hyperlipidemia * (ICD-9-CM 272.4) 10/02/09 EGAN,JAMES                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70610 -                 ..
B70611 -           11.  Inflamed Seborrheic Keratosis (ICD-9-CM 702.11)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70612 -                03/12/07 LIN,BERTHA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70614 -                 ..
B70615 -           12.  Rosacea * (ICD-9-CM 695.3) 03/12/07 LIN,BERTHA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70617 -                 ..
B70618 -           13.  Dermatitis * (ICD-9-CM 692.9) 03/12/07 LIN,BERTHA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70620 -                 ..
B70621 -           14.  Tinea Unguium * (ICD-9-CM 110.1) 03/12/07 LIN,BERTHA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70623 -                 ..
B70624 -           15.  Tinea * (ICD-9-CM 110.9) 03/12/07 LIN,BERTHA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70626 -                 ..
B70627 -           16.  Rosacea conjunctivitis (ICD-9-CM 372.31) 03/02/07                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70628 -                MARGULIES,LINDA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70630 -                 ..
B70631 -           17.  Rosacea * (ICD-9-CM 695.3) 03/02/07 MARGULIES,LINDA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70633 -                 ..
B70634 -           18.  Blepharitis NOS 02/21/07 MARGULIES,LINDA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70636 -                 ..
B70637 -           19.  Achalasia * (ICD-9-CM 530.0) 12/22/05 SANDHU,HARKESH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70639 -                 ..
B70640 -           20.  Abn.  LFT's 08/16/05 SANDHU,HARKESH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70642 -                 ..
B70643 -           21.  Obesity 06/29/05 SANDHU,HARKESH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70645 -                 ..
B70646 -           22.  Rosacea 06/29/05 SANDHU,HARKESH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70648 -                 ..
B70649 -           23.  Tinea Unguium 06/29/05 SANDHU,HARKESH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70651 -             ..
B70652 -            Patient has answered NKA (no known allergies)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
B70654 -         ..
B70655 -    6.  Active Outpatient Medications (including Supplies):                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70656 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70657 -        1.  ATORVASTATIN CALCIUM 40MG TAB TAKE ONE TABLET BY MOUTH ONCE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70658 -            DAILY TO LOWER CHOLESTEROL. (REPLACES ROSUVASTATIN)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70659 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70660 -            Active                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70662 -  ..
B70663 - Atorvastatin is Lipitore discussed as being deferred due to statin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70664 - intollerance, above. ref SDS 0 UU7J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70666 -  ..
B70667 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70668 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70669 -        2.  OMEPRAZOLE 20MG EC CAP TAKE ONE CAPSULE BY MOUTH TWICE A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70670 -            HOLD DAY 15 MINUTES BEFORE A MEAL FOR SEVERE ACID REFLUX                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70671 -            AND ESOPHAGEAL NARROWING.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70673 -             ..
B70674 -            Active                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70675 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70677 -  ..
B70678 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70679 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70680 -    7.  PHYSICAL EXAM - Date:  131017 0948                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70681 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70682 -        T....................... 97.7 F (36.5 C)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70683 -        P....................... 61                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70684 -        R....................... 20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70685 -        B/P..................... 129/64                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70686 -        Wt...................... 179.5 (81.59 KG) (ACTUAL STANDING WEIGHT)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70687 -        Body Mass Index......... 29*                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70688 -        Pulse Oximetry.......... 99%                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70689 -        Pain....................  0 - No pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70691 -         ..
B70692 -        VITALS: 06/03/2013 09:31 BP:129/70 HR:65 Wt:185.7 lb [84.4 kg                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70694 -         ..
B70695 -        Head atraumatic, PERRL.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70696 -        Carotid upstrokes normal, no bruits noted                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70697 -        Thyroid normal to palpation.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70698 -        JVP wnl.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70699 -        Cor: Regular, no ectopy, no sig mrg.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70700 -        Lungs clear of rales, ronchi and wheezes.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70701 -        Extremities without cyanosis, clubbing or edema.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70703 -         ..
B70704 -    8.  LAB Review                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70705 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70706 -        ...[Doctor Egan lists results for lab performed on 131015 0724.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70707 -        ref SDS 31 BE6O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70709 -         ..
B70710 -    9.  ASSESSMENT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70711 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70712 -        1.  CAD.  Stable, asymptomatic.  No diagnostic testing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70713 -            currently indicated.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70715 -             ..
B70716 -        2.  Hyperlipidemia. uncontrolled.  Multiple statin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70717 -            intolerances.  Discussed potential use of colestipol but                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70718 -            there is little chance that this agent would allow us to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70719 -            achieve LDL goal of < 100 mg/dl and I am concerned with his
B70720 -            chronic hyperbilirubinemia.  Ezetemibe might be of some                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70721 -            value but would not achieve goal and may or may not prevent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70722 -            atherogenesis.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70724 -  ..
B70725 - Concern for hyperlipidemia and chronic hyperbilirubinemia caused by                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70726 - statin agents to lower cholesterol, reflects discussion during the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70727 - meeting, above. ref SDS 0 LV5J and ref SDS 0 VY6H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70728 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70729 -            [...below on 131017 1000 VA medical chart Progress Notes                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70730 -            Doctor Egan makes referral to SF VA Medical Center for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70731 -            consult on participation clinical trials, ref SDS 0 EU9F,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70732 -            with experimental agents such as AMG 145 and REGN 727 to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70733 -            resolve multiple statin intolerances. ref SDS 0 CN4H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70735 -             ..
B70736 -            [On 131103 1739 received letter from SFVA schedule meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70737 -            on 131120 1000, to develop clinical trial care for lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70738 -            cholesterol. ref SDS 34 Q27Z                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70740 -             ..
B70741 -            [On 140203 0830 lab reports T Bilirubin increased to 2.1,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
B70742 -            nearly 100% above healthy range. ref SDS 36 015M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
B70744 -             ..
B70745 -            [On 140814 1530 lab reports T Bilirubin increased 2.5;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70746 -            patient history shows chronic hyperbilirubinemia                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70747 -            ref SDS 38 G34G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
B70749 -  ..
B70750 - Progress Notes continue...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
B70751 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70752 -   10.  PLAN:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
B70753 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70754 -        1.  Current medications reconciled, no changes made.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
B70756 -             ..
B70757 -        2.  After thorough discussion we have elected to ask the help                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70758 -            of Endocrine at SFVA in managing his hyperlipidemia,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70759 -            consult submitted.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70761 -  ..
B70762 - Plan to resolve chronic hyperlipidemia with participation in clinical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
B70763 - trials of agents that avoid side effects of statins, reflects                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70764 - discussion during the meeting, above. ref SDS 0 8B3M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
B70765 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70766 -            [On 131103 1739 received letter from SFVA schedule meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
B70767 -            on 131120 1000, to develop clinical trial care for lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
B70768 -            cholesterol. ref SDS 34 Q27Z                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
B70770 -             ..
B70771 -        3.  RTC 6 months, will f/u Dr Sandhu next month.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70772 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70773 -              [On 140430 0900 submit agenda to Doctor Egan with copy to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70774 -              Doctor Sandhu for follow up meeting. ref SDS 37 HY6O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
B70775 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70776 -   11.  /es/ James Egan, MD                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
B70777 -        Staff Physician, Cardiology                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
B70778 -        Signed:  2013 10 17 1040 PDT                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
B70779 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70780 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70781 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70782 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70783 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70784 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70785 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70786 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70787 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70788 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70789 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70790 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70791 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70792 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70793 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B70794 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
B708 -