THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: August 19, 2005 10:00 AM Friday; Rod Welch

Millie Taxotere treatment begin 7th cycle with Xeloda at Kaiser.

1...Summary/Objective
2...Port Catheter Flush Scheduled When Patient Off Treatments
3...Blood Counts Good Dose Chemotherapy Taxol Normal
4...CA 15-3 39 Drops from 46 to Normal Again After 6th Treatment Cycle
5...Preparation for Treatment Required One (1) Attempt to Connect Port
6...Taxotere Full Dose Even though Blood Counts Below Targets
7...Alert Energetic After Treatment Marked Change from Prior Treatments


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CONTACTS 

SUBJECTS
1st Treatment 1st Cycle Taxotere Xeloda Capacitibine Chemotherapy Tr

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 61 0000. ref SDS 58 0000.
040502 -
040503 - This is the final and 7th treatment with Taxotere and capecitabine
040504 - (Xeloda) scheduled by the primary care physician on 050729.
040505 - ref SDS 60 VP4N   The nurse brought Millie a teddy bear as a gift from
040506 - the Clinic staff to signify "graduation" from current treatment
040507 - regimine.  Good news CA 15-3 test last week on 050812 dropped back to
040508 - 39. ref SDS 0 3K6L
040509 -
040510 -
040511 -
040512 -
040514 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Barbara Smith is the nurse today.
040903 -  ..
040904 - Zan from the pharmacy visited Millie in the Chemotherapy Clinic.
040906 -  ..
040907 - Zan asked about side effects and whether the dose should be adjusted
040908 - again.
040910 -  ..
040911 - Millie related patient history in the diary on 050809, ref SDS 62
040912 - 0001, following guidance from Zan on 050415 to keep a diary.
040913 - ref SDS 49 2W6I
040914 -
040915 -       After meeting with Zan, Millie indicated she forgot to mention
040916 -       all of the side effects; this can be corrected by submitting the
040917 -       record.
040919 -  ..
040920 - Zan seemed to indicate that while Millie is experiencing some physical
040921 - and emotional trauma tolerating side effects of Taxotere and
040922 - capecitabine (Xeloda), her experience is at the low end of the scale
040923 - for suffering that most patients experience with these drugs.  Zan did
040924 - not present information on the number of patients Kaiser has treated
040925 - with Taxotere and capecitiabine.  This was prescribed in Millie's case
040926 - on 050329, ref SDS 47 FP57, after notice from UCSF received on 041117,
040927 - ref SDS 38 OU6S; capecitabine is not on the list of drugs Kaiser
040928 - prescribes, reported on 041130. ref SDS 39 FY5F
040930 -  ..
040931 - Zan said that Millie is fortunate that peeling and blisters on hands
040932 - and feet have been very moderate in her case after six (6) cycles of
040933 - treatment.  Zan feels the dose for the current treatment can therefore
040934 - remain the same.  This aligns with planning by the primary care
040935 - physician on 050729 to maintain the dose in order to avoid progress of
040936 - disease in the run up to a decision on surgery.  CA 15-3 falling back
040937 - to 39, as reported today, ref SDS 0 3K6L, may support the decision to
040938 - maintain drug strength for this current treatment.
040940 -  ..
040941 - Zan showed a pink or salmon colored hospital form, where he had jotted
040942 - some comments from the discussion just now, and indicated this will be
040943 - the report filed in the medical chart for the doctor to understand the
040944 - scope of patient side effects.  On 041014 review found handwritting in
040945 - the medical chart is illegible and difficult to interpret, because
040946 - context from situational awareness during verbal communication is not
040947 - entered in the medical chart due to limited time, and the perception
040948 - that accuracy and context are unnecessary overkill. ref SDS 35 W78K
040950 -  ..
040951 - As a result, Zan prepared a subscription for capecitabine (Xeloda)
040952 - that is the same dose as the prior treatments, since reducing the
040953 - dose by 25% on 050520.
040954 -
040955 -
040957 -  ..
040958 - Port Catheter Flush Scheduled When Patient Off Treatments
040959 -
040960 - Millie asked Barbara to schedule a meeting to flush the port catheter,
040961 - since today is her last chemo treatment, and Kaiser's guidance says
040962 - that a port needs to be flushed every 4 - 6 weeks when not getting
040963 - regular chemo treatments.
040965 -  ..
040966 - Barbara scheduled a meeting here at the Kaiser Walnut Creek
040967 - Chemotherapy Clinic for 050923 1000.
040968 -
040969 -
040970 -
040971 -
040972 -
040973 -
040974 -
040975 -
040976 -
040977 -
0410 -

SUBJECTS
Blood Tests White Cell Count Good 2nd Cycle 1st Treatment Chemothera
Urine Tests No Evident Problems
Blood Test Results Pass for Treatment

0805 -
080601 -  ..
080602 - Blood Counts Good Dose Chemotherapy Taxol Normal
080603 -
080604 - Follow up ref SDS 61 Q659, ref SDS 58 Q659.
080605 -
080606 - Millie had blood drawn this morning at 0600 by Kaiser in Martinez.
080608 -  ..
080609 - Barbara submitted the report showing...
080610 -
080611 -    Patient   Provider  Category   View      FR Date   To Date
080617 -     ..
080618 -    Procedure              Results             Reference Range
080620 -     ..
080622 -
080623 -                  ** Martinez Medical Offices **
080625 -     ..
080626 -    @CBC
080627 -    WBC x 10-3               7.8 K/uL           3.5   -     12.5
080628 -    RBC x 10-6    L         3.32 M/uL           3.60  -      5.10
080629 -    Hemoglobin    L         11.2 g/dL          11.5   -     15.0
080630 -    Hematocrit    L         32.8 %             34.0   -     46.0
080631 -    MCV                       99 fL            80.0   -    100.0
080632 -    RDW            H        18.7 %             11.9   -     14.3
080633 -    Plt x10-3              272   K/uL         140     -    400
080634 -     ..
080635 -    Neutrophils    H          83 %             50     -     70
080636 -    Lymphocytes               14 %             20     -     50
080637 -    Monocyte                   3 %              0     -     11
080638 -    Eosinophils                0 %              1     -      5
080639 -    Basophil                   0%               0     -      2
080640 -    Bands              No Report %              0     -      5
080641 -    Manual Diff?           Chemo
080643 -     ..
080644 -    CA 15-3        Test Remote Collect         -<     -     39
080646 -     ..
080647 -    Seg Neutrophils    No Report %             50     -     70
080649 -     ..
080650 -    DIFF Method         Auto Dif
080651 -    Anisocytosis       No Report+
080652 -    Macrocytes         No Report+
080653 -    Plt estimate         Adequate
080655 -     ..
080656 -    Alkaline Phos             45 U/L           38     -    126
080657 -    Bili, Tot Adult         <0.3 mg/dL        0.2     -    1.3
080658 -    Creatinine               0.7 mg/dL        0.6     -    1.2
080659 -    Phosphorus     Test Remote Collect
080660 -    Alt (SGPT)                29 U/L           11     -     66
080661 -    AST (SGOT)         No report U/L           11     -     66
080662 -    Glucose Random            93 mg/dL         60     -    159
080663 -
080665 -     ..
080666 -    Cuomdin (Anticoag Ther WARFARIN
080667 -    PT, Patient             22.3 Sec         9.2           11.6
080668 -    PT, INR                  2.1 Ratio         2              3
080669 -
080670 -
080671 -
080672 -
080673 -
080674 -
0807 -

SUBJECTS
CA 15-3 78 Smaller Rise than 10 Points Reported on 040318

0903 -
090401 -  ..
090402 - CA 15-3 39 Drops from 46 to Normal Again After 6th Treatment Cycle
090403 -
090404 - Follow up ref SDS 61 2N5J, ref SDS 58 2N5J.
090405 -
090406 - Results not available for CA 15-3 on the blood test today, per above.
090407 - ref SDS 0 5K6K
090409 -  ..
090410 - Barbara submitted results on the blood test for 050729...
090411 -
090414 -  ..
090415 - CA 15-3 dropped to 45, only one below 46 on the prior test, reported
090416 - during the meeting with the surgeon on 050727. ref SDS 59 YK6K  This
090417 - test was performed on blood drawn the morning before starting the 6th
090418 - cycle of treatment, and so does not reflect the 6th cycle.
090420 -  ..
090421 - A subsequent and most recent test on 050812 shows...
090422 -
090425 -  ..
090426 - Great news CA 15-3 dropped to 39 from 45; moving back from the bounce
090427 - reported on 050727, ref SDS 59 YK6K, and reflecting the 6th cycle of
090428 - treatment given on 050729.  The drop in CA 15-3 fits analysis on
090429 - 050729 that maintained dosage of treatment. ref SDS 60 GJ5M
090431 -  ..
090432 - Millie ordered another CA 15-3 test for the blood draw this morning,
090433 - and will get another next week before going on vacation.  Want to see
090434 - a pattern, per analysis by primary care physician on 040812.
090435 - ref SDS 27 CT9J
090436 -
090437 -
090438 -
090439 -
090440 -
090441 -
090442 -
0905 -

SUBJECTS
Prepare for Treatment Connect Equipment for Port Catheter
Tagiment Dexatron Administered to Prevent Alergic Reaction to Taxol
Port Catheter Required 3 Tried to Connect Infusion Equipment Prepare

1205 -
1206 - 1012
120701 -  ..
120702 - Preparation for Treatment Required One (1) Attempt to Connect Port
120703 -
120704 - Follow up ref SDS 61 EB7J, ref SDS 58 EB7J.
120705 -
120706 - Vitals taken by Tauna...
120707 -
120708 -    Blood preasure    128  75
120709 -    Pulse              70
120710 -    Temperature        97.6
120712 -  ..
120713 - Barbara took admin with Sheri to verify Millie's identification and
120714 - treatment protocol spec.
120716 -  ..
120717 - Millie explained having taken Decadron tablets according to the
120718 - prescription to take two tablets twice a day, per instructions on
120719 - 050415. ref SDS 49 8U4O
120721 -  ..
120722 - Barbara gave Millie a pill for Compazine 10 prior to treatment that
120723 - reduces nausea rather than as a drip treatment to avoid allergic
120724 - reaction.
120726 -  ..
120727 - Barbara made installation to the port....
120729 -       ..
120730 -      Interlink System Vented Paclitaxel set
120732 -  ..
120733 - Millie's blood counts are good, so there is no requirement to take
120734 - Nupigen again to strengthen the immune system.
120736 -  ..
120737 - Started saline flush.
120738 -
120739 -
120741 -  ..
1208 -
1209 -
1210 - 1008
1211 -
121101 - Benedryl started.
121102 -
121103 -
121105 -  ..
1212 -
1213 -
1214 - 1020
1215 -
121501 - Benedryl completed.
121502 -
121503 -
121504 -
121505 -
1216 -

SUBJECTS
Taxol Treatment Delayed 30 Minutes Because Lab Has Not Prepared Trea
AC Adriamycin Cytoxin Treatment Begun Today on New Regimine Replacin

1504 -
1505 - 1023
150601 -  ..
150602 - Taxotere Full Dose Even though Blood Counts Below Targets
150603 -
150604 - Follow up ref SDS 61 4N5M, ref SDS 58 4N5M.
150606 -  ..
150607 - Taxotere started.
150609 -  ..
150610 - Millie is getting a full dose of Taxotere because her blood counts are
150611 - very close to minimum. ref SDS 61 0N7Q
150612 -
150613 -
150614 -
150616 -  ..
1507 -
1508 - 1122
1509 -
150901 - Equipment beeped indicating treatment is over.
150902 -
150903 - Taxotere treatment completed.
150905 -  ..
150906 - Saline flush was run for a few minutes.
150908 -  ..
150909 - Babara removed the drip treatment tube from the port, and applied
150910 - Hepren to reduce clotting, and avoid infection.
150912 -  ..
150913 - Barbara did not get vitals at the end of treatment, as was done last
150914 - time.
150915 -
150916 -   Temperature.........
150917 -   Pulse...............
150918 -   Blood Pressure......
150919 -
150920 -
150921 -
150922 -
150924 -  ..
1510 -
1511 -
1512 - 1145
1513 -
151301 - We went to the Pharmacy and picked up the prescription for...
151302 -
151303 -            Xeloda
151304 -
151305 -
151306 -
151307 -
151308 -
151309 -
151310 -
151311 -
1514 -

SUBJECTS
Tired Wobbly on Feet after Treatment In Asleep by 1900
Tired Wobbly on Feet after Treatment Asleep by 1900 Not Today After

1704 -
1705 - 1207
170601 -  ..
170602 - Alert Energetic After Treatment Marked Change from Prior Treatments
170603 -
170604 - Follow up ref SDS 61 F54N, ref SDS 58 F54N.
170605 -
170606 - Millie seemed okay after treatment today.  No immediate wobbliness.
170607 - She was okay to drive, and seemed alert the rest of the day.
170609 -  ..
170610 - Millie drove us from Walnut Creek to the VA in Matinez, to pick up
170611 - some meds; we then drove to Clayton and split a hamburger for lunch.
170612 -
170614 -  ..
1707 -
1708 -
1709 - 1424
1710 -
171001 - Millie took a nap until about 1700.
171002 -
171004 -  ..
1711 -
1712 -
1713 - 1737
1714 -
171401 - Millie helped fix dinner; and after dinner she took her Xeloda pills.
171402 -
171403 -
171404 -
171405 -
171406 -
171407 -
171408 -
171409 -
171410 -
171411 -
1715 -