THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rod@welchco.com


S U M M A R Y


DIARY: March 12, 2014 05:20 PM Wednesday; Rod Welch

VA letter notify comments Progress Notes meeting 13Feb2014.

1...Summary/Objective
2...Progress Notes Meeting 140213 Transmitted VA System Email
3...VA System Email Transmitted Progress Notes Meeting 140213


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CONTACTS 

SUBJECTS
VA Pharmacy Ezetimibe Order Refill Treat Cholesterol LDL 249 Prescri                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
5703 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5703 -    ..
5704 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
5705 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
570501 - Follow up ref SDS A4 0000. ref SDS A3 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
570502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570504 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570505 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570507 -  ..
5706 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5707 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5708 - Background                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
5709 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
570901 - EGD on 101210, seems to show progress recovering from esophagitis; the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
570902 - doctor dilated the LESV from 11 to 14 cm, reported on 101210 0930,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
570903 - ref SDS 49 XG6J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570905 -  ..
570906 - Follow up EGD planned for February, ref SDS 49 L94L.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
570908 -  ..
570909 - Doctor Lee prescribed doubling dose of Omeprazole to increse recover                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
570910 - from esophagitis, reported on 101210 0930. ref SDS 49 ZN4M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
570912 -  ..
570913 - On 101216 appears Doctor Lee ordered refill for omeprazole. ref SDS 51                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570914 - 8785                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
570916 -  ..
570917 - On 110320 0750 ordered refill Omeprazole to treat Achalasia,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570918 - ref SDS 58 5N3O,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
570920 -  ..
570921 - On 110626 0721 ordered refill Omeprazole to treat Achalasia.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570922 - ref SDS 62 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570924 -  ..
570925 - On 110913 2238 ordered refill Omeprazole to treat Achalasia,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570926 - ref SDS 63 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570928 -  ..
570929 - On 120326 1549 ordered refill Omeprazole to treat Achalasia,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570930 - ref SDS 70 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570932 -  ..
570933 - On 120330 1439 received refill Omeprazole to treat Achalasia.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
570934 - ref SDS 71 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570936 -  ..
570937 - On 120906 1100 Doctor Egan reduced dose Omeprazole 20 mg from 40 mg,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
570938 - which increased effective treatments with current prescription.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570939 - ref SDS 74 W165                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570941 -  ..
570942 - On 120925 1300 Doctor Lee increased dose Omeprazole 40 mg from 20 mg,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570943 - which decreases effective treatments under current prescription.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
570944 - ref SDS 75 K37G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570946 -  ..
570947 - On 120927 1214 could not order refill prescription for Omeprazole.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
570948 - ref SDS 76 3Z4M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570950 -  ..
570951 - On 121001 0820 VA ordered new prescription Omeprazole with 3 remaining                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
570952 - refills, ref SDS 78 5N3O, VA also ordered Fluconazole 200 mg, which is                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570953 - not explained in the record, ref SDS 78 EO5H, and further which                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570954 - increases side effects for Rosuvastatin, ref SDS 78 0450, but on plus                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
570955 - side Fluconazole resolves electrolytes abnormalites, in this case                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
570956 - Total Bilirubin is nearly 100% over healthy range, causing peripheral                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570957 - neuropathy. ref SDS 78 ZH6J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
570959 -  ..
570960 - On 121003 1438 received in the mail Omeprazole with incorrect dose                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
570961 - prescription. ref SDS 79 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
570963 -  ..
570964 - On 121003 1438 received in the mail RX # 10864663B which conflicts                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
570965 - with RX #10864663A, ref SDS 78 5N3O and dose instructions to take 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
570966 - pills twice a day, ref SDS 78 MH65, conflict with the doctor's order                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
570967 - to take 1 pill twice per day.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
570969 -  ..
570970 - On 130416 1100 Doctor Lee reported the VA placed hold that prevented                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
570971 - patient from ordering any of 3 refills of Omeprazole; the doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
570972 - cancelled the prior order and placed new order for current                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
570973 - prescription with 3 refills of Omeprazole. ref SDS 82 RG9K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
570975 -  ..
570976 - On 130423 1140 received refill for Omeprazole. ref SDS 84 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
570978 -  ..
570979 - On 131115 0800 meeting Doctor Lee EGD Dilation, continued prescription                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
570980 - for Omeprazole to aid digestion. ref SDS 87 R74M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
570982 -  ..
570983 - On 131121 1604 ordered refill for Omeprazole. ref SDS 89 AG9I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
570985 -  ..
570986 - On 131205 1448 received prescription for Atorvastatin 20 MG,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
570987 - ref SDS 92 5N3O, ordered by Doctor Alba during the meeting at the VA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
570988 - on 131121 0930. ref SDS 88 6H6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
570990 -  ..
570991 - On 131219 0930 Doctor Alba ordered Ezetimibe 10 mg to take with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570992 - Atorvastatin 10 mg, during meeting at VA. ref SDS 93 6H6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
570994 -  ..
570995 - On 131230 1450 received Ezetimibe from VA to combine with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
570996 - Atorvastatin. ref SDS 94 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
570998 -  ..
570999 - On 140127 1821 ordered refill Ezetimibe from VA. ref SDS 95 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571001 -  ..
571002 - On 140201 1353 received refill Ezetimibe from VA.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571004 -  ..
571005 - On 140226 2035 only have 4 pills for Atorvastatin and Ezetimibe, so                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571006 - ordered refills. ref SDS 99 4P5M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571007 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571008 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571009 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571010 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571012 -  ..
5711 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5712 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5713 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
5714 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
571401 - Progress Notes Meeting 140213 Transmitted VA System Email                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
571402 - VA System Email Transmitted Progress Notes Meeting 140213                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
571403 - 
571404 - Follow up ref SDS A4 5N3O, ref SDS A3 5N3O.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
571405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571406 - Sent letter to VA saying...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
571407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571408 -    1.  Subject:  Prog Notes 13 Feb 2014 Comments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
571409 -        Date:  2014-03-12 18:13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571416 -         ..
571417 -    2.  Subject Progress Notes preliminarily are missing the header;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571418 -        assume it is something like...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571420 -         ..
571421 -        LOCAL TITLE:  ENDOCRINE-METABOLISM CLINIC (MED)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571422 -        STANDARD TITLE:  ENDOCRINOLOGY OUTPATITNE NOTE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571423 -        DATE OF NOTE:  FEB 13, 2014 @ 0830                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
571424 -        ENTRY DATE:  MAR __ 2014 @______                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
571425 -        AUTHOR:  ALBA, DIANA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
571426 -        EXP COSIGNER:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571427 -        URGENCY:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571428 -        STATUS:  COMPLETED                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
571430 -         ..
571431 -    3.  At the bottom...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
571432 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571433 -        Signed:  __/__/2014 ____                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571435 -         ..
571436 -    4.  Can you please submit this?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
571438 -         ..
571439 -    5.  Have tried getting it through ROI channels.  Martinez has had                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571440 -        numerous personnel changes.  The most recent attendant, Jeff,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571441 -        said today that Bless faxed a request to ROI at San Francisco                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571442 -        VA Med Center last week, would not say when.  He called                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571443 -        Kathleen, who has transferred to Sacramento, for assistance.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571444 -        She had the job for a year on a temporary basis, and was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571445 -        terrific, emailing Progress Notes.  For some reason, she could                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571446 -        not help Jeff today, her former boss, go through the mechanics                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571447 -        of accessing the record in San Francisco, doing a copy and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571448 -        attaching to an email.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
571450 -         ..
571451 -    6.  There is no rush on this - whenever you have a moment to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571452 -        complete the record is fine.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571454 -         ..
571455 -    7.  Heads up - not criticism, because I like working with you, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571456 -        respect your medical practice.  That said there are many                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571457 -        grammatical errors in the notes, which you might consider                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
571458 -        correcting for the next issue in May.  If you need a list, just                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571459 -        me let know.  I realize this may not be a good use of your                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571460 -        time.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
571462 -  ..
571463 - Implements planning to submit comments on Progress Notes for meeting                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571464 - on 140213, as set out in the letter to the VA on 140310 0939.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
571465 - ref SDS A4 M33I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571467 -  ..
571468 - Letter to VA continrues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571469 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571470 -    8.  Additionally, the notes show a sentence that says in part...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571471 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571472 -        "...however I don't think that direct measured of LDL-C is of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571473 -        any value to his treatment." [see the record on 140213 0830.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571474 -        ref SDS 97 E66J...].                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571476 -         ..
571477 -    9.  You may have intended to say "LDL-P" rather than LDL-C, since                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571478 -        the gravamen of the notes taken by the 4-corners rests entirely                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571479 -        on lowering LDL-C to "goal," though without stating the goal.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571481 -         ..
571482 -   10.  For some reason no other lipid "goals" are mentioned in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
571483 -        Progress Notes.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571485 -         ..
571486 -   11.  Recall during the meeting, Doctor Feingold seemed to indicate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571487 -        that measuring LDL-P is unnecessary because it can be assumed                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571488 -        from triglyceride (TG)/HDL ratio.  The notes say nothing about                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571489 -        a 20% rise in HDL 61-Labcorp, nor a 60% drop in TG 47-VA, nor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571490 -        what LDL-P level can be drawn from these valuations.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
571492 -         ..
571493 -   12.  The notes further say in part...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
571494 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571495 -        "For these patients, measuring and lowering LDL-P is considered                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571496 -        a primary goal...due to its stronger association with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
571497 -        cardiovascular risk." [...reported on 140213 0830. ref SDS 97                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
571498 -        S35H...].                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
571500 -         ..
571501 -   13.  VA's focus on LDL-C is appreciated, and setting aside                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
571502 -        consideration of discordance [...see history considering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571503 -        "discordance" in relation to VA Progress Notes in the record on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571504 -        140213 0830. ref SDS 97 I35L...], what are the goals for HDL                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
571505 -        and TG to lower LDL-P that has the strongest association with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571506 -        CVD risk?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
571508 -         ..
571509 -   14.  As well, some mention might be helpful in the Notes of diet,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571510 -        along with exercise increase to nearly 1000 miles in 3 months                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571511 -        to complement medication for dramatic rise in HDL 21% and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
571512 -        reduction of TG 60%, given that research indicates Atorvastatin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571513 -        and Ezetimibe have been found to increase HDL 5%-9%, and lower                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571514 -        TG 30%-40% [...reported on 131125 0005. ref SDS 90 PU6I...] -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
571515 -        see AHA article Circulation published 030428...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571516 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571517 -              https://circ.ahajournals.org/content/107/19/2409.full                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
571519 -         ..
571520 -   15.  LDL-C lowered 63% on VA lab, and 75% on Labcorp.  The same AHA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571521 -        source indicates LDL-C lowered 50%-60% with Atorvastatin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571522 -        Ezetimibe, suggesting some other factor may be at play.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571524 -         ..
571525 -   16.  As well there is nothing mentioned in the notes on evaluating                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571526 -        regression of atherosclerosis systemic plaque.  Since elevated                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571527 -        HDL in combination with low TG drive regression, should some                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571528 -        mention be cited in the Notes on this opportunity for lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571529 -        CVD risk? [...discussed during the meeting on 140213 0830,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571530 -        ref SDS 97 JZ4O, citing research on 131125 0005. ref SDS 90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571531 -        E13K...].                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
571532 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571533 -            [On 140519 0800 follow up meeting with Doctor Alba;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
571534 -            attending physician Doctor Feingold advised that complex                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571535 -            anatomy of blood vessels intertwined by CABG surgery                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571536 -            prevents radiology analysts from reading CCTA scan tests                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571537 -            to evaluate regression of atherosclerosis. ref SDS A5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571538 -            J83H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571540 -         ..
571541 -   17.  Finally, the Notes say in part...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
571542 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
571543 -        "Mr Welch states that he would like to stop medication and then                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571544 -        recheck lipids in a couple of months, to see what would                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571545 -        happened to LDL-C and LDL-P."                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571547 -         ..
571548 -   18.  Sometimes we say things in the heat of meetings, which are not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571549 -        intended, but somehow get said anyway.  This happens as well in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
571550 -        written correspondence and reports, e.g., inadvertantly                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571551 -        substituting LDL-C for LDL-P, see above. ref SDS 0 IL87  If                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
571552 -        that happened in this case, I apologize.   My intent is to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571553 -        continue current regimen, and test in 3 months to see if good                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571554 -        results on 140201 and 140203 can be maintained, since                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
571555 -        previously initial good results with Simvastatin and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
571556 -        Rosuvastatin did not continue during 2011 and 2012.  Down the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
571557 -        road, if good results continue in 6/9/12 months or so, then we                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
571558 -        might consider dropping meds, if CT testing shows plaque has                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
571559 -        dramatically regressed - its an option.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
571561 -         ..
571562 -   19.  Again, you have done great work in this case.  Don't worry                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
571563 -        about changing the Notes, if its more trouble than its worth.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
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