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440 Davis Court #1602
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S U M M A R Y


DIARY: December 18, 2010 04:42 PM Saturday; Rod Welch

Omeprazole causing dehydration feet peeling and bleeding.

1...Summary/Objective
........Side Effects of Omeprazole Capsules
........Common Side Effects
........Dangerous Side Effects
........Other Side Effects
........Side Effects of Omeprazole
2...Blood Pressure Increases Omeprazole Side Effect
........Does omeprazole Oral have side effects?
........Infrequent side effects of omeprazole Oral:
........FDA Warns of Fracture Risk From Acid Reflux Drugs
........PPI Antacids Linked to Hip, Wrist, and Spine Fracture


..............
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CONTACTS 

SUBJECTS
Medical Problems Stomach Pain Fatigue Dry Feet Peeling Cracking Mino                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
1203 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
1203 -    ..
1204 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
1205 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
120501 - Follow up ref SDS 4 0000, ref SDS 3 ZN4M.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120504 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120506 -  ..
1206 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
1207 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
1208 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
1209 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
120901 - Past week noticed rising stomach pain, fatigue, urinating, and feet                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120902 - have been very dry, with peeling and cracking of skin causing minor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120903 - bleeding, reported in case study on 101010 0744. ref SDS 1 11Y4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120904 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120905 -            [On 101219 1402 letter notifies medical team of rising                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120906 -            symptoms which may relate to Omeprazole, and requests                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
120907 -            adjustments in dose, remedial measures. ref SDS 5 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
120909 -             ..
120910 -            [On 150611 0713 new study reports correlation between PPI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
120911 -            (e.g., Omeprazole) and damage to endothelial lining of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
120912 -            blood vessels, and 16-21% increase in risk of heart attack.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
120913 -            ref SDS 9 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120915 -  ..
120916 - Symptoms indicate dehydration from frequent urination despite drinking                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
120917 - considerable liquid.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120919 -  ..
120920 - On 101210, dose for Omeprazole was doubled from 40 to 80 mg per day,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120921 - is 4 times the standard 20 mg prescribed for daily use. ref SDS 3 ZN4M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
120923 -  ..
120924 - Research today on the Internet found that Omeprazole may cause some of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
120925 - these symptoms, ref SDS 0 VM87, including frequent urinating,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
120926 - ref SDS 0 8Z33, and fatigue that diminishes work capacity to make                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
120927 - driving a risk, ref SDS 0 UA4M, similar to the EGD test explained at                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120928 - the VA during the meeting on 101207 1000. ref SDS 2 2Y3M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120929 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120930 -        Livestrong.com
120931 -         ..
120932 -        Side Effects of Omeprazole Capsules                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
120933 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120934 -              http://www.livestrong.com/article/52946-side-effects-omeprazole-capsules/                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
120936 -         ..
120937 -        Omeprazole is a medication used to decrease the amount of acid                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120938 -        in your stomach. It is used to manage gastroesophageal reflux                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
120939 -        disease (condition where your stomach acid moves up your                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120940 -        esophagus), gastric ulcers and other conditions affected by                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120941 -        stomach acid production. According to Drugs.com, omeprazole is                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120942 -        available as a capsule and its initial dose is 20 milligrams                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120943 -        daily. Your doctor may decide to increase this dosage                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
120944 -        depending upon your condition.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120946 -         ..
120947 -        Common Side Effects                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
120948 -        
120949 -        According to Drugs.com, omeprazole can cause stomach pain,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
120950 -        flatulence (gas) and diarrhea. This stomach pain may be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120951 -        stabbing or dull in nature. Gas is harmless but may be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
120952 -        embarrassing in social situations. You may also experience                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
120953 -        nausea or vomiting. Loose stools can make you dehydrated and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120954 -        as a result, you can develop a headache. Drink plenty of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120955 -        fluids to prevent dehydration and call your doctor if any of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120956 -        these symptoms worsen or continue.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
120958 -         ..
120959 -        Dangerous Side Effects                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
120960 -        
120961 -        Omeprazole can also cause difficulty swallowing.  Eating foods                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120962 -        or drinking liquids can cause you to choke.  Inform your                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120963 -        doctor when you have these symptoms as they can all be life                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120964 -        threatening.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
120965 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120966 -            [On 150611 0713 new study reports correlation between PPI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
120967 -            (e.g., Omeprazole) and damage to endothelial lining of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
120968 -            blood vessels, and 16-21% increase in risk of heart attack.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
120969 -            ref SDS 9 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120970 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120971 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120973 -         ..
120974 -        Other Side Effects                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
120975 -        
120976 -        Chest pain, constipation, a lost voice, sneezing and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
120977 -        drowsiness are other side effects of omeprazole, says the Mayo                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120978 -        Clinic. Chest pain is the result of decreased blood flow to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120979 -        your heart. Constipation is a benign side effect that requires                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120980 -        attention if you haven't had a bowel movement in at least                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
120981 -        three to five days. Avoid driving or participating in projects                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120982 -        that require your full attention if you are drowsy.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
120983 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120984 -            [...below on 101218 1642 research indicates high blood                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
120985 -            pressure side effect omeprazole. ref SDS 0 KI6G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
120987 -             ..
120988 -            [...below on 101218 1642 research indicates FDA warns bone                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
120989 -            fracture side effect of omeprazole. ref SDS 0 096L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
120990 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120992 -  ..
120993 - Another sources says...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
120994 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120995 -        Ehow.com
120996 -         ..
120997 -        Side Effects of Omeprazole                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
120998 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
120999 -        By an eHow Contributor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
121000 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
121001 -              http://www.ehow.com/about_5127656_side-effects-omeprazole.html                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
121003 -         ..
121004 -        The moderate side effects of omperazole include a frequent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
121005 -        need to urinate, difficulty urinating and painful urination.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
121006 -        An omperazole user may get a sore throat, a change in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
121007 -        voice and have a general feeling of not feeling well. While                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
121008 -        taking omeprazole a person could also develop a skin rash,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
121009 -        itching, red, irritated eyes and red, itching, peeling skin. A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
121010 -        person can also feel very weak and experience unusual                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
121011 -        tiredness. Bleeding can occur, along with crusting sores on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
121012 -        the lips. Blisters, chills, a fever and sores in the mouth may                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
121013 -        also be present.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
121014 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
121015 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
121016 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
1211 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
1303 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
130401 -  ..
130402 - Another sources says...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
130404 -  ..
130405 - Blood Pressure Increases Omeprazole Side Effect                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
130406 - 
130407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130408 -        Webmd                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
130409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130410 -        Omperazole Oral                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
130411 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130412 -              http://www.webmd.com/drugs/mono-2250-OMEPRAZOLE+DELAYED+RELEASE+TABLET+-+ORAL.aspx?drugid=3766&drugnam                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
130414 -         ..
130415 -        Does omeprazole Oral have side effects?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130417 -         ..
130418 -        Fda Alert from WebMD Medical News                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
130419 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130420 -            FDA Warns of Fracture Risk From Acid Reflux                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
130421 -            Drugs......... see below......... ref SDS 0 096L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
130423 -         ..
130424 -        The following side effects are associated with omeprazole                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
130425 -        Oral:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
130427 -         ..
130428 -        Common side effects of omeprazole Oral:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
130430 -         ..
130431 -        Head Pain............................ Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
130432 -        Stomach Cramps....................... Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
130434 -         ..
130435 -        Infrequent side effects of omeprazole Oral:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
130437 -         ..
130438 -        Acute Infection of the Nose, Throat or Sinus         Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
130439 -        High Blood Pressure                                  Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130441 -             ..
130442 -            [On 101010 0744 case study on exercise and medications                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
130443 -            shows Omeprazole paused today (111201). ref SDS 1 734L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130445 -             ..
130446 -            [On 111128 0202 letter to medical team asks about                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
130447 -            increasing medication to rosuvastatin 20 mg or trying some                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
130448 -            other line of care in order to reduce cholesterol LDL < 70,
130449 -            ref SDS 7 EB3U, according to the VA work plan on 110817                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
130450 -            1030. ref SDS 6 DG36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
130452 -             ..
130453 -            [On 111201 0928 sudden increase blood pressure may be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
130454 -            caused by 2 years taking Omeprazole; and high dose for past                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
130455 -            12 months. ref SDS 8 ZM5H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
130457 -             ..
130458 -            [On 150611 0713 new study reports correlation between PPI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
130459 -            (e.g., Omeprazole) and damage to endothelial lining of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
130460 -            blood vessels, and 16-21% increase in risk of heart attack.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
130461 -            ref SDS 9 5N3O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130462 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130464 -         ..
130465 -        Incomplete or Infrequent Bowel Movements             Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130466 -        Itching                                              Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130467 -        Backache                                             Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130468 -        Dizzy                                                Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130469 -        Cough                                                Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130470 -        Chest Pain                                           Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130471 -        Feel Like Throwing Up                                Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130472 -        Throwing Up                                          Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130473 -        Gas                                                  Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130474 -        Diarrhea                                             Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130475 -        Feeling Weak                                         Less Severe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
130476 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130477 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
130478 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
1305 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
1403 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
140401 -  ..
140402 - Another sources says...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
140403 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140404 -        Webmd                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
140406 -         ..
140407 -        FDA Warns of Fracture Risk From Acid Reflux Drugs                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
140408 -        PPI Antacids Linked to Hip, Wrist, and Spine Fracture                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
140409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140410 -              http://www.webmd.com/heartburn-gerd/news/20100525/fda-warns-of-fracture-risk-from-acid-reflux-drugs                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
140411 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140412 -        By Daniel J. DeNoon                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
140413 -        WebMD Health News                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
140414 -        Reviewed by Laura J. Martin, M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140416 -         ..
140417 -        Date................................. May 25, 2010                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
140418 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140419 -        1.  Popular PPI antacids -- Aciphex, Dexilant, Nexium,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
140420 -            Prevacid, Prilosec, Protonix, Vimovo, and Zegerid -- raise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140421 -            the risk of bone fracture, especially when used for a year                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140422 -            or more or at high doses, the FDA warns.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140424 -             ..
140425 -        2.  The warning comes after U.S. and Canadian researchers                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
140426 -            linked the use of PPIs (proton pump inhibitors) to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
140427 -            fracture risk in middle-aged adults.  Another U.S. study                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140428 -            suggests that the drugs may also increase risk of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
140429 -            infection with C. difficile, a bacterium that can cause                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140430 -            severe diarrhea.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
140431 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140432 -        3.  "There is a possible increased risk of fractures of the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140433 -            hip, wrist, and spine if you take certain drugs for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
140434 -            heartburn, acid reflux, or ulcers," the FDA today warned                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140435 -            consumers.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140437 -             ..
140438 -        4.  The action follows FDA review of six studies that link                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
140439 -            PPIs to fractures, although the studies do not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
140440 -            definitively prove that PPIs are the cause of the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
140441 -            fractures seen in the studies.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
140443 -             ..
140444 -        5.  Most of the increased fracture risk is seen in people over                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140445 -            age 50.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140447 -             ..
140448 -        6.  The federal agency will now require the warning to be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
140449 -            added to the package labels of both the prescription and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140450 -            nonprescription versions of the drugs.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
140452 -             ..
140453 -        7.  The drugs all are proton pump inhibitors (PPIs), the most                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
140454 -            powerful class of antacid drugs. It's the third                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
140455 -            highest-selling class of drugs in the U.S. Each year,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
140456 -            doctors write 113.4 million prescriptions for the drugs.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140457 -            Three -- Prevacid, Prilosec, and Zegerid -- are available                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
140458 -            without prescription.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
140460 -             ..
140461 -        8.  The drugs do a great job of reducing stomach acid. They're                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140462 -            not only far more powerful than simple antacids (such as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140463 -            Maalox, Rolaids, and Tums) but also reduce stomach acid                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140464 -            more than the H2RA drugs Axid, Pepcid, Tagamet, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
140465 -            Zantac.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140467 -             ..
140468 -        9.  These powerful drugs are supposed to be used only for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
140469 -            serious conditions, but often are taken for simple                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
140470 -            heartburn. There's no doubt they're effective, but the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
140471 -            benefit for minor conditions may not be worth the risk.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140473 -             ..
140474 -       10.  The FDA offers the following advice to patients:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
140475 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140476 -            1.  If your doctor recommended that you take a PPI, don't                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
140477 -                stop taking the medication until you discuss it with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140478 -                him or her.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
140479 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
140480 -            2.  The greatest risk from PPIs is among people who take                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
140481 -                high doses or remain on the drugs for a year or more.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
140483 -                 ..
140484 -            3.  Over-the-counter PPIs should be taken for only 14 days                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140485 -                for treatment of frequent heartburn.  No more than                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
140486 -                three 14-day courses should be taken in a single year.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140488 -                 ..
140489 -            4.  Discuss any concerns you may have about taking PPIs                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
140490 -                with your doctor.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
140492 -                 ..
140493 -            5.  Report any possible PPI side effects to the FDA either                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
140494 -                online or by phone at (800) 332-1088.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
140495 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
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1406 -