Welch Company
San Francisco, CA


S U M M A R Y


DIARY: November 17, 2011 02:15 PM Thursday; Rod Welch

VA lab cholesterol LDL fast 12 hours test Rosuvastatin effectiveness.

1...Summary/Objective
2...Total Bilirubin 1.3 Recovery Impaired Liver after Simvastatin
3...Salt Sodium Declines Near Danger Too Low
4...Glucose Declines Again Risk Diabetes Further Reduced
5...LDL 200 Huge Increase Risk CAD Goal Reduce LDL < 70 Failed
6...Lipid History....
7...LDL Cholesterol 100 Point Changes Less than 3 Months
8...Large Variations LDL Less 3 Months Indicates Unreliable Testing
9...Errors Common LDL Cholesterol Testing
10...LDL Testing Fraught with Error Test Results Variability
........Reliability of low-density lipoprotein cholesterol,
........non-high-density lipoprotein cholesterol, and apolipoprotein B
........measurement.
........Effect of a dietary portfolio of cholesterol-lowering foods
........given at 2 levels of intensity of dietary advice on serum
........lipids in hyperlipidemia: a randomized controlled trial
........Month-to-month variability of lipids, lipoproteins, and
........apolipoproteins and the impact of acute infection in
........adolescents.
........Reliability of lipid, lipoprotein, and apolipoprotein
........measurements
11...Rosuvastatin Side Effects Myopathy Muscle Pain
12...Myopathy Muscle Pain Side Effects Rosuvastatin


..............
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CONTACTS 
SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0403 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0403 -    ..
0404 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
0405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040501 - Follow up ref SDS 14 0000, ref SDS 13 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040504 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040505 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040507 -  ..
0406 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0408 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040901 - Visited Lab on ground floor VA in Martinez.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040902 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040903 - On 111013, interim lab, ref SDS 14 GM65, for 6 - 8 weeks to test                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040904 - results switching from Simvastatin to Rosuvastatin for managing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040905 - cholesterol, planned by Doctor Egan on 110817 1030, ref SDS 12 JQ5F,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040906 - and reported by Buena in a call earlier on 111013 1048. ref SDS 13 H291                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040908 -  ..
040909 - Lab today tests effectiveness reducing cholesterol LDL < 70 ordered by
040910 - Doctor Egan in a meeting at the VA in Martinez on 110817 1030,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040911 - ref SDS 12 JQ54, and reported by Ally on 111013 1404. ref SDS 14 EO7O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040913 -  ..
040914 - Attendant said lab will test for...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040915 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040916 -               Lipid                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040917 -               Electrolyte                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
040918 -               Myopathy                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040920 -  ..
040921 - Attendant said to expect results posted tomorrow.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040923 -  ..
040924 - Total Bilirubin 1.3 Recovery Impaired Liver after Simvastatin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040925 - Salt Sodium Declines Near Danger Too Low                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
040926 - Glucose Declines Again Risk Diabetes Further Reduced                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040927 - 
040928 - Follow up ref SDS 14 GM65, ref SDS 11 GM65.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040930 -         ..
040931 -        CHEM PROFILE........... 2011 11 17 1427                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040932 -        PLASMA                Results    Units            Range                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040933 -        GLUCOSE                 108      mg/dL       74     -  118                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040934 -        GLUfast                          mg/dL       Ref: <=99
040935 -        NA (salt)               139      mmol/L     136     -  144                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040936 -        K                        4.1     mmol/L       3.4   -    4.8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040937 -        CL                      103      mmol/L      98     -  106                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040938 -        CO2                      30      mmol/L      23     -   33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040939 -        BUN                      11      mg/dL        8     -   26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040940 -        CREAT                    0.89    mg/dL         .5   -    1.1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040941 -        eGFR                   >60       mL/min      Ref: >=60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040942 -        CALCIUM                  9.0     mg/dL        8.7   -   10.2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040943 -        CA CORR                          mg/dL        8.7   -   10.2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040944 -        PO4                              mg/dL        2.4   -    4.5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040945 -        MG                               mg/dL        1.8   -    2.5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040946 -        ALK PHO                 95       IntUnits/L  37     -  107                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040947 -        T. BIL                   1.3  H  mg/dL         .3   -    1.2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040948 -        D. BILI                          mg/dL         .1   -     .4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040949 -        AST                     25       IntUnits/L   8     -   42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040950 -        ALT                     24       IntUnits/L   5     -   55                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040951 -        ALBUMIN                  4.4     g/dL         3.3   -    4.8                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040952 -        PROTEIN                  7.4     g/dL         6.5   -    8.1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040953 -        LDH                              IntUnits/L  90     -  208                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040954 -        AMYLASE                          Units/L     28     -  100                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040955 -        LIPASE                           Units/L      7     -   58                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040956 -        NH3                              mcmol/L     15     -   56                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040957 -        URIC AC                          mg/dL        4.8   -    8.7                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040958 -        Comments:                 a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040960 -                  ..
040961 -             a.  TEST PERFORMED BY VA MARTINEZ, 150 MUIR ROAD, MARTINEZ CA.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040963 -                  ..
040964 -             b.  Evaluation for CREAT:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040965 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040966 -                 Effective 7/2/08, new standardized method for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040967 -                 creatinine in place.  Note reference range change.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040968 -                 Previous range 0.5-1.2 mg/dL.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040970 -                  ..
040971 -             c.  Evaluation for ALK PHO:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040972 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040973 -                 The normal range is for an adult population less than                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040974 -                 50 years old. Alk Phos increases with age over 50 to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040975 -                 about 60% higher values by ages greater than 75 years                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040976 -                 old.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040978 -                  ..
040979 -             d.  Evaluation for eGFR:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040980 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040981 -                 eGFR Units = mL/min/1.73 square meters                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040983 -  ..
040984 - Glucose and salt (NA) both increase - reflect decline hiking from 40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040985 - to only 2 miles per week, past month or so, shown in case study on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040986 - 101010 0744. ref SDS 9 UT6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040988 -  ..
040989 - Total bilirubin 1.3 holding below 2.0 high in prior lab on 110727                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040990 - 1238. ref SDS 11 GM65 - significant decline after ending Simvastatin,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040991 - shown by interim lab a few weeks ago on 111013 1404. ref SDS 14 557J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040992 - Hopefully indicates recovery of any impaired liver function, cited in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040993 - research on 111013 1404. ref SDS 14 LC8J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040994 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040995 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040996 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040997 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0410 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
050401 -  ..
050402 - LDL 200 Huge Increase Risk CAD Goal Reduce LDL < 70 Failed
050403 - 
050404 - Follow up ref SDS 11 E19L, ref SDS 10 E19L.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
050405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050406 - Work plan changed simvastatin 40 mg to rosuvastatin 10 mg on 110817                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050407 - 1030. ref SDS 12 DG36  Lab today evaluate requirement increase dose                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050408 - rosuvastatin 20 mg. 110817 1030, ref SDS 12 JQ54                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050410 -  ..
050411 - Assessment lab results shown below. ref SDS 0 RA5O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050412 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050413 -        LIPID PANEL............ 2011 11 17 1427                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
050414 -        PLASMA                Results    Units             Range                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050415 -        CHOL                   260  H    mg/dL       Ref: <=200
050416 -        TRIGLYC                 84       mg/dL       Ref: <=150
050417 -        HDL                     43       mg/dL       Ref: >=40                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050418 -        LDL                    200  H    mg/dL       Ref: <=160
050419 -        LDL Dir                          mg/dL       Ref: <=160
050420 -        TRIG NF                          mg/dL       Ref: <=150
050421 -        Comments:                 a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050422 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050441 -  ..
050442 - Research indicates LDL is presented 2 ways:  calculated, which is less                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050443 - accurate, and direct, which is more expensive.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
050445 -  ..
050446 - Research also indicates tests for LDL cholesterol are not reliable,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050447 - shown below, ref SDS 0 N29Y, so hard to decide course of action.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050448 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050450 -  ..
050451 - Lipid History....                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050453 -  ..
050454 - See assessment of lab results, below. ref SDS 0 RA5O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050455 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050456 -        Collection DT  Spec   CHOLESTEROL      Target Range                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
050457 -        111117 0215    PLASM  260 H  mg/dL        <= 200 ...... ref SDS 0 IM9N
050458 -        110727 1238    PLASM  163   ........................... ref SDS 11 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050459 -        101207 0906    PLASM  151   ........................... ref SDS 10 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050460 -        100721 0800    PLASM  261 H ........................... ref SDS 8 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050461 -        100610 1033    PLASM  217 H ........................... ref SDS 7 QV4F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050462 -        090813 1500    PLASM  233 H ........................... ref SDS 5 8P5F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050463 -        060616 1059    PLASM  238 H ........................... 060623 0840, ref SDS 4 UO6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050464 -        050906 1204    PLASM  257 H ........................... ref SDS 2 DG8G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050465 -        050709 1000    PLASM  277 H ........................... ref SDS 1 G69K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050467 -  ..
050468 - Graph of cholesterol shown on 090813 1500. ref SDS 5 NQ86                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050470 -  ..
050471 - Graph of HDL and LDL are primary risk factors for CAD, see graph                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050472 - below. ref SDS 0 7M42                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050474 -                               ..
050475 -                              TRIGLYC                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050476 -        111117 0215    PLASM   84    mg/dL        <= 150 ...... ref SDS 0 IM9N
050477 -        110727 1238    PLASM   81   ........................... ref SDS 11 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050478 -        101207 0906    PLASM   41   ........................... ref SDS 10 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050479 -        100721 0800    PLASM   87   ........................... ref SDS 8 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050480 -        100610 1033    PLASM   83   ........................... ref SDS 7 QV4F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050481 -        090813 1500    PLASM  118   ........................... ref SDS 5 8P5F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050482 -        060616 1059    PLASM   68   ........................... 060623 0840, ref SDS 4 UO6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050484 -                                ..
050485 -                               HDL                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050486 -        111117 0215    PLASM   43    mg/dL        >=  40 ...... ref SDS 0 IM9N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050487 -        110727 1238    PLASM   45   ........................... ref SDS 11 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050488 -        101207 0906    PLASM   47   ........................... ref SDS 10 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050489 -        100721 0800    PLASM   35 L ........................... ref SDS 8 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050490 -        100610 1033    PLASM   36 L ........................... ref SDS 7 QV4F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050491 -        090813 1500    PLASM   30 L ........................... ref SDS 5 8P5F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050492 -        060616 1059    PLASM   32 L ........................... 060623 0840, ref SDS 4 UO6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050494 -                               ..
050495 -                              LDL-CHO                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050496 -        111117 0215    PLASM  200 H  mg/dL        <= 160 ...... ref SDS 0 IM9N
050497 -        110727 1238    PLASM  102   ........................... ref SDS 11 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050498 -        101207 0906    PLASM   96   ........................... ref SDS 10 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050499 -        100721 0800    PLASM  209 H ........................... ref SDS 8 E19L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050500 -        100610 1033    PLASM  164 H ........................... ref SDS 7 QV4F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050501 -        090813 1500    PLASM  179 H ........................... ref SDS 5 8P5F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050502 -        060616 1059    PLASM  192 H ........................... 060623 0840, ref SDS 4 UO6K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050504 -            [On 111128 0202 letter to medical team asks about                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050505 -            increasing medication to rosuvastatin 20 mg or trying some                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050506 -            other line of care in order to reduce cholesterol LDL < 70,
050507 -            ref SDS 17 EB3U, according to the VA work plan on 110817                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050508 -            1030. ref SDS 12 DG36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050510 -             ..
050511 -            [On 111128 2038 increased medication to rosuvastatin 20 mg,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
050512 -            shown in case study on patient history on 101010 0744.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050513 -            ref SDS 9 NV7I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050515 -  ..
050516 - Previously, 2 years ago, Doctor Egan assesd coronary artery disease                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050517 - (CAD) correlates with research on hyperlipidemia in the record for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050518 - 091002 0900. ref SDS 6 8X3G  Aligned with prior analysis by Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
050519 - Sandhu on 060505 0830. ref SDS 3 OE3L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050521 -  ..
050522 - Hyperlipidemia - cholesterol risk factors reviewed also on 091002.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050523 - ref SDS 6 2F8K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050525 -  ..
050526 - Currently, LDL 200 rising from 102 for prior lab on 110727 1238,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050527 - ref SDS 11 E19L, does not meet objective of LDL < 70, planned in
050528 - meeting at the VA prescribing rosuvastatin 10 mg to replace                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050529 - simvastatin 40 mg, reported on 110817 1030. ref SDS 12 DG36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050531 -  ..
050532 - HDL has not increased, also, conflicting with objectives at that time                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050533 - on 110817 1030. ref SDS 12 IO6F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050535 -  ..
050536 - Significant cholesterol rise to LDL 200 may reflect artery strictures                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050537 - limiting blood flow possibly aligning with recent increase in blood                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050538 - pressure, roughly averaging 115 75 from October 2010, until about a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050539 - month ago, shown in case study on 101010 0744. ref SDS 3 QJ5I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050540 - Beginning OA 111030, blood pressure suddenly increased to about 135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050541 - 75, with many readings above 145. ref SDS 3 UT6K  At about that same                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
050542 - time hiking decreased from 40 down to 2 miles per week.  In recent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050543 - days, blook pressure trending down slightly with hiking increased                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050544 - back to 40 miles per week.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
050546 -  ..
050547 - Additionally, missed a week taking rosuvastatin 10 mg because forgot                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050548 - to bring pills home from assignment providing case management in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050549 - Southern California, reported on 111105, also in case study.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
050550 - ref SDS 3 WWSQ                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050551 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050552 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050554 -  ..
050555 - LDL Cholesterol 100 Point Changes Less than 3 Months                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050556 - Large Variations LDL Less 3 Months Indicates Unreliable Testing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050557 - 
050558 - Big increases in LDL over past 3 months correlates with similar                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050559 - increase over 1 month last year on 100721 0800, ref SDS 8 PTPP, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050560 - seems incongruous, undermining reliability of lipid testing.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
050562 -  ..
050563 - 210 mg/dL                              +209 (10721 0000 (ref SDS 8 E19L)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
050564 -                                        |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050565 - 200                                    |  +--+      +-- 200 (111117 0215, ref SDS 0 IM9N)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050566 -            192 (060623 0840, ref SDS 4 UO6K) |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050567 - 190        |                           |     |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050568 -            |                           |     |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050569 - 180        +-----/  /----- 179 (090813 1500, ref SDS 5 8P5F)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050570 -                            |           |     |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050571 - 170                        |           |     |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050572 -                            |           |     |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050573 - 160                        +---------- 164 (100610 1046, ref SDS 7 QV4F)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
050574 -                                              |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050575 - 150                                          |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050576 -                                              |      |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050577 - 140                                         /       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050578 -                                            |        |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050579 - 130                                        |        |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050580 -                                            |        |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050581 - 120                                        |        |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050582 -                                            |        |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050583 - 110                                        |        |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050584 -                                            |  +---- 102 (110727 0000, ref1SDS 11 E19L)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050585 - 100                                        |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050586 -                                             96 (101207 0000, ref SDS 10 E19L)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050587 -  90                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050588 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050589 -  80
050590 -            ..
050591 -  70       ==================== G O A L ==========================                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050592 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050593 -  60                            Simvastatin          Rosuvastatin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050594 -                                091104           110817  111128. ref SDS 9 NV7I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050595 -  40                            20 mg     40 mg  10 mg   20 mg                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
050596 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050597 -  20
050598 -  ..
050599 -  10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050600 -      <---2006--->/../<---2009---><---2010---><---2011---><---2012--->
050601 -      1  3  6  9      1  3  6  9  1  3  6  9  1  3  6  9  1  3  6  9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050602 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050603 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050604 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0507 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0603 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060401 -  ..
060402 - Errors Common LDL Cholesterol Testing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060403 - LDL Testing Fraught with Error Test Results Variability                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060404 - 
060405 - Big changes of 100 mg/DL up and down in LDL cholesterol within 1 - 3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060406 - month intervals shown in patient history, per above. ref SDS 0 5X6U                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060408 - How can body chemestry change so quickly with diet and exercise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060409 - relatively stable?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060411 -  ..
060412 - Research indicates reliability of lipid cholesterol testing has been a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060413 - problem since 1988, ref SDS 0 PUPU, and continues to the present day,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060414 - as shown in following article published by the National Health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060415 - Institute this year, saying testing for LDL cholesterol is "fraught                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060416 - with error." ref SDS 0 N29Y                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060418 -  ..
060419 - Research on the Internet shows....                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060420 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060421 -    1.  Pubmed.gov                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060422 -        US National Library of Medicine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060423 -        National Institutes of Health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060425 -         ..
060426 -        Journal of Clinical Lipidology                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060427 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060428 -        2011 Jul-Aug 5(4) 264-72                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060429 -        Epub.................................... 2011 May 27                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060431 -         ..
060432 -        Reliability of low-density lipoprotein cholesterol,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060433 -        non-high-density lipoprotein cholesterol, and apolipoprotein B                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060434 -        measurement.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060435 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060436 -                  http://www.ncbi.nlm.nih.gov/pubmed/21784371                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060438 -             ..
060439 -            Maine Standards Company, 765 Roosevelt Trail, Windham, ME                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060440 -            04062, USA. jcontois@mainestandards.com                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060442 -             ..
060443 -        1.  Abstract                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060444 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060445 -            There is little understanding of the reliability of laboratory                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
060446 -            measurements among clinicians.  Low-density lipoprotein                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060447 -            cholesterol (LDL-C) measurement is the cornerstone of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060448 -            cardiovascular risk assessment and prevention, but it is                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060449 -            fraught with error.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060451 -             ..
060452 -        2.  Therefore, we have reviewed issues related to accuracy and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060453 -            precision for the measurement of LDL-C and the related                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060454 -            markers non-high-density lipoprotein cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060455 -            (non-HDL-C) and apolipoprotein B.  Despite the widespread                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060456 -            belief that LDL-C is standardized and reproducible,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060457 -            available data suggest that results can vary significantly                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060458 -            as the result of methods from different manufacturers.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060459 -            Similar problems with direct HDL-C assays raise concerns                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060460 -            about the reliability of non-HDL-C measurement.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
060462 -             ..
060463 -        3.  The root cause of method-specific bias relates to the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060464 -            ambiguity in the definition of both LDL and HDL, and the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060465 -            heterogeneity of LDL and HDL particle size and composition.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060466 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060467 -               [On 111125 2028 CNN television broadcast analysis saying                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
060468 -               measuring LDL cholesterol is not effective for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060469 -               evaluating coronary health risks, ref SDS 16 LJ7F,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060470 -               recommends measuring small particle LDL cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060471 -               using coronary calcium san techology. ref SDS 16 LW75                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
060473 -                ..
060474 -               [On 111128 0202 letter to medical team cites lab today                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060475 -               reporting LDL 200, ref SDS 17 EA4V, and asks about                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060476 -               increasing medication to rosuvastatin 20 mg or trying                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060477 -               some other line of care in order to reduce cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060478 -               LDL < 70, ref SDS 17 EB3U, according to the VA work plan
060479 -               on 110817 1030. ref SDS 12 DG36                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060481 -                ..
060482 -               [On 111128 2038 increased medication to rosuvastatin 20 mg,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060483 -               shown in case study on patient history on 101010 0744.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060484 -               ref SDS 9 NV7I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060486 -             ..
060487 -        4.  Apolipoprotein B appears to provide a more reliable                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060488 -            alternative, but assays for it have not been as rigorously                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060489 -            tested as direct LDL-C and HDL-C assays.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060491 -             ..
060492 -        5.  Copyright  2011 National Lipid Association. Published by                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060493 -            Elsevier Inc. All rights reserved.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060495 -             ..
060496 -        6.  PMID: 21784371 [PubMed - indexed for MEDLINE]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060497 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060498 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060499 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060501 -  ..
060502 - Another article says...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
060503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060504 -    2.  Pubmed.gov                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060505 -        US National Library of Medicine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060506 -        National Institutes of Health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060507 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060508 -        Journal American Medical Association                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060510 -         ..
060511 -        Date.................................... 2011 Aug 24;306(8):831-9                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060513 -         ..
060514 -        Effect of a dietary portfolio of cholesterol-lowering foods                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060515 -        given at 2 levels of intensity of dietary advice on serum                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060516 -        lipids in hyperlipidemia: a randomized controlled trial                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060517 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060518 -              http://www.ncbi.nlm.nih.gov/pubmed/21862744                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060520 -         ..
060521 -        Authors:  Jenkins DJ, Jones PJ, Lamarche B, Kendall CW,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060522 -        Faulkner D, Cermakova L, Gigleux I, Ramprasath V, de Souza R,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060523 -        Ireland C, Patel D, Srichaikul K, Abdulnour S, Bashyam B,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060524 -        Collier C, Hoshizaki S, Josse RG, Leiter LA, Connelly PW,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060525 -        Frohlich J.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060527 -         ..
060528 -        Clinical Nutrition and Risk Factor Modification Center, St                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060529 -        Michael's Hospital, 61 Queen St E, Toronto, ON M5C 2T2,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060530 -        Canada. cyril.kendall@utoronto.ca                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060532 -             ..
060533 -        1.  Abstract                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060534 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060535 -            CONTEXT:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060537 -             ..
060538 -            Combining foods with recognized cholesterol-lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060539 -            properties (dietary portfolio) has proven highly effective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060540 -            in lowering serum cholesterol under metabolically                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060541 -            controlled conditions.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060543 -             ..
060544 -        2.  OBJECTIVE:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060545 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060546 -            To assess the effect of a dietary portfolio administered at                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060547 -            2 levels of intensity on percentage change in low-density                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060548 -            lipoprotein cholesterol (LDL-C) among participants                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060549 -            following self-selected diets.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
060551 -             ..
060552 -        3.  DESIGN, SETTING, AND PARTICIPANTS:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060553 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060554 -            A parallel-design study of 351 participants with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060555 -            hyperlipidemia from 4 participating academic centers                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060556 -            across Canada (Quebec City, Toronto, Winnipeg, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060557 -            Vancouver) randomized between June 25, 2007, and February                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060558 -            19, 2009, to 1 of 3 treatments lasting 6 months.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060560 -             ..
060561 -        4.  INTERVENTION:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060562 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060563 -            Participants received dietary advice for 6 months on either                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060564 -            a low-saturated fat therapeutic diet (control) or a dietary                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060565 -            portfolio, for which counseling was delivered at different                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060566 -            frequencies, that emphasized dietary incorporation of plant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060567 -            sterols, soy protein, viscous fibers, and nuts.  Routine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060568 -            dietary portfolio involved 2 clinic visits over 6 months                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060569 -            and intensive dietary portfolio involved 7 clinic visits                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060570 -            over 6 months.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
060572 -             ..
060573 -        5.  MAIN OUTCOME MEASURES:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060574 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060575 -            Percentage change in serum LDL-C.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060577 -             ..
060578 -        6.  RESULTS:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060579 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060580 -            In the modified intention-to-treat analysis of 345                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060581 -            participants, the overall attrition rate was not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060582 -            significantly different between treatments (18% for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060583 -            intensive dietary portfolio, 23% for routine dietary                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060584 -            portfolio, and 26% for control; Fisher exact test, P =                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060585 -            .33).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060587 -             ..
060588 -        7.  The LDL-C reductions from an overall mean of 171 mg/dL (95%                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060589 -            confidence interval [CI], 168-174 mg/dL) were -13.8% (95%                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060590 -            CI, -17.2% to -10.3%; P < .001) or -26 mg/dL (95% CI, -31
060591 -            to -21 mg/dL; P < .001) for the intensive dietary
060592 -            portfolio; -13.1% (95% CI, -16.7% to -9.5%; P < .001) or
060593 -            -24 mg/dL (95% CI, -30 to -19 mg/dL; P < .001) for the
060594 -            routine dietary portfolio; and -3.0% (95% CI, -6.1% to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060595 -            0.1%; P = .06) or -8 mg/dL (95% CI, -13 to -3 mg/dL; P =                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060596 -            .002) for the control diet.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060598 -             ..
060599 -        8.  Percentage LDL-C reductions for each dietary portfolio were                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060600 -            significantly more than the control diet (P < .001,
060601 -            respectively).  The 2 dietary portfolio interventions did                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060602 -            not differ significantly (P = .66).  Among participants                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060603 -            randomized to one of the dietary portfolio interventions,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060604 -            percentage reduction in LDL-C on the dietary portfolio was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060605 -            associated with dietary adherence (r = -0.34, n = 157, P <
060606 -            .001).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060608 -             ..
060609 -        9.  CONCLUSION:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060610 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060611 -            Use of a dietary portfolio compared with the low-saturated                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060612 -            fat dietary advice resulted in greater LDL-C lowering                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060613 -            during 6 months of follow-up.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060614 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060616 -             ..
060617 -       10.  TRIAL REGISTRATION:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060618 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060619 -            clinicaltrials.gov Identifier: NCT00438425                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060620 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060622 -  ..
060623 - Another article says...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
060624 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060625 -    3.  Pubmed.gov                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060626 -        US National Library of Medicine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060627 -        National Institutes of Health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060628 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060629 -        Journal of Pediatrics                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060631 -         ..
060632 -        Date.................................... 1998 Aug;133(2):242-6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060634 -         ..
060635 -        Month-to-month variability of lipids, lipoproteins, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060636 -        apolipoproteins and the impact of acute infection in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060637 -        adolescents.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060638 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060639 -              http://www.ncbi.nlm.nih.gov/pubmed/9709713                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060641 -         ..
060642 -        Authors: Gidding SS, Stone NJ, Bookstein LC, Laskarzewski PM,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060643 -                 Stein EA.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
060645 -         ..
060646 -        Department of Pediatrics, Northwestern University Medical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060647 -        School, Chicago, Illinois, USA.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060648 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060650 -             ..
060651 -        1.  Abstract                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060652 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060653 -            OBJECTIVE:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060655 -             ..
060656 -            To assess month-to-month variability of total cholesterol,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060657 -            triglycerides, high-density lipoprotein-cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060658 -            (HDL-C), calculated low-density lipoprotein-cholesterol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060659 -            (LDL-C), apolipoprotein A1, apolipoprotein B, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
060660 -            lipoprotein (a), as well as factors that could influence                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060661 -            variability, including recent acute infection in an                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060662 -            adolescent population.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060664 -             ..
060665 -        2.  METHODS:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060666 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060667 -            Sixty-three high school students had fasting lipids and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060668 -            lipoproteins measured at 4 separate times during the school                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060669 -            year and another venipuncture 3 to 7 days after recovery                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060670 -            from an acute infection.  Erythrocyte sedimentation rate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060671 -            was also measured.  Coefficients of variation were                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060672 -            calculated for each study variable.  The influence of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060673 -            recent infection on variability was assessed.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060675 -             ..
060676 -        3.  RESULTS:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060677 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060678 -            The 50th and 95th percentiles, respectively, for the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060679 -            coefficient of variation for each variable were as follows:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060680 -            total cholesterol, 7.3% and 13.6%; triglycerides, 22% and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060681 -            47.3%; HDL-C, 7.9% and 16.8%; LDL-C, 12.1% and 25%;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060682 -            apolipoprotein A1, 6.3% and 15.2%; apolipoprotein B, 9.5%                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060683 -            and 17.2%; and lipoprotein (a), 19.3% and 40%.  Recent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060684 -            infection significantly lowered HDL-C (4 mg/dL; P < .0001)
060685 -            and apolipoprotein A1 (7 mg/dL; P < .005).
060687 -             ..
060688 -        4.  CONCLUSIONS:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
060689 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060690 -            Clinicians evaluating lipids and lipoproteins serially                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060691 -            should expect significant visit-to-visit variation in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060692 -            triglycerides and calculated LDL-C values.  Assessment of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060693 -            HDL-C and apolipoprotein A1 should not be done within 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060694 -            weeks of an acute infection.  Apolipoproteins B and A1 have                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060695 -            slightly less variability than their respective lipoprotein                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060696 -            cholesterol values (LDL-C and HDL-C).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060698 -             ..
060699 -            PMID: 9709713 [PubMed - indexed for MEDLINE]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
060700 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060702 -  ..
060703 - Another article says...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060704 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060705 -    4.  Pubmed.gov                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060706 -        US National Library of Medicine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060707 -        National Institutes of Health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060708 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060709 -        Journal of Clinical Lipidology                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060711 -         ..
060712 -        Clin Chem............................... 1988;34(8B):B84-94.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060714 -         ..
060715 -        Reliability of lipid, lipoprotein, and apolipoprotein                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060716 -        measurements                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060717 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060718 -              http://www.ncbi.nlm.nih.gov/pubmed/3042204                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060720 -         ..
060721 -        Author: Naito, HK                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
060722 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060723 -            Publications...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
060724 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060725 -              http://www.ncbi.nlm.nih.gov/pubmed?term=%22Naito%20HK%22[Author]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060727 -         ..
060728 -        Department of Biochemistry, Cleveland Clinic Foundation, OH                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060729 -        44195.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
060731 -             ..
060732 -        1.  Abstract                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060733 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060734 -            The National Heart, Lung, and Blood Institute national                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060735 -            awareness program on cholesterol and heart disease has                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060736 -            placed new demands on laboratorians to utilize and perform                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060737 -            more reliable measurements of lipids, lipoproteins, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060738 -            apolipoproteins.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
060740 -             ..
060741 -        2.  The general public's awareness and the clinicians' concerns                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
060742 -            about the reliability of laboratory testing make it                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060743 -            paramount that the analytical problems and issues are                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060744 -            identified and solutions are provided to increase the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060745 -            current state of reliability of the measurement of these                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
060746 -            blood constituents.  To accomplish this, the initial step                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060747 -            is to assess the current state of reliability of lipid,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
060748 -            lipoprotein, and apolipoprotein measurements in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
060749 -            clinical laboratories.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
060751 -             ..
060752 -        3.  Accuracy and precision of measurements of total                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
060753 -            cholesterol, triglycerides, high-density lipoprotein                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060754 -            cholesterol, and apolipoproteins A-I and B are extensively                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
060755 -            discussed, and general as well as some specific                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
060756 -            recommendations are provided for some of the apparent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
060757 -            problems.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
060759 -             ..
060760 -            PMID: 3042204 [PubMed - indexed for MEDLINE]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
060761 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060762 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060763 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060764 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060765 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
060766 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0608 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0703 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
070401 -  ..
070402 - Rosuvastatin Side Effects Myopathy Muscle Pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070403 - Myopathy Muscle Pain Side Effects Rosuvastatin                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070404 - 
070405 - Follow up ref SDS 14 DO5O. ref SDS 10 JQ5F.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
070406 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070407 -        CARDIAC ENZYMES........ 2011 11 17 1427                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
070408 -        PLASMA                Results    Units            Range                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
070409 -        CK                      101 IntUnits/L       36     -  340                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
070410 -        TRPONIN                          ng/ml        0     -    0.07                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
070411 -        CK-MB                            ng/ml        0.6   -    3.5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
070412 -        MYOGLOB                          ng/ml       20     -   82                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
070413 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070415 -  ..
070416 - CK dropping from 110 for test 4 weeks ago to 111013, ref SDS 14 DO5O,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
070417 - down to 101 is not significant.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070419 -  ..
070420 - There has been significant improvement in shoulder range of motion                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
070421 - without pain, reviewed on 111013 1404. ref SDS 12 RG5L  This was also                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
070422 - reported to Doctor Sandhu a few days later on 111018 0800. ref SDS 14                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
070423 - NP5G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
070425 -  ..
070426 - Not clear in the record what baseline to use for CK diagnostic, called                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
070427 - out on 111013 1404. ref SDS 12 RH3K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
070428 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070429 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070430 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070431 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070432 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070433 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070434 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070435 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
070436 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0705 -