Welch Company
San Francisco, CA


S U M M A R Y


DIARY: August 2, 2011 04:39 PM Tuesday; Rod Welch

Simvastatin risks death control cholesterol thrombus hemostasis stenosis.

1...Summary/Objective
....2...Weighing Benefits High-Dose Simvastatin against Risk of Myopathy
2...Simvastatin 80 MG Max Average Lower LDL 46%
3...Simvastatin Prone Drug Drug Conflict Interaction FDA Study
4...Simvastatin Myopathy Side Effect 80 MG Muscle Ache Weakness FDA Study
5...Myopathy Side Effect Simvastatin 80 MG Muscle Ache Weakness FDA Study
6...LDL 70 Goal Very High Risk CAD History Heart Attack
....LDL cholesterol: Low, lower, and lower still
....7...LDL Targets
........New Cholesterol Guidelines
........NCEP's latest upgraded recommendations
7...Risk Assessment Heart Disease How to Calculate
........Assessing Your Own Risk For Heart Disease
8...Proactive Remedy Reduce Risk Heart Disease
........What To Do If You Are At High Risk For Heart Disease
9...Cholesterol Produced by Body Essential for Life
....1...The Truth About Cholesterol
...13...Cholesterol Is Not A Major Cause Of Arterial Disease
...18...Why Metal Deposition In Artery Linings (Endothelium) Is So Important
...28...Vitamin C Deficiency
...36...High Levels Of Lipoprotein (a. Cause Accelerated Arteriosclerosis
...38...Arteriosclerosis Caused By Elevated Homocysteine And Its Correction
...47...Inflammatory Conditions In the Body Predispose To Artery Damage
...53...Dangerous Foods Cause Arteriosclerosis
...65...Increased Clotting Can Produce Heart Attacks And Strokes
...72...Many Health Problems Are Associated With Statin Drug Usage


..............
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CONTACTS 

SUBJECTS
Cholesterol LDL Low-density Lipoprotein Low Levels Reduce Risks Adve

1303 -
1303 -    ..
1304 - Summary/Objective
1305 -
130501 - Follow up ref SDS 9 6F8F.
130502 -
130503 -
130505 -  ..
1306 -
1307 -
1308 - Progress
1309 -
130901 - Received call today from Richard.  He reported public news reports on
130902 - television that statin drugs to control cholesterol, particularly
130903 - simvastatin, has caused deaths. 110802 1005, ref SDS 9 6F8F
130905 -  ..
130906 - Current medications for meeting with Doctor Egan at VA in Martinez
130907 - Cardiology Department on 110415 0900, ref SDS 7 E83F, lists
130908 - simvastatin. ref SDS 7 II95
130910 -  ..
130911 - VA reports plan to consider increasing Simvastatin from 40 mg per day
130912 - to 80 mg, shown on 110415 0900, ref SDS 7 MG3I, and shown in medical
130913 - chart. 110415 0900, ref SDS 7 E637
130915 -  ..
130916 - Objectives to avoid coronary artery disease (CAD) by reducing risk of
130917 - blood clots, also thromus and hemostasis, explained in part in
130918 - Wikipedia, as aggregation of platletts in blood vessels that slows
130919 - and eventually stops the flow of blood...
130920 -
130921 -              http://en.wikipedia.org/wiki/Thrombus
130923 -  ..
130924 - Cholesterol is an element that can cause blood clots, which may be the
130925 - same as "stenosis" reported in findings from angiogram test on 091021,
130926 - and presented in the record on 100928 0706. ref SDS 4 3495
130928 -  ..
130929 - Research on the Internet
130930 -
130931 -    1.  The New England Journal of Medicine
130932 -
130933 -        Health Policy and Reform
130934 -        Remaking Health Care
130936 -         ..
130937 -        Perspective
130939 -         ..
130940 -    2.  Weighing Benefits High-Dose Simvastatin against Risk of Myopathy
130941 -
130942 -              http://healthpolicyandreform.nejm.org/?p=14715
130944 -         ..
130945 -        NEJM | June 15, 2011 | Topics: Drugs, Devices, and the FDA
130947 -         ..
130948 -        Amy Egan, M.D., M.P.H., and Eric Colman, M.D.
130949 -
130951 -  ..
130952 - Simvastatin 80 MG Max Average Lower LDL 46%
130953 -
130954 -
130955 -    3.  Statins are the most widely prescribed class of drugs for
130956 -        treating dyslipidemia  in particular, elevated levels of
130957 -        low-density lipoprotein (LDL) cholesterol.  Nearly 20 years of
130958 -        research provide convincing evidence that statin-related
130959 -        reductions in LDL cholesterol decrease the risk of major
130960 -        adverse cardiovascular events in people with or without a
130961 -        history of known cardiovascular disease.  A meta-analysis
130962 -        including more than 90,000 patients has shown that for every 39
130963 -        mg per deciliter that statins lower the LDL cholesterol level,
130964 -        the risk of major adverse cardiovascular events is reduced by
130965 -        approximately 25%.1 The average LDL cholesterol lowering effect
130966 -        of the highest doses of approved statins are 63% for
130967 -        rosuvastatin (40 mg), 57% for atorvastatin (80 mg), 46% for
130968 -        simvastatin (80 mg), 41% for pitavastatin (4 mg), 40% for
130969 -        lovastatin (80 mg), 34% for pravastatin (80 mg), and 31% for
130970 -        fluvastatin (80 mg).2
130971 -
130972 -            [On 110817 1030 VA ended treatment with Simvastatin, which
130973 -            has reduced LDL by 50% but LDL 102 on lab 110727, well
130974 -            above LDL < 70 planned by VA, so Doctor Egan prescribed
130975 -            rosuvastatin 10 mg to replace Simvastatin. ref SDS 10 DG36
130977 -             ..
130978 -            [On 110818 1051 letter to medical team confirming change
130979 -            from simvastatin to rosuvastatin and work plan for testing
130980 -            effects of this change in 6 weeks, and to perform lab in 3
130981 -            months. ref SDS 11 4P7X
130982 -
130983 -
1310 -

SUBJECTS
Simvastatin Myopathy Side Effect 80 MG Muscle Ache Weakness Fatal Rh

3103 -
310401 -  ..
310402 - Simvastatin Prone Drug Drug Conflict Interaction FDA Study
310403 - Simvastatin Myopathy Side Effect 80 MG Muscle Ache Weakness FDA Study
310404 - Myopathy Side Effect Simvastatin 80 MG Muscle Ache Weakness FDA Study
310405 -
310406 -
310407 -    4.  Despite their cardiovascular benefits, all statins are
310408 -        associated with myopathy, ranging in severity from asymptomatic
310409 -        increases in creatine kinase to muscle aches or weakness to
310410 -        fatal rhabdomyolysis.  Recently, concerns have been raised
310411 -        about a disproportionate increase in the risk of myopathy with
310412 -        high-dose simvastatin. This possible association was the
310413 -        subject of a drug-safety communication issued by the Food and
310414 -        Drug Administration (FDA) on March 19, 2010.  Since that time,
310415 -        the FDA has completed a comprehensive review of data from the
310416 -        Study of the Effectiveness of Additional Reductions in
310417 -        Cholesterol and Homocysteine (SEARCH) clinical trial, other
310418 -        large clinical trials of high-dose statins, and the agencys
310419 -        Adverse Event Reporting System (AERS).
310420 -
310421 -            [On 110817 1030 meeting with Doctor Egan discussed symptoms
310422 -            and risks of worsening myopathy from continuing and/or
310423 -            increasing simvastatin dose to 80 mg, ref SDS 10 QF61,
310424 -            Doctor Egan switched treatment to rosuvastatin 10 mg.
310425 -            ref SDS 10 DG36
310427 -             ..
310428 -            [On 110826 1338 myppathy shoulder pain due to high dose
310429 -            simvastatin 40 mg and after switching to rosuvastatin 10 mg
310430 -            seems less playing golf for first time in over a year.
310431 -            ref SDS 12 QG7G
310433 -         ..
310434 -    5.  The SEARCH trial was a 6.7-year, randomized, double-blind trial
310435 -        comparing the efficacy and safety of 80 mg of simvastatin with
310436 -        those of 20 mg of simvastatin, with or without vitamin B12 and
310437 -        folate, in survivors of myocardial infarction.  The primary
310438 -        efficacy end point of the trial was the incidence of major
310439 -        adverse cardiovascular events, defined as death from coronary
310440 -        causes, myocardial infarction, stroke, or arterial
310441 -        revascularization.
310443 -         ..
310444 -    6.  At the end of the trial, the incidence of major adverse
310445 -        cardiovascular events was 25.7% in the 20-mg group, as compared
310446 -        with 24.5% in the 80-mg group (relative risk, 0.94; 95%
310447 -        confidence interval, 0.88 to 1.01; P=0.10).  In part because of
310448 -        greater use of off-study LDL cholesterollowering medication in
310449 -        the 20-mg group, the difference between the two treatment
310450 -        groups in mean levelsof LDL cholesterol was 13 mg per deciliter
310451 -        instead of the expected 20 mgper deciliter.  Nonetheless, the
310452 -        6% reduction in the relative risk of major adverse
310453 -        cardiovascular events observed in the SEARCH trial is
310454 -        consistent with the 13-mg-per-deciliter difference in LDL
310455 -        cholesterol levels.3
310457 -         ..
310458 -    7.  Myopathy - defined as a serum creatine kinase level more than
310459 -        10 times the upper limit of normal with unexplained muscle
310460 -        weakness or pain - developed in 52 patients in the 80-mg group
310461 -        (0.9%) but in only 1 patient in the 20-mg group(0.02%).
310462 -        Rhabdomyolysis - defined as unexplained muscle pain or weakness
310463 -        with a serum creatine kinase level more than 40 times the upper
310464 -        limit of normal - developed in 22 patients in the 80-mg group
310465 -        (0.4%) but in no patientsin the 20-mg group.  There were no
310466 -        deaths related to rhabdomyolysis.
310468 -         ..
310469 -    8.  It is critical to note that the risks of myopathy and
310470 -        rhabdomyolysis with the 80-mg dose of simvastatin decreased
310471 -        from 5 per 1000 person-years and 2 per 1000 person-years,
310472 -        respectively, during the first 12 months of treatment to 1 per
310473 -        1000 person-years and 0.4 per 1000 person-years, respectively,
310474 -        after the first 12 months of treatment.  This reduction
310475 -        indicates that in patients who are at risk for myopathy with
310476 -        high-dose simvastatin  for instance, those withcommon variants
310477 -        of SLCO1B1, which encodes a hepatic statin transporter  this
310478 -        risk will tend to manifest early in the course of treatment.4
310480 -         ..
310481 -    9.  Of the statins on the market, simvastatin is particularly prone
310482 -        to drugdrug interactions, in part because it is extensively
310483 -        metabolized by the CYP3A4 enzyme system.  Data from the SEARCH
310484 -        trial indicate that much of the increase in risk for myopathy
310485 -        noted in the high-dose simvastatin group was due to the
310486 -        concomitant use of medications such as amiodarone, diltiazem,
310487 -        and amlodipine.  Hence, judicious concomitant use of other
310488 -        medications with simvastatin will reduce the risk of myopathy.
310490 -         ..
310491 -   10.  The FDAs review of additional data from large clinical trials
310492 -        of high doses of statins indicates that the incidence of
310493 -        myopathy  defined as a serum creatine kinase level more than
310494 -        10 times the upper limit of normal with or without unexplained
310495 -        muscle weakness or pain though very low for all statins, was
310496 -        approximately 3 times as high with the 80-mg dose of
310497 -        simvastatin as with superior LDL cholesterollowering doses of
310498 -        rosuvastatin and atorvastatin.  The FDA also conducted analyses
310499 -        of U.S. rhabdomyolysis reports in AERS associated with use of a
310500 -        statin and with an outcome of death, from the date of initial
310501 -        marketing approval of each statin through January 1, 2010.
310502 -        With the caveat that spontaneous adverse-event reporting
310503 -        systems have recognized limitations (e.g., reporting rates are
310504 -        not incidence rates), the rates of reported fatal
310505 -        rhabdomyolysis were higher with 80 mg of simvastatin than with
310506 -        80 mg of atorvastatin or with 20 mg and 40 mg of rosuvastatin.
310508 -         ..
310509 -   11.  Thus, on the basis of the totality of the data, the FDA
310510 -        recommends that the 80-mg dose of simvastatin be used only in
310511 -        patients who have been taking this dose chronically (e.g.,
310512 -        for 12 months or more) without signs or symptoms of clinically
310513 -        significant muscle toxicity.  For these patients, the agency
310514 -        believes that the cardiovascular benefits of high-dose
310515 -        simvastatin outweigh the low absolute risk of myopathy.
310516 -        Patients who require a greater reduction inLDL cholesterol than
310517 -        can be achieved with 40 mg of simvastatin should be given an
310518 -        alternative LDL cholesterollowering therapy (e.g., a statin
310519 -        with greater potency that poses a lower risk of myopathy, such
310520 -        as atorvastatin or rosuvastatin).
310522 -         ..
310523 -   12.  To help ensure that high-dose simvastatin therapy is not
310524 -        initiated in new patients and that patients receiving any dose
310525 -        of simvastatin do not receive concomitant medications that
310526 -        could increase plasma concentrations of simvastatin to
310527 -        inappropriate levels, the FDA, exercising its authority under
310528 -        the FDA Amendments Act of 2007, has mandated safety-labeling
310529 -        changes for Zocor(simvastatin) and Vytorin (ezetimibe and
310530 -        simvastatin).  The key componentsof the labeling changes are
310531 -        shown in the box Under its Safe Use initiative, the FDA is
310532 -        working with creators of drug formularies, pharmacy benefit
310533 -        managers, and professional medical societies to increase
310534 -        awareness andimplementation of the new safety-labeling changes.
310536 -         ..
310537 -   13.  During the next year, the FDA will closely monitor
310538 -        prescription-use data to determine whether the safety-labeling
310539 -        changes and the communication outreach are having their
310540 -        intended effects of limiting new initiation of high-dose
310541 -        simvastatin therapy and guiding appropriate use of concomitant
310542 -        medications with simvastatin.  If evidence indicates that these
310543 -        measures are not effective,the agency will consider additional
310544 -        regulatory action, including withdrawal of high-dose
310545 -        simvastatin from the market.
310547 -         ..
310548 -   14.  Disclosure forms provided by the authors are available with the
310549 -        full text of this article at NEJM.org.
310551 -         ..
310552 -   15.  This article (10.1056/NEJMp1106689) was published on June 15,
310553 -        2011, at NEJM.org.
310555 -         ..
310556 -   16.  Source Information
310558 -         ..
310559 -   17.  From the Division of Metabolism and Endocrinology Products,
310560 -        Office of New Drugs, Center for Drug Evaluation and Research,
310561 -        U.S.  Food and Drug Administration, Silver Spring, MD.
310563 -         ..
310564 -   18.  References...
310566 -         ..
310567 -   19.  References
310568 -
310569 -        1.  Baigent C, Keech A, Kearney PM, et al. Efficacy and safety of
310570 -            cholesterol-lowering treatment: prospective meta-analysis of data from
310571 -            90,056 participants in 14 randomised trials of statins. Lancet
310572 -            2005;366:1267-1278[Erratum, Lancet 2005;366:1358, 2008;371:2084.]CrossRef
310573 -            | Web of Science | Medline
310575 -             ..
310576 -        2.  Smith MEB, Lee NJ, Haney E, Carson S.  Drug class review:  HMG-CoA
310577 -            reductase inhibitors (statins) and fixed-dose combination products
310578 -            containing a statin.  Final report.  Update 5.  Portland:  Oregon
310579 -            Health &Science University, November 2009.
310580 -
310581 -            (http://www.ncbi.nlm.nih.gov/books/NBK47273/pdf/TOC.pdf.)
310583 -             ..
310584 -        3.  Study of the Effectiveness of Additional Reductions in
310585 -            Cholesteroland Homocysteine (SEARCH) Collaborative Group.
310586 -            Intensive lowering of LDL cholesterol with 80 mg versus 20 mg
310587 -            simvastatin daily in 12,064 survivors of myocardial infarction: a
310588 -            double-blind randomised trial. Lancet 2010;376:1658-1669CrossRef
310589 -            |Web of Science | Medline
310591 -             ..
310592 -        4.  The SEARCH Collaborative Group. SLCO1B1 variants and
310593 -            statin-induced myopathy  a genomewide study. N Engl J Med
310594 -            2008;359:789-799Full Text | Web of Science | Medline
310595 -
310597 -  ..
310598 - Another source reports....
310599 -
310600 -        Aboutlawsuits.com
310601 -        News and Information about Personal Injury Lawsuits
310602 -
310603 -        Simvastatin Lawsuit News and Information
310604 -
310605 -              http://www.aboutlawsuits.com/topics/simvastatin/
310607 -         ..
310608 -        Zocor Lawsuits
310610 -         ..
310611 -        High doses of the cholesterol drug Zocor, or generic
310612 -        simvastatin, have been linked to an increased risk of serious
310613 -        and potentially life threatening muscle problems. The FDA has
310614 -        warned that side effects of Zocor at 80 mg doses may increase
310615 -        the risk of muscle injury, myopathy or rhabdomyolysis.
310616 -
310617 -              http://www.aboutlawsuits.com/zocor-muscle-warning-high-dose-18713/
310619 -         ..
310620 -        As a result of its findings, the FDA is recommending that 80 mg
310621 -        Zocor only be given to people who have already used it for a
310622 -        year or more without problems.  The agency is asking doctors
310623 -        not to start any new patients on doses that high.  If patients
310624 -        do not achieve cholesterol control on 40 mg Zocor, FDA
310625 -        expertsurge doctors to try them on another treatment instead of
310626 -        upping the dosage.
310627 -
310628 -            [On 110817 1030 meeting with Doctor Egan discussed symptoms
310629 -            and risks of worsening myopathy from continuing and/or
310630 -            increasing simvastatin dose to 80 mg, ref SDS 10 QF61,
310631 -            Doctor Egan switched treatment to rosuvastatin 10 mg.
310632 -            ref SDS 10 DG36
310634 -  ..
310635 - Article lists comments from patients with anecdotal evidence of
310636 - harmful side effects from simvastatin...
310637 -
310638 -    1.  Comment by I. Annette Williams on 9 June 2011:
310640 -         ..
310641 -        Several years my doctor put me on Simvastatin.  It did lower
310642 -        mycholesterol rather quickly.  After several months, I began
310643 -        experiencing muscle weakness only in my lower body, which
310644 -        verygradually increased.  I discussed with my physician and
310645 -        sheassured me it wasn?t the medication as I would experience
310646 -        this throughout my entire body.  On subsequent visits, my
310647 -        doctor (and her nurse), still argued that it was not the
310648 -        drug.During my visits they kept using the description ?muscle
310649 -        pain? and I kept correcting them and telling them it was
310650 -        ?muscle weakness.? They both got quite nasty with me.  I
310651 -        finally took myself off the drug as the effects were getting
310652 -        worse.  For months afterward I went through a myriad of
310653 -        symptoms from lower body muscle wasting, dry eyes to muscle
310654 -        cramps.  I was previously a very active person, doing lots of
310655 -        walking and running in my weekend hobby of dog handling.  At
310656 -        myworst point, if I walked 50 feet on a level surface, my lower
310657 -        body became so fatigued that I would have to stop and recover
310658 -        for a few minutes before I could continue.  I would best
310659 -        describe it as similar to the effects of working out doing
310660 -        repetitions until the muscles simply can?t do any more.  Then
310661 -        you sit or stretch and rest, then do more sets/repetitions of
310662 -        exercise.  It has taken me a couple of years to get back to
310663 -        something near recovery, and I?m still atabout 70% of my
310664 -        previous capacity.  This has had and is continuing to have a
310665 -        major impact on my physical abilities.
310667 -         ..
310668 -    2.  Comment by patricia on 10 June 2011:
310670 -         ..
310671 -        I had a heart attack feb 1 of this year and when i was sent
310672 -        home i had my simvistatin dosage changed from 20 mg to 80 mg.
310673 -        for the past 4 months i have had pain in my legs, starting just
310674 -        above the knees down. i went to my heart doctor and he did a
310675 -        dopplar test on both legs and ruled out p.a.d. i went tomy
310676 -        family doctor today and tried to explain the pain i was having
310677 -        and he put me on lyraca.. i dont know which drug scaresme the
310678 -        most. does anyone else have the burning pain in your legs?
310680 -         ..
310681 -    3.  Comment by Tammy on 11 June 2011:
310682 -
310683 -        Several years ago my doctor put me on Simvastatin. It did
310684 -        lower my cholesterol but not as much as my endocrinologist
310685 -        wanted. She increased my dose a couple of times. When I
310686 -        started taking 40mg I began experiencing muscle pain and
310687 -        weakness in my upper arms and shoulders after only two weeks.
310689 -         ..
310690 -        I thought I had overexerted in some way and believed these
310691 -        symptoms would go away. A month later I was feeling much
310692 -        worse, so much so that my husband had to help me to get
310693 -        dressed. I started to think that it may be my Simvastatin
310694 -        because the symptoms started only after my dose had been
310695 -        increased.
310697 -         ..
310698 -        I finally took myself off the drug as the effects were getting
310699 -        worse.  I went to my family doctor and she assured me it wasn?t
310700 -        the medication as I would experience this throughout my entire
310701 -        body.  My symptoms had gotten better, but I was still
310702 -        experiencing impairment in the use of my arms.  I decided to
310703 -        see my family doctor and on this subsequent visit, my doctor
310704 -        still argued that it was not the drug and suggested that it may
310705 -        be arthritis.  During my next visit with my endocrinologist I
310706 -        explained these symptoms to her, what my family doctor had
310707 -        said, and that she suggested that it might be arthritis.  She
310708 -        ordered a test for arthritis, the results of which were
310709 -        negative, and I was told to follow up with my family doctor
310710 -        again.
310712 -         ..
310713 -        She also told me that my cholesterol had significantly
310714 -        increased and that I needed to be on some type of medicine.
310715 -        She prescribed Zetia, but it made me sick so I stopped taking
310716 -        it.  I returned to my family doctor, but she still insisted
310717 -        that if my symptoms had been caused by the medicine, my whole
310718 -        body would be affected and the pain and weakness wouldn?t be
310719 -        localized in my upper arms and shoulders.  My symptoms were
310720 -        getting better, but I still didn?t have full use of my arms and
310721 -        had continued pain and weakness.  I had another visit with my
310722 -        endocrinologist and had still had high cholesterol.
310724 -         ..
310725 -        She suggested that since the Zetia made me sick that I take
310726 -        Crestor because even though it was a statin as well, it could
310727 -        be taken at a low dose and still be as effective as a high dose
310728 -        of Simvastatin.
310730 -         ..
310731 -        I started taking the Crestor and just as quickly as when I had
310732 -        my Simvastatin dose increased, I my symptoms started getting
310733 -        worse again.  It has been about a year and a half since this
310734 -        all started and I have gotten back to something near recovery,
310735 -        but I continue to have pain, weakness, and impaired use of my
310736 -        arms.  This has had and is continuing to have a major impact on
310737 -        my physical abilities.
310739 -         ..
310740 -    4.  Comment by Penny on 15 June 2011:
310741 -
310742 -        Trying to figure out if zocor is causing all my pain.  I have
310743 -        been taking abt 7 years In the last 5 years I have had a
310744 -        rotator cuff tear, capsular release of same shoulder, tarsal
310745 -        tunnel in my ankle and now frozen shoulder in other shoulder.
310746 -        My doc wants to do capsular release on this.  None of this
310747 -        runs in my family, I have been evaled by neurologist,
310748 -        rheumotologist and don? t have diabetes .  But I have been in
310749 -        pain so long, I don? t know what it means to be pain free.  My
310750 -        doc says it can? t be the zocor.  But ortho is just stumped
310751 -        why this keeps happening looking for advice
310753 -  ..
310754 - This report of anecdotal pain possibly associated with simvastatin may
310755 - indicate that left shoulder pain reported on 101126, shown in case
310756 - study on 101010 0744, ref SDS 5 6E5I, and after increasing Simvastatin
310757 - 40 mg per day, prescribed on 100721 0800. ref SDS 3 RP4F, from taking
310758 - simvastatin 20 mg beginning on 091220 0527, ref SDS 1 OX5X, and shown
310759 - in medical chart for meeting with Doctor Sandhu at VA on 100104 0930.
310760 - ref SDS 2 WR4H
310761 -
310762 -            [On 110817 1030 meeting with Doctor Egan discussed symptoms
310763 -            and risks of worsening myopathy from continuing and/or
310764 -            increasing simvastatin dose to 80 mg, ref SDS 10 QF61,
310765 -            Doctor Egan switched treatment to rosuvastatin 10 mg.
310766 -            ref SDS 10 DG36
310768 -             ..
310769 -            [On 110826 1338 myppathy shoulder pain due to high dose
310770 -            simvastatin 40 mg and after switching to rosuvastatin 10 mg
310771 -            seems less playing golf for first time in over a year.
310772 -            ref SDS 12 QG7G
310773 -
310774 -
310775 -
310776 -
310777 -
3108 -

SUBJECTS
Default Null Subject Account for Blank Record

3203 -
320401 -  ..
320402 - LDL < 70 Goal Very High Risk CAD History Heart Attack
320403 -
320404 -
320405 - Research on Internet found....
320406 -
320407 -        Harvard Medical School
320408 -        Family Health Guide
320410 -     ..
320411 -    LDL cholesterol: Low, lower, and lower still
320412 -
320413 -    November 2004 update
320414 -
320415 -              http://www.health.harvard.edu/fhg/updates/update1104b.shtml
320416 -
320417 -    1.  A federal panel of experts released a revised set of
320418 -        cholesterol guidelines in July, 2004. The overall message on
320419 -        "bad" LDL cholesterol is much the same as it has been: Lower is
320420 -        better and how low your level should be depends on your
320421 -        cardiovascular risk factors.
320423 -         ..
320424 -    2.  But the standard for what low LDL means keeps on getting lower.
320425 -        These revisions say that an LDL level under 70 should be a
320426 -        "therapeutic option" for people at the highest risk for
320427 -        cardiovascular disease; the previous guidelines set under 100
320428 -        as the LDL goal for people at high cardiovascular risk and
320429 -        didn't have a separate very-high-risk category or mention
320430 -        therapeutic options. The revisions also ratchet down the
320431 -        thresholds for prescribing cholesterol-low erin g medications,
320432 -        so more people will be advised to take pills to meet LDL
320433 -        targets. (For more detail on the revisions see "LDL Targets"
320434 -        below.)
320435 -
320436 -            [On 110817 1030 VA end treatment with Simvastatin, which
320437 -            reduced LDL by 50% but LDL 102 on lab 110727, ref SDS 8
320438 -            E19L, well above LDL < 70 planned by VA, and Simvastatin
320439 -            even if increased to 80 mg cannot further lower LDL, and
320440 -            Simvastatin 80 mg has adverse side effects of debilitating
320441 -            myopathy; so Doctor Egan prescribed rosuvastatin 10 mg to
320442 -            replace Simvastatin, which is more potent and so has the
320443 -            chance to reach medical goal LDL < 70. ref SDS 10 DG36
320445 -         ..
320446 -    3.  The main impetus for the revisions came from some pretty
320447 -        remarkable results from studies of the statin drugs such as
320448 -        atorvastatin (Lipitor) and simvastatin (Zocor). The studies
320449 -        involved only people with heart disease, so the lessons learned
320450 -        don't directly apply to everyone, but there are certainly
320451 -        enough people with heart disease to make them important.  Two
320452 -        findings stand out. First, if LDL levels are pushed down to 60
320453 -        or so with statins, the risk of heart attack and other
320454 -        cardiovascular events falls further than if LDL levels are
320455 -        pushed down to just 90 or so. How much further varied with the
320456 -        study, but it was enough to matter. Second, although statins
320457 -        have been known to cause serious liver and muscle problems,
320458 -        side effects in these studies were relatively rare, and they
320459 -        were large studies involving thousands of people.
320461 -         ..
320462 -    4.  You can try to lower your cholesterol levels by changing what
320463 -        you eat, but studies have shown that the average person
320464 -        achieves only modest reductions (4%-13%) through dietary
320465 -        changes alone. Standard doses of statins reliably lower LDL
320466 -        levels by 30%-40%, so as a practical matter the vast majority
320467 -        of people who need to significantly cut their LDL levels need
320468 -        to take a statin.
320470 -         ..
320471 -    5.  The latest guidelines just tweak advice directed at people in
320472 -        the higher cardiovascular risk groups, but they are important
320473 -        because they're part of a larger trend. Over the past 20 years
320474 -        as new evidence about LDL rolls in, experts have been pushing
320475 -        their recommendations about the "ideal" LDL level lower and
320476 -        lower. So far, the experts recommend statins only for people
320477 -        who have heart disease or major heart disease risk factors.
320478 -        But that could change.  Some are already saying that many more
320479 -        people should be taking statins and that everyone should try to
320480 -        lower their LDL levels. The average American LDL level is now
320481 -        about 130.
320483 -         ..
320484 -    6.  We're not there yet, but perhaps someday there will be a
320485 -        consensus that nearly everyone should make aggressive attempts
320486 -        to lower their LDL cholesterol with statins. If the overall LDL
320487 -        recommendation were to become 50-70, taking a statin may become
320488 -        part of the daily health routine.
320490 -         ..
320491 -    7.  LDL Targets
320492 -
320493 -        If you are at...
320494 -
320495 -        1.  Very High Risk
320496 -
320497 -            1.  Presence of established cardiovascular disease and one
320498 -                of the following...
320500 -                 ..
320501 -            2.  Multiple major risk factors for cardiovascular disease,
320502 -                especially diabetes
320504 -                 ..
320505 -            3.  Severe and poorly controlled risk factors, especially
320506 -                smoking
320508 -                 ..
320509 -            4.  Multiple risk factors for metabolic syndrome,
320510 -                especially high triglycerides (200 or over) and low HDL
320511 -                (below 40)
320513 -                 ..
320514 -            5.  A history of heart attack or unstable angina.
320516 -             ..
320517 -            Guidelines say...
320519 -             ..
320520 -            An LDL of less than 70 is a "therapeutic option" if you
320521 -            fall into this new category.
320523 -             ..
320524 -        2.  High Risk
320525 -
320526 -            1.  A history of heart disease (heart attack, unstable or
320527 -                stable angina, a heart procedure such as angioplasty or
320528 -                bypass) or one of the following:
320530 -                 ..
320531 -            4.  Diabetes
320533 -                 ..
320534 -            5.  Evidence of diseased blood vessels (peripheral artery
320535 -                disease,blocked carotid arteries, transient ischemic
320536 -                attacks, etc.)
320538 -                 ..
320539 -            6.  Two or more risk factors for heart disease (cigarette
320540 -                smoking, high blood pressure, a family history of
320541 -                premature heart disease, age).
320543 -             ..
320544 -            Guidelines say...
320546 -             ..
320547 -            An LDL of less than 100 achieved with cholesterol-lowering
320548 -            medications if lifestyle changes haven't lowered it to this
320549 -            level.
320551 -             ..
320552 -        3.  Moderately High Risk
320553 -
320554 -                Having two or more risk factors for heart disease that
320555 -                create a 10%-20% chance of having a heart attack in the
320556 -                next 10 years.You can find a heart attack risk
320557 -                calculator at www.nhlbi.nih.gov/health/index.htm#tools.
320559 -             ..
320560 -            Guidelines say...
320562 -             ..
320563 -            An LDL of less than 130, but a "therapeutic option" to
320564 -            lower your LDL to less than 100.
320565 -
320567 -             ..
320568 -        4.  Moderate Risk
320570 -                 ..
320571 -                Having two or more risk factors for heart disease that
320572 -                create less than a 10% chance of having a heart attack
320573 -                in the next 10 years.
320575 -             ..
320576 -            Guidelines say...
320578 -             ..
320579 -            An LDL of less than 130.
320581 -             ..
320582 -        5.  Low Risk
320584 -                 ..
320585 -                Having one or no risk factors for heart disease
320587 -             ..
320588 -            Guidelines say....
320590 -             ..
320591 -            An LDL of less than 160.
320592 -
320594 -  ..
320595 - Another source says...
320596 -
320597 -    1.  About.com
320598 -        Heart Health Center
320599 -
320600 -        New Cholesterol Guidelines
320601 -        NCEP's latest upgraded recommendations
320602 -
320603 -              http://heartdisease.about.com/od/cholesteroltriglycerides/a/cholrecs.htm
320604 -
320605 -        By Richard N. Fogoros, M.D., About.com GuideUpdated October
320606 -        26, 2010
320607 -
320608 -        About.com Health's Disease and Condition content is reviewed
320609 -        by our Medical Review Board
320611 -         ..
320612 -        Jul 11 2011
320614 -         ..
320615 -    2.  Since the full report of the National Cholesterol Education
320616 -        Program Adult Treatment Panel III (NCEP ATP III) was
320617 -        publishedin 2002, new clinical evidence has suggested that - at
320618 -        least in high-risk and intermediate-risk patients - reducing
320619 -        LDL cholesterol to very low levels (i.e., to below 70mg/dL
320620 -        instead of the currently recommended 100 -130 mg/dL)
320621 -        significantly reduces the risk of death and cardiovascular
320622 -        events.
320624 -         ..
320625 -    3.  In response, the NCEP commented on this new information, ing an
320626 -        update on the ATP III guidelines in 2004.  In general, th e ATP
320627 -        III guidelines now recommend that LDL cholesterol levelsbe
320628 -        brought below 100 mg/dL in high-risk and moderate riskpatients.
320629 -        This is substantially lower than the target levels of 130 mg/dL
320630 -        or below in the past.
320632 -         ..
320633 -    4.  Specifically, the new recommendations are:
320634 -
320635 -        1.  High-risk patients
320636 -
320637 -            (those with a 10-year risk* of a cardiac event or 20%):
320638 -            The LDL cholesterol should be lowered to below 100 mg/dL,
320639 -            and consideration should be given to lowering it to below
320640 -            70 mg/dL.
320642 -             ..
320643 -        2.  Moderately high-risk patients
320644 -
320645 -            (those with a 10-year risk*a cardiac event between 10 and
320646 -            20%):  LDL cholesterol should be lowered to below 130 mg/dL
320647 -            and consideration should be given to lowering it to below
320648 -            100 mg/dL.
320650 -             ..
320651 -        3.  Intermediate-risk patients
320652 -
320653 -            (those with a 10-yer risk* of acardiac event less than
320654 -            10%):  LDL cholesterol should be lowered to below 130
320655 -            mg/dL.
320657 -             ..
320658 -        4.  Low-risk patients
320659 -
320660 -            (those with a 10-year risk* of a cardiac event less than
320661 -            1%):  LDL cholesterol should be below 160 mg/dL.
320663 -         ..
320664 -    5.  Most observers in the field have come out in strong support
320665 -        ofthese new recommendations, though there are some critics.
320666 -        Onone hand, some critics argue that even the new
320667 -        recommendations are not strong enough in light of recent
320668 -        clinical trials, and that a target of 70 mg/dL or lower
320669 -        shouldbe emphasized much more strongly. On the other hand,
320670 -        others (those fond of slamming the pharmaceutical industry)
320671 -        point out that many members of the NCDP ATP III panel have
320672 -        ties to the companies that make statin drugs, and that their
320673 -        recommendations are biased.
320675 -         ..
320676 -    6.  My own reading of the new data finds the evidence that there
320677 -        is benefit in reducing LDL cholesterol in high-risk patients
320678 -        to very low levels is compelling, and the 2004 revision to
320679 -        theATP III guidelines are, if anything, conservative.
320681 -         ..
320682 -    7.  You can find out how to assess your own 10-year risk of heart
320683 -        disease here...
320684 -
320685 -              http://heartdisease.about.com/od/assessyourrisk/a/assessrisk.htm
320687 -         ..
320688 -    8.  Sources:
320689 -
320690 -        Grundy SM, Cleeman JI, Bairey Merz CN, et al. Implications of
320691 -        recent clinical trials for the National Cholesterol Education
320692 -        Program Adult Treatment Panel III guidelines. Circulation.
320693 -        2004;110:227-239.
320694 -
320695 -
320696 -
3207 -

SUBJECTS
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3303 -
330401 -  ..
330402 - Risk Assessment Heart Disease How to Calculate
330403 -
330404 -
330405 -    1.  About.com
330406 -        Heart Health Center
330407 -
330408 -        Assessing Your Own Risk For Heart Disease
330409 -
330410 -              http://heartdisease.about.com/od/assessyourrisk/a/assessrisk.htm
330412 -         ..
330413 -        Docs often neglect this vital step - fortunately, you can do
330414 -        it yourself
330415 -
330416 -        By Richard N. Fogoros, M.D., About.com Guide
330418 -         ..
330419 -        Updated July 29, 2010
330421 -         ..
330422 -    2.  It is important for you to know how to assess your own risk
330423 -        for heart disease.
330425 -         ..
330426 -    3.  The bad news about heart disease is that it remains extremely
330427 -        prevalent in our society. The good news is that the factors
330428 -        that determine our risk of developing heart disease are, to a
330429 -        large extent, under our control. We ourselves have a lot to
330430 -        say about whether we will develop early cardiac disease.
330432 -         ..
330433 -    4.  Your doctor is supposed to assess your risk for you, and coach
330434 -        you on what you should be doing to reduce that risk.  But,
330435 -        despite pleas from medical experts and professional societies
330436 -        to do so, many doctors are still bad at performing risk
330437 -        assessments, and are particularly terrible about spending the
330438 -        necessary time to instruct their patients on appropriate steps
330439 -        to reduce that risk.
330440 -
330441 -    5.  (Note well: Doing a simple risk assessment is one of the most
330442 -        important jobs the primary care physician does. The failure
330443 -        todo such a risk assessment probably ought to be considered
330444 -        evidence that your doctor may be doing sub-standard work.
330445 -        Manyof the things doctors need to think about are complicated
330446 -        - this one isn't.)
330448 -         ..
330449 -    6.  Fortunately, the tools exist today for you to accurately
330450 -        estimate your own risk of getting heart disease, without
330451 -        waiting for your doctor to initiate the action. And lots of
330452 -        information is available as to what to do about it if your
330453 -        risk is elevated.
330455 -         ..
330456 -    7.  To assess your own risk, here's what you need to know
330458 -         ..
330459 -    8.  You need to gather the following information:
330460 -
330461 -        1.  whether you smoke or not
330462 -        2.  your total and HDL cholesterol levels
330463 -        3.  your blood pressure
330464 -        4.  whether you have evidence of diabetes or metabolic syndrome
330465 -        5.  whether you are overweight for your age and height
330466 -        6.  whether close relatives have had premature heart disease
330468 -         ..
330469 -    9.  With this information, you can place yourself into one of
330470 -        three categories: low, intermediate, or high.
330472 -         ..
330473 -   10.  To be in the low risk category, all of the following must be
330474 -        present:
330475 -
330476 -        1.  Non-smoker
330477 -
330478 -        2.  total cholesterol less than 200 mg/dL, HDL cholesterol
330479 -            greater than 40 mg/dL
330480 -
330481 -        3.  systolic BP less than 120, diastolic BP less than 80
330482 -
330483 -        4.  no evidence of diabetes
330484 -
330485 -        5.  not overweight
330486 -
330487 -        6.  no family history of premature cardiovascular disease
330489 -         ..
330490 -   11.  You are in the high risk category if you have any of the
330491 -        following...
330492 -
330493 -        1.  known coronary artery disease or other vascular disease.
330494 -
330495 -        2.  type 2 diabetes
330496 -
330497 -        3.  over age 65 with multple (more than one) risk factors.
330499 -         ..
330500 -   12.  And you are in the intermediate risk group if you don't fit
330501 -        into either the low or high risk groups.
330503 -         ..
330504 -   13.  If you are at low risk, you do not need any special medical
330505 -        interventions to reduce your risk, except perhaps for routine
330506 -        coaching on maintaining a healthy lifestyle. About 35% of
330507 -        U.S.adults fall into this category.
330509 -         ..
330510 -   14.  If you are in the high risk group, your doctor should strongly
330511 -        consider placing you on appropriate treatments that have been
330512 -        proven to reduce the risk of heart attack and death,such as
330513 -        statin drugs, beta blockers, and/or aspirin.  In addition, your
330514 -        doctor may want to do a stress/thallium study to assess whether
330515 -        you may have significant coronary artery disease already.
330516 -        About 25% of U.S. adults are in the high-risk category.  Here
330517 -        is more on what to do if you are in the high risk category.
330519 -         ..
330520 -   15.  If you are in the intermediate risk group, you should should
330521 -        take aggressive steps to modify the risk factors keeping you
330522 -        out of the low risk category.  Also, you should discuss with
330523 -        your doctor whether further testing should be done to
330524 -        characterize your risk more accurately.  Such testing might
330525 -        include having your C-reactive protein (CRP) level measured,
330526 -        and perhaps getting a calcium scan.  Roughly 40% of U.S.
330527 -        adultsare in the intermediate risk category.
330529 -         ..
330530 -   16.  Again, if your doctor has not performed a formal cardiac risk
330531 -        assessment, you should estimate your risk yourself.  And, if
330532 -        your risk appears to be intermediate or high, you need to
330533 -        talkto your doctor about taking aggressive measures to
330534 -        preventheart disease.
330535 -
330536 -
330537 -
3306 -

SUBJECTS
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3403 -
340401 -  ..
340402 - Proactive Remedy Reduce Risk Heart Disease
340403 -
340404 -
340405 -    1.  About.com
340406 -        Heart Health Center
340407 -
340408 -        What To Do If You Are At High Risk For Heart Disease
340409 -
340410 -              http://heartdisease.about.com/cs/riskfactors/a/highrisk.htm
340412 -         ..
340413 -        By Richard N. Fogoros, M.D., About.com Guide
340415 -         ..
340416 -        Updated July 28, 2010
340418 -         ..
340419 -    2.  So you've assessed your risk of developing heart disease, and
340420 -        it turns out to be high. What do you do now?
340422 -         ..
340423 -    3.  Because some high-risk patients will already have significant
340424 -        CAD, a non-invasive evaluation ought to be strongly
340425 -        consideredto rule out this possibility. This evaluation
340426 -        generally will consist of a stress/thallium study. In some
340427 -        cases a cardiac calcium scan might be appropriate.
340429 -  ..
340430 - Doctor Egan ordered a stress test, performed on 110406 1230.
340431 - ref SDS 6 OF8F
340433 -  ..
340434 - Article What to Do High Risk CAD continues...
340435 -
340436 -    4.  At the same time, your doctor should also lay out a clear
340437 -        planfor attacking all modifiable risk factors -- including
340438 -
340439 -        1.  diet,
340440 -        2.  weight loss,
340441 -        3.  smoking cessation,
340442 -        4.  hypertension [...blood pressure...], and
340443 -        5.  cholesterol --
340444 -        6.  stress -- reduce medical mistakes
340445 -
340446 -        ...and should initiate therapy immediately.  Your doctor
340447 -        should offer you all the resources at his/her disposal to
340448 -        encourage and assist in exercise, weight loss, and smoking
340449 -        cessation, and should ride you pretty hard about
340450 -        accomplishing these things.
340452 -  ..
340453 - Doctor Egan has done a good job on these issues.
340455 -  ..
340456 - Article What to Do High Risk CAD continues...
340457 -
340458 -    5.  He/she should display an especially aggressive attitude
340459 -        towardreducing LDL cholesterol, increasing HDL cholesterol,
340460 -        and controlling the blood pressure, since accomplishing these
340461 -        tasks is usually primarily the doctor's responsibility, and
340462 -        since doing so often requires using the right drug therapy in
340463 -        the right doses. In general, controlling cholesterol and
340464 -        hypertension will require fairly frequent office visits and
340465 -        frequent measurements of blood pressure and/or cholesterol
340466 -        levels, as well as many medication adjustments. This all
340467 -        should be done on a fairly aggressive schedule, with clear
340468 -        targets in mind.
340470 -  ..
340471 - Cholesterol is measured every 6 months, most recently on 110727 1238.
340472 - ref SDS 8 E19L
340474 -  ..
340475 - Blood pressure is taken everyday, listed with patient history of
340476 - medication and exercise, reported in case study on 101010 0744.
340477 - ref SDS 5 QJ5I
340479 -  ..
340480 - Article What to Do High Risk CAD continues...
340481 -
340482 -    6.  However, also keep in mind that doctors are human, and human
340483 -        nature makes it difficult to pull out all the stops for a
340484 -        patient who is refusing to act in his/her own best interests.
340485 -        It's hard to motivate yourself as a doctor to go the extra
340486 -        mile for the patient who just won't make a genuine and
340487 -        persistent effort to exercise, lose weight, or stop smoking.
340488 -        Which brings us to -
340489 -
340490 -
340491 -
340492 -
340493 -
340494 -
3405 -

SUBJECTS
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3503 -
350401 -  ..
350402 - Cholesterol Produced by Body Essential for Life
350403 -
350404 - Research today found an article...
350405 -
350406 -    1.  The Truth About Cholesterol
350407 -
350408 -        By Dr. James Howenstine, MD.............. ref SDS 0 T68I
350409 -        February 20, 2005
350410 -        NewsWithViews.com
350411 -
350412 -              http://www.newswithviews.com/Howenstine/james23.htm
350414 -         ..
350415 -    2.  Cholesterol is not really the villain portrayed in the
350416 -        pharmaceutical ads.  It is actually a vital substance needed in
350417 -        every cell of the body as it is the chemical precursor from
350418 -        which the body produces bile acids, provitamin D3, male and
350419 -        female sex hormones, and adrenal hormones (hydrocortisone and
350420 -        aldosterone that regulates sodium and potassium balance).
350421 -        Cholesterol is needed to construct the important membranes
350422 -        which surround cells.
350424 -         ..
350425 -    3.  The body is able to manufacture cholesterol but is unable to
350426 -        destroy this substance.  Cholesterol is removed from the body
350427 -        combined with bile acids.  This removal is increased by dietary
350428 -        fiber and diminished in the absence of dietary fiber.  Up to
350429 -        94% of cholesterol and bile acids are reabsorbed and reused
350430 -        when dietary fiber is lacking.[1] This is one reason that low
350431 -        fiber diets may increase blood cholesterol levels.
350433 -         ..
350434 -    4.  The body can make cholesterol whether there is any cholesterol
350435 -        in the diet or not.  By removing all cholesterol from the diet,
350436 -        the blood cholesterol will only fall by about 20% to 25%.
350438 -         ..
350439 -    5.  Cholesterol is dissolved and kept in solution as a flowing
350440 -        liquid when there are adequate amounts of essential fatty
350441 -        acids.  The melting point of cholesterol, where it would
350442 -        deposit on artery walls, is 300 degrees F.  When lecithin is
350443 -        present, the melting point of cholesterol falls to 180 degrees
350444 -        where it is still insoluble. However, when the essential fatty
350445 -        acids linoleic and linolenic are present in sufficient
350446 -        quantity, the melting point of cholesterol falls to 32 degrees
350447 -        which is below normal body temperature.  Even in the presence
350448 -        of an arterial injury, cholesterol will have a more difficult
350449 -        time depositing with fibrin and platelets on an injured artery
350450 -        surface because the essential fatty acids have made the blood
350451 -        more fluid.
350453 -         ..
350454 -    6.  After gazing at a television advertisement depicting an
350455 -        attractive young woman collapse on the street with a heart
350456 -        attack because her cholesterol was 280 mg. % you would
350457 -        certainly be justified in having considerable fear if your
350458 -        cholesterol is elevated. Massive amounts of money are being
350459 -        spent by pharmaceutical firms on advertisements to convince the
350460 -        public that their lives are in great danger if their
350461 -        cholesterol levels are high.
350463 -         ..
350464 -    7.  These firms have gained nearly total control over the
350465 -        curriculums taught in medical schools, the articles published
350466 -        in medical journals and who receives research grants and what
350467 -        they are going to be allowed to study in these grants.  This
350468 -        control over research expenditures prevents research that might
350469 -        lead to cures of serious diseases (cancer, schizophrenia, HIV,
350470 -        Alzheimer's Disease).  Conventional medical therapy uses drugs
350471 -        which generally have no ability to cure these diseases.
350472 -        Persons thinking outside the box who might discover information
350473 -        that would disturb the current pharmaceutical dogma about
350474 -        diseases will experience considerable difficulty getting funds.
350476 -         ..
350477 -    8.  Of great importance the pharmaceutical industry has established
350478 -        the precedent with the state boards of medical license that any
350479 -        therapies that do not use pharmaceutical drugs are quackery
350480 -        which is dangerous to the public and should be suppressed.
350481 -        This pressure to conform to pharmaceutical drug use has caused
350482 -        great personal anguish and financial loss to many innovative
350483 -        physicians who have dared to treat patients with alternative
350484 -        therapies that do cure patients.  Often these physicians must
350485 -        spend large amounts of money defending themselves from attempts
350486 -        to remove their licenses.
350488 -         ..
350489 -    9.  The current dogmas about treating cholesterol are formulated by
350490 -        a committee named National Cholesterol Education Program NCEP.
350491 -        This committee is a part of the National Institute of Health
350492 -        within the National Heart, Lung and Blood Institute.
350494 -         ..
350495 -   10.  Their most recent recommendations (2004) included more
350496 -        aggressive efforts to lower blood cholesterol.  The lower limit
350497 -        of safety for LDL cholesterol was lowered from 130 mg. to 100
350498 -        mg.  Cholesterol lowering drugs were recommended for all
350499 -        diabetics and elderly patients with high cholesterol levels.
350500 -        If implemented, these recommendations would add about 4,000,000
350501 -        persons to the multitudes already taking statin drugs. (What a
350502 -        bonanza for drug company profits).  Six out of the nine
350503 -        members[2] of the NCEP making these new recommendations are
350504 -        affiliated with the drug companies that manufacture statin
350505 -        drugs. Do you think this is a coincidence?
350507 -         ..
350508 -   11.  This 2004 call for the "aggressive and increased use of statin
350509 -        medication to treat high blood cholesterol values" would not be
350510 -        alarming if there would actually be many lives saved by these
350511 -        new recommendations.  The disturbing part of this information
350512 -        is that there is little credible scientific information to
350513 -        support these changes and there is a large amount of valid
350514 -        scientific information suggesting that many persons taking
350515 -        statin drugs are suffering serious even fatal side effects.
350516 -        Obviously increasing the number of persons taking statin drugs
350517 -        would greatly increase the number of patients being injured by
350518 -        these drugs.
350520 -         ..
350521 -   12.  Two years ago Dr. Julian Whitaker proposed to the FDA that the
350522 -        package insert supplied with a statin drug contain information
350523 -        that statin drugs decrease the levels of the critical nutrient
350524 -        CoQ 10 in patients.  He wisely suggested. that all patients
350525 -        taking statin drugs should also be taking 100 to 200 mg. of CoQ
350526 -        10 daily to avoid complications (heart failure, muscle
350527 -        breakdown with potentially fatal kidney failure
350528 -        {myoglobulinuria}, muscle weakness, peripheral neuritis,
350529 -        transient global amnesia etc.) The FDA ignored Dr.  Whitaker's
350530 -        suggestion because admitting that there was a danger from
350531 -        statin drugs, even if true, might hurt the sales of statin
350532 -        drugs.
350534 -         ..
350535 -   13.  Cholesterol Is Not A Major Cause Of Arterial Disease
350536 -
350537 -        Several factors appear to be of greater importance than
350538 -        cholesterol in causing arterial disease.  Among these are
350539 -        deposition of toxic metals in the lining endothelium of
350540 -        arteries, Vitamin C deficiency, excessive amounts of
350541 -        lipoprotein (a), inflammation in arteries, excessive clotting
350542 -        of blood, homocysteine elevation (hyperhomocystinemia) and
350543 -        dangerous foods.
350545 -         ..
350546 -   14.  An important study by Dr. Harlan Krumholz revealed that persons
350547 -        with low cholesterol levels over the age of 70 died twice as
350548 -        often from heart attacks[3] as older persons with high
350549 -        cholesterol values.  Most studies in old persons have shown
350550 -        that cholesterol is not a risk factor for coronary artery
350551 -        disease.  Approximately 90% of cardiovascular disease is seen
350552 -        in persons over 60 years of age.  Almost all studies have shown
350553 -        that high cholesterol is not a risk factor for women.[4] This
350554 -        leaves cholesterol as a risk factor for less than 5% of those
350555 -        persons dying of a heart attack.
350557 -         ..
350558 -   15.  High cholesterol values protect against infection. In a review
350559 -        of 19 studies involving 68,000 persons low cholesterol values
350560 -        revealed an increased risk for dying from lung and
350561 -        gastrointestinal diseases.  Both lung and g.i. diseases are
350562 -        often related to infections. This information was confirmed by
350563 -        a 15 year study of 100,000 healthy persons in the San Francisco
350564 -        area.  Persons entering this study with low cholesterol values
350565 -        were more often admitted to hospitals because of infectious
350566 -        diseases.[5] Patients with a history of a sexually transmitted
350567 -        disease or liver disease were twice as likely to develop HIV
350568 -        infection[6] over 7 to 8 year follow up if they had a low
350569 -        cholesterol value when entering the study.
350571 -         ..
350572 -   16.  Patients with severe heart failure have high levels of
350573 -        endotoxins and cytokines in their blood.  Endotoxins are toxic
350574 -        substances derived from gram negative bacteria.  Cytokines are
350575 -        hormones secreted from white blood cells responding to an
350576 -        inflammatory process in the body. A medical team in Germany
350577 -        learned that the strongest predictor for death in a patient
350578 -        with heart failure was the concentration of cytokines[7] in the
350579 -        blood.  They felt that bacteria in the gut found it easier to
350580 -        penetrate tissues when the pressure in abdominal veins was
350581 -        elevated by heart failure. Endotoxins were highest in patients
350582 -        with edema and endotoxin levels fell significantly when heart
350583 -        failure improved with therapy.  Patients with heart failure
350584 -        whose immune function is unable to respond to bacterial
350585 -        antigens (anergy) had a higher mortality than patients who
350586 -        still responded to bacterial antigens.  In addition the
350587 -        mortality was higher in those patients who had the lowest
350588 -        cholesterol, LDL, and triglyceride values.  The risk of dying
350589 -        in a group of 1000 patients with heart failure followed for 5
350590 -        years was 62% in patients whose cholesterol was below 129
350591 -        mg/dl. whereas patients whose cholesterol was over 223 mg./dl
350592 -        had only one half this risk of death.
350594 -         ..
350595 -   17.  When arteries are examined visually, by xrays or ultrasound
350596 -        there has never been any correlation between changes in
350597 -        cholesterol values and the extent of arteriosclerosis.
350599 -         ..
350600 -   18.  Why Metal Deposition In Artery Linings (Endothelium) Is So Important
350601 -
350602 -        After more than 30 years of use intravenous chelation therapy
350603 -        (EDTA) has become an accepted form of therapy because it has
350604 -        been found to be an effective, safe relatively inexpensive way
350605 -        to reverse occluded arteries to the heart, brain, kidneys and
350606 -        extremities.  Chelation is known to have powerful anti-oxidant
350607 -        effects but this may not afford a complete explanation for the
350608 -        benefits observed.
350610 -         ..
350611 -   19.  An important new concept about chelation relates to the inner
350612 -        lining of blood vessels (endothelium).  This lining tissue
350613 -        generates the powerful arterial vessel dilator nitric oxide.
350614 -        The endothelium also produces prostacyclin which decreases the
350615 -        clotting of blood and also causes dilating of arteries.  A
350616 -        third important endothelial product is heparin, a potent
350617 -        substance that helps prevent clots from forming.  Excessive
350618 -        deposition of heavy metals in the endothelium diminishes the
350619 -        endothelium's ability to produce nitric oxide, prostacyclin,
350620 -        and heparin.[8] Chelation may restore the body's ability to
350621 -        create these important substances by removing these metals
350622 -        (iron, cadmium, lead, mercury) from the endothelial lining.
350623 -        Additionally removal of excess iron can decrease the risk of
350624 -        subsequent heart attacks.[9] By improving blood circulation,
350625 -        chelation may benefit patients with angina pectoris,
350626 -        claudication, impotence, macular degeneration, glaucoma,
350627 -        pancreatitis, gout, rheumatoid and osteoarthritis, chronic
350628 -        fatigue syndrome, fibromyalgia, dementia, multiple sclerosis,
350629 -        and cancer.  Several of the pioneers in chelation therapy are
350630 -        alive in good health in their 90's after receiving thousands of
350631 -        intravenous chelation treatments.
350633 -         ..
350634 -   20.  The latest improvement in chelation permits this therapy to be
350635 -        adminstered orally.  Oral chealtion obviously will not be as
350636 -        fast as intravenous chelation but this is not an important
350637 -        issue for most patients who have massive amounts of metals
350638 -        needing removal. Doing chelation orally is simpler and less
350639 -        expensive than the intravenous approach.
350641 -         ..
350642 -   21.  Lead poisons enzyme systems in the body. The bones of modern
350643 -        man contain 1000 times more lead[10] than the bones of men
350644 -        living 400 years ago.  It takes 7 to 20 years for the body to
350645 -        completely replace the tissue in bone.  Since bone is the
350646 -        primary storage area for lead there is clearly no necessity in
350647 -        most patients for rapid chelation by intravenous therapy.
350648 -        Nearly all health problems (learning disorders, cancer, heart
350649 -        disease, infections, AHHD, autism, hypertension etc.) are made
350650 -        worse by the high levels of lead found in our bodies.  Lead is
350651 -        an important cause for hypertension and removal of lead from
350652 -        patients with hypertension often permits blood pressure values
350653 -        to return to normal.  Recent studies have implicated lead in
350654 -        the genesis of cataracts.  The EDTA present in chelating
350655 -        solutions binds lead so it can be excreted by the kidneys.
350657 -         ..
350658 -   22.  One of the leading authorities in chelation therapy, Dr.  Garry
350659 -        Gordon, has developed an oral chelation product Essential Daily
350660 -        Defense EDD.  EDD contains Niacin, garlic powder, Calcium EDTA,
350661 -        MSM (Methyl Sulfane Methane), Malic Acid, Betaine HCL,
350662 -        Carrageenan, Papain, Silica, dl Methionine, Beta-Sitosterol,
350663 -        Crataegus 6x (Hawthorne Berry), Modified Cellulose Gum,
350664 -        Cholesterol Free Stearic Acid, and Gelatin.
350666 -         ..
350667 -   23.  Iron is now being recognized as a health hazard. The malic acid
350668 -        in EDD derived from apples binds iron and decreases iron stores
350669 -        in the body.  This does not proceed to a state where iron
350670 -        deficiency anemia appears but it does lead to decreased
350671 -        production of free radicals which is, of course, desirable.
350673 -         ..
350674 -   24.  One of the most important components in EDD is the sulfated
350675 -        polysaccharide derived from red algae.  This polysaccharide
350676 -        interacts with EDTA to produce a definite decrease in the
350677 -        clotting tendency of blood (lower viscosity due to heparin).
350678 -        This decrease in viscosity permits blood to flow more freely
350679 -        which decreases the work load on the heart.  Additionally, this
350680 -        heparin anti-clotting effect acquired with EDD therapy makes it
350681 -        nearly impossible for a patient to have a heart attack, stroke
350682 -        or gangrene.  In this state of absent clotting and high
350683 -        anti-oxidant activity arteriosclerotic plaques are slowly and
350684 -        steadily dissolved.  There is no problem with bleeding.  Blood
350685 -        clots in arteries often occur in sites where there is no or
350686 -        minimal plaque formation.  The anticlotting effect of heparin
350687 -        produced by chelation may help explain the nearly complete
350688 -        disappearance of strokes and heart attacks in patients
350689 -        receiving chelation therapy.  Patients with severe
350690 -        arteriosclerosis may need 6 to 9 capsules daily along with
350691 -        other measures to improve arteries (anti-oxidants, correct
350692 -        diet, cessation of cigarettes etc.) The garlic, which EDD
350693 -        contains, binds mercury facilitating its removal from the body.
350695 -         ..
350696 -   25.  Anyone taking EDD needs to be taking a good vitamin mineral
350697 -        supplement because EDD over time might deplete the body of
350698 -        minerals.  Half of all Americans are taking a daily Multiple
350699 -        Vitamin Mineral Supplement.  The results of this
350700 -        supplementation are less than optimal because our bodies are
350701 -        being steadily poisoned by toxic substances found in our water,
350702 -        food, and air.  Oral chelation is proving so effective in
350703 -        improving health that many practitioners have largely switched
350704 -        from intravenous to oral forms of chelation.
350706 -         ..
350707 -   26.  Oral and intravenous chelation are complex so therapy ideally
350708 -        should be guided by a practitioner experienced in chelation.
350709 -        At times the metals simply move from one site in the body to
350710 -        another instead of leaving the body.  There is no doubt that
350711 -        removing metals from the endothelial membranes improves
350712 -        oxygenation and nutrient entry into cells resulting in improved
350713 -        health.  Because of the toxic metal, chemical, herbicide and
350714 -        pesticide exposure we all are exposed to I think everyone
350715 -        should consider taking EDD or a similar oral chelation product
350716 -        and remain on it permanently. Many leaders in the natural
350717 -        health field are already doing so.
350719 -         ..
350720 -   27.  Essential Daily Defense can be obtained from Longevity Plus
350721 -        sales@longevityplus.net or 800-580-7567. and from Natural
350722 -        Health team at 1-800-416-2806 or www. naturalhealthteam.com
350724 -         ..
350725 -   28.  Vitamin C Deficiency
350726 -
350727 -        The late Dr. Linus Pauling and his associates were convinced
350728 -        that the arteriosclerotic plaque is formed because of a
350729 -        deficiency of Vitamin C.  In their explanation of
350730 -        arteriosclerosis the structural protein (collagen) of arteries
350731 -        is lacking due to Vitamin C deficiency. This causes the body to
350732 -        supply lipoprotein (a) to these weak areas in an attempt to
350733 -        patch the weakness.  This substance lipoprtotein (a) is very
350734 -        sticky and when it deposits onto an injured artery surfaces it
350735 -        seizes platelets, calcium, fibrin and cholesterol from the
350736 -        blood which causes a deposit (plaque) that narrows the opening
350737 -        in the artery.  These narrowed openings can proceed to clot
350738 -        over (heart attack, stroke, or gangrene), produce symptoms
350739 -        (angina, leg pain with exertion, brain symptoms from lack of
350740 -        adequate blood flow) and small pieces of fibrin clot may break
350741 -        off the plaque and are thrown to arteries more distant again
350742 -        producing strokes, heart attack and gangrene.
350744 -         ..
350745 -   29.  In 1994 Linus Pauling and his associates announced that
350746 -        arteriosclerosis could be cured by a substance important in
350747 -        making collagen (lysine 6 grams daily) and large doses of
350748 -        Vitamin C (6 grams daily).  The Pauling associates have never
350749 -        seen an individual who was taking 10 grams of Vitamin C daily
350750 -        who had any evidence of arteriosclerosis.  Ninety five per cent
350751 -        of patients with advanced arteriosclerosis admitted they took
350752 -        no Vitamin C or less than 500 mg. daily.  These findings have
350753 -        been confirmed by the Life Extension Foundation of Hollywood,
350754 -        Florida.
350756 -         ..
350757 -   30.  The Pauling associates relate that end stage arteriosclerosis
350758 -        patients have been completely cured by high dosage Vitamin C
350759 -        and lysine often within weeks.  These individuals lose their
350760 -        anginal pain, blood pressure drops to normal, arterial
350761 -        blockages disappear, lipid profiles become normal, and energy
350762 -        increases. They become able to pass treadmill tests normally.
350764 -         ..
350765 -   31.  Human beings and guinea pigs are unable to manufacture Vitamin
350766 -        C.  Depriving guinea pigs of vitamin C leads to the production
350767 -        of arteriosclerotic lesions similar to human arteriosclerosis.
350768 -        No plaque forms in control guinea pigs getting Vitamin C.  Dr.
350769 -        Kilmer.  McCulley has shown that guinea pigs depleted of
350770 -        Vitamin C get high blood levels of homocysteine whereas the
350771 -        control guinea pigs have normal homocysteine values.
350773 -         ..
350774 -   32.  Animals other than guinea pigs do not develop arteriosclerosis.
350775 -        Arteriosclerotic plaques were studied by Dr. Earl P.  Benditt
350776 -        with an electron microscope[11] in 1977.  His studies showed
350777 -        that plaques contain almost no cholesterol.  They are actually
350778 -        composed of new cell growth resembling what would be seen in a
350779 -        tumor.  The absence of cholesterol is certainly not what would
350780 -        expect if cholesterol circulating in the blood was the cause of
350781 -        the atherosclerotic plaque.
350783 -         ..
350784 -   33.  The human arteriosclerosis plaques are often located at sites
350785 -        where injury to blood vessels occurs from the impact of the
350786 -        arterial stream of blood rather than in a random fashion which
350787 -        should occur if a toxic material in blood i.e. cholesterol was
350788 -        the cause of arteriosclerosis.  This explains why major plaque
350789 -        formation often occurs at the sites where the forceful blood
350790 -        stream from the aorta strikes the arteries to the heart and the
350791 -        arteries to the brain.  Dr.  Pauling's findings have been
350792 -        ignored by the conventional medical community because to accept
350793 -        such convincing insights would spell the end of the multi
350794 -        billion dollar coronary bypass industry and the lucrative sales
350795 -        of cholesterol lowering drugs.
350797 -         ..
350798 -   34.  All this evidence makes a strong argument that lack of vitamin
350799 -        C plays a role in causing arteriosclerosis and that taking
350800 -        large quantities of vitamin C along with lysine should help
350801 -        narrowed arteries open back up.  Large dosages of vitamin C are
350802 -        safe but may cause loose stools.
350804 -         ..
350805 -   35.  Another aspect of Vitamin C therapy that has considerable
350806 -        importance is the widely acknowledged role that Vitamin C has
350807 -        in healing infections (polio, HIV etc.) The healing of
350808 -        infections might also be a reason for favorable response of
350809 -        arteries to high doses of Vitamin C therapy as infections are
350810 -        becoming recognized as a probable cause for arteriosclerosis.
350812 -         ..
350813 -   36.  High Levels Of Lipoprotein (a. Cause Accelerated Arteriosclerosis
350814 -
350815 -        Elevation of blood levels of Lipoprotein (a^]is considered one
350816 -        of the best predictors of impending trouble with heart disease.
350817 -        Lipoprotein (a) is a substance found in the blood that has a
350818 -        "sticky" character.  It has a strong tendency to attach to
350819 -        sites of artery damage.  This permits a clumping together with
350820 -        platelets, calcium, cholesterol and fibrin derived from
350821 -        circulating blood at this location decreasing the size of the
350822 -        artery.  Free flow of blood past this site is obstructed which
350823 -        may produce symptoms (angina, brain ischemic symptoms and
350824 -        muscle ischemic symptoms i.e. claudication) or actual occlusion
350825 -        of an artery (stroke, heart attack, gangrene).
350827 -         ..
350828 -   37.  The amino acid N-Acetyl Cysteine has been found to be the most
350829 -        effective agent to lower lipoprotein (a) levels in the blood.
350830 -        With NAC therapy lipoprotein (a) levels may decrease by up to
350831 -        70 %.  Obtaining lipoprotein (a) values during health
350832 -        evaluations is a wise idea. Patients with elevated levels of
350833 -        lipoptotein (a) should take N-acetyl cysteine 500 mg. twice
350834 -        daily.  This can be obtained from Natural Health Team and
350835 -        health food stores.
350837 -         ..
350838 -   38.  Arteriosclerosis Caused By Elevated Homocysteine And Its Correction
350839 -
350840 -        Methionine from red meat, milk and milk products is converted
350841 -        in the body into homocysteine.  When the body's stores of B6
350842 -        (pyridoxine), folic acid and B12 fail to bring this
350843 -        homocysteine down to normal values there is a three times
350844 -        greater risk of heart attack in males than in males with normal
350845 -        homocysteine values.
350847 -         ..
350848 -   39.  Dr. Kilmer McCulley gets credit for discovering the critical
350849 -        role homocysteine plays in the genesis of arteriosclerosis.
350850 -        Homocysteine stops the production of the valuable vasodilating
350851 -        nitric acid, causes blood to thicken, and facilitates the
350852 -        oxidation of LDL cholesterol, thus setting the stage for an
350853 -        atherosclerotic plaque and blood clots to form.  As more
350854 -        patients are studied it has become evident that elevated levels
350855 -        of homocysteine are a common cause for arteriosclerosis (at
350856 -        least 40 % of patients).  If you have artery problems,
350857 -        measuring homocysteine in the blood will frequently provide
350858 -        clear evidence that homocysteine is causing the problem, not
350859 -        cholesterol.
350861 -         ..
350862 -   40.  A Norwegian[12] study discovered that in 587 patients with
350863 -        coronary heart disease the risk of death within four years was
350864 -        proportional to total plasma homocysteine level.  The risk rose
350865 -        from 3.8 % with homocysteine below 9 micromols per liter to
350866 -        24.7 % in patients with homocysteine levels above 15 micromols
350867 -        per liter.
350869 -         ..
350870 -   41.  The only way to be certain that you are getting the proper
350871 -        dosage of folic acid, Vitamin B 12, Vitamin B6 and
350872 -        trimethylglycine to treat homocysteine excess is to have
350873 -        regular blood homocysteine tests.  Each 3 unit increase in HC
350874 -        causes a 35% increase[13] in the risk of heart attack.
350876 -         ..
350877 -   42.  Trimethylglycine (TMG) also called Glycine Betaine is the most
350878 -        effective[14] agent to lower homocysteine levels.  The usual
350879 -        dose is 500 mg. three times daily.  If Homocysteine levels have
350880 -        not fallen adequately, up to 9000 mg. daily of TMG may be
350881 -        needed daily.
350883 -         ..
350884 -   43.  Folic acid (800 mcg with each meal) and 1000 mcg. of B 12 daily
350885 -        is also needed.
350887 -         ..
350888 -   44.  B6 (pyridoxine) reduces HC by a different method than folic
350889 -        acid.  The dose of B6 should be 100 to 200 mg. daily.
350891 -         ..
350892 -   45.  In a patient with previous bypass surgery, anginal chest pain
350893 -        reappeared along with new areas of blockage of heart arteries.
350894 -        This man was taking 15,000 mcg. of folic acid daily.  His blood
350895 -        homocysteine (HC) level was very high risk at 18.  On 6 grams
350896 -        daily of trimethylglycine, his HC fell to 4 in one month.
350898 -         ..
350899 -   46.  Trimethylglycine functions in treating elevated HC levels by
350900 -        donating methyl groups, which convert HC to the harmless
350901 -        aminoacid methionine.  Trimethylglycine (Glycine Betaine) can
350902 -        be purchased in health food stores.
350904 -         ..
350905 -   47.  Inflammatory Conditions In the Body Predispose To Artery Damage
350906 -
350907 -        Inflammation in the body is strongly associated with the
350908 -        development of occlusion in arteries.  For this reason blood
350909 -        tests that measure inflammatory reactions (sedimentation rate,
350910 -        C reactive protein) have been found to be of great value in
350911 -        detecting persons who are at higher risk of developing heart
350912 -        attacks and strokes.
350914 -         ..
350915 -   48.  Bacteria and viruses from inflammatory conditions in the body
350916 -        (gingivitis) and acute infections (cytomegalovirus, Chlamydia
350917 -        pneumonia (TWAR bacteria), Coxsackie, herpes, etc. appear to be
350918 -        responsible for 25 % of heart attacks and a similar percentage
350919 -        of strokes.  Evidence of bacterial and viral infections in the
350920 -        walls of arteries have been found by electron microscopy and
350921 -        immunoflourescence microscopy in many patients. Two hundred
350922 -        reviews about infectious relationships to arteriosclerosis[15]
350923 -        have been published but this evidence has been largely ignored
350924 -        as it does not encourage the use of statin drugs which remains
350925 -        the prime focus of the pharmaceutical industry with their
350926 -        control over the media and medical community.  Infectious
350927 -        disease causes deleterious affects on blood clotting with
350928 -        sludgy blood flow which promotes vascular occlusion.
350929 -        Discovering and treating inflammatory conditions like
350930 -        gingivitis may permit patients to avoid vascular occlusions.
350932 -         ..
350933 -   49.  During the weeks preceding a heart attack or stroke many
350934 -        patients have experienced a bacterial or viral infection.
350935 -        Thirty seven of 166 patients with a stroke had a bacterial or
350936 -        viral infection[16] within 7 days of the vascular accident.
350937 -        Eleven of 40 male patients below age 50 had suffered an
350938 -        influenza like illness within[17] 36 hours of onset of their
350939 -        heart attack.
350941 -         ..
350942 -   50.  During infections an inflammatory infectious reaction may be
350943 -        occurring in the arteries.  Infections also are associated with
350944 -        slow sludgy blood flow which would make it easier for a clot to
350945 -        occlude an already narrowed artery where blood flow is already
350946 -        slower than normal.
350948 -         ..
350949 -   51.  There appears to be a conflict between the concept that high
350950 -        cholesterol causes arterial disease and the observation that
350951 -        high levels of cholesterol have an ability to protect against
350952 -        infection.  The high cholesterol causing arteriosclerosis
350953 -        theory is damaged by the observations that:
350954 -
350955 -        1.  Persons with high cholesterol do not have any more
350956 -            arteriosclerosis than persons with low cholesterol values
350958 -             ..
350959 -        2.  Lowering cholesterol values by drugs does not cause a
350960 -            decrease in the amount of arterial disease
350962 -             ..
350963 -        3.  High cholesterol is associated with longevity in older
350964 -            persons.  High cholesterol occurs in elderly persons with
350965 -            the lowest mortality rates and appears to protect against
350966 -            infectious illnesses.
350968 -             ..
350969 -        4.  Less than 50 % of persons having heart attacks have abnormal
350970 -            cholesterol values
350972 -         ..
350973 -   52.  Measuring indices of inflammation appears to be a wise
350974 -        preventative health measure.  There is evidence that the statin
350975 -        drugs have an anti-inflammatory effect and this may be the main
350976 -        reason for any beneficial effects seen with statin therapy
350977 -        rather than actual lowering of cholesterol values.
350979 -         ..
350980 -   53.  Dangerous Foods Cause Arteriosclerosis
350981 -
350982 -        The proper diet for patients with angina and heart attacks to
350983 -        follow has been a source of controversy.  The two parts of the
350984 -        world that have the lowest incidence of arteriosclerotic heart
350985 -        disease are the island of Crete and the Japanese island of
350986 -        Kohama.  People in both these places eat a diet that is high in
350987 -        linolenic acid, an essential fatty acid. The Cretans get their
350988 -        linolenic acid from walnuts and purslane, whereas the Japanese
350989 -        islanders are getting their linolenic acid from non genetically
350990 -        modified soybeans and canola oil (rapeseed oil).
350992 -         ..
350993 -   54.  Researchers in France followed 605 patients after a first heart
350994 -        attack, with one half receiving the American Heart Association
350995 -        Diet (low cholesterol) and the other half receiving the Cretan
350996 -        Diet (lots of whole grains, roots, and green vegetables, fish,
350997 -        daily fruit, chicken and olive oil).  The study was terminated
350998 -        at 27 months and all patients were switched to the Cretan diet
350999 -        because of dramatic benefits from this diet (see chart)
351000 -
351001 -               American Heart Association Diet
351002 -               Total # of Heart Attacks 33
351003 -               Deaths from Heart attacks 16
351004 -               Sudden Death 8
351006 -                ..
351007 -               Mediterranean Diet Cretan
351008 -               Total # of Heart Attacks 8
351009 -               Deaths from Heart attacks 3
351010 -               Sudden Death 0
351012 -         ..
351013 -   55.  Linolenic acid has two desirable qualities. It makes blood less
351014 -        likely to clot and prevents ventricular arrhythmias.  Note the
351015 -        8 sudden deaths on the AHA diet and the absence of sudden death
351016 -        in the Cretan diet.
351018 -         ..
351019 -   56.  Sudden death is caused by an electrical gradient being
351020 -        established between an area of well oxygenated heart muscle and
351021 -        an adjacent area of poorly oxygenated heart muscle.  This
351022 -        gradient often permits a dangerous heart rhythm (ventricular
351023 -        fibrillation) to occur.  This is a condition where purposeless,
351024 -        small, feeble muscle contractions move no blood and cause
351025 -        instant death.  This is seen often in smokers, when the
351026 -        nicotine constricts a coronary artery so much a gradient is
351027 -        created leading to ventricular fibrillation.  When smokers quit
351028 -        cigarettes their incidence of sudden death instantly returns to
351029 -        the same as a nonsmoker.  Tragically, in approximately 35% of
351030 -        individuals, the presence of serious coronary artery
351031 -        arteriosclerosis is uncovered by the occurrence of sudden
351032 -        death.
351034 -         ..
351035 -   57.  Linolenic acid is found mainly in seeds (flax, hemp, soybean,
351036 -        walnut, pumpkin).  It is easily destroyed by light, air, and
351037 -        heat.  By the end of 27 months, the blood linolenic acid levels
351038 -        in the French patients had reached the same range as those seen
351039 -        in Crete. Notice that all foods consumed in the Cretan diet
351040 -        will spoil (no processed food).
351042 -         ..
351043 -   58.  The processed food diet consumed by 90% of Americans certainly
351044 -        contributes to promoting arteriosclerosis.  The U.S. soil has
351045 -        been seriously depleted of nutrients with important minerals
351046 -        lacking.  Selenium is no longer found in much of the U.S. soil.
351047 -        This mineral has dramatic effects in lowering the incidence of
351048 -        cancer when 200 mcg. is consumed daily.
351050 -         ..
351051 -   59.  Highly significant deterioration in the health of U.S. citizens
351052 -        was brought about by the introduction of Nitrogen, Phosphorus,
351053 -        Potassium NPK chemical fertilizer which has promoted the
351054 -        development of chronic degenerative diseases.  This use of
351055 -        chemical fertilizer instead of manure caused the protein
351056 -        content of vegetables to drop.  Additionally farmers no longer
351057 -        can afford to replace the vital soil minerals.  This has lead
351058 -        to steadily decreasing deficiencies in the mineral content of
351059 -        food grown from U.S. soil.  Humans lacking the trace minerals
351060 -        from food have failure of proper enzyme function. The trace
351061 -        minerals (zinc, chromium, manganese, vanadium, selenium etc)
351062 -        are vital to normal enzyme performance in the body.  Many soil
351063 -        samples lack some or most of these minerals and the quantity of
351064 -        minerals in U.S. soil has been steadily declining since the
351065 -        introduction of NPK fertilizer.
351067 -         ..
351068 -   60.  Numerous foods have been genetically modified which subjects
351069 -        the consumer to a myriad of unnecessary dangerous problems.  No
351070 -        testing for safety could be done on GMO foods because these GMO
351071 -        foods were likely to increase the incidence of cancer and
351072 -        degenerative diseases like arteriosclerosis.  Powerful
351073 -        agribusiness forces wanted GMO foods released.
351075 -         ..
351076 -   61.  One of the world's leading geneticists Dr. Mae-Wan Ho states
351077 -        "Genetic engineering bypasses conventional breeding by using
351078 -        artificially constructed, parasitic, genetic elements,
351079 -        including viruses as vectors to carry and smuggle genes into
351080 -        cells. The insertion of foreign genes into the host genome has
351081 -        long been known to have many harmful and fatal effects[18]
351082 -        including cancer of the organism".
351084 -         ..
351085 -   62.  Ninety percent of U.S. families are using synthetic chemical
351086 -        oils to cook food.  These are dangerous transfats that the body
351087 -        has a hard time processing.  Use of this synthetic food causes
351088 -        massive production of free radicals and leads to the
351089 -        development of Type 2 diabetes, arteriosclerosis and cancer.
351091 -         ..
351092 -   63.  The substances Americans think they use in cooking (corn,
351093 -        saffola, canola, sunflower, and soy oils) are actually
351094 -        chemicals compounds manufactured at high temperatures using
351095 -        harsh chemicals that completely remove all nutrient value from
351096 -        food. These chemical oils will not spoil, have no nutritional
351097 -        value and are very hard for the body to process and eliminate.
351098 -        Prolonged usage of these synthetic chemical oils leads to
351099 -        arteriosclerosis, Type 2 diabetes and cancer.  These synthetic
351100 -        oils are a major factor in the deteriorating health of the
351101 -        American people.
351103 -         ..
351104 -   64.  The nutrients, vitamins, minerals and fiber have been largely
351105 -        removed from white bread, white flour, and white rice.  Non
351106 -        organic food consumed by most persons has heavy metals,
351107 -        pesticides, herbicides, chemicals and estrogenic hormones.  A
351108 -        simple remedy would be to eat only organic food that spoils.
351110 -         ..
351111 -   65.  Increased Clotting Can Produce Heart Attacks And Strokes
351112 -
351113 -        An increased tendency of blood to clot can have a major
351114 -        influence in causing vascular occlusions in persons with
351115 -        narrowed arteries.  Among the conditions which make blood clot
351116 -        easier are fibrinogen excess, increase in number of platelets,
351117 -        abnormal platelet function, lipoprotein [a] excess, high blood
351118 -        lipids values and infections. Screening tests for fibrinogen
351119 -        excess are prudent as systemic enzyme therapy with products
351120 -        like Vitalzym or Wobenzyme may correct the increased clotting
351121 -        tendency and prevent vascular accidents from occurring.
351123 -         ..
351124 -   66.  Males living in Kampala, Kenya in 1960 were found to have the
351125 -        same degree of arteriosclerosis in their heart arteries as
351126 -        those living in St.  Louis, Missouri.  However, an autopsy
351127 -        study of 2237 males in St.  Louis and 827 males in Kampala
351128 -        revealed only one well healed heart attack in the Ugandan males
351129 -        whereas in the black and white males in St.  Louis one quarter
351130 -        of the deaths were caused by heart attacks.  There was
351131 -        extensive clotting in the arteries in St.  Louis males and
351132 -        nearly none in Kampala males. The population of Uganda at that
351133 -        time were grain vegetarians existing on corn and millet.
351134 -        Millet contains a protease inhibitor that prevents blood from
351135 -        clotting which may explain the lack of blood clots in the
351136 -        arteriosclerotic arteries of the Ugandan males.
351138 -         ..
351139 -   67.  Dr. Kilmer McCully,[19] who discerned the importance of
351140 -        homocysteine in producing -arteriosclerosis, believes that B6
351141 -        (pyridoxine) has unique anti-oxidant[20] properties that cause
351142 -        the human body to be protected from damage from sugar loaded
351143 -        diets by blocking the infectious problems usually caused by
351144 -        excess sugar. Studies have shown that individuals consuming
351145 -        Western diets are more depleted of B6 than other vitamins.
351146 -        Fats, which constitute 30 to 40 % of the calories in the
351147 -        Western diet, are lacking in water soluble B vitamins.
351148 -        Additionally, foods grown in soils fertilized for decades by
351149 -        NPK (Nitrogen, Phosphorus, Potassium) fertilizer (USA) are low
351150 -        in micronutrients including B6 even if grown organically.  In
351151 -        addition to both these problems Vitamin B6 is fragile so much
351152 -        of the B6 found in western food is lost in food processing,
351153 -        storage, transport and cooking.
351155 -         ..
351156 -   68.  To compound this problem sugar intake depletes[21] B6 from the
351157 -        body.  The air we inhale, our food and medicines are full of
351158 -        substances that destroy B6 in our bodies and thus increase our
351159 -        need for it.  Stress, which is high and rising, depletes the
351160 -        body of B6 as does the new sources of electromagnetic
351161 -        radiation[22] according to Dr. Robert Becker.
351163 -         ..
351164 -   69.  The simple taking of B6 (Pyridoxine) in doses of 100 mg or
351165 -        more.daily decreased the incidence of heart attacks by 70 % in
351166 -        two large medical practices.  Additionally, B6 decreases the
351167 -        incidence of cancer[23] even in persons who continue to
351168 -        smoke.[24]
351170 -         ..
351171 -   70.  The Ireland Boston Brothers Heart Study[25] compared the health
351172 -        of a brother eating Irish food with a brother who had
351173 -        immigrated to the U.S.  At that time the Irish brothers were
351174 -        eating approximately 1  pounds of butter weekly and had
351175 -        oatmeal daily for breakfast. The brother living in the U.S. was
351176 -        eating the standard low cholesterol and saturated fat and high
351177 -        polyunsaturated fat diet consumed by most Americans.  Many were
351178 -        surprised by the results which showed that there were far more
351179 -        heart attacks in the U.S. brothers that those in Ireland.  The
351180 -        protease inhibitor found in oatmeal appeared to be protecting
351181 -        the Irish brothers from heart attacks while the synthetic low
351182 -        saturated fat diet in the U.S. was proving to be dangerous.
351184 -         ..
351185 -   71.  In England during the 1800s persons ate lots of saturated fats
351186 -        like butter, lard, meat, milk and eggs and there were almost no
351187 -        heart attacks discovered by reviewing London hospital records.
351188 -        In the 1960s persons living in Udaipur, India ate large
351189 -        quantities of ghee (butter) but had very few deaths from heart
351190 -        attacks. Sharp increases in deaths from heart attacks were
351191 -        noted in Udaipur in the 1980s when inexpensive margarine had
351192 -        replaced ghee as the primary fat eaten.  Obviously type and
351193 -        character of the food we eat has major influences on heart
351194 -        disease.
351196 -         ..
351197 -   72.  Many Health Problems Are Associated With Statin Drug Usage
351198 -
351199 -        Among the health conditions related to therapy with statin drugs are:
351200 -
351201 -        1.  Congestive Heart Failure
351202 -
351203 -            The decrease in CoQ 10 blood levels caused by statin
351204 -            therapy diminishes the energy output of heart muscle cells
351205 -            leading to congestive heart failure.  A mysterious rise in
351206 -            the incidence of heart failure has been noted in the U.S.
351207 -            in recent years which may well relate to the continually
351208 -            increasing use of statin drugs
351210 -             ..
351211 -        2.  Muscle Weakness
351212 -
351213 -            Weakness of muscles when taking statin drugs probably
351214 -            relates to decreased muscle cell energy production caused
351215 -            by diminished levels of CoO Q 10.  When severe this muscle
351216 -            weakness may progress to a state where muscle soreness and
351217 -            pain appears.  In this state the muscle cells break up
351218 -            releasing muscle protein and enzymes into the blood.  If
351219 -            the muscle damage is extensive kidney failure
351220 -            (myoglobulinuria) and severe acidosis due to lactic acid
351221 -            production may occur (often a fatal problem).
351223 -             ..
351224 -        3.  Hyperinsulinemia
351225 -
351226 -            Rise in fasting insulin values by 13 % is seen after statin
351227 -            therapy is started.  This is undesirable because high
351228 -            levels of insulin increase the construction of
351229 -            arteriosclerotic plaques over time.  Also high insulin
351230 -            values accelerate the rate of development of both diabetes
351231 -            and aging.
351233 -             ..
351234 -        4.  Anti-Oxidant Blood Levels Decrease
351235 -
351236 -            Alpha Tocopherol and Beta Carotene levels in the blood fall
351237 -            by up to 22 % in patients taking statin drugs.  Decreasing
351238 -            one's anti-oxidant stores in the blood is obviously
351239 -            undesirable as this means that our ability to remove free
351240 -            radicals will be impaired.
351242 -             ..
351243 -        5.  Peripheral Neuritis
351244 -
351245 -            The cause for peripheral neuritis is often obscure.  The
351246 -            incidence of peripheral neuritis is 15 times greater in
351247 -            persons taking statin drugs than in control subjects.  This
351248 -            could also relate to deficiency of CoQ 10.
351250 -             ..
351251 -        6.  Transient Global Amnesia TGA
351252 -
351253 -            This interesting neurologic disorder causes patients to
351254 -            have a total loss of memory for several hours.  During
351255 -            these episodes the person does not know who he or she is,
351256 -            does not know what they are doing and often has a complete
351257 -            loss of memory about their past history.  Recently it has
351258 -            been discovered that many persons taking statin drugs have
351259 -            experienced TGA and that there are thousands of persons
351260 -            with memory dysfunction, extreme forgetfulness,
351261 -            incapacitating confusion and profound disorientation for
351262 -            every person who has an episode of TGA.  The relationship
351263 -            of these memory problems to usage of statin drugs is nearly
351264 -            completely unknown in the medical community.  Stopping the
351265 -            statin drug leads to recovery which may take several
351266 -            months.
351268 -             ..
351269 -        7.  Liver Injury
351270 -
351271 -            Abnormal results of liver function tests are common in
351272 -            persons taking statin drugs.  Severe abnormalities are
351273 -            uncommon and the abnormal liver function disappears when
351274 -            statin therapy is stopped.  The package insert gives
351275 -            guidelines for the levels where abnormal liver tests should
351276 -            cause therapy to be terminated.
351278 -             ..
351279 -        8.  Stroke risk goes up when cholesterol values are lowered below 140 mg.
351280 -
351281 -            Dr Gilbert Gordon suggests keeping cholesterol values near
351282 -            220 mg.[26] to preserve the natural antioxidant benefits of
351283 -            cholesterol for the body.
351285 -         ..
351286 -   73.  A large population study of cholesterol levels in patients
351287 -        taking statin drugs revealed a decrease in deaths from heart
351288 -        disease but this occurred at the expense of an equivalent
351289 -        increase in deaths from suicide and cancer.  Lowering
351290 -        cholesterol decreases the number of receptors for serotonin on
351291 -        brain cell membranes.  Serotonin acts to suppress aggressive
351292 -        behavior so lowered serotonin levels could lead to increased
351293 -        violence and suicide.
351295 -         ..
351296 -   74.  Possibly of greater importance several early studies of the
351297 -        results of statin therapy suggested that there might be an
351298 -        increased risk of developing cancers and lymphomas in persons
351299 -        taking statin drugs.  These studies were ignored and aggressive
351300 -        marketing of statins began. Such adverse results could easily
351301 -        take more than 10 years of statin usage to become manifest and
351302 -        the rapidly increasing rates of cancer might tend to obscure
351303 -        cancers being caused by statin therapy.  Certainly some of this
351304 -        increase in cancer incidence could be due to the rapidly
351305 -        increasing statin drug usage. Knowing that CoQ 10 is a fine
351306 -        therapy for cancer suggests that lowering the levels of CoQ 10
351307 -        with statin drugs might increase the risk of cancer.  All
351308 -        persons using statin drugs should be taking 100 to 200 mg. of
351309 -        CoQ 10 daily which could probably prevent some of these adverse
351310 -        effects.
351312 -         ..
351313 -   75.  The availability of natural substances like food (flax oil) to
351314 -        lower cholesterol and fish oil to lower triglycerides suggests
351315 -        that these natural products might be able to safely replace the
351316 -        more expensive and somewhat dangerous statin drugs.  Many
351317 -        physicians are not aware of the necessity for patients taking
351318 -        statin drugs (Mevacor, Lipitor, Lescol, Zocor, Pravachol, etc.)
351319 -        to take regular doses of Co Q10 (at least 100 mg. to 200 mg.
351320 -        daily).  If you take statins be sure you get CoQ 10.
351322 -         ..
351323 -   76.  Footnotes:
351324 -
351325 -            1.  Fats That heal Fats That Kill Udo Erasmus page 68 Alive Books
351326 -                Vancouver, Canada
351327 -
351328 -            2.  Well Being Journal September/October 2004 pg. 44
351330 -                 ..
351331 -            3.  Krumholz HM et al Lack of association between cholesterol and
351332 -                coronary artery mortality and morbidity and all-cause mortality in
351333 -                persons older than 70 years. Journal of the Americam Medical
351334 -                Association 272, 1335-40, 1990
351336 -                 ..
351337 -            4.  Ravnskov U. Quarterly Journal of Medicine 96, 927-934, 2003
351339 -                 ..
351340 -            5.  Iribarren C et al Serum total cholesterol and risk of
351341 -                hospitalization, and death from respiratory disease.  International
351342 -                Journal of Epidemiology 26, 1191-1202, 1992
351344 -                 ..
351345 -            6.  Claxton AJ et al Association between serum total cholesterol and HIV
351346 -                infection in a high risk cohort of young men Journal of Acquired
351347 -                Immune Deficiency Syndromes and Human Retrovirology 17, 51-57, 1998
351349 -                 ..
351350 -            7.  Rauchhaus M et al Plasma cytokine parameters and mortality in
351351 -                patients with heart failure. Circulation 102, 3060-3067, 2000
351353 -                 ..
351354 -            8.  Arnold, J., Clean out your arteries -at home, without the needle,
351355 -                and at a fraction of the cost.Health Sciences Institute Members Alert
351356 -                August 2003 pg. 1-4
351358 -                 ..
351359 -            9.  Sullivan, J.L., Iron and the sex differences in heart disease risk
351360 -                Lancet 1981 June 13; 1(8233):1293-1294
351362 -                 ..
351363 -           10.  Dr. Garry Gordon
351365 -                 ..
351366 -           11.  Benditt, Earl P. Scientific American Feb. 1977 pg 74-80
351368 -                 ..
351369 -           12.  New England Journal Of Medicine July 24, 1997
351371 -                 ..
351372 -           13.  American Journal Of Epidemiology 1996, 143:9:845-859
351374 -                 ..
351375 -           14.  Disease Prevention and Treatment (Life Extension Media) 3rd Edition
351376 -                page 86
351378 -                 ..
351379 -           15.  Ravenskov, Uffe Cholesterol Not Guilty New Research Shows
351380 -                Cholesterol is Natural and Beneficial The Benefits of High Cholesterol
351381 -                Well Being Journal Sept/Oct 2004 pg 43
351383 -                 ..
351384 -           16.  Grau AJ et al Recent Bacterial and viral infection is a risk factor
351385 -                for cerebrovascular ischemia Neurology 50, 196-203, 1998
351387 -                 ..
351388 -           17.  Mattila KJ Viral and bacterial infections in patients with acute
351389 -                myocardial infarction. Journal of Internal Medicine 225, 293-296, 1989
351391 -                 ..
351392 -           18.  Ciola Greg Beware of the Coming Food Apocalypse GMOs (genetically
351393 -                modified organisms) pg. 9
351395 -                 ..
351396 -           19.  Surfontein, William S. DSc. Interview near Pretoria, South Africa,
351397 -                1992
351399 -                 ..
351400 -           20.  Vir SC et al Vitamin B6 levels in the elderly Vitamin Nut Res
351401 -                1977;47:364-372
351403 -                 ..
351404 -           21.  Louis J Iguarro, M.D. Nobel Laureate 1998 for his discovery of
351405 -                functions of nitric acid in the body. Interview in Bland JS, Funct Med
351406 -                Update 2002 Sept
351408 -                 ..
351409 -           22.  Becker, Robert O. MD Cross Currents: The Perils of
351410 -                Electropollution. Los Angeles, Ca: Tarche,r 1990.
351412 -                 ..
351413 -           23.  Maksymowych AB et al Efficacy of Pyridoxal treatment in controlling
351414 -                the growth of melanomas in cell cultures and an animal pilot study
351415 -                Anticancer Research 1993, 13; 1925-1938
351417 -                 ..
351418 -           24.  Hattersley JG Enough Vitamin B6 Reduces Heart Attacks by 70
351419 -                %.Townsend Letter forDoctors & Patients August/September 2004 pg. 125
351421 -                 ..
351422 -           25.  Stare F World Review of Nutrition and Dietetics Vol 12, 1970 pg
351423 -                1-42
351425 -                 ..
351426 -           26.  Dr. Garry Gordon Chelation Discussion Group Feb 11, 2004 How low
351427 -                for cholesterol?
351428 -
351430 -  ..
351431 - 2005 Dr. James Howenstine - All Rights Reserved
351433 -  ..
351434 - Dr. James A. Howenstine is a board certified specialist in internal
351435 - medicine who spent 34 years caring for office and hospital patients.
351436 - After 4 years of personal study he became convinced that natural
351437 - products are safer, more effective, and less expensive than
351438 - pharmaceutical drugs.  This research led to the publication of his
351439 - book A Physicians Guide To Natural Health Products That Work.
351440 - Information about these products and his book can be obtained from
351441 - amazon.com and at www.naturalhealthteam.com and phone 1-800-416-2806
351442 - U.S.  Dr.  Howenstine can be reached at jimhow@racsa.co.cr and by mail
351443 - at Dr.  James Howenstine, C/O Remarsa USA SB 37, P.O.  Box 25292,
351444 - Miami, Fl. 33102-5292.
351445 -
351446 -
351447 -
351448 -
351449 -
351450 -
351451 -
351452 -
3515 -