THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: December 2, 2008 02:56 PM Tuesday; Rod Welch

Millie letter from Kaiser pathology findings HER2 neu negative FISH 1.1.

1...Summary/Objective


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SUBJECTS
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0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 17 0000. ref SDS 16 0000.
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040507 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Background on objectives and requirements for biopsy on 081107
040902 - reported in the record earlier this morning on 081202. ref SDS 14 WR5I
040904 -  ..
040905 - Millie sent a letter this morning on 081202 1038 to Doctor Daamen at
040906 - Kaiser, ref SDS 14 UV5I, asking for specific findings in the pathology
040907 - report for the biopsy on 081107 that support a conclusion of triple
040908 - negative. ref SDS 14 GZ3T
040910 -  ..
040911 - Millie received a response from the doctor today 081202 1253 and
040912 - reporting efforts to verify conclusion of pathology report that biopsy
040913 - on 081107 was triple negative status.  Since this is different from
040914 - Millie's requirements to verify findings in relation to possible
040915 - evolving standards, ref SDS 15 4P4F, Millie sent a letter to clarify
040916 - objectives...
040918 -  ..
040919 - Millie sent a letter to the doctor today 081202 1314 clarifying
040920 - objective to get findings from pathology, ref SDS 16 3E9J, consisting
040921 - of numbers showing correlation with criteria that supports conclusion
040922 - of triple negative status in order to evaluate prospects of status
040923 - change in relation to reports that criteria for triple negative may
040924 - have changed. ref SDS 16 RE5V
040926 -  ..
040927 - Millie received a response from Kaiser today 081202 1428 saying that
040928 - the pathology lab submitted the specimen from the biopsy on 081107 for
040929 - FISH testing, and got confirmation of HER2 neu negative, ref SDS 17
040930 - PV4I, but did not get numerical analysis supporting the conclusion of
040931 - negative. ref SDS 17 4P5N
040933 -  ..
040934 - Later this afternoon, Millie received another letter from Doctor
040935 - Daamen with additional findings, saying...
040936 -
040937 -    1.  Subject: Clarify Pathology Results Biopsy Nov 7th
040938 -        Date: Tue, 2 Dec 2008 14:28:55 -0800
040945 -         ..
040946 -        here's the FISH report- appears to be 1.1, ref SDS 0 MA6T,
040947 -        though you should clarify with your oncologist...
040949 -         ..
040950 -    2.  TISSUE CHROMOSOME ANALYSIS
040952 -         ..
040953 -    3.  Laboratory #: T08-10616 Tissue Type: PARAFFIN EMBEDDED
040955 -         ..
040956 -    4.  Date Obtained: 11/07/08 Date of Report: 11/28/08
040958 -         ..
040959 -    5.  Date Received: 11/18/08
040961 -         ..
040962 -    6.  Req Prov: Zoe Tang Req Fac: San Francisco
040964 -         ..
040965 -    7.  Gen Ctr: San Francisco
040967 -         ..
040968 -    8.  Indication: BREAST CANCER (NOS) Status: Affected
040970 -         ..
040971 -    9.  Other Reasons: HER-2/neu by IHC, BREAST, IHC08-11299
040973 -         ..
040974 -   10.  RESULT
040976 -         ..
040977 -   11.  Number of flasks analyzed: Stains: GTW FISH
040979 -         ..
040980 -   12.  Number of cells/colonies: Band Level:
040982 -         ..
040983 -   13.  Karyotype: FISH Negative: HER2/17cen = 3.3/3.0 = 1.1
040984 -        (200 tiles analyzed)
040986 -  ..
040987 - Report of HER2 "1.1" appears to address issue presented on 071007,
040988 - ref SDS 1 S68T, and resolves purpose of biopsy to test for status
040989 - change ordered by UCSF on 081016, ref SDS 5 J36R, as further shown in
040990 - the work plan on 081029. ref SDS 8 SF3P
040991 -
040992 -            [On 081202 Millie letter to Kaiser commends Doctor Daamen
040993 -            for outstanding work investigating details of patient test
040994 -            history that affect options treating cancer to extend and
040995 -            enhance quality of life. ref SDS 18 FG5G
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