THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: April 24, 2007 09:03 AM Tuesday; Rod Welch

Millie confirm schedule starting 4th cycle cetuximab clinical study.

1...Summary/Objective
2...Schedule Starting Cetuximab 4th Cycle at UCSF on 070426
3...Coordination Blood Draw Exam Treatment Notify Kaiser on Blood Tests

ACTION ITEMS.................. Click here to comment!

1...I will update blood test results on Friday or by Monday or so

CONTACTS 

SUBJECTS
Schedule Blood Test ANC INR CA 15-3 Examination Treatment 070426 Coo

1303 -
1303 -    ..
1304 - Summary/Objective
1305 -
130501 - Follow up ref SDS 33 0000. ref SDS 32 0000.
130502 -
130503 -
130504 -
130506 -  ..
1306 -
1307 -
1308 - Progress
1309 -
130901 - Schedule Starting Cetuximab 4th Cycle at UCSF on 070426
130902 - Coordination Blood Draw Exam Treatment Notify Kaiser on Blood Tests
130903 -
130904 - Follow up ref SDS 33 407N, ref SDS 32 407N.
130905 -
130906 - Millie submitted ref DIT 1 0001 to Jackie with a copy to Catherine
130907 - coordinating treatment on Thursday, 070426 0800, and following the
130908 - prior practice on 070329. ref SDS 36 Q659  Copy notifies Gloria INR
130909 - will be tested on Thursday to manage Coumadin treatments.  A copy to
130910 - Michele provides an opportunity to post blood test results to Kaiser's
130911 - medical chart, which were missing on 070330. ref SDS 38 128S
130913 -  ..
130914 - Millie says to Jackie at UCSF...
130915 -
130916 -    1.  Just a heads up to coordinate ordering blood tests for
130917 -        Thursday. ref DIT 1 0001
130919 -         ..
130920 -    2.  I got a call last night from UCSF to meet with you and Brigid
130921 -        on 070426 0800.  The earliest I can get a blood draw in the
130922 -        Infusion Clinic is 0800.  I will come down to the 2nd floor for
130923 -        our meeting in the Breast Care Center as soon as the blood draw
130924 -        is completed, probably about 0815, if everything goes smoothly.
130925 -        ref DIT 1 H45K
130927 -  ..
130928 - This plan follows prior practice on 070329 initiating blood testing as
130929 - early as possible, ref SDS 36 Q659, without Millie having to make a
130930 - special trip to get a blood drawn the day before treatment, and also
130931 - gives the medical team time to assess safety of treatments with
130932 - cetuximab that require NEUTS 1.50 (ANC 1500).
130934 -  ..
130935 - Subsequently, Millie considered that the blood test could be done
130936 - after meeting with the medical team, by relying on the interim blood
130937 - test done last week on 070419 that showed NEUTS rising to 1.87 (ANC
130938 - 1870). ref SDS 39 P560  As shown below, Millie called UCSF to revise
130939 - the schedule. ref SDS 0 1V3F
130940 -
130941 -            [On 070426 blood test results NEUTS 1.47 (ANC 1470) below
130942 -            Kaiser's standard of 1500, and well below UCSF requirements
130943 -            of 1800 for safe treatments with cetuximab. ref SDS 40 GV7L
130945 -  ..
130946 - Millie's letter continues...
130947 -
130948 -    3.  Please include INR and CA 15-3 in the scope of the lab slip.
130949 -        ref DIT 1 1G6G
130951 -         ..
130952 -    4.  By copy to Catherine, I am coordinating to alert the Infusion
130953 -        Clinic that a blood draw is needed at 0800, and further that
130954 -        since I am meeting with you and Brigid OA 0815, I will probably
130955 -        be a little late for treatment currently scheduled at 0830,
130956 -        maybe closer to 0900.  I think this fits Catherine's schedule.
130957 -        ref DIT 1 H46J
130959 -         ..
130960 -    5.  By copy to Gloria at Kaiser's Coagulation Control Clinic in
130961 -        Martinez, this confirms my letter on 070330, ref SDS 37 ZH4H,
130962 -        notifying that INR will be reported following the blood test at
130963 -        UCSF on 070426. ref DIT 1 H47H
130965 -         ..
130966 -    6.  By copy to Michele at Kaiser, this transmits results of the
130967 -        last blood test on 070329 for the Medical Chart. ref SDS 36
130968 -        A64L, ref DIT 1 H47N
130970 -         ..
130971 -    7.  Notice line 470940 in patient history shows "NEUTS" 1.81.
130972 -        Kaiser calls this "ANC."  Multiply the number by 1000 to get an
130973 -        equivalent value for Kaiser, so in this case ANC = 1810 by
130974 -        multiplying 1.81 x 1000. ref SDS 36 QY6H, ref DIT 1 H48K
130976 -         ..
130977 -    8.  Hope that's not too confusing. ref DIT 1 FE8O
130979 -         ..
130980 -    9.  [Primary care physician] reported in the Medical Chart for
130981 -        070330 that "Labs" are "at UCSF." ref SDS 38 128S  He usually
130982 -        uses "cut and paste" to log blood test results into the Medical
130983 -        Chart, including recent history on CA 15-3 listed in the record
130984 -        meeting at UCSF on 070329. ref SDS 35 087J, ref DIT 1 H49K
130986 -         ..
130987 -   10.  If helpful, you can also list the history on ANC (NEUTS).
130988 -        ref SDS 36 P560, ref DIT 1 TI4I
130990 -         ..
130991 -   11.  I will update blood test results on Friday or by Monday or so
130992 -        of next week. ref DIT 1 YJ4N
130993 -
130994 -
130996 -  ..
1310 -
1311 -
1312 - 1128
1313 -
131301 - Called UCSF Infusion Clinic.
131302 -
131303 - Talked to Adrian.
131305 -  ..
131306 - Adrian will pull Millie's chart and note coordination in Millie's
131307 - letter to Chatherine, per above. ref SDS 0 QF3F
131309 -  ..
131310 - Talked to Catherine.
131312 -  ..
131313 - She will put a note in Millie's chart that she needs blood draw at
131314 - 0800 on Thursday, and to include INR and CA 15-3, along with ANC, in
131315 - case Jackie does not have time to submit a lab slip.
131317 -  ..
131318 - Catherine's looking forward to treating Millie on Thursday OA 0900,
131319 - per letter to Jackie. ref SDS 0 MF6X
131320 -
131322 -  ..
1314 -
1315 -
1316 - 1234
1317 -
131701 - Letter to Mil notified of coordination.
131702 -
131704 -  ..
1318 -
1319 -
1320 - 1708
1321 -
132101 - Millie advised that she called Jackie this afternoon, and proposed
132102 - waiting to do blood tests until after starting treatment in the
132103 - Infusion Clinic, which occurs after meeting for examination to decide
132104 - on continuing treatment.
132106 -  ..
132107 - Normal standard of care for chemotherapy treatments called out in the
132108 - protocol for cetuximab Consent documents reviewed on 070116,
132109 - ref SDS 14 5U7Z, evaluates blood counts that show patients can safely
132110 - tolerate chemotherapy, reported on 070201. ref SDS 16 XR40  This was
132111 - illustrated on 060810 when Kaiser cancelled treatment because blood
132112 - tests showed ANC was too low. ref SDS 7 5K4F  More recently, on 070301
132113 - Doctor Rugo ordered extra blood tests to verify treatment could be
132114 - safely given, after Millie's ANC registered below the minimum level.
132115 - ref SDS 24 H93H
132117 -  ..
132118 - Ordering blood tests after examinations conflicts with patient
132119 - history, and cancer care requirements to provide diagnostic data for
132120 - the doctor to examine the patient and approve chemotherapy treatment.
132122 -  ..
132123 - Millie noticed that, since blood counts have been improving, the test
132124 - on Thursday will likely be okay. and so testing after examination
132125 - presents only a small risk of low blood counts weakening the immune
132126 - system and increasing exposure to infectious diseases.  How this
132127 - change in protocol affects UCSF standards for comprehensive cancer
132128 - care is the doctor's call.
132130 -  ..
132131 - If blood is drawn after examination, UCSF may order that treatment be
132132 - delayed an hour or so until test results are received from the Lab in
132133 - accordance with standard practice to verify patients can be treated
132134 - safely with chemotherapy.  Delay could be minimized by getting an
132135 - earlier blood draw at 0800, as occurred on 070329, ref SDS 36 0001,
132136 - and presented in the letter to UCSF earlier today, ref SDS 0 QF3F, and
132137 - also discussed with Catherine. ref SDS 0 GR3F
132138 -
132139 -
132140 -
132141 -
132142 -
132143 -
132144 -
132145 -
1322 -

































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