THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rod@welchco.com


S U M M A R Y


DIARY: June 20, 2018 03:30 PM Wednesday; Rod Welch

PRP treat knees feet metatarsalgia Tailor's Bunion Halux Valgus Doctor Tucker meeting in Novato.

1...Summary/Objective
........Platelet-Rich Plasma (PRP) Therapy for Arthritis
........Application of Platelet-Rich Plasma to Disorders of the Knee Joint
2...Develope Scope of Work for Regeneration PRP Injection Treatments
3...PRP Treatment Layout Injection Sites
........Right Leg Injections
........Left Leg
........Right Foot
........Left Foot
4...Blood Draw for PRP Completed with One Needle Stick
5...PRP Injections Mostly Pain Free
6...Follow Up Treatments Might be Needed
7...Discharge Instructions and Payment
........PRP  POST INJECTION GUIDELINES AND EXERCISES
8...Driving from Novato to Concord


..............
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CONTACTS 
0201 - Doctor Gloria Tucker                                                                                                                                               
020101 - Dr. Gloria Tucker                                                                                                                                                
020103 - Medical Offices                                                                                                                                                  

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0403 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0403 -    ..
0404 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
0405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040501 - Follow up ref SDS 38 0000. ref SDS 37 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040504 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040505 -            [On 180820 1039 scheduled follow up with 5th PRP treatment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
040506 -            on 180825 1515. ref SDS 40 E27M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
040507 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040508 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040509 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040511 -  ..
0406 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0408 - Background                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040901 - On 180105 1118 Jane called and advised of cancellation, so ordered PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040902 - treatment in feet and knees by Doctor Gloria Tucker. ref SDS 24 O46F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040904 -  ..
040905 - On 180105 1321 letter to Doctor Thuillier in VA Orthopedics notified                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040906 - have been unable to download radiologist report on MRI of both feet                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040907 - performed on 171229. ref SDS 25 O46F  Further explained plan on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040908 - driving to VAMCSF to get the report from VA Release of Information                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040909 - (ROI). ref SDS 25 I492  Also planned to schedule meeting with Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040910 - Thuillier for review results of MRI studies on feet and knees. 180105                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040911 - 1321, ref SDS 25 I495                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040913 -  ..
040914 - On 180105 1630 Doctor Tucker performed 3rd PRP injection treatment for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040915 - feet and knees again. ref SDS 26 0001                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040917 -  ..
040918 - On 180108 letter to Doctor Thuillier reported PRP treatment in both                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040919 - feet and both knees on 180105 1630, ref SDS 26 HP5O, and related                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040920 - research indicating PRP yields measurable increase in minisucs                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040921 - cartilage over 6 months. ref SDS 26 JX67                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040923 -  ..
040924 - On 180110 1100 meeting Doctor Thuillier. ref SDS 28 JN9H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040926 -  ..
040927 - On 180423 0908 called Jane and scheduled meeting with Doctor Thuillier                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040928 - on 180425 1145. ref SDS 30 OL9L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040930 -  ..
040931 - On 180425 1145 meeting Doctor Thuillier review progress recover feet                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040932 - and knee injuries using PRP injection treatments, ref SDS 31 V54H, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
040933 - order additional care. ref SDS 31 4J6H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
040935 -  ..
040936 - On 180427 0458 letter to Doctor Thuillier confirm understandings from                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040937 - meeting on 180425. ref SDS 32 V54H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
040939 -  ..
040940 - On 180516 1015 meeting Doctor Thuillier got name of "smartwool" socks.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040941 - ref SDS 36 GW5N  The doctor suggested trying Doctor Scholl's Corn                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040942 - Removers using Salicylic Acid to recover from Tailor's Bunion on left                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040943 - side of left foot, and from calluses on both big toes. ref SDS 36 GW7M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
040944 - Doctor Thuillier indicated PRP treatments have been strong remedies                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040945 - for metatrsalgia, plantar plate tear, hallux valgus, and Tailor's                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040946 - Bunion.  He is investigating how VA can pay for the treatments.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040947 - ref SDS 36 GG6J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040949 -  ..
040950 - On 180521 1045 called Connie in Doctor Tucker's office, and she                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040951 - scheduled PRP treatment on 180620 1530. ref SDS 37 V54H  Connie                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040952 - submitted letter confirming work plan. ref SDS 37 PQ6J  She included                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040953 - directions to new office location. ref SDS 37 P58O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
040955 -  ..
040956 - On 180522 2318 submitted letter to Doctor Tucker confirming PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040957 - treatment on 180620 1530, and setting scope for care. ref SDS 38 E476                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040958 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040959 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040960 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040961 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040962 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040964 -  ..
0410 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0411 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0412 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0413 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041301 - Arrived OA 1330.  Checked in and met Paul, the doctor's husband.  He                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041302 - said the doctor just left and will return at 1530 for the treatment.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041304 -  ..
041305 - Kathy and I went to the Pachacho Mall and walked around.  Finally                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041306 - bought a sandwich at Subway for lunch.  Returned to the doctor's                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041307 - office at 1500.  Paul said the doctor still has not arrived.  Went                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041308 - for a walk until 1530.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041310 -  ..
041311 - The 4th PRP treatment performed today, was scheduled with Connie on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041312 - 180521 1045. ref SDS 37 V54H  Letter to the doctor the next day                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041313 - explained priority for PRP injection treatment, reported on 180522                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041314 - 2318, ref SDS 38 E476  The letter cites scope for prior treatment on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041315 - 180105 1630. ref SDS 26 VO3F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041317 -  ..
041318 - Doctor Tucker requested priority for treatment today?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041320 -  ..
041321 - Explained that when treatment was ordered on 180522, needed PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041322 - injections to cure Tailor's Bunion on left foot. ref SDS 38 E476                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041324 -  ..
041325 - Subsequently, Podiatry treatment at the VA has improved condition of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041326 - left foot Tailor's Bunion using Ammonium Lactate 12% lotion, reported                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041327 - in a letter to Doctor Tang at VAMCSF on 180611 1052. ref SDS 39 VL4U                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041328 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041329 -            [On 180820 1039 scheduled follow up with 5th PRP treatment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041330 -            on 180825 1515. ref SDS 40 E27M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041331 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041332 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041334 -  ..
041335 - Discussed scope of treatment today, presented in a letter to Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041336 - Tucker on 171208 1242. ref SDS 34 CJ60                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041338 -  ..
041339 - Scope was reviewed again in another letter on 171227. ref SDS 38 FN52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041341 -  ..
041342 - On 171227 1300, Doctor Thuillier in VA Orthotpedics ordered MRI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041343 - studies on both feet and both knees, to find changes in anatomy that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041344 - reconcile clinical improvement reducing severe osteoarthritis pain.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041345 - 171227 0915, ref SDS 37 E54H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041347 -  ..
041348 - On 171229 0615 went to Radiology at VAMCSF.  Jonus did MRI scans on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041349 - both knees to evaluate recovery osteoarthritis. ref SDS 39 FZ5L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041351 -  ..
041352 - Doctor Tucker said earlier today, she read the MRI findings on left                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041353 - knee shown in the record on 171229 0745, ref SDS 39 ZG6H, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041354 - referenced in the copy she received of the letter sent to Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041355 - Thuiller earlier today on 180105 1321. ref SDS 25~O46F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041357 -  ..
041358 - The doctor said there is not a lot of reporting on MRI studies finding                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041359 - regeneration of cartiage in joints.  This aligns with results of MRI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041360 - on 171229 0745, ref SDS 39 PSWR, which says in part...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041361 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041362 -            Unchanged complete degenerative tearing of the medial                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041363 -            meniscus and partial tearing of the lateral meniscus with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041364 -            extrusion of the body with intrasubstance degeneration.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041366 -  ..
041367 - This finding indicates PRP did not regnerate cartilage.  Why then has                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041368 - there been no pain in the left knee?  The right knee was treated with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041369 - Supartz on 170731 1500, ref SDS 20 0001, 5 days after PRP treatment on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041370 - 170726.  It's known that hyaluronic acid in Supartz lubricates the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041371 - joint to reduce pain.  This worked well in the right knee for about 4                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041372 - months, then pain began to recur, so Glucosamine Chondroitin has been                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041373 - taken to continue lubricating the right knee joint for pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041374 - management.  Since PRP does not inject hyaluronic acid, how has it                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041375 - prevented pain in the left knee for over 5 months and counting?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041377 -  ..
041378 - Doctor Tucker seemed to say PRP eliminated pain hiking 630 miles since                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041379 - injections on 170726, cited in the letter to Doctor Thuillier on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041380 - 180105 1321, ref SDS 25 I48O, by regenerating (healing??) soft tissue.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041381 - The doctor mentioned specifically collagen, ligaments, muscles, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041382 - further indicated MRI technology cannot assess these soft tissue                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041383 - improvements.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041385 -  ..
041386 - After the meeting, research found on the Internet...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041387 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041388 -        Arthritis-Health                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041390 -         ..
041391 -        Platelet-Rich Plasma (PRP) Therapy for Arthritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041392 -        
041393 -        By John J Wilson, MD, MS                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041394 -        Updated................................ 2014 01 07 | Peer Reviewed                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041395 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041396 -              https://www.arthritis-health.com/treatment/injections/platelet-rich-plasma-prp-therapy-arthritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041398 -  ..
041399 - The article says in part...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041400 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041401 -        PRP injections are formulated from your own immune system's                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041402 -        platelets, which are extracted from a blood sample, then                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041403 -        concentrated to make the injection.  This seems to stimulate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041404 -        healing through the production of collagen and to alter pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041405 -        receptors, which reduces pain.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041407 -  ..
041408 - This seems to support Doctor Tucker's theory, per above. ref SDS 0                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041409 - T14I  Would be helpful to have study measuring collagen before and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041410 - after PRP treatment.  What signals increased collagen?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041412 -  ..
041413 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041414 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041415 -        What Does Platelet-Rich Plasma Therapy Do?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041417 -         ..
041418 -        Experts are unsure exactly how PRP therapy may alleviate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041419 -        symptoms for certain orthopedic conditions.  Doctors who use                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041420 -        PRP therapy to treat osteoarthritis theorize that the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041421 -        platelet-rich plasma might:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041422 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041423 -        1.  Inhibit inflammation and slow down the progression of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041424 -            osteoarthritis1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041426 -  ..
041427 - MRI study may support this explanation.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041429 -  ..
041430 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041431 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041432 -        2.  Stimulate the formation of new cartilage2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041434 -  ..
041435 - MRI study seems not to support this explanation.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041437 -  ..
041438 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041439 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041440 -        3.  Increase the production of natural lubricating fluid in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041441 -            joint, thereby easing painful joint friction3                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041443 -  ..
041444 - MRI study seems silent on this.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041446 -  ..
041447 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041448 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041449 -        4.  Contain proteins that alter a patient's pain receptors and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041450 -            reduce pain sensation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041452 -         ..
041453 -        It could be that platelet-rich plasma does all of these things,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041454 -        or none.5 More large-scale, high-quality clinical studies are                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041455 -        needed before scientists can know.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041456 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041458 -  ..
041459 - Pubmed article sounds promising...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041460 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041461 -        NCBI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041462 -        PMC                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041463 -        US National Library of Medicine                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041464 -        National Institutes of Health (NIH)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041466 -         ..
041467 -        Cartilage                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041468 -        Cartilage: 2013 Oct, 4 (4) 295-312                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041470 -         ..
041471 -        PMCID:  PCM4297162                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041472 -        doi:  10.1177/1947603513497553                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041474 -         ..
041475 -        Application of Platelet-Rich Plasma to Disorders of the Knee Joint                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041476 -        
041477 -        Omitted - authors and copyright and license information                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041478 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041479 -              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297162/                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041481 -         ..
041482 -        Abstract                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041484 -         ..
041485 -        Importance. The promising therapeutic potential and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041486 -        regenerative properties of platelet-rich plasma (PRP) have                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041487 -        rapidly led to its widespread clinical use in musculoskeletal                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041488 -        injury and disease. Although the basic scientific rationale                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041489 -        surrounding PRP products is compelling, the clinical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041490 -        application has outpaced the research.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041492 -         ..
041493 -        Objective. The purpose of this article is to examine the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041494 -        current concepts around the basic science of PRP application,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041495 -        different preparation systems, and clinical application of PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041496 -        in disorders in the knee.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041498 -  ..
041499 - Many articles mention varying results based on "different preparation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041500 - systems, as here.  In this case, where results seem favorable after                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041501 - only 5 months on the left knee, and both feet, specifications on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041502 - "preparation" and "product composition" should be reported to evaluate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041503 - repetitive results.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041505 -  ..
041506 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041507 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041508 -        Basic Scientific Rationale of Platelet-Rich Plasma Use in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041509 -        Articular Cartilage Degradation and Repair                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041511 -         ..
041512 -        On a molecular level, results have indicated a beneficial                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041513 -        effect of PRP on chondrocytes and mesenchymal stem cells.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041514 -        Increased cell proliferation and synthesis of proteoglycans and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041515 -        collagen type II has been demonstrated when cell cultures of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041516 -        chondrocytes56,57 and mesenchymal stem cells58 are treated with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041517 -        PRP compared with controls treated with platelet-poor plasma or                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041518 -        fetal bovine serum.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041520 -  ..
041521 - This seems to align with Doctor Tucker's explanation that PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041522 - increases collagen, per above. ref SDS 0 T14I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041524 -  ..
041525 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041526 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041527 -        Clinical Application of Platelet-Rich Plasma Use in Articular                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041528 -        Cartilage Degradation and Repair in the Knee                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041530 -         ..
041531 -        Osteoarthritis                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041533 -         ..
041534 -        In an uncontrolled prospective study, 14 patients with knee OA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041535 -        were treated with PRP produced using anticoagulated blood                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041536 -        processed in the GPS III system.61 These authors reported                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041537 -        reduced pain and improved functional outcome after a series of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041538 -        injections with PRP.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041540 -  ..
041541 - This aligns with Welch case on left knee.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041543 -  ..
041544 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041545 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041546 -        They also reported improvement in the ultrasonographic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041547 -        measurement of femoral articular cartilage thickness in 6 out                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041548 -        of 13 patients at 6 months and in the satisfaction survey at                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041549 -        the 1-year follow-up examination, 8 of 13 patients reached                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041550 -        their goals at 1 year (Table 3).                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041552 -  ..
041553 - There is no evidence of cartilage thickness improvement in Welch,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041554 - after 5 months, at least using measurements applied by radiologists                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041555 - for MRI study on 171229.  Conceivably, more refined measurement                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041556 - methodology might register either increase or decrease in cartilage of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041557 - left knee joint.  Since PRP injected on 170726, was deminimus, i.e.,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041558 - less than protocol, per Doctor Tucker below, ref SDS 0 TR68, perhaps                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041559 - another MRI in 6 months after treatment today, will show increased                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041560 - miniscus.  If so, this would further reconcile clinical improvement                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041561 - feeling no pain in left knee hiking 630 miles between MRI on 170726,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041562 - and recent follow up MRI on 171229.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041563 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041564 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041566 -  ..
041567 - Develope Scope of Work for Regeneration PRP Injection Treatments                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041568 - 
041569 - Follow up ref SDS 24 PPVQ.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041570 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041571 - Doctor Tucker asked about pain medication.  How long since taking                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041572 - NSAID drugs?  She said these should have been stopped for at least                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041573 - the past 7 days.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041575 -  ..
041576 - Cited letter to the medical team (including Doctor Tucker) on 171103,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041577 - reported all pain medication was stopped 4 weeks earlier ref SDS 33                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041578 - S273  Ending pain medication actually began on 171018, shown in diary                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041579 - listing daily exercise, diet, vitals and medication in case study                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041580 - beginning on 160101 0700. ref SDS 9 PM5F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041582 -  ..
041583 - Based on understanding for rational basis that PRP in left knee                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041584 - reduced pain through improving multiple joint deficits, made                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041585 - following decisions...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041586 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041587 -        Because the meeting today, was scheduled ad hoc from a call                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041588 -        this morning, reported on 180105 1118, ref SDS 26 GO9L, it was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041589 -        not possible to have a driver.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041591 -         ..
041592 -        Driver is needed when injections require strong medication to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041593 -        manage pain, which then impairs ability to drive, based on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041594 -        prior care, reported on 170816 1400, ref SDS 24 J97M  On that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041595 -        occasion, the body suffered severe side effects from                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041596 -        post-procedure pain medication. ref SDS 24 RN5H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041598 -         ..
041599 -        Without driver, should not do deep injections to left and right                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041600 -        feet plantar plate tears, nor to arches, which both caused                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041601 -        severe pain and so required pain medication for prior PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041602 -        injections on 170816 1400. ref SDS 24 1H6M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041604 -         ..
041605 -        Doctor Tucker agreed to defer injections into the arch today,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041606 -        but noted efficacy to relieve hallus valgus in both feet.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041608 -         ..
041609 -        We noted simple procedure of placing felt pad spreaders between                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041610 -        toes has been successful preventing feet pain and increased                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041611 -        blisters caused by hallus valgus injuries, as recommended by                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041612 -        Doctor Thuillier during the meeting at the VA on 171227 0915.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041613 -        ref SDS 37 3B3H  This reduces urgency for injecting hallus                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041614 -        valgus today, so that PRP can be injected in left knee.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041616 -         ..
041617 -        Will consider PRP injecting hallus valgus during subsequent                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041618 -        treatments, when a driver is available and/or conscious                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041619 -        sedation can be performed.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041621 -         ..
041622 -        Primary PRP injection objective is right knee, presented in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041623 -        letter on 171208 1242, ref SDS 34 YM3I, and to achieve pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041624 -        relief comparable to total relief experienced with left knee                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041625 -        during hiking, reported in the letter to the medical team on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041626 -        171103 1141, ref SDS 33 S293, further presented in the letter                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041627 -        to Doctor Tucker on 171208 1242. ref SDS 34 CK36  This was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041628 -        confirmed in recent letter on 171227 1328. ref SDS 38 FN52                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041630 -         ..
041631 -        Next inject both feet metatarsals only, and not inject bottom                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041632 -        of feet to specifically treat plantar plate.  These seem                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041633 -        largely healed.  Injecting metatartsals today, may also                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041634 -        additonally treat plantar plate area without direct injections.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041636 -         ..
041637 -        Tailor's bunion inject PRP on both feet.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041639 -         ..
041640 -        Remaining PRP plasma, if any, can be injected into left knee.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041642 -  ..
041643 - Doctor Tucker said she was surprised the left knee responded so well                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041644 - to PRP injection on 170726, which used less than standard protocol for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041645 - knee injections.  She explained this occurred, because at that time,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041646 - the left knee was injected last with only what remained after                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041647 - injecting both feet metatarsals and plantar plate tear on bottom of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041648 - right foot.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041650 -  ..
041651 - Longevity of recovery was discussed.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041653 -  ..
041654 - Doctor Tucker seemed to say the single injections into both feet and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041655 - left knee could last 1 - 5 years.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041657 -  ..
041658 - Discussed research indicating some patients get injections every 6                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041659 - months or at least annually.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041661 -  ..
041662 - The doctor seemed to say that properly applied PRP injection                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041663 - treatments should last at least multiple years.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041665 -  ..
041666 - Since the left knee did not receive a full amount of PRP injection,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041667 - supplementing the first injection today, is good insurance for longer                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041668 - results.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041670 -  ..
041671 - Finally, most patients don't hike 2,500 miles per year, with running                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041672 - and sprinting included.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041674 -  ..
041675 - The doctor seemed to indicate that running and sprinting in particular                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041676 - reduce longevity of PRP care.  She recommended agains it.  This                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041677 - conflicts with reporting that many professional atheltes are extending                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041678 - their careers by getting PRP injections, cited in the letter to Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041679 - Tucker on 171212 1657. ref SDS 35 RX52  These athletes run and sprint,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041680 - endemic to tennis, baseball, et al.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041682 -  ..
041683 - As a result, multiple PRP injections to feet and knees are required to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041684 - achieve longevity normally expected for patients who receive only                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041685 - single injections.  Hopefully, injections today, will last 2 - 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041686 - years.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041687 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041689 -  ..
041690 - PRP Treatment Layout Injection Sites                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041691 - 
041692 - Follow up ref SDS 24 VO3F, ref SDS 17 PP4N.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041693 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041694 - In procedure room laying on treatment table, Doctor Tucker again                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041695 - marked locations on both feet and both knees to be injected.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041697 -         ..
041698 -        Right Leg                                     Injections                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041699 -        
041700 -        Knee joint...........................................  1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041701 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041703 -         ..
041704 -        Left Leg                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041705 -        
041706 -        Knee joint...........................................  1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041707 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041709 -         ..
041710 -        Right Foot                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041711 -        
041712 -        Follow up ref SDS 24 0108.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041713 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041714 -        Metatarsalgia                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041715 -        Between little toe and ring toe................. 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041716 -        Between ring toe and middle toe................. 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041717 -        Between middle and long toe..................... 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041718 -        Between long toe and big toe.................... 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041720 -         ..
041721 -        Tailor's bunion................................. 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041723 -         ..
041724 -        Total right foot...............................  5      5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041726 -         ..
041727 -        Left Foot                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041728 -        
041729 -        Follow up ref SDS 24 YY3G.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041730 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041731 -        Metatarsalgia                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041732 -        Between little toe and ring toe................. 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041733 -        Between ring toe and middle toe................. 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041734 -        Between middle and long toe..................... 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041735 -        Between long toe and big toe.................... 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041737 -         ..
041738 -        Tailor's Bunion................................. 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041740 -         ..
041741 -        Total right foot...............................  5      5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041743 -         ..
041744 -        Total injections...................................... 12                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041745 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041747 -  ..
041748 - Blood Draw for PRP Completed with One Needle Stick                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041749 - 
041750 - Follow up ref SDS 24 YY6N, ref SDS 17 FG7F.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041751 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041752 - Doctor Tucker drew blood for PRP platelet extraction.  She used outer                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041753 - side of left arm inner elbow, which was successful for prior treatment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041754 - on 170816 1400, ref SDS 24 YY6N, and previously on 170726 1600.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041755 - ref SDS 17 TZ8N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041757 -  ..
041758 - This took only 1 stick today.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041759 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041761 -  ..
041762 - PRP Injections Mostly Pain Free                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041763 - 
041764 - Follow up ref SDS 24 K65M, ref SDS 17 GU6N.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041765 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041766 - Doctor Tucker initially, marked all locations for PRP injections.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041767 - She sprayed numbing agent on each location.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041769 -  ..
041770 - The doctor made markings around the knee caps to consider possible                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041771 - multiple injection points.  However, she ultimately made only 1                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041772 - injection, and advised this is a standard protocol location for knees.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041774 -  ..
041775 - Doctor Tucker injected each location with lidocain to further numb                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041776 - needle penetrations.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041778 -  ..
041779 - Right knee - after waiting mintutes for lidocain to take effect, PRP                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041780 - was injected into the right knee joint, using standard protocol                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041781 - amount, discussed above. ref SDS 0 059O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041783 -  ..
041784 - This was completely pain free.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041786 -  ..
041787 - Right foot - PRP was next injected into 4 locations on top of right                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041788 - foot metatarsals.  The outer 2 injections were pain free.  The middle                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041789 - injections caused severe pain.  The doctor noted this reflected these                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041790 - middle toes have been worn down by hiking, running and sprinting.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041792 -  ..
041793 - Tailor's bunion right foot was injected with small amount.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041795 -  ..
041796 - Left foot - same scenario as right foot, with considerable pain                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041797 - injecting middle metatarsals.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041799 -  ..
041800 - Pain was only at moments of needle penetration, similar but less                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041801 - severe than prior procedure on 170816 1400. ref SDS 24 1A3I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041803 -  ..
041804 - Tailor's bunion left foot was injected with small amount.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041805 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041806 -            [On 180315 shown in case study on 160101 0700 tailor's                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041807 -            bunion on left foot now requires dressing to relieve shoe                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041808 -            pressure during hikes.  Tailor's bunion right foot does not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041809 -            require dressing. ref SDS 10 4B6L                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041811 -  ..
041812 - Left knee - remainting PRP was injected into left knee.  This was                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041813 - completely pain free.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041814 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041815 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041817 -  ..
041818 - Follow Up Treatments Might be Needed                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041819 - Discharge Instructions and Payment                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041820 - 
041821 - Follow up ref SDS 24 WV5I, ref SDS 17 S93J.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041822 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041823 - Doctor Tucker cleaned forefeet which had leaked blood slightly.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041825 -  ..
041826 - On standing up from the treatment table, there was mild pain at level                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041827 - 1 - 2 in the feet where injections were made.  This was much less                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041828 - severe than after deep injections to plantar plate and arches done on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041829 - 170816 1400. ref SDS 24 J97T  As a result, pain medication was not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041830 - needed today.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041832 -  ..
041833 - Doctor Tucker said not to hike for a week, then follow prior protocol.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041834 - On 170727 1747 Doctor Tucker called and said walking 1 mile 2 days                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041835 - after feet injections stimulates PRP healing (regeneration) processes,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041836 - and then slow for about 3 miles helps distribute PRP in the feet.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041837 - ref SDS 18 0W6V                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041839 -  ..
041840 - After treatment today, research found...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041841 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041842 -        The Stemcell Orthopedic Institute of Texas                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041843 -        Call 210 293 3136                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041845 -         ..
041846 -        PRP  POST INJECTION GUIDELINES AND EXERCISES                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041847 -        
041848 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041849 -              https://stemcellorthopedicinstituteoftexas.com/platelet-rich-plasma-therapy-prp/after-prp-therapy/                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041850 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041851 -        1.  Medication Guidelines                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041852 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041853 -            For a minimum of two weeks post-injection, it is important                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041854 -            for the efficacy of the treatment that all                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041855 -            anti-inflammatory medications (NSAIDS) are discontinued.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041856 -            You can take Tylenol (Acetaminophen) and Celebrex, but we                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041857 -            ask that you avoid other NSAIDS such as aspirin, Naproxen                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041858 -            (Aleve) and Ibuprofen (Advil, Motrin) because they will                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041859 -            inhibit platelet function.  Other prescription medication                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041860 -            should be reviewed with your procedure physician.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041862 -             ..
041863 -            Apply moist heat to treated area for the first 24 hours.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041865 -             ..
041866 -        2.  Activity Guidelines                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041867 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041868 -            FIRST WEEK&Treated areas should remain immobile.  For the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041869 -            first two weeks, we encourage you to resume normal day-to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041870 -            day activities&BUT NO exercise of the treated extremity.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
041872 -             ..
041873 -            SECOND WEEK& light exercises and progressively build back                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041874 -            to normal exercise after 4 weeks.  Controlled and moderate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041875 -            movement is important for the proper stimulation of tissue                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041876 -            to rebuild in a linear and physiologic fashion.  However,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041877 -            we strongly advise that you avoid heavy lifting or high                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041878 -            exercise levels because these activities will compromise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041879 -            the progress we are trying to make                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041881 -             ..
041882 -            AFTER TWO WEEKS&you are cleared by your physician to resume                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041883 -            exercising the area.  However, we ask that you gradually                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041884 -            increase the intensity of your workouts so as not to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041885 -            re-injure the tissue.  Use pain in the area of injection as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041886 -            a guide to how far you push yourself.  This is not like                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041887 -            physical therapy after surgery.  We do not want you to push                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041888 -            through the pain.  Instead, ease off the intensity if the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041889 -            pain persists.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
041891 -  ..
041892 - The question is whether damaged tissue heals, i.e., regenerates, e.g.,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041893 - miniscus cartilage, ligaments.  How long does this take?  1 week,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041894 - month, 6 months, a year.  Once healed, how long will "healed" miniscus                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041895 - cartilage, metatarsal cartilage last hiking 11 - 15 miles per day?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
041897 -  ..
041898 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041899 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041900 -            If you feel any of the following symptoms immediately                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041901 -            contact our office: prolonged redness, swelling, fevers,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041902 -            chills, muscle weakness as well as numbness and/or                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041903 -            tingling.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041904 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041906 -  ..
041907 - The doctor also cautioned against using NSAID pain medications for 2                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041908 - weeks after injections, since NSAID drugs block/reduce blood flow                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041909 - needed for PRP healing process.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041911 -  ..
041912 - Thanked Doctor Tucker for great work.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041913 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041914 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041916 -  ..
0420 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0421 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0422 - 1842                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
0423 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
042301 - Jane had already left, so Doctor Tucker prepared the bill...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
042302 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042303 -                             $900                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
042304 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042312 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042313 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042315 -  ..
0424 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0425 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0426 - 1613                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
0427 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
042701 - Driving from Novato to Concord                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042702 - 
042703 - Follow up ref SDS 24 VJ3G.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
042704 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042705 - After leaving the doctor's office traffic was okay on 101 for the 5                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
042706 - miles to highway 37 off ramp.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
042708 -  ..
042709 - Traffic moved well for 2 or 3 miles on highway 37 with 2 lanes in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
042710 - both directions.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
042712 -  ..
042713 - Fortunately, traffic speed remained normal all the way to Vallejo.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
042715 -  ..
042716 - Made it to Vallejo and transitioned onto US 80 toward San Francisco.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
042717 - There was moderate rain, and in the dark took wrong turn off, so                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
042718 - missed highway 780 to Benecia- Martinez bridge.  Was fortunate to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
042719 - quickly find an onramp for highway 80 West to Sacramento.  Took this                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
042720 - to 680, and then to Benecia-Martinez bridge and home.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
042721 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
042723 -  ..
0428 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0429 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0430 - 2010                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
0431 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
043101 - Arrived home, and transferred the record from c23 to c22.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
043102 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043103 - Began writing up the record meeting with Doctor Tucker.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
043104 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043105 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043106 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043107 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043108 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043109 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043110 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043111 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043112 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043113 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043114 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
043115 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
0432 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
Distribution. . . . See "CONTACTS"