THE WELCH COMPANY
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rod@welchco.com


S U M M A R Y


DIARY: April 10, 2017 04:23 PM Monday; Rod Welch

Rob China trip presentation request study on hiking increasing HDL 30 to HDL 73.

1...Summary/Objective


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CONTACTS 

SUBJECTS
China Presentation Exercise Health Hiking Raise HDL EPCs Regress Ath                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0503 -    ..
0504 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
0505 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
050501 - Follow up ref SDS 26 0000. ref SDS 25 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
050502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050504 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050505 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050507 -  ..
0506 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0507 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0508 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0509 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
050901 - Rob called this afternoon and requested the study showing HDL rises                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050902 - with increased hiking, for consideration in his presentation on the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050903 - China trip, he mentioned a few days ago on 170408 1704. ref SDS 26                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
050904 - B44O                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050906 -  ..
050907 - After the call, sent letter to Rob saying...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
050908 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050909 -    1.  Subject:  Hiking Raised HDL 30 to 73                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050910 -        Date:  2017-04-10 19:20                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
050922 -         ..
050923 -    2.  In connection with your presentation in China, as you requested                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050924 -        today, ref SDS 0 0O5I, attached is Excel study correlating                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050925 -        hiking the past 5 years with elevating HDL 30 at the time of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050926 -        CABG x4 (heart) surgery in October 2009, to HDL 73 in Feb 2016,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050927 -        and again HDL 72 in Feb this year.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050928 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050929 -              F:\05\00003\SM\CC\BNKG\120216cc\130101cc\hiking_miles_3.xlsx                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050931 -         ..
050932 -    3.  Related are findings in a coronary CT angiography CCTA) test                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050933 -        the VA performed on 2015 Oct 19, showing 6 years after heart                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050934 -        bypass surgery, there is no evidence of atherosclerosis.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050935 -        ref SDS 9 SU62                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050937 -         ..
050938 -    4.  This link to an SDS record has comments.  Doctor Simpson in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050939 -        Cardiology at the VA/UCSF Medical Center in San Francisco, has                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050940 -        been a continuing source of support and wisdom in my care.  Our                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050941 -        meeting on Wednesday, we will review these issues.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050943 -         ..
050944 -    5.  Last year on June 18th, I had an MRI on the brain in connection                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050945 -        with stroke symptoms. ref SDS 10 J738  A month later on Jul 15,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
050946 -        Doctor Yoo wrote in Neurology Progress Notes:  "The etiology of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050947 -        the patient's stroke remains unclear, but given the absence of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050948 -        vertebrobasilar disease, is likely cardioembolic." ref SDS 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
050949 -        TV4F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
050951 -         ..
050952 -    6.  A month later on Aug 2nd, Stanford Neuroscience issued 2nd                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050953 -        opinion that no stroke occurred. [...shown in letter received                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050954 -        in the record on 160820 0940. ref SDS 12 OE7M...].  However,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050955 -        everyone concurred MRI found no plaque blockages in the brain.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050956 -        There were 2 more MRI's done in August.  They further confirmed                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050957 -        "absence of vertebrobasilar disease," i.e., lack of plaques in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050958 -        the circulatory system of the brain, and thus align with                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050959 -        findings in the CCTA the year before.  Accordingly, I am drawn                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050960 -        to the notion that elevated HDL regresses existing plaque, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050961 -        prevents deadly buildup of atherosclerosis.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050963 -         ..
050964 -    7.  This record then might offer anecdotal support for your                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
050965 -        presentation in China on the potential for endurance exercise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050966 -        to regress atherosclerosis by elevating HDL > 60.  My sense is                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
050967 -        that hiking works better than running because it reduces the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050968 -        risk of injury, so that exercise is maintained.  The few                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050969 -        injuries I've had, including now, occurred from running and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050970 -        sprinting during hikes.  Biking and swimming may work just as                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050971 -        well, but I am not aware of studies showing this outcome.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050973 -         ..
050974 -    8.  As we discussed, I mentioned to Marsha over dinner with Kathy                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050975 -        last week after visiting mom at the hospital in Medford, this                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050976 -        possible chance to extend quality of life [...reported on                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050977 -        170402 1705, ref SDS 23 HN4L...].  I started doing 3 miles a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
050978 -        day for 50 minutes 3 - 5 times a week, to help Millie because                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050979 -        Doctor Johnson said it would raise her WBC, so she would not                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050980 -        miss chemotherapy treatments at Kaiser in Walnut Creek.  [...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050981 -        reported on 030606 1630. ref SDS 1 JP7G...].  In the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050982 -        beginning, I couldn't keep up with her.  It was a "labor of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050983 -        love" staggering around Lafayette Reservoir.  Gradually, we                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050984 -        both got stronger, eventually hiking up to 8 miles per day 4 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050985 -        6 times per week.  This simple regimen enabled Mil to get her                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050986 -        treatments and survive stage IV cancer for nearly 10 years.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
050987 -        However, I wound up getting heart surgery, because HDL 30                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
050988 -        cannot protect against atherosclerosis.  This indicated that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
050989 -        for my genetics 3 miles a day 3 - 5 times a week did not raise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050990 -        HDL.  It was not enough for me.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050992 -         ..
050993 -    9.  At that time in October 2009, I was unaware that HDL was even                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
050994 -        important.  I gathered from meetings with the medical team that                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050995 -        lowering LDL would prevent atherosclerosis from getting worse.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
050996 -        There was never discussion of HDL nor triglycerides.  Four                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
050997 -        years later during a meeting at the VA in San Francisco, Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
050998 -        Diana Alba commented on HDL [...reported on 131121 0930.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
050999 -        ref SDS 8 F16F  After the meeting, research seemed to indicate                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
051000 -        that hiking can raise both EPC blood elements in the bone                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
051001 -        marrow, and raise HDL produced in the liver.  More                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
051002 -        interestingly, raising HDL > 60 rapidly regresses                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
051003 -        atherosclerosis, and elevated EPCs repair the lining of blood                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
051004 -        vessels where plaque is removed by HDL.  The question was how                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
051005 -        to do that?                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
051007 -         ..
051008 -   10.  So, I began experimenting to see what it would take to raise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
051009 -        HDL, and just assumed that EPCs would rise as well, since both                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
051010 -        are driven by hiking.  After a few years, found myself doing 11                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
051011 -        - 15 miles a day, 7 days a week and getting stronger.  Didn't                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
051012 -        plan it, but suddenly that's what the numbers showed, and HDL                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
051013 -        increased right along with the mileage, as shown in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
051014 -        attached study.  Next step was tackling Half Dome to see how                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
051015 -        all this translates to overall performance.  Seemed like a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
051016 -        miracle.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
051018 -         ..
051019 -   11.  Merely, because I need 3 - 4 hours a day, doesn't mean the next                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
051020 -        person does.  Genetic variability can yield meaningful results                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
051021 -        for many with less effort, even much less effort.  For everyone                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
051022 -        it is an experiment to discover and balance investment in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
051023 -        health along with the bounty of life's vast ocean of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
051024 -        opportunities.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
051026 -         ..
051027 -   12.  Good luck in China, and congratulations on being invited to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
051028 -        speak with other prestigious notables in the field of exercise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
051029 -        and health.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
051031 -         ..
051032 -   13.  Best,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
051034 -         ..
051035 -   14.  Rod                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
051037 -         ..
051038 -   15.  PS.  Including some correspondence with the medical team for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
051039 -        context on these issues.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
051040 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
051041 -        1.  Letter to Doctor Simpson order labs on 170409 2317. ref SDS 27 X45G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
051042 -        2.  Letter to Doctor Simpson order labs on 170228 0153. ref SDS 14 I35I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
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0511 -