THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rod@welchco.com


S U M M A R Y


DIARY: June 21, 2016 08:24 PM Tuesday; Rod Welch

VA research EGD dilation with conscious sedation causing strokes.

1...Summary/Objective
........Complications of upper GI endoscopy
........Infectious Complications
........Perforation Complications


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
0403 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0403 -    ..
0404 - Summary/Objective                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
0405 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040501 - Follow up ref SDS 16 0000. ref SDS 15 0000.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040502 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040503 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040504 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040506 -  ..
040507 - On 160622 1428 letter notified Doctor Yoo and Doctor                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040508 - Simpson that hiking to support line of care for stroke-like                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040509 - symptoms went well; reported minor neurapathy in left                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040510 - fingers of left hand occurred and subsided for short                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040511 - periods throughout the hike.; also reported new MCL injury                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040512 - right knee will prevent hiking for 10 days or more.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040513 - ref SDS 17 5F6F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040515 -  ..
040516 - On 160622 1802 Doctor Simpson called to follow up this letter on work                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040517 - plan in relation to stroke symptoms; he was pleased Zio XT heart                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
040518 - monitor was installed the day before stroke symptoms occurred, so                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040519 - affect on heart rythms can be evaluated. ref SDS 18 LK5I                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040520 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040521 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040522 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040524 -  ..
0406 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0407 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0408 - Progress                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
0409 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
040901 - On 160617 0800 EGD dilation procedure performed by Doctor Lee in GI                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040902 - Clinic at VA Medical Center in Sacramento. 160617 0800, ref SDS 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
040903 - 0001  After the procedure, experienced stroke symptoms reported also                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040904 - on 160617 1637. ref SDS 11 5F6F                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040906 -  ..
040907 - MRI angiogram radiology study of the brain was performed the next day                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040908 - on 160618 1348. ref SDS 13 PX8M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040910 -  ..
040911 - Doctor Yoo advised that MRA shows film of fluid inflammation across a                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040912 - "large" section of the brain. ref SDS 12 MX8L  The doctor said this                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                         
040913 - could be caused by...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040914 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040915 -        1.  Bacteria                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040916 -        2.  Virus infection                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040917 -        3.  Tumor/cancer growth                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040919 -  ..
040920 - The MRI neuroradiologist report lists findings of...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040921 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040922 -        1.  MRI brain:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040923 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040924 -            1.  No hemorrhage, herniation hydrocephalus. ref SDS 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
040925 -                WK7K                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040927 -                 ..
040928 -            2.  Right superior cerebellar focus of reduced diffusion,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040929 -                without significant hypointensity on ADC map.  There is                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040930 -                associated focal FLAIR signal hyperintensity and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040931 -                enhancement compatible with a likely subacute right SCA                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040932 -                territory infarct. ref SDS 13 IY8H                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040934 -                 ..
040935 -            3.  Diffuse right holohemispheric subarachnoid enhancement,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040936 -                predominantly in the right frontal and right occipital                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040937 -                lobes. ref SDS 13 GM8M                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040939 -             ..
040940 -        2.  MRA:                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040941 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040942 -            1.  No hemodynamically significant stenosis.  Likely left                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040943 -                anterior choroidal artery infundibulum.  Fetal type                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040944 -                right PCA. ref SDS 13 VN4G                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040945 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040946 -            2.  Aortic arch and branch vessels are patent. ref SDS 13                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040947 -                J738                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040948 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040950 -  ..
040951 - Since symptoms followed EGD dilation with conscious sedation, the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040952 - question arises whether stroke symptoms sometimes occur after such                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040953 - procedures.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040955 -  ..
040956 - Research found...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040957 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040958 -        American Society for Gastrointenstinal Endoscopy                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           
040959 -        Volume 44, No 7, 2002                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
040960 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040961 -        Page 784                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040963 -         ..
040964 -        Complications of upper GI endoscopy                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
040965 -        
040966 -        Major complications related to diagnostic procedures can be                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
040967 -        broken down into cardioplumonary complications, complications                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040968 -        related to sedation, infectious complications, perforation, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040969 -        bleeding.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
040971 -         ..
040972 -        Cardiopulmonary Complications/                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040973 -        Complications Related to Sedation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
040975 -         ..
040976 -        Cardiopulmonary complicatinos related to sedation and analgesia                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040977 -        are the most common type of complications seen with diagnostic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040978 -        endoscopy, accounting for up to 46% of those reported in the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
040979 -        above-mentioned ASGE survey were related to sedation.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
040980 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040981 -            [On 160911 0908 further research explains types of uses for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040982 -            gastroscope instruments for endoscopy procedures.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
040983 -            ref SDS 22 FB3N                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
040985 -         ..
040986 -        These complications range from minor changes in vital signs to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040987 -        myocardial infarctions, respiratory depression, and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
040988 -        shock/hypotension.  Additionally, with the introduction of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040989 -        pulse oximetry, a greater number of nonclinically relevant                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040990 -        evetns have been reported.  It is estimated that oxygen                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
040991 -        desaturation may occur in up to 70% of patients undergoing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
040992 -        various endoscopic examinations; more sever desaturation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
040993 -        occurs less commonly.  Factors leading to oxygen desaturation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040994 -        include difficulty with intubation, which may be related to the                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040995 -        size of the endoscope.  Patient factors include age and history                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
040996 -        of cardiovascular/pulmonary disease.  Complications may arise                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
040997 -        related to the procedure itself, such as vasovagal reflex                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
040998 -        secondary to the intubation process and/or to overinsufflation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
040999 -        of air.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041000 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041002 -         ..
041003 -        Infectious Complications                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041004 -        
041005 -        Infectious complications related to diagnostic endoscopy                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041006 -        result either from the procedure itself or from the use of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041007 -        contaminated equipment.  Transient bacteremia may occur during                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041008 -        a diagnostic endoscopic procedure and is found more often for                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041009 -        therapeutic procedures.  The incidence is relatively low and                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041010 -        the rate of bacterial endocarditis or other complications in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041011 -        patients not at risk for endocarditis (e.g. normal cardiac                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041012 -        valves) is extremely low and estimated to be 1 in 5 to 10                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041013 -        million.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041015 -  ..
041016 - On 160618, Doctor Yoo listed causes of large area of inflammation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041017 - over the top of the brain found in MRI, to be...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041018 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041019 -               1.  Bacteria                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041020 -               2.  Virus infection                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041021 -               3.  Tumor/cancer growth                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041023 -  ..
041024 - Since MRI found no evidence of tumor/cancer, there remains                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041025 - possibility of bacteria and/or virus infection to have caused                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     
041026 - inflammation over top of head, along with other stroke symptoms.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  
041027 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041028 -            [On 160726 1117 national reporting Olympic gastrointestinal                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041029 -            scopes have design flaw that makes them difficult to clean,                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            
041030 -            and resulted in may patients suffering maladies, including                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041031 -            deaths. ref SDS 20 JF5J                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041033 -             ..
041034 -            [On 160727 0004 letter to Doctor Massa, attending physician                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        
041035 -            with Neurology, notifies of research on EGD procedures                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041036 -            shows contaminated gastroscopes can cause complications of                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041037 -            bacteria virus infections, as occurred during EGD dilation                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041038 -            procedure on 160617. ref SDS 21 S135                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041040 -  ..
041041 - Article continues...                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          
041042 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041043 -        Issues related to contaminated equipment ahve been reviewed in                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041044 -        the ASGE documents entitled "Infection Control During                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041045 -        Gastrointestinal Endoscopy";  Guidelines for Clinical                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
041046 -        Applicatino and Transmission.  The reader is referred to these                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041047 -        documents for a discussion of appropriate cleaning procedures                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041048 -        to prevent such contamination.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041049 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041050 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041051 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041053 -         ..
041054 -        Perforation Complications                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 
041055 -        
041056 -        Performation of the upper GI tract related to diagnostic                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041057 -        endoscopy is relatively low.  In teh above-mentioned 1974 ASGE                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             
041058 -        survery, teh performation rate was 0.03%.   Predisposing                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041059 -        factors to perforations include the presence of anterior                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041060 -        cervical osteophytes, Zenker's diverticulum, esophageal                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
041061 -        strictures, and malignancies.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041063 -         ..
041064 -        Pain is the most common and reproducible symptoms related to                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041065 -        performation.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              
041067 -  ..
041068 - While esophageal strictures are involved in this case, there was no                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
041069 - pain symptom arising from EGD dilation procedure on 160617.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
041070 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041071 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041072 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041073 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041074 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041075 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041076 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041077 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041078 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041079 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041080 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041081 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041082 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041083 -                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   
041084 -