THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: October 23, 2008 09:43 PM Thursday; Rod Welch

UCSF requests FNA rather than core biopsy to test status change.

1...Summary/Objective
2...UCSF Uses FNA to Test Status Change But Core May Work at Kaiser
3...Biopsy Positive Aspiration Cancer Neck Cetuximab Clinical Study
4...UCSF Ends Millie's Chemo with Cetuximab Carboplatin Clinical Study
5...Sunitinib Drug Trial Doctor Rugo Meeting at UCSF Plan Millie's Treatment


..............
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CONTACTS 

SUBJECTS
Default Null Subject Account for Blank Record

0403 -
0403 -    ..
0404 - Summary/Objective
0405 -
040501 - Follow up ref SDS 6 0000, ref SDS 5 NZ5N.
040502 -
040503 -
040504 -
040505 -
040506 -
040508 -  ..
0406 -
0407 -
0408 - Progress
0409 -
040901 - Millie received a call from Doctor Daamen at Kaiser earlier today
040902 - saying the FNA biopsy yesterday is positive for breast cancer.
040903 - ref SDS 6 NZ5N  The doctor further reported the Kaiser lab requests
040904 - Millie have a core biopsy to check for status change, ref SDS 6 W15N,
040905 - requested by UCSF in the work plan on 081016. ref SDS 4 J36R
040907 -  ..
040908 - Doctor Daamen wrote a letter at 1527 to the medical team, including
040909 - the primary care physician, and to Doctor Rugo, Brigid, and Megan at
040910 - UCSF, explaining results, and the request by the Kaiser Lab that
040911 - Millie get a core biopsy to test for status change. ref SDS 6 VE5J
040913 -  ..
040914 - Millie recieved 5 letters from UCSF all at once, from 1850 to 1936,
040915 - indicating they may have been held up at the UCSF server, or by heavy
040916 - Internet traffic.
040918 -  ..
040919 - Brigid's first letter went to the medical team at Kaiser, with copies
040920 - to Doctor Rugo, Megan, and Millie...
040921 -
040922 -    1.  Subject:  FNA Biopsy on 081022 Positive for Cancer; Need Core Biopsy to TestStatus Change
040923 -        Date: Thu, 23 Oct 2008 18:50:31 -0700
040930 -         ..
040931 -    2.  I discussed this with Dr.Rugo and we feel that maybe a
040932 -        follow-up FNA might be reasonable to avoid a core vs. open
040933 -        biopsy?? We will defer to Dr.Johnson as her primary oncologist.
040935 -  ..
040936 - Brigid responds to Doctor Daamen at Kaiser, her letter to the medical
040937 - team at 1527, reported in another record today. ref SDS 6 4Q9Q
040939 -  ..
040940 - Brigid's letter from UCSF concludes...
040941 -
040942 -    3.  thanks
040944 -         ..
040962 -
040964 -  ..
040965 - Brigid's second letter went only to Millie, responding to Millie's
040966 - letter to the medical team today 081023 1555, ref SDS 6 PR9X, and
040967 - specifically responding to Millie's request for Brigid to respond to
040968 - Doctor Daamen's letter at Kaiser, ref SDS 6 VM4P, which Brigid did,
040969 - per above. ref SDS 0 1Y7N
040970 -
040971 -    1.  Subject:  FNA Biopsy Positive for Cancer; Need Core Biopsy to Test Status Change
040972 -        Date: Thu, 23 Oct 2008 18:55:24 -0700
040976 -         ..
040977 -    2.  Hi Millie,
040978 -
040979 -        Dr.Rugo feels that another FNA might be reasonable to obtain
040980 -        enough tissue to obtain markers but will defer to Dr.Johnson as
040981 -        which procedure would be best at Kaiser to obtain the markers.
040983 -  ..
040984 - Brigid responded to Millie alone saying the same thing that was in the
040985 - letter to the medical team, including Kaiser, per above. ref SDS 0
040986 - 1Y7N  Since Millie got a copy of the letter to the medical team, and
040987 - since it says the same thing, this second letter increases confusion
040988 - and reduces understanding by allocating time to make sure the letters
040989 - are identical.
040991 -  ..
040992 - UCSF letter to Millie concludes...
040993 -
040994 -    3.  thanks
040995 -
041011 -
041013 -  ..
041014 - Brigid wrote another letter to only Millie explaining that UCSF sent a
041015 - letter saying the same thing to Kaiser (the primary care physician).
041016 -
041017 -    1.  Subject:  FNA Biopsy Positive for Cancer; Need Core Biopsy to Test Status Change
041018 -        Date: Thu, 23 Oct 2008 18:56:46 -0700
041022 -         ..
041023 -    2.  We also sent same email to Dr.Johnson
041025 -  ..
041026 - This second letter to Millie is very thoughtful of Brigid, saying they
041027 - sent the content of the letter to Millie at 1855, ref SDS 0 ZY6I, to
041028 - the primary care physician at Kaiser.  Brigid may have forgotten that
041029 - she copied Millie with her letter to Kaiser at 1850, per above.
041030 - ref SDS 0 1Y7N
041032 -  ..
041033 - This makes it appear that the 2 letters to Millie are redundant, and
041034 - reflect difficulty keeping track of complex details with limited time.
041035 - Three lettes saying the same thing increases difficulty for busy
041036 - people to make sense of complex work. explained in NWO, ref OF 12
041037 - AY9L, and in POIMS. ref OF 4 05A9
041039 -  ..
041040 - UCSF letter to Millie concludes...
041041 -
041042 -    3.  thanks
041043 -
041044 -        Brigid S. Miralda FNP
041045 -        UCSF Breast Care Center
041046 -        415-353-7070
041047 -        fax 415-353-9898
041049 -         ..
041050 -        CONFIDENTIALITY NOTICE: This email is for the sole use of the intended
041051 -        recipient and may contain information that is confidential and
041052 -        privileged under state and federal privacy laws. If you receive this
041053 -        email in error, be aware that any unauthorized use, disclosure, copying,
041054 -        or distribution is strictly prohibited. Please contact the sender
041055 -        immediately and delete and/or destroy all copies of this message.
041056 -
041057 -
041059 -  ..
041060 - UCSF Uses FNA to Test Status Change But Core May Work at Kaiser
041061 -
041062 - Doctor Rugo's first letter went to the medical team at Kaiser,
041063 - including Doctor Daamen, Doctor Johnson, and to Millie, and to Brigid
041064 - and Megan at UCSF, and it responds to Millie's letter to Kasier today
041065 - 081023 1932, and the medical team confirming Doctor Daamen's schedule
041066 - for Millie to get a core biopsy at Kaiser tomorrow at 1130.
041067 - ref SDS 7 LX5H
041068 -
041069 -    1.  Subject: RE: Core Biopsy at Kaiser Friday 1130 Is It Needed?
041070 -        Date: Thu, 23 Oct 2008 19:34:55 -0700
041075 -         ..
041076 -    2.  We usually get HER2 status from FNAs and  avoid core biopsies
041077 -        or excisions.  Depends on what works for Dr.  Johnson and
041078 -        Kaiser!
041080 -  ..
041081 - This responds to Millie's letter today 081023 1932 addressed to Doctor
041082 - Daamen at Kaiser Head and Neck in Walnut Creek, but a copy was sent to
041083 - UCSF asking Doctor Rugo to comment on Kaiser's proposal to retest for
041084 - status change with a core biopsy, rather than an FNA biopsy ordered by
041085 - UCSF. ref SDS 7 JZ8X
041086 -
041094 -
041096 -  ..
041097 - Biopsy Positive Aspiration Cancer Neck Cetuximab Clinical Study
041098 - UCSF Ends Millie's Chemo with Cetuximab Carboplatin Clinical Study
041099 - Sunitinib Drug Trial Doctor Rugo Meeting at UCSF Plan Millie's Treatment
041100 -
041101 - Doctor Rugo's second letter responded to an earlier letter from Millie
041102 - today 081023 1555, ref SDS 6 PR9X, which cited Doctor Daamen's letter
041103 - from Kaiser also on 081023 1527, which was submitted independently by
041104 - Kaiser and directly to UCSF, ref SDS 6 4Q9Q, and reported the biopsy
041105 - yesterday 081022 was positive for breast cancer. ref SDS 6 VE5J
041106 -
041107 -    1.  Subject: RE: FNA Biopsy Positive for Cancer; Need Core Biopsy to Test Status Change
041108 -        Date: Thu, 23 Oct 2008 19:36:25 -0700
041115 -         ..
041116 -    2.  You had chemo this morning?  AT this point, with the positive
041117 -        needle aspiration, you should stop chemotherapy here at UCSF
041118 -        until we decide what to do.
041120 -  ..
041121 - Progression of cancer determined by biopsy today reflects lowering
041122 - dose of Carboplatin chemotherapy on 080501, ref SDS 1 PVUQ, which was
041123 - described as an error in the record on 080529, ref SDS 2 PVUQ, and
041124 - indicated by cancer marker CA 15-3 142 rising to highest level in 7
041125 - years of patient history, reported on 080716. ref SDS 3 IT77
041126 -
041127 -            [On 081113 CT test neck finds swelled lymph node in left
041128 -            supraclavicular. ref SDS 13 5O6N
041130 -  ..
041131 - Doctor Rugo received a copy of Doctor Daamen's letter from Kaiser
041132 - earlier today, reporting that the biopsy yesterday on 081022 was
041133 - positive for cancer. ref SDS 6 VE5J
041134 -
041135 -            [On 081024 primary care phsyician prescribes treatment for
041136 -            Millie at UCSF with sunitinib metronomic and multi-agent
041137 -            protocol, ref SDS 10 XZ8W, because Millie's advancing
041138 -            cancer has become resistant to chemotherapy and so requires
041139 -            double agent drugs, and Kaiser only has single agent
041140 -            treatments which will be ineffective to treat Millie's 5th
041141 -            relapse of IBC, and further, becauser Kaiser's experience
041142 -            with sunitinib indicates this can be effective for Millie.
041143 -            ref SDS 10 ER4I
041145 -             ..
041146 -            [On 081120 pathology report for FNA biopsy on 081022, seems
041147 -            to support UCSF decision today on 081023 that Millie has
041148 -            suffered progression of cancer, and so must end treatment
041149 -            with cetuximab, because this chemotherapy is no longer
041150 -            effective, ref SDS 0 D65G, and Millie needs immediate
041151 -            treatment with another chemotherapy drug. ref SDS 15 LG45
041153 -  ..
041154 - This seems unclear in the record.  It may be that positive aspiration
041155 - from the biopsy is required for Millie to start treatment with the
041156 - sunitinib clinical study.  Why though does finding adenopathy require
041157 - ending otherwise effective treatment with cetuximab and Carboplatin?
041158 -
041159 -            [On 081024 since Doctor Rugo seems to cancel Millie's
041160 -            treatment for cancer at UCSF on 081107, Kaiser scheduled
041161 -            Millie for core biopsy to prepare for starting new cancer
041162 -            treatment on the sinitinib clinical study. ref SDS 9 W159
041164 -             ..
041165 -            [On 081113 UCSF prescribes new treatment with sunitinib .
041166 -            ref SDS 12 Q79M
041168 -             ..
041169 -            [On 081114 Millie begins treatment with sunitinib
041170 -            metronomic protocol. ref SDS 14 505G
041172 -  ..
041173 - Adenopathy was reported in the right axillary, beginning with the CT
041174 - test on 070211.
041176 -  ..
041177 - UCSF letter continuess...
041178 -
041179 -    3.  Megan, lets discuss tomorrow.
041181 -  ..
041182 - Doctor Rugo developed a work plan last week on 081016 during the
041183 - meeting with the medical team at 0830. ref SDS 4 J36R  At that time,
041184 - the doctor proposed treating Millie in the sunitinib clinical trial.
041185 - ref SDS 4 J38U
041187 -  ..
041188 - UCSF letter continuess...
041189 -
041190 -    4.  We get markers from needle aspirations, hopefully this can be
041191 -        done rather than the core?
041193 -  ..
041194 - The UCSF work plan shows an FNA biopsy was ordered to check for status
041195 - change. ref SDS 4 J36R
041197 -  ..
041198 - This responds to Doctor Daamen's letter earlier today sent to the
041199 - medical team saying that testing for status change requires core
041200 - biopsy rather than an FNA biopsy ordered by UCSF. ref SDS 6 4Q5V
041201 -
041202 -            [On 081024 Doctor Daamen responded to the medical team
041203 -            saying the Kaiser Lab reports checking for status change
041204 -            requires core biopsy. ref SDS 8 4P4L
041206 -             ..
041207 -            [On 081024 Doctor Wong confirms Kaiser cannot check for
041208 -            status change with core biopsy, ref SDS 9 KE6J; and relates
041209 -            that core biopsy is higher risk for Millie's patient
041210 -            profile than using less invasive FNA biopsy possible at
041211 -            UCSF. ref SDS 9 W183
041213 -             ..
041214 -            [On 081029 sunitinib work plan update proposes doing FNA
041215 -            biopsy at UCSF to check for status change. ref SDS 11 SF3P
041216 -
041224 -
041225 -
041226 -
041227 -
041228 -
041229 -
041230 -
041231 -
041232 -
041233 -
041234 -
0413 -