THE WELCH COMPANY
440 Davis Court #1602
San Francisco, CA 94111-2496
415 781 5700
rodwelch@pacbell.net


S U M M A R Y


DIARY: September 18, 2008 08:30 AM Thursday; Rod Welch

Millie meeting UCSF 8th cycle cetuximab Carboplatin treat IBC.

1...Summary/Objective
2...Agenda Progress Review Meeting
3...CA 15-3 95 Cancer Marker May Indicate Response to Treatment
4...CA 15-3 95 Cancer Marker Stable Aligns Favorable CT and Examination
5...Emotional Roller Coaster Stress Anxiety Wellness Support Group
6...Blood Counts Good NEUTS 2.07 Carboplatin Approved Today
7...Neutropenia Controled Chemotherapy Treatment Approved Today
8...Neutropenia Controlled with Neupogen No Missed Treatments This Cycle
9...Chemotherapy Tolerance Remains Effective for High Level Exercise
10...Neupogen Side Effects Fatigue, Bone Pain, Headaches Minimal
11...Exercise Continues High Level of Effort Neupogen Side Effects Moderate
12...Interstitional Lung Disease CT Test 080718 Heavy Chest Hiking Reduced
13...CT Test 080911 Shows Stable Improving IBC Response to Treatment
14...Schedule CT Test 081107 at Kaiser Walnut Creek After Treatment at UCSF
15...Examination Indicates Continuing Recovery 4th Relapse IBC
16...Axillary Sites Palpation Aligns CT Tests Minimal to No Swelling
17...Lump Left Supraclavicular Area of Neck Palpation No Findings
18...IBC Inflammation Rash Seem Stable and Possibly Subsiding
19...Photographs Show IBC Disease Subsiding All Sites
20...Treatment Options Work Plan
21...Progression Disease Kaiser Approves UCSF for Continuing Treatment
22...Current Medications Submitted with Kaiser's Medical Chart


..............
Click here to comment!

CONTACTS 

SUBJECTS
Meeting Examination Doctor Review Strategy  Wrk Plan 7th Cycle 1st T

1303 -
1303 -    ..
1304 - Summary/Objective
1305 -
130501 - Follow up ref SDS J8 0000. ref SDS I4 0000.
130502 -
130503 - Examination today shows stable IBC conditions, ref SDS 0 YW6M, and no
130504 - adenopathy, including left supraclavicular. ref SDS 0 4C6O  Aligns
130505 - with favorable CT test on 080911, ref SDS 0 4U6L, which found no
130506 - continuing Interstitional lung disease. ref SDS 0 NW6O  No evidence of
130507 - advancing cancer aligns with cancer marker CA 15-3 95 showing slight
130508 - decline over the past 4 weeks. ref SDS 0 VS9M  Rising blood counts
130509 - from increasing Neupogen, ref SDS 0 6Y5K, improved control of
130510 - neutropenia.  This prevented missing treatments for cycle 7,
130511 - ref SDS 0 KF4L, which in turn helped maintain response to treatment
130512 - even with lower dose of chemotherapy Carboplatin.  Stable cancer
130513 - conditions even with reduced treatment may reflect rising exercise
130514 - that increases immune system ability to resist cancer, ref SDS 0 2L5M;
130515 - and better fitness helps alot relieve to emotional stress. ref SDS 0
130516 - LT6I  Of courese, favorable examination and test findings today
130517 - greatly relieve emotional stress and anxiety. ref SDS 0 MM5N  Success
130518 - using Millie's Power Port for the CT test at Kaiser in Oakland,
130519 - further relieved fear and doubt about the future. ref SDS 0 SN8H  UCSF
130520 - expedited care today by coordinating examination with blood work and
130521 - chemotherapy treatment. ref SDS 0 GY3N  Communication for referral
130522 - coordination improved with medical team conducting meetings based on
130523 - agenda linked to patient history. ref SDS 0 QH4I
130524 -
130525 -
130526 -
130527 -
130528 -
130529 -
130530 -
130531 -
130532 -
130533 -
130534 -
130536 -  ..
1306 -
1307 -
1308 - Progress
1309 -
130901 - Agenda Progress Review Meeting
130902 -
130903 - Follow up ref SDS J8 YY3N.
130904 -
130905 - Millie submitted, ref DIP 4 0001 to UCSF yesterday on 080917 with an
130906 - agenda for the meeting this morning...
130907 -
130908 -        1.  Millie approved return to work thwarted
130909 -            UCSF approval enabled $20K severance
130910 -            pay-out; Millie retired, but looking
130911 -            for work - emotional roller
130912 -            coaster.................................. ref SDS 0 MM5N
130914 -             ..
130915 -        2.  Blood draw need vials and work order
130916 -            delivered to Infusion Clinic on
130917 -            5th floor................................ ref SDS 0 6Y5K
130919 -             ..
130920 -        3.  CT test on 080911 review results......... ref SDS 0 4U6L
130922 -             ..
130923 -        4.  Interstitional lung disease.............. ref SDS 0 056G
130925 -             ..
130926 -        5.  CT scan schedule next test at Kaiser
130927 -            Oakland................................... ref SDS 0 MF5L
130929 -             ..
130930 -        6.  Examination IBC seems continuing
130931 -            to improve............................... ref SDS 0 4C6K
130933 -             ..
130934 -        7.  Left supraclavicular lump................ ref SDS 0 4C6O
130935 -
130936 -            Neutropenia rising affects treatment
130937 -            options.................................. ref SDS 0 KF4L
130939 -             ..
130940 -            Progression Disease rising CA 15-3 96
130941 -            Kaiser approves follow on treatment
130942 -            at UCSF.................................. ref SDS 0 9W6H
130944 -             ..
130945 -        8.  Current medications...................... ref SDS 0 8A9G
130947 -  ..
130948 - The UCSF schedule received on 080904 lists the meeting today at 0900,
130949 - which is the same time as treatment in the Infusion Clinic, and then
130950 - seeing the doctor at 1130 today.  Millie got a call from UCSF
130951 - yesterday saying to meet the medical team at 0900, as scheduled.
130952 - Brigid explained during the meeting this morning that she changed the
130953 - schedule to meet with Millie this morning at 0830 after getting the
130954 - blood draw at 0800, and before treatment at 0900 in the Infusion
130955 - Clinic.  The meeting with the doctor scheduled for 1130 was cancelled
130956 - because Millie is doing well.
130957 -
130958 -            [...below, Brigid palpates no adenopathy in left
130959 -            supraclavicular, ref SDS 0 366L, and finds IBC rash sites
130960 -            stable to improving. ref SDS 0 YX3H
130962 -             ..
130963 -            [On 081016 examination indicates increased IBC intensity on
130964 -            left arm and small IBC nodules in the breast bone area,
130965 -            conflicting with stable cancer marker; other IBC rash sites
130966 -            seem stable to improved, consistent with stable cancer
130967 -            marker. ref SDS M2 J34U
130969 -  ..
130970 - Brigid reported today that she received a copy of the agenda Millie
130971 - submitted yesterday.  Jill also reported receiving Millie's letter
130972 - transmitting an agenda on 080917. ref SDS L5 4P7F  Jill commended
130973 - Millie's "organization" of the record noticed from the agenda.
130975 -  ..
130976 - This improved work last month on 080821, when Lynn did not get a copy
130977 - of the agenda submitted to UCSF for the meeting, ref SDS J8 YY3N,
130978 - repeating problems a few months earlier on 080529. ref SDS G1 4E69
130980 -  ..
130981 - Brigid introduced Megan today, who will be replacing Jill as the new
130982 - Clinical Research Coordinator for Millie's case.  Last month on
130983 - 080821, Jill replaced Jonathan, ref SDS J8 GY4M, who had replaced
130984 - Thomas the month before on 080724. ref SDS I4 YY63  Thomas had
130985 - replaced another "Megan" the month before on 080626, ref SDS H3 YY5U,
130986 - who had been assigned to replace Jackie on 080501. ref SDS F3 SR5M
130988 -  ..
130989 - Jill advised that the first Megan has moved on in her career either to
130990 - medical school, or other advanced training.
130991 -
130992 -
130993 -
130994 -
130995 -
1310 -

SUBJECTS
Default Null Subject Account for Blank Record

2103 -
210401 -  ..
210402 - CA 15-3 95 Cancer Marker May Indicate Response to Treatment
210403 -
210404 - Follow up ref SDS J8 GP3M, ref SDS B1 087J.
210405 -
210406 - Millie had a blood draw this morning in the Infusion Clinic at UCSF.
210407 - ref SDS L6 FW5N  Results for the cancer marker CA 15-3 95 were
210408 - reported a week later 080925. ref SDS L8 VK6H
210409 -
210410 -                               +- U=UCSF
210411 -                         +- K=Kaiser
210412 -         Test Date             |           Date Received
210413 -          080918......... 95 H U........... 080918, ref SDS L6 VK6H
210414 -          080821......... 96 H U........... 080821, ref SDS J9 VK6H
210415 -          080724......... 71 H U........... 080724, ref SDS I5 TR4K
210416 -          080708.........141 H K........... 080708, ref SDS H6 L74K
210417 -          080626......... 72 H U........... 080626, ref SDS H4 PW7I
210418 -          080529......... 66 H U........... 080529, ref SDS G2 IJ8L
210419 -          080501......... 59 H U........... 080501, ref SDS F4 U34O
210420 -          080403......... 66 H U........... 080403, ref SDS E6 A16M
210421 -          080313...cetuximab Carboplatin... 080313, ref SDS E2 TZ8I
210422 -          080306......... 59 H U........... 080306, ref SDS E0 A16M
210423 -          080207......... 63 H U........... 080207, ref SDS D4 A16M
210424 -          080110......... 51 H U........... 080110, ref SDS D1 A16M
210425 -          071213......... 48 H U........... 071213, ref SDS D0 A16M
210426 -          071115......... 43 H U........... 071115, ref SDS C9 A16M
210427 -          071018......... 75 H K........... 071018, ref SDS C8 5K6K
210428 -          070920......... 38 H U........... 070920, ref SDS C3 A16M
210429 -          070816......... 28 H U........... 070816, ref SDS C2 A16M
210430 -          070719...**.... ?? H U........... 070719, ref SDS C0 A16M
210431 -          070621......... 30 H U........... 070621, ref SDS B8 A16M
210432 -          070524......... 37 H U........... 070524, ref SDS B3 A16M
210433 -          070511......... 56 H K........... 070516, ref SDS A8 RH9H
210434 -          070426......... 29 ..U........... 070426, ref SDS A3 A16M
210435 -          070329......... 33 H U........... 070406, ref SDS 96 EQ6I
210436 -          070301......... 36 H U........... 070307, ref SDS 78 A16M
210437 -          070215......... 52 H K........... 070307, ref SDS 73 ER5O
210438 -          070208......... 55 H K........... 070307, ref SDS 73 ER5O
210439 -          070201.....cetuximab begins...... 070201, ref SDS 71 G68I
210440 -          070131......... 56 H K........... 070202, ref SDS 72 087J
210441 -          070123......... 52 H K........... 070202, ref SDS 72 087J
210442 -          070118......... 68 H K........... 070123, ref SDS 67 GK5B
210443 -          070104......... 56 H K........... 070110, ref SDS 63 087J
210444 -          061218......... 74 H K........... 061227, ref SDS 57 6P9F
210445 -          061214......... 63 H............. 061227, ref SDS 57 6P9F
210446 -          061201....Pause treatments..... . 061201, ref SDS 53 GJ5M
210447 -          061130......... 67 H............. 061201, ref SDS 53 087J
210448 -          061116......... 66 H............. 061201, ref SDS 53 087J
210449 -          061110......... 56 H............. 061201, ref SDS 53 087J
210450 -          061109......... 61 H............. 061110, ref SDS 52 087J
210451 -          061026......... 57 H............. 061110, ref SDS 52 087J
210452 -          061019......... 56 H............. 061020, ref SDS 50 087J
210453 -          060928......... 51 H............. 060929, ref SDS 47 087J
210454 -          060907......... 68 H............. 060929, ref SDS 47 087J
210455 -          060813......... 73 H............. 060817, ref SDS 44 U24M
210456 -          060809......... 87 H............. 060810, ref SDS 43 2N5J
210457 -          060721.begin capacitabine Taxotr. 060721, ref SDS 39 0001
210458 -          060708......... 71 H............. 060711, ref SDS 38 087J
210459 -          060616......... 63 H............. 060623, ref SDS 37 UQ5Q
210460 -          060522......... 59 H............. 060605, ref SDS 36 UQ5Q
210461 -          060501......... 49 H............. 060522, ref SDS 35 MC4F
210462 -          060421......... 44 H............. 060428, ref SDS 33 087J
210463 -          060330......... 40 H............. 060428, ref SDS 33 087J
210464 -          060303......... 36............... 060428, ref SDS 33 087J
210465 -          060210......... 33............... 060217, ref SDS 32 087J
210466 -          060109......... 34............... 060126, ref SDS 31 KV59
210467 -          051223......... 34............... 060106, ref SDS 30 087J
210468 -          051202....**... 28............... 060106, ref SDS 30 087J
210469 -          051116......... 31............... 051121, ref SDS 29 087J
210470 -          051109......... 30............... 051121, ref SDS 29 087J
210471 -          051102......... 34............... 051121, ref SDS 29 087J
210472 -          051021..Mastectomy surgery....... 051021, ref SDS 28 0001
210473 -          050916..End capecitabine Taxotere 050916, ref SDS 26 407N
210474 -          050909......... 45 H............. 051007, ref SDS 27 087J
210476 -  ..
210477 - Note:  CA 15-3 history prior to 2006 listed on 070426. ref SDS A2 CY4F
210478 -
210479 -
210481 -  ..
210482 - CA 15-3 95 Cancer Marker Stable Aligns Favorable CT and Examination
210483 -
210484 - Follow up ref SDS J8 VS9M, ref SDS A2 GJ5M.
210485 -
210486 - Patient history applying CA 15-3 cancer marker is shown in a case
210487 - study on 030710. ref SDS 7 IA7H
210489 -  ..
210490 - Millie had a blood test at Kaiser on 080708 for Power Port surgery.
210491 - ref SDS H6 MF4K  Results CA 15-3 141 were received on 080712, and
210492 - reported to UCSF at that time. ref SDS H7 K14R  This was a significant
210493 - increase from 72 reported at UCSF 2 weeks earlier on 080626.
210494 - ref SDS H4 PW7I  Kaiser's lab report on 080708 has a comment that the
210495 - blood sample was slightly hemolyzed.  Results may be affected.
210496 - ref SDS H6 05YW  At that time, on 080712 Millie asked about new drugs
210497 - to treat progression of disease. ref SDS H7 K15P
210499 -  ..
210500 - The test at UCSF a few weeks later on 080724 shows CA 15-3 71, which
210501 - seemed to indicate continuing response to treatment in the clinical
210502 - study. ref SDS I5 TR4K  Results at UCSF seemed further to indicate
210503 - that CA 15-3 141 at Kaiser on 080708 was actually corrupted, and so
210504 - did not show progerssion of disease.  Results 4 weeks later on 080821
210505 - CA 15-3 96 causes concern that testing at Kaiser on 080708 might have
210506 - been accurate indicating cancer is rising.
210508 -  ..
210509 - On 080829 primary care physician at Kaiser recommended Millie discuss
210510 - with UCSF options for changing chemotherapy drugs to prevent cancer
210511 - from spreading. ref SDS K7 RP9R
210513 -  ..
210514 - Results for the test today received a few days later, showing decline,
210515 - and essential stable cancer marker, CA 15-3 95, ref SDS 0 GP3M, seem
210516 - to align with the report on the CT test last week on 080911 also
210517 - showing stable condition, reviewed on 080912, ref SDS L2 4K5H, and
210518 - discussed with the medical team today, per below. ref SDS 0 MF9K
210519 - Stable cancer marker further aligns with examination today finding no
210520 - evidence of adenopathy in the left supraclavicular, ref SDS 0 4C6O,
210521 - and that IBC rash sites seem stable to improved. ref SDS 0 YW6M
210522 -
210523 -
210524 -
210525 -
2106 -

SUBJECTS
Meeting Examination Doctor Review Strategy  Wrk Plan 7th Cycle 1st T

3103 -
310401 -  ..
310402 - Emotional Roller Coaster Stress Anxiety Wellness Support Group
310403 -
310404 - Follow up ref SDS J8 MM5N, ref SDS I4 W992.
310405 -
310406 - Brigid reported receiving Millie's letter yesterday on 080917
310407 - explaining increased energy, and also emotional relief as a result of
310408 - a successful CT test using the Power Port, correcting prior problems.
310409 - ref SDS L5 SH3R
310411 -  ..
310412 - She asked how Millie is feeling today, after concerns reviewed 4 weeks
310413 - ago on 080821? ref SDS J8 VN6M
310415 -  ..
310416 - Emotional issues this period include...
310417 -
310418 -    1.  Rise and fall of the cancer marker reported today makes the
310419 -        future more uncertain about changing treatment, per above.
310420 -        ref SDS 0 PP5G
310421 -
310422 -    2.  Improvement in blood counts enabling treatment today, relieves
310423 -        stress last month when treatment was missed due to neutropenia,
310424 -        reported below. ref SDS 0 7R5J
310426 -         ..
310427 -    3.  Continual mistakes in schedule for Neupogen treatments and
310428 -        repeated corrections increase worry about medical management,
310429 -        reported on 080823. ref SDS K1 WJ4O
310431 -         ..
310432 -    4.  CT testing at Kaiser using Power Port on 080911, ref SDS L1
310433 -        LK3R, significantly relieved worry, as reported in Millie's
310434 -        letter to the medical team yesterday on 080817. ref SDS L5 SG9T
310436 -         ..
310437 -    5.  CT test results showing stable conditions and no evident rise
310438 -        in cancer, which seems conflicting with cancer marker, per
310439 -        below, causes "roller coaster" of emotions.
310441 -  ..
310442 - Background on stress, anxiety, and worry from long term cancer is
310443 - reported on 080403. ref SDS E5 MK8F  Earlier on 070921 the doctor
310444 - ordered Atavin to relieve anxiety and worry about cancer relapse
310445 - compounded by difficulties with referral coordination and errors in
310446 - medical management. ref SDS C4 QY9V
310448 -  ..
310449 - Prozac was prescribed on 080305 ref SDS D8 KT4J, to cope with rising
310450 - emotional trauma, which continues today, listed above. ref SDS 0 H76K
310451 - Millie has not taken medication, and has relied on exercise to relieve
310452 - stress, reported on 080403. ref SDS E5 336H  Patient history on 080915
310453 - shows increased exercise that reflects better fitness. ref SDS L4 FN5K
310455 -  ..
310456 - Case study on emotional roller coaster was reported during examination
310457 - at Kaiser on 070105, ref SDS 62 Y642  Rising complexity of health
310458 - care, compare 33 medical issues on 061201, ref SDS 53 LU3J, with the
310459 - list of 45 issues on 070524, ref SDS B1 LU3J, compound communication
310460 - problems cited on 070301. ref SDS 77 O24J  Case study on 061020 shows
310461 - doctors describe Millie's complex patient history requires significant
310462 - effort to maintain order. ref SDS 50 T25H
310463 -
310464 -
310465 -
310466 -
310467 -
310468 -
3105 -

SUBJECTS
Default Null Subject Account for Blank Record

3203 -
320401 -  ..
320402 - Blood Counts Good NEUTS 2.07 Carboplatin Approved Today
320403 - Neutropenia Controled Chemotherapy Treatment Approved Today
320404 -
320405 - Follow up ref SDS J8 6Y5K.
320406 -
320407 - Millie went to the 5th floor at 0800 for a blood draw. ref SDS L6 LO4G
320409 -  ..
320410 - The work order was already prepared, ready for implementation by the
320411 - Infusion Clinic, as set out in the letter last night listing the
320412 - agenda for today. ref SDS L5 SG6T  This continued solving problems
320413 - communication, reported on 080821. ref SDS J8 XJ7M
320415 -  ..
320416 - Brigid checked the computer.  Results for the blood this morning test
320417 - were already posted by the lab on the 5th floor.
320419 -  ..
320420 - NEUTS 2.07 today is well above UCSF criteria for safe chemotherapy
320421 - shown in the blood test report performed in the Infusion Clinic this
320422 - morning. ref SDS L6 QY6H
320424 -  ..
320425 - Improved blood counts and getting treatment relieves emotional trauma
320426 - from disappointing results last month that prevented treatment,
320427 - discussed on 080821, ref SDS J8 4A4G, with consequent rise of cancer
320428 - marker, and discussed again today, per above. ref SDS 0 H76K
320430 -  ..
320431 - Brigid commended Millie for asking Kaiser to schedule Neupogen
320432 - treatments according to Doctor Rugo's guidance on 080821 that optimum
320433 - effects restoring blood counts occur when Neupogen is received at
320434 - least 24 hours after treatment with chemotherapy. ref SDS J8 4B4L
320435 - This was applied at Kaiser on 080823. ref SDS K1 JP5O  Schedule errors
320436 - on 080905, ref SDS K9 3D5F, were corrected by Kaiser on 080913.
320437 - ref SDS L3 WJ4O
320439 -  ..
320440 - Today, Brigid discussed the prescription for Neupogen.
320442 -  ..
320443 - Chemotherapy Orders for the past 6 cycles beginning on 080529 has
320444 - prescribed 2 Neupogen treatments for each week Millie gets
320445 - chemotherapy treatments with Carboplatin. ref SDS G2 PWSY  On 080609
320446 - Kaiser set up a schedule for Millie to get Neupogen treatments ordered
320447 - by UCSF. ref SDS G6 L16I  Neupogen stimulates bone marrow replenishing
320448 - the blood supply, which is reduced by chemotherapy, reported on
320449 - 030606. ref SDS 6 JP7G
320451 -  ..
320452 - Brigid noted advantages of minimizing Neupogen treatments.
320454 -  ..
320455 - Considered getting only 1 or no Neupogen today, because NEUTS 2.07 in
320456 - the blood test today is well above 1.50, the level required for safe
320457 - chemotherapy treatment today.  Millie recalled that 4 weeks ago
320458 - Carboplatin chemotherapy treatment was missed on 080821, ref SDS J8
320459 - MX7G, when Neupogen was skipped following the 4th week in the cycle,
320460 - when Millie does not get Carboplatin chemotherapy, reported on 080814.
320461 - ref SDS J7 UK3K
320462 -
320464 -  ..
320465 - Neutropenia Controlled with Neupogen No Missed Treatments This Cycle
320466 -
320467 - Case study indicates better control of neutropenia, reported in the
320468 - record today on getting chemotherapy treatment. ref SDS L6 OK67
320470 -  ..
320471 - Millie has not missed prescribed chemotherapy treatments due to low
320472 - blood counts, since 080821, ref SDS J8 4B84, following decision at
320473 - that time to treat low blood counts with Neupogen on all 4-weeks of
320474 - the cycle, even when Millie does not get chemotherapy. ref SDS J8 4B95
320475 - Last week is an example.  On 080911 Millie's blood counts NEUTS 1.43
320476 - were below the minimum, and Millie did not get chemotherapy because
320477 - the 4th week of the cycle is a bye week for chemotherapy. ref SDS L0
320478 - PU6K  This was similar to 080814, ref SDS J7 3L8Y, when Neupogen
320479 - treatment was avoided, because many patients recover blood counts
320480 - after missing chemotherapy for 2 weeks. ref SDS J7 UK3K
320482 -  ..
320483 - Since Millie has received cancer treatments for more than 7 years, and
320484 - since not many patients survive that long, reported on 080606,
320485 - ref SDS G5 0T6I, effects of chemotherapy accumulate.  Her body now
320486 - recovers blood counts to restore the immune system less quickly than
320487 - patients just starting chemotherapy.  As a result, missing Neupogen
320488 - following treatment for the 4th week of cycle 6 on 080814, caused
320489 - Millie to miss chemotherapy the following week on 080821. ref SDS J8
320490 - 4B84
320492 -  ..
320493 - The problem was avoided this past week by getting 2 Neupogen
320494 - treatments at Kaiser last week, reported on 080913, ref SDS L3 9W9I,
320495 - following treatment at UCSF for the 4th week of cycle 7 on 080911.
320496 - ref SDS L0 PU6K
320498 -  ..
320499 - Experience controlling neutropenia that allows getting prescribed
320500 - chemothearpy treatments supportes continuing with 2 Neupogen
320501 - treatments for the first 3 weeks when Millie gets both cetuximab and
320502 - Carboplatin, and to assess on the 4th week whether to get Neupogen
320503 - based on blood counts at that time.
320504 -
320505 -
320506 -
3206 -

SUBJECTS
Default Null Subject Account for Blank Record

3303 -
330401 -  ..
330402 - Chemotherapy Tolerance Remains Effective for High Level Exercise
330403 - Neupogen Side Effects Fatigue, Bone Pain, Headaches Minimal
330404 - Exercise Continues High Level of Effort Neupogen Side Effects Moderate
330405 -
330406 - Follow up ref SDS J8 LT6I.
330407 -
330408 - Brigid noted Millie's fitness keeping up regular exercise in the gym,
330409 - and hiking, related in Millie's letter yesterday submitting an agenda
330410 - for the meeting today. ref SDS L5 SH3R  Increased fitness helps cope
330411 - with emotional challenges of long term care recovering from cancer,
330412 - reported today, per above, ref SDS 0 MM5N and previously starting the
330413 - 7th cycle on 080821. ref SDS J8 MM5N  Emotional balance maintained
330414 - through exercise helps avoid reliance on drugs, e.g., Prozac, reported
330415 - to Kaiser on 080502, ref SDS F5 QU4M, and cited again during the
330416 - meeting today at UCSF. ref SDS 0 ZK5L
330418 -  ..
330419 - Millie thanked the doctor for guiding care the past 18 months that has
330420 - increased quality of life, cited in Millie's letter to UCSF on 080804,
330421 - reporting Millie has recovered vitality and strength to return to
330422 - work. ref SDS I8 GU5P
330424 -  ..
330425 - The report on chemotherapy and Neupogen side effects in the record for
330426 - treatment in the Infusion Clinic today, ref SDS L6 SB8I, aligns with
330427 - prior reporting on 080810 that shows good tolerance of both
330428 - chemotherapy and Neupogen, which has not reduced ability nor interest
330429 - in exercise. ref SDS J3 9W9I  The recent report on 080915 indicates
330430 - occassional side effects are difficult, but manageable, ref SDS L4
330431 - 9W9I, shown by continued heavy exercise. ref SDS L4 KO6F
330433 -  ..
330434 - Favorable findings from examination and testing today despite missing
330435 - treatments and reduced dose of chemotherapy Carboplatin may reflect
330436 - reduced side effects of cetuximab that enable increased exercise to
330437 - improve fitness that strengthens the immune system, discussed below.
330438 - ref SDS 0 YW6M  Vigorous exercise during treatment for cancer
330439 - illustrates reduced side effects of "targeted" treatment for cancer
330440 - with cetuximab.
330442 -         ..
330443 -        [On 081014 Millie's fitenss increases from increased exercise,
330444 -        that may be helping resist cancer. ref SDS L9 P49N
330446 -         ..
330447 -        [On 081018 report in seminar that recent research indicates
330448 -        exercise improves recovery from cancer and resists recurrence
330449 -        by 60%. ref SDS M3 IT68
330450 -
330451 -
330452 -
330453 -
3305 -

SUBJECTS
Default Null Subject Account for Blank Record

3403 -
340401 -  ..
340402 - Interstitional Lung Disease CT Test 080718 Heavy Chest Hiking Reduced
340403 -
340404 - Follow up ref SDS J8 056G, ref SDS I8 GU6P.
340405 -
340406 - The agenda for the meeting today reports favorable results for the CT
340407 - test on 080911, reviewed the next day on 080912. ref SDS L5 SG5Q  As
340408 - shown on 080912, the test makes no findings on Interstitial lung
340409 - disease, ref SDS L2 TS4J, which was reported in the prior CT test on
340410 - 080718, reviewed on 080723. ref SDS I3 TS4J
340412 -  ..
340413 - Background on Interstitional disease in Millie's patient history is
340414 - shown in a case study on 080723. ref SDS I3 7W6F  This presents 6
340415 - questions about risk of complications in Millie's case. ref SDS I3
340416 - 6A4J
340418 -  ..
340419 - The question arises from Millie's long treatment with cetuximab
340420 - beginning on 070201.  Interstitional lung disease is described in the
340421 - study consent documents as a serious side effect of cetuximab.
340422 - ref SDS 64 0256
340424 -  ..
340425 - During the meeting on 080724 UCSF could not consider findings of
340426 - Interstitional lung disease nor on risk of complications for Millie's
340427 - health care, because they did not get a copy of the CT test report
340428 - from Kaiser in time for the meeting. ref SDS I4 GG6J
340430 -  ..
340431 - A month later, Millie sent a letter with an agenda for meeeting with
340432 - UCSF on 080821.  She reported heaviness in her chest days earlier
340433 - while hiking, and this was less pronounced by the date of the meeting
340434 - on 080821. ref SDS J8 R37H  Scope and seriousness of Interstitional
340435 - lung disease as a rare side effect of cetuximab, which Millie has now
340436 - received for the past 85 weeks in a row, set out in the record meeting
340437 - on 080821, ref SDS J8 VB8J, including whether increased exercise helps
340438 - moderate the advance of this disease in Millie's case, was not
340439 - discussed with the medical team on 080821 due to limited time.
340440 - ref SDS J8 VB9I
340442 -  ..
340443 - There was no discussion of Interstitional lung disease during the
340444 - meeting today, perhaps because the more recent CT test on 080911 did
340445 - not report findings, as shown on 080912, ref SDS L2 TS4J, and as shown
340446 - below. ref SDS 0 MF6F
340447 -
340448 -
340449 -
340450 -
340451 -
3405 -

SUBJECTS
Default Null Subject Account for Blank Record

3503 -
350401 -  ..
350402 - CT Test 080911 Shows Stable Improving IBC Response to Treatment
350403 -
350404 - Follow up ref SDS J8 4U6L, ref SDS I4 TG96.
350405 -
350406 - Millie had a CT test on 080911, ref SDS L1 LK3R, required to evaluate
350407 - progress responding to treatment under the clinical study protocol.
350408 - Results were received the next day on 080912, ref SDS L2 6V5I, and
350409 - reviewed at that time. ref SDS L2 OO6M  Yesterday, on 080917 Millie
350410 - reported understandings from the CT test in a letter setting the
350411 - agenda for the meeting today, which described findings show everything
350412 - stable. ref SDS L5 SG5Q
350414 -  ..
350415 - Today, Brigid reviewed the CT test report findings and seemed to
350416 - conclude that swelled lymph nodes in the right axillary appear stable,
350417 - as shown in the record on 080912, ref SDS L2 4K5H   This aligns with
350418 - stable cancer marker, CA 15-3 95, reported a few days later for the
350419 - blood test today, per above, ref SDS 0 GP3M, further discussing
350420 - analysis and implications. ref SDS 0 RS3K
350421 -
350422 -        [...below, Brigid reported that palpation of right axilla
350423 -        cannot identify swelling, which aligns with the CT test
350424 -        reporting very small nodes. ref SDS 0 4C6K
350426 -  ..
350427 - Brigid noted that no findings of swelling in the left supraclavicular
350428 - aligns with examination today palpating no swelling in this area, per
350429 - below. ref SDS 0 4C6O
350431 -  ..
350432 - On 080827 Millie's letter to Kaiser and the medical team requested
350433 - that the CT test on 080912 focus on left side of the neck. ref SDS K3
350434 - 509V
350435 -
350436 -            [On 081022 Doctor Daamen takes biopsy of swelled lymph node
350437 -            in left supraclavicular, and reviews CT test on 080911, and
350438 -            says the scans did not include enough of the neck to
350439 -            evaluate the node in the left supraclavicular. ref SDS M4
350440 -            516F
350442 -  ..
350443 - Interstitional lung disease was not discussed today, per above.
350444 - ref SDS 0 NW6O, to follow up findings reviewed on 080723, ref SDS I3
350445 - TS4J, in the report on the CT test performed 080718, perhaps because
350446 - the report for the test last week on 080911 makes not findings of
350447 - Interstitional lung disease, reported the next day on 080912.
350448 - ref SDS L2 TS4J
350449 -
350450 -
350451 -
3505 -

SUBJECTS
Default Null Subject Account for Blank Record

3603 -
360401 -  ..
360402 - Schedule CT Test 081107 at Kaiser Walnut Creek After Treatment at UCSF
360403 -
360404 - Follow up ref SDS J8 MF5L.
360405 -
360406 - The letter yesterday to the medical team planning the meeting today
360407 - discusses scheduling the next CT test on 081113. ref SDS L5 SH5Q  The
360408 - next test is actually needed on 081107, which is 8 weeks after the
360409 - last test at Kaiser in Oakland on 080911. ref SDS L1 358L
360411 -  ..
360412 - During the meeting, Brigid concurred with doing the next CT test on
360413 - 081107, 8 weeks after the test last week.  This aligns with Doctor
360414 - Rugo's guidance on 080811 for doing CT tests on an 8 week schedule.
360415 - ref SDS J4 4T4N
360416 -
360417 -        [On 081016 work plan specifies CT test at Kaiser on 081107 for
360418 -        screening to participate in a new drug trial for sunitinib
360419 -        clinical study. ref SDS M2 J44X
360420 -
360421 -
360422 -
360423 -
360424 -
3605 -

SUBJECTS
Default Null Subject Account for Blank Record

3703 -
370401 -  ..
370402 - Examination Indicates Continuing Recovery 4th Relapse IBC
370403 - Axillary Sites Palpation Aligns CT Tests Minimal to No Swelling
370404 -
370405 - Follow up ref SDS J8 4C6K, ref SDS I4 FH7M.
370406 -
370407 - Brigid advised that palpation finds no evidence of swelling in the
370408 - left or right axillary.  This aligns with prior examinations, most
370409 - recently starting cycle 7 on 080821, ref SDS J8 4C6K, and starting the
370410 - prior cycle 6 on 080724. ref SDS I4 FH7M
370412 -  ..
370413 - This further aligns with the CT test on 080911.  As seen from
370414 - discussion today with the medical team, per above, ref SDS 0 MF9K,
370415 - Review the next day on 080912 seemed to indicate stable to improved
370416 - conditions on the right axilla where nodes are reported so small that
370417 - palpation is difficult, ref SDS L2 4K5H, and further the CT test found
370418 - no evidence of swelling in the left side. ref SDS L2 WM9L
370419 -
370420 -
370421 -
3705 -

SUBJECTS
Default Null Subject Account for Blank Record

3803 -
380401 -  ..
380402 - Lump Left Supraclavicular Area of Neck Palpation No Findings
380403 -
380404 - Follow up ref SDS J8 4C6O.
380405 -
380406 - The letter submitted to the team yesterday on 080917 for the agenda
380407 - today cites the letter on 080829 reporting Kaiser noticed swelling in
380408 - the left supraclavicular, and is willing to approve follow on
380409 - treatment if UCSF diagnoses progression of disease. ref SDS L5 SH5T
380411 -  ..
380412 - Today, Brigid could not find the slight lump in the area of the left
380413 - supraclavicular, which Lynn reported during examination 4 weeks ago on
380414 - 080821, ref SDS J8 4C6O, and which was reported again the following
380415 - week by Millie's primary care physician during examination at Kaiser,
380416 - cited in a letter to the medical team later that day. ref SDS K7 RP8T
380418 -  ..
380419 - This aligns with the CT test on 080911 that presents no findings in
380420 - the left supraclavicular, shown by review in the record the next day
380421 - on 080912. ref SDS L2 5O6N  Since Millie needs another CT in about 3
380422 - weeks on 081107, we can ask for review of the scans to pay close
380423 - attention to the left supraclavicular area.
380424 -
380425 -            [On 081016 doctor orders biopsy of left supraclavicular to
380426 -            evaluate progression of cancer. ref SDS M2 J36R
380428 -             ..
380429 -            [On 081022 Doctor Daamen takes biopsy of swelled lymph node
380430 -            in left supraclavicular, and reviews CT test on 080911, and
380431 -            says the scans did not include enough of the neck to
380432 -            evaluate the node in the left supraclavicular. ref SDS L2
380433 -            516F
380435 -             ..
380436 -            [On 081023 Kaiser reports pathology of biopsy positive for
380437 -            breast cancer. ref SDS M5 4Q9Q
380439 -  ..
380440 - The blood test today yielded results a week later showing the cancer
380441 - marker decreased over the past 4 weeks from 96 to CA 15-3 95 today.
380442 - ref SDS L6 VK6H  This stable condition aligns with examination today
380443 - and the CT test on 080911 that find swelling in the left
380444 - supraclavicular, which suggests there has been no growth of disease to
380445 - increase the cancer marker.
380447 -             ..
380448 -            [On 081016 cancer marker CA 15-3 95 continues stable
380449 -            consistent with continued response to treatment.
380450 -            ref SDS M1 VK6H
380452 -  ..
380453 - Millie has not complained of stiff neck the past 4 weeks, extending to
380454 - 8 weeks the period of not feeling symptoms of rising adenopathy in the
380455 - left supraclavicular, reported on 080821. ref SDS J8 E34I
380456 -
380457 -
380458 -
380459 -
380460 -
3805 -

SUBJECTS
Default Null Subject Account for Blank Record

3903 -
390401 -  ..
390402 - IBC Inflammation Rash Seem Stable and Possibly Subsiding
390403 -
390404 - Follow up ref SDS J8 YW6M.
390405 -
390406 - Millie's letter to UCSF yesterday comments on hopes that IBC rash
390407 - looks stable. ref SDS L5 SH4U
390409 -  ..
390410 - Today, Brigid looked carefully at all of the IBC sites and determined
390411 - that conditions seem improved to stable, continuing review last month
390412 - on 080821 by Lynn, who noted that IBC disease at all sites does not
390413 - give the impression of significant intensity compared with other
390414 - patients. ref SDS J8 YX49  At that time, on 080821 Doctor Rugo also
390415 - made examination and commented favorably on continuing improvement.
390416 - ref SDS J8 YX52
390418 -  ..
390419 - Examination today finding stable IBC rash seems to align with finding
390420 - no evident adenopathy in the right axilla, ref SDS 0 4C6K, nor the
390421 - left supraclavicular, ref SDS 0 366L, and further aligns with the
390422 - recent CT test on 080911, where review on 080912 indicates no
390423 - significant rise of adenopathy, ref SDS L2 OO6M; similarly, the cancer
390424 - marker has been stable for 2 months, per above, ref SDS 0 GP3M, after
390425 - having increased significantly the prior 2 months, reported on 080821.
390426 - ref SDS J9 VK6H
390428 -  ..
390429 - Favorable findings from examination and tests treating the 4th relapse
390430 - of IBC reflects improved control this cycle of neutropenia, cited
390431 - above, ref SDS 0 KF4L, which previously caused Millie to miss 20% of
390432 - prescribed chemotherapy treatments with Carboplatin, reported in case
390433 - study of patient history on getting treatment today in the Infusion
390434 - Clinic. ref SDS L6 OK67  Favorable findings today were achieved
390435 - despite error reported on reducing the dose of chemothapy treatment,
390436 - beginning on 080529. ref SDS G2 PVUQ
390438 -  ..
390439 - Continued response to treatment of IBC after 7 cycles of Carboplatin
390440 - where 20% of treatments were missed, and the dose was reduced, may be
390441 - aided by Millie's ability to improve fitness and thereby strengthen
390442 - the immune system through increased exercise, enabled by reduced side
390443 - effects of "targeted" treatment with cetuximab, discussed above.
390444 - ref SDS 0 LT6I  The primary care physician at Kaiser reported on
390445 - 030606 that exercise maintains the immune system that helps resist
390446 - advance of cancer. ref SDS 6 JP7G  Millie's experience from treatment
390447 - with the cetuximab and Carboplatin clinical study aligns with
390448 - published studies showing exercise aids the immune system, ref SDS 24
390449 - F88M, and improves quality of life with better strength and range of
390450 - motion, reviewed on 050609. ref SDS 24 F93X
390451 -
390452 -            [On 081014 Millie's fitenss increases from increased
390453 -            exercise, that may be helping resist cancer. ref SDS L9
390454 -            P49N
390456 -             ..
390457 -            [On 081016 cancer marker CA 15-3 95 continues stable
390458 -            consistent with continued response to treatment.
390459 -            ref SDS M1 VK6H
390461 -             ..
390462 -            [On 081016 examination indicates increased IBC intensity on
390463 -            left arm and small IBC nodules in the breast bone area,
390464 -            conflicting with stable cancer marker; other IBC rash sites
390465 -            seem stable to improved, consistent with stable cancer
390466 -            marker. ref SDS M2 J34U
390468 -             ..
390469 -            [On 081016 doctor orders biopsy of left supraclavicular to
390470 -            evaluate progression of cancer. ref SDS M2 J36R
390472 -             ..
390473 -            [On 081018 report in seminar that recent research indicates
390474 -            exercise improves recovery from cancer and resists
390475 -            recurrence by 60%. ref SDS M3 IT68
390477 -             ..
390478 -            [On 081022 Doctor Daamen takes biopsy of swelled lymph node
390479 -            in left supraclavicular, and reviews CT test on 080911, and
390480 -            says the scans did not include enough of the neck to
390481 -            evaluate the node in the left supraclavicular. ref SDS L2
390482 -            516F
390484 -             ..
390485 -            [On 081023 Kaiser reports pathology of biopsy positive for
390486 -            breast cancer. ref SDS M5 4Q9Q
390487 -
390488 -
3905 -

SUBJECTS
Default Null Subject Account for Blank Record

4003 -
400401 -  ..
400402 - Photographs Show IBC Disease Subsiding All Sites
400403 -
400404 - Follow up ref SDS J8 G74J, ref SDS E5 SA5J.
400405 -
400406 - Background on purpose of photographs and difficulties managing patient
400407 - medical history is reported in the record on 080331. ref SDS E3 GM5I
400409 -  ..
400410 - On 080821, 4-weeks ago, Jill took photographs to evaluate progression
400411 - of disease during examination by Lynn, and Doctor Rugo. ref SDS J8
400412 - G74J
400414 -  ..
400415 - UCSF has been taking pictures on an 8 week schedule, so no pictures
400416 - were taken today.
400417 -
400418 -
400419 -
4005 -

SUBJECTS
Default Null Subject Account for Blank Record

4103 -
410401 -  ..
410402 - Treatment Options Work Plan
410403 - Progression Disease Kaiser Approves UCSF for Continuing Treatment
410404 -
410405 - Millie's letter to the medical team on 080829 reported primary care
410406 - physician at Kaiser approved continuing treatment at UCSF after
410407 - progression of disease from current clinical trial, ref SDS K7 RP9R,
410408 - and cited in Millie's letter to the medical team yesterday, 080917 for
410409 - the agenda to guide the meeting today. ref SDS L5 SH5T
410411 -  ..
410412 - Today, there wasn't enough time for discussion of follow on treatments
410413 - approved by the primary care physician at Kaiser after examination on
410414 - 080829 showing possible progression of disease.  Favorable examination
410415 - and stable test results, ref SDS 0 YW6M, may have seemed like planning
410416 - for follow on treatment was unnecessary.
410417 -
410418 -            [On 081015 agenda for meeting with medical team at UCSF
410419 -            requests review of future treatments. ref SDS M0 K45V
410421 -             ..
410422 -            [On 081016 Doctor Rugo proposes follow on treatment with
410423 -            Sunitinib clinical study, ref SDS M2 J38U, which is
410424 -            another targeted chemotherapy; and additionally, Millie
410425 -            will qualify for participation in another clinical trial
410426 -            opening in about 4 months. ref SDS M2 J35X
410428 -             ..
410429 -            [On 081016 Doctor proposes FNA biopsy to check for
410430 -            status change ER PR HER2 neu, which could increase
410431 -            treatments for Millie. ref SDS M2 J36R
410433 -             ..
410434 -            [On 081018 Doctor Stritter speaking at a Wellness Community
410435 -            event related her research showing promising potential for
410436 -            Millie's treatment with Sunitinib. ref SDS M3 PQ6X
410438 -             ..
410439 -            [On 081022 Doctor Daamen takes biopsy of swelled lymph node
410440 -            in left supraclavicular, and reviews CT test on 080911, and
410441 -            says the scans did not include enough of the neck to
410442 -            evaluate the node in the left supraclavicular. ref SDS L2
410443 -            516F
410445 -             ..
410446 -            [On 081023 Kaiser reports pathology of biopsy positive for
410447 -            breast cancer. ref SDS M5 4Q9Q
410448 -
410449 -
410450 -
410451 -
4105 -

SUBJECTS
Default Null Subject Account for Blank Record

4203 -
420401 -  ..
420402 - Current Medications Submitted with Kaiser's Medical Chart
420403 -
420404 - Follow up ref SDS J8 8A9G, ref SDS I4 8A9G.
420405 -
420406 - Background on Millie's current medications listed at UCSF was reviewed
420407 - during the meeting last month starting cycle 6 on 080724, ref SDS I4
420408 - 8A9G, when Millie cited the list discussed for cycle 5 on 080626,
420409 - ref SDS H3 8A9G, which was presented at Kaiser on 080502. ref SDS F5
420410 - E43I  The list is summarized in Kaiser's medical chart on 080502.
420411 - ref SDS F5 7Y6F
420413 -  ..
420414 - Millie advised there has been no change in the list which previously
420415 - appeared on 080724 to be incomplete. ref SDS I4 PK7I
420417 -  ..
420418 - Brigid can update UCSF records on Millie's current medications using
420419 - the procedure applied this morning to update the UCSF medical chart
420420 - for Millie with results on prior blood tests.  She will similarly add
420421 - medications to the UCSF medical chart that are listed in Kaiser's
420422 - medical chart from meeting with the primary care physician on 080502,
420423 - ref SDS F5 7Y6F, and which was submitted in Millie's letter to UCSF on
420424 - 080821. ref DIP 3 YO5V
420425 -
420426 -
420427 -
420428 -
420429 -
420430 -
420431 -
420432 -
4205 -